Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1.

PubWeight™: 2.31‹?› | Rank: Top 2%

🔗 View Article (PMID 21248850)

Published in Nature on January 20, 2011

Authors

Bjoern O Schroeder1, Zhihong Wu, Sabine Nuding, Sandra Groscurth, Moritz Marcinowski, Julia Beisner, Johannes Buchner, Martin Schaller, Eduard F Stange, Jan Wehkamp

Author Affiliations

1: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.

Articles citing this

(truncated to the top 100)

Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79

Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol (2012) 3.21

Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48

Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol (2011) 1.45

The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol (2013) 1.41

Antimicrobial peptides: old molecules with new ideas. J Invest Dermatol (2011) 1.34

Antimicrobial peptides in 2014. Pharmaceuticals (Basel) (2015) 1.30

Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals? Int J Antimicrob Agents (2011) 1.28

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. Eur J Immunol (2011) 1.27

The potter's wheel: the host's role in sculpting its microbiota. Cell Mol Life Sci (2011) 1.25

Human antimicrobial peptides and proteins. Pharmaceuticals (Basel) (2014) 1.23

Risks associated with high-dose Lactobacillus rhamnosus in an Escherichia coli model of piglet diarrhoea: intestinal microbiota and immune imbalances. PLoS One (2012) 1.20

Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol Med (2013) 1.17

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov (2014) 1.17

Labile disulfide bonds are common at the leucocyte cell surface. Open Biol (2011) 1.14

The innate immune response during urinary tract infection and pyelonephritis. Pediatr Nephrol (2013) 1.10

Human alpha defensin 5 expression in the human kidney and urinary tract. PLoS One (2012) 1.08

Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice. PLoS Genet (2013) 1.04

Fundamental role for HIF-1α in constitutive expression of human β defensin-1. Mucosal Immunol (2013) 1.00

Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus. Biochemistry (2011) 0.99

Intestinal redox biology and oxidative stress. Semin Cell Dev Biol (2012) 0.99

Defensins: antifungal lessons from eukaryotes. Front Microbiol (2014) 0.99

Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated Escherichia coli urinary tract infections. Infect Immun (2014) 0.97

Intestinal barrier in inflammatory bowel disease. World J Gastroenterol (2014) 0.97

Hydrogen sulfide signaling in the gastrointestinal tract. Antioxid Redox Signal (2013) 0.97

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia. Am J Physiol Cell Physiol (2015) 0.96

Host-microbe interactions shaping the gastrointestinal environment. Trends Immunol (2014) 0.95

NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5. Biochemistry (2012) 0.94

Single-cell, real-time detection of oxidative stress induced in Escherichia coli by the antimicrobial peptide CM15. Proc Natl Acad Sci U S A (2015) 0.92

Redox biology of the intestine. Free Radic Res (2011) 0.92

Cationic host defence peptides: potential as antiviral therapeutics. BioDrugs (2013) 0.92

Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide. J Biol Chem (2012) 0.91

Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications. Curr Med Chem (2012) 0.91

Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor. Open Biol (2012) 0.91

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin. Mucosal Immunol (2013) 0.91

Reduction of human defensin 5 affords a high-affinity zinc-chelating peptide. ACS Chem Biol (2013) 0.91

Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg (2012) 0.91

Database-Guided Discovery of Potent Peptides to Combat HIV-1 or Superbugs. Pharmaceuticals (Basel) (2013) 0.90

Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryot Cell (2013) 0.90

Bovicin HJ50-like lantibiotics, a novel subgroup of lantibiotics featured by an indispensable disulfide bridge. PLoS One (2014) 0.90

Blood platelets in the progression of Alzheimer's disease. PLoS One (2014) 0.89

β-Defensin 1 plays a role in acute mucosal defense against Candida albicans. J Immunol (2015) 0.88

The intestinal microbiota: its role in health and disease. Eur J Pediatr (2015) 0.88

Antimicrobial proteins in intestine and inflammatory bowel diseases. Intest Res (2014) 0.88

Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.87

Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis. J Biol Chem (2011) 0.86

Post-translational Modifications of Natural Antimicrobial Peptides and Strategies for Peptide Engineering. Curr Biotechnol (2012) 0.86

