Published in Nature on January 24, 2002
Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species. J Hered (2009) 7.18
Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol (2009) 6.10
Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med (2011) 5.60
Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev (2008) 5.28
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res (2008) 4.23
Designing antimicrobial peptides: form follows function. Nat Rev Drug Discov (2011) 4.16
Platforms for antibiotic discovery. Nat Rev Drug Discov (2013) 3.66
AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol (2009) 3.40
Variation in immune defence as a question of evolutionary ecology. Proc Biol Sci (2003) 3.38
Studies on anticancer activities of antimicrobial peptides. Biochim Biophys Acta (2007) 3.24
Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol (2012) 3.21
Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol (2010) 3.12
Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol (2007) 2.79
Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 2.43
Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides. Proc Natl Acad Sci U S A (2008) 2.35
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci U S A (2003) 2.32
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature (2011) 2.31
Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS Pathog (2006) 2.27
T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol (2015) 2.24
A novel family in Medicago truncatula consisting of more than 300 nodule-specific genes coding for small, secreted polypeptides with conserved cysteine motifs. Plant Physiol (2003) 2.19
On the epidemiology of influenza. Virol J (2008) 2.17
Ultrashort antibacterial and antifungal lipopeptides. Proc Natl Acad Sci U S A (2006) 2.15
Experimental evolution of resistance to an antimicrobial peptide. Proc Biol Sci (2006) 2.12
Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother (2005) 2.11
Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). J Cyst Fibros (2007) 2.07
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med (2008) 2.04
CAMP: a useful resource for research on antimicrobial peptides. Nucleic Acids Res (2009) 2.02
Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation. Biophys J (2003) 1.99
A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr Eye Res (2005) 1.97
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev (2010) 1.97
Clostridium difficile associated infection, diarrhea and colitis. World J Gastroenterol (2009) 1.97
Foldamers with heterogeneous backbones. Acc Chem Res (2008) 1.96
De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A (2002) 1.95
The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. PLoS Pathog (2009) 1.94
Symbiont-mediated protection. Proc Biol Sci (2008) 1.92
Cell-penetrating peptides and antimicrobial peptides: how different are they? Biochem J (2006) 1.92
Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR. Proc Natl Acad Sci U S A (2006) 1.87
Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides. Antimicrob Agents Chemother (2006) 1.87
Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol (2012) 1.86
Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract. Kidney Int (2013) 1.81
Membrane thinning due to antimicrobial peptide binding: an atomic force microscopy study of MSI-78 in lipid bilayers. Biophys J (2005) 1.81
Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations. Nat Rev Microbiol (2009) 1.79
Antimicrobial peptides: primeval molecules or future drugs? PLoS Pathog (2010) 1.76
Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides. Proc Natl Acad Sci U S A (2008) 1.76
Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol (2005) 1.75
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A (2006) 1.75
Mechanisms of antimicrobial, cytolytic, and cell-penetrating peptides: from kinetics to thermodynamics. Biochemistry (2009) 1.72
Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores. Proc Natl Acad Sci U S A (2008) 1.70
Solid-state NMR investigation of the membrane-disrupting mechanism of antimicrobial peptides MSI-78 and MSI-594 derived from magainin 2 and melittin. Biophys J (2006) 1.70
Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci (2006) 1.68
Comparative and developmental study of the immune system in Xenopus. Dev Dyn (2009) 1.68
Interfacial folding and membrane insertion of designed peptides studied by molecular dynamics simulations. Proc Natl Acad Sci U S A (2005) 1.66
Applications of biological pores in nanomedicine, sensing, and nanoelectronics. Curr Opin Biotechnol (2010) 1.66
A quantitative model for the all-or-none permeabilization of phospholipid vesicles by the antimicrobial peptide cecropin A. Biophys J (2007) 1.64
Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. Proc Natl Acad Sci U S A (2007) 1.64
Understanding nature's design for a nanosyringe. Proc Natl Acad Sci U S A (2004) 1.62
Optically pure, water-stable metallo-helical 'flexicate' assemblies with antibiotic activity. Nat Chem (2011) 1.61
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. Proc Natl Acad Sci U S A (2009) 1.58
The roles of antimicrobial peptides in innate host defense. Curr Pharm Des (2009) 1.58
Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr Eye Res (2005) 1.58
Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A streptococcus M1T1 clone. J Infect Dis (2010) 1.57
Synthetic peptides that exert antimicrobial activities in whole blood and blood-derived matrices. Antimicrob Agents Chemother (2002) 1.57
Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections. PLoS Pathog (2014) 1.56
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun (2005) 1.55
Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach. J Am Chem Soc (2008) 1.54
Vitamin D effects on pregnancy and the placenta. Placenta (2010) 1.53
PspA protects Streptococcus pneumoniae from killing by apolactoferrin, and antibody to PspA enhances killing of pneumococci by apolactoferrin [corrected]. Infect Immun (2004) 1.53
Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J Am Chem Soc (2009) 1.53
De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications. Acc Chem Res (2010) 1.52
Activation of the complement system generates antibacterial peptides. Proc Natl Acad Sci U S A (2004) 1.51
Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayers. Biophys J (2007) 1.50
Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. Infect Immun (2010) 1.48
Tolerogenic plasmacytoid DC. Eur J Immunol (2010) 1.48
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48
Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Clin Diagn Lab Immunol (2004) 1.47
Roles of antimicrobial peptides such as defensins in innate and adaptive immunity. Ann Rheum Dis (2003) 1.46
Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids (2011) 1.45
Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol (2011) 1.45
Damage of the bacterial cell envelope by antimicrobial peptides gramicidin S and PGLa as revealed by transmission and scanning electron microscopy. Antimicrob Agents Chemother (2010) 1.44
Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector. Cell Host Microbe (2016) 1.44
Antimicrobial peptides: natural effectors of the innate immune system. Semin Immunopathol (2007) 1.43
Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection. Infect Immun (2006) 1.41
Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids in Candida albicans. Proc Natl Acad Sci U S A (2009) 1.41
The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect Immun (2004) 1.40
Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells. Infect Immun (2007) 1.38
Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One (2010) 1.38
Antimicrobial peptides. Pharmaceuticals (Basel) (2013) 1.37
In search of a novel target - phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy. Biochim Biophys Acta (2011) 1.36
The contact system--a novel branch of innate immunity generating antibacterial peptides. EMBO J (2006) 1.36
Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies. Antimicrob Agents Chemother (2006) 1.36
Population trends associated with skin peptide defenses against chytridiomycosis in Australian frogs. Oecologia (2005) 1.36
Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids. MBio (2013) 1.35
Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR. Biophys J (2005) 1.34
Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. J Biol Chem (2005) 1.34
Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression. J Exp Med (2008) 1.33
Beyond NMR spectra of antimicrobial peptides: dynamical images at atomic resolution and functional insights. Solid State Nucl Magn Reson (2009) 1.33
Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation. J Immunol (2004) 1.33
MprF-mediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing. Infect Immun (2003) 1.32