Published in Nucleic Acids Res on February 01, 2002
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Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res (2005) 2.41
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A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun (1999) 1.14
A novel MSP/DHPLC method for the investigation of the methylation status of imprinted genes enables the molecular detection of low cell mosaicisms. Hum Mutat (2001) 1.05
High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science (2004) 4.67
A test of climate, sun, and culture relationships from an 1810-year Chinese cave record. Science (2008) 3.94
Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. Cancer Discov (2011) 3.45
CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res (2008) 3.40
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Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J (2003) 2.69
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions. Heart Rhythm (2006) 2.63
Nomograms for predicting annual resolution rate of primary vesicoureteral reflux: results from 2,462 children. J Urol (2009) 2.59
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. J Virol (2004) 2.47
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Characterization of cardiac tumors in children by cardiovascular magnetic resonance imaging: a multicenter experience. J Am Coll Cardiol (2011) 2.24
Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Science (2010) 2.21
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. Proc Natl Acad Sci U S A (2013) 2.09
Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol (2010) 2.08
Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis. Clin Cancer Res (2010) 2.07
Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics (2008) 2.02
Structure-based design of novel inhibitors of the MDM2-p53 interaction. J Med Chem (2012) 2.01
Polycystins and mechanosensation in renal and nodal cilia. Bioessays (2004) 1.96
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol (2006) 1.95
Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet (2009) 1.94
Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. J Virol (2010) 1.92
Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann Surg (2009) 1.90
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res (2010) 1.88
Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol (2005) 1.88
Activity-dependent development of callosal projections in the somatosensory cortex. J Neurosci (2007) 1.87
Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci (2008) 1.87
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol (2007) 1.86
The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res (2005) 1.85
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol (2002) 1.85
Gastric cancers overexpress S100A calcium-binding proteins. Cancer Res (2002) 1.81
Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol (2010) 1.81
Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Mol Cell Biol (2007) 1.81
Interactive atrial neural network: Determining the connections between ganglionated plexi. Heart Rhythm (2006) 1.76
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer. Cancer (2010) 1.70
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol (2008) 1.70
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. J Virol (2003) 1.70
Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties. Pancreas (2007) 1.68
Specification of Arabidopsis floral meristem identity by repression of flowering time genes. Development (2007) 1.68
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol (2003) 1.67
The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area. J Am Soc Nephrol (2004) 1.66
Pkd1 inactivation induced in adulthood produces focal cystic disease. J Am Soc Nephrol (2008) 1.65
MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC Cancer (2012) 1.61
Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem (2006) 1.58
Low serum micronutrient concentrations predict frailty among older women living in the community. J Gerontol A Biol Sci Med Sci (2006) 1.58
Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem (2002) 1.57
MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer. Cancer Res (2011) 1.57
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A (2012) 1.51
MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer. Carcinogenesis (2011) 1.51
Thoracic