Understanding the roles of gingival beta-defensins. J Oral Microbiol (2012) 0.86

Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation. Oncotarget (2016) 0.86

Antimicrobial activities of chemokines: not just a side-effect? Front Immunol (2012) 0.86

Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide. Proc Natl Acad Sci U S A (2015) 0.86

Taste receptors in innate immunity. Cell Mol Life Sci (2014) 0.86

Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulation. PLoS One (2012) 0.85

Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection. Int J Colorectal Dis (2012) 0.85

Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines. Antimicrob Agents Chemother (2013) 0.85

Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides. Antimicrob Agents Chemother (2013) 0.85

Alternative approaches to antifungal therapies. Exp Dermatol (2012) 0.85

Enterohemorrhagic and enteropathogenic Escherichia coli evolved different strategies to resist antimicrobial peptides. Gut Microbes (2012) 0.84

Structural location determines functional roles of the basic amino acids of KR-12, the smallest antimicrobial peptide from human cathelicidin LL-37. RSC Adv (2013) 0.83

Enteric alpha defensins in norm and pathology. Ann Clin Microbiol Antimicrob (2012) 0.83

The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate? Eur J Clin Nutr (2016) 0.83

The novel human β-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss. J Biol Chem (2013) 0.82

The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity. J Biol Chem (2013) 0.82

Lights, Camera, Action! Antimicrobial Peptide Mechanisms Imaged in Space and Time. Trends Microbiol (2015) 0.81

Oxygen metabolism and barrier regulation in the intestinal mucosa. J Clin Invest (2016) 0.81

Antimicrobial protein and Peptide concentrations and activity in human breast milk consumed by preterm infants at risk of late-onset neonatal sepsis. PLoS One (2015) 0.81

Immunology: Peptide gets in shape for self-defence. Nature (2011) 0.81

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide. Mucosal Immunol (2014) 0.81

The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis. J Immunol Res (2014) 0.81

Amplifying renal immunity: the role of antimicrobial peptides in pyelonephritis. Nat Rev Nephrol (2015) 0.80

Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases. Pathogens (2013) 0.80

A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation. J Invest Dermatol (2012) 0.80

Synergistic effects of antimicrobial peptides and antibiotics against Clostridium difficile. Antimicrob Agents Chemother (2014) 0.80

Racemization as a stereochemical measure of dynamics and robustness in shape-shifting organic molecules. Proc Natl Acad Sci U S A (2011) 0.80

Novel phenotype of mouse spermatozoa following deletion of nine β-defensin genes. Asian J Androl (2015) 0.79

Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies. Front Neurosci (2016) 0.78

Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5. Sci Rep (2016) 0.78

Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins. PLoS One (2013) 0.78

The Role of Bitter and Sweet Taste Receptors in Upper Airway Immunity. Curr Allergy Asthma Rep (2015) 0.78

Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota. Sci Rep (2016) 0.78

Race-dependent association of sulfidogenic bacteria with colorectal cancer. Gut (2017) 0.77

Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements. J Biol Chem (2011) 0.77

Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother (2013) 0.77

pH-dependent solution structure and activity of a reduced form of the host-defense peptide myticin C (Myt C) from the mussel Mytilus galloprovincialis. Mar Drugs (2013) 0.77

Structure-function analysis of Avian β-defensin-6 and β-defensin-12: role of charge and disulfide bridges. BMC Microbiol (2016) 0.77

Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B. Toxins (Basel) (2016) 0.77

Host genetics of invasive Aspergillus and Candida infections. Semin Immunopathol (2014) 0.77

Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa. J Leukoc Biol (2015) 0.77

Determining multiallelic complex copy number and sequence variation from high coverage exome sequencing data. BMC Genomics (2015) 0.77

Neutrophil-mediated inflammation in the pathogenesis of Clostridium difficile infections. Anaerobe (2016) 0.76

Cystic fibrosis-related oxidative stress and intestinal lipid disorders. Antioxid Redox Signal (2015) 0.76

The Disulfide Bond of the Peptide Thanatin Is Dispensible for Its Antimicrobial Activity In Vivo and In Vitro. Antimicrob Agents Chemother (2016) 0.76

Defensins and sepsis. Biomed Res Int (2014) 0.76

Toward More GI-Friendly Anti-Inflammatory Medications. Curr Treat Options Gastroenterol (2015) 0.76

PredSTP: a highly accurate SVM based model to predict sequential cystine stabilized peptides. BMC Bioinformatics (2015) 0.75

pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents. Pharmaceuticals (Basel) (2016) 0.75

Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247. Proc Natl Acad Sci U S A (2016) 0.75

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins. Sci Rep (2016) 0.75

The drosomycin multigene family: three-disulfide variants from Drosophila takahashii possess antibacterial activity. Sci Rep (2016) 0.75

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc Natl Acad Sci U S A (2016) 0.75

Articles cited by this

Antimicrobial peptides of multicellular organisms. Nature (2002) 23.50

The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol (2009) 13.87

Molecular analysis of commensal host-microbial relationships in the intestine. Science (2001) 12.04

Thioredoxin. Annu Rev Biochem (1985) 9.82

Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol (2004) 8.45

Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem (2000) 7.25

Ultrasensitive assays for endogenous antimicrobial polypeptides. J Immunol Methods (1991) 4.64

The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat Rev Microbiol (2006) 4.29

Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85

hBD-1: a novel beta-defensin from human plasma. FEBS Lett (1995) 3.79

Interdependence of hypoxic and innate immune responses. Nat Rev Immunol (2009) 3.29

Defensins. Curr Opin Immunol (1994) 2.55

Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. J Clin Microbiol (2003) 1.55

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29

Enzymatic reduction-oxidation of protein disulfides by thioredoxin. Methods Enzymol (1984) 1.29

Antimicrobial peptides in the first line defence of human colon mucosa. Peptides (2003) 1.24

Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease. Scand J Gastroenterol (2008) 1.22

Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity. Antimicrob Agents Chemother (2010) 1.14

The antimicrobial peptide DEFB1 is associated with caries. J Dent Res (2010) 1.13

Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production. Gastroenterology (2006) 1.11

A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts. J Microbiol Methods (2005) 1.05

A 3' UTR transition within DEFB1 is associated with chronic and aggressive periodontitis. Genes Immun (2009) 1.03

Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3. Microbes Infect (2009) 1.03

Structure-activity relationships in beta-defensin peptides. Biopolymers (2008) 1.02

Human antimicrobial proteins effectors of innate immunity. J Endotoxin Res (2007) 1.02

Anaerobic infections: update on treatment considerations. Drugs (2010) 0.95

Antimicrobial peptides as effector molecules of mammalian host defense. Contrib Microbiol (2003) 0.91

Potential role of thioredoxin in immune responses in intestinal lamina propria T lymphocytes. Eur J Immunol (2005) 0.89

Purification of antimicrobial peptides from human skin. Methods Mol Biol (2010) 0.86

Articles by these authors

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10

Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05

T-helper-1-cell cytokines drive cancer into senescence. Nature (2013) 4.47

Some like it hot: the structure and function of small heat-shock proteins. Nat Struct Mol Biol (2005) 4.29

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut (2012) 4.24

The Hsp90 chaperone machinery. J Biol Chem (2008) 3.79

The heat shock response: life on the verge of death. Mol Cell (2010) 3.71

Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem (2005) 3.02

Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol (2005) 3.00

Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial. Gut (2010) 2.88

NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun (2004) 2.47

Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science (2012) 2.44

In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cell Microbiol (2007) 2.35

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90. Nat Struct Mol Biol (2009) 2.30

A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology (2002) 2.15

Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis (2003) 2.06

NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem (2005) 2.06

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis. Nat Struct Mol Biol (2009) 2.03

c-Maf regulates IL-10 expression during Th17 polarization. J Immunol (2009) 1.99

Molecular chaperones--cellular machines for protein folding. Angew Chem Int Ed Engl (2002) 1.95

The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion. Infect Immun (2002) 1.91

The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones. Biochim Biophys Acta (2011) 1.90

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell (2009) 1.90

Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome. Am J Gastroenterol (2009) 1.88

How antibodies fold. Trends Biochem Sci (2009) 1.88

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med (2010) 1.86

Bartonella adhesin a mediates a proangiogenic host cell response. J Exp Med (2004) 1.84

Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs. Infect Immun (2002) 1.82

Structure, function and regulation of the hsp90 machinery. Biomed J (2013) 1.81

Response of refractory colitis to intravenous or oral tacrolimus (FK506). Inflamm Bowel Dis (2002) 1.80

Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem (2005) 1.77

p53 contains large unstructured regions in its native state. J Mol Biol (2002) 1.75

The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol (2007) 1.73

Extraintestinal manifestations and complications in inflammatory bowel diseases. World J Gastroenterol (2006) 1.73

Crohn's disease: a defensin deficiency syndrome? Eur J Gastroenterol Hepatol (2003) 1.72

Conformational switching of the molecular chaperone Hsp90 via regulated phosphorylation. Mol Cell (2012) 1.70

In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion. Mol Microbiol (2007) 1.68

Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest (2007) 1.67

Human defensins. J Mol Med (Berl) (2005) 1.66

Asymmetric activation of the hsp90 dimer by its cochaperone aha1. Mol Cell (2010) 1.65

Interleukin 23 expression in pyoderma gangrenosum and targeted therapy with ustekinumab. Arch Dermatol (2011) 1.62

The N-terminal domain of p53 is natively unfolded. J Mol Biol (2003) 1.62

Disassembling protein aggregates in the yeast cytosol. The cooperation of Hsp26 with Ssa1 and Hsp104. J Biol Chem (2005) 1.59

Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol (2002) 1.59

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci (2010) 1.57

Inflammatory Bowel Disease. Dtsch Arztebl Int (2016) 1.56

Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle. J Biol Chem (2003) 1.56

Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling. Mol Cell Biol (2007) 1.54

The ATPase cycle of the endoplasmic chaperone Grp94. J Biol Chem (2007) 1.54

Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiology (2008) 1.52

The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104. J Biol Chem (2003) 1.52

Conserved conformational changes in the ATPase cycle of human Hsp90. J Biol Chem (2008) 1.52

Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun (2007) 1.48

The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90. EMBO J (2006) 1.48

The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb. J Biol Chem (2005) 1.47

Sti1 is a novel activator of the Ssa proteins. J Biol Chem (2003) 1.43

The chaperone Hsp90: changing partners for demanding clients. Trends Biochem Sci (2013) 1.41

IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis. J Am Chem Soc (2004) 1.41

Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. Hepatology (2012) 1.39

Hsp42 is the general small heat shock protein in the cytosol of Saccharomyces cerevisiae. EMBO J (2004) 1.39

The expression patterns of peritoneal defensins. Perit Dial Int (2007) 1.39

[Suspected cases of severe side effects after infliximab (Remicade) in Germany]. Med Klin (Munich) (2003) 1.38

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions. Nat Struct Mol Biol (2011) 1.38

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J (2012) 1.36

Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling. J Biol Chem (2007) 1.33

The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol (2011) 1.33

The ATPase cycle of the mitochondrial Hsp90 analog Trap1. J Biol Chem (2008) 1.32

The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle. J Mol Biol (2004) 1.31

Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach. Proc Natl Acad Sci U S A (2011) 1.30

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis. Differentiation (2008) 1.30

Substrate transfer from the chaperone Hsp70 to Hsp90. J Mol Biol (2005) 1.29

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29

Paneth's disease. J Crohns Colitis (2010) 1.29

Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol (2004) 1.29

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. J Biol Chem (2004) 1.28

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle. Nat Struct Mol Biol (2010) 1.27

Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol (2005) 1.27

Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J Leukoc Biol (2004) 1.26

Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways. J Invest Dermatol (2010) 1.26

Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain. Mol Cell (2008) 1.26

β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One (2011) 1.25

Folding mechanism of the CH2 antibody domain. J Mol Biol (2004) 1.25

Defensins and other antimicrobial peptides in inflammatory bowel disease. Curr Opin Gastroenterol (2007) 1.25

Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One (2009) 1.24

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction. Autophagy (2011) 1.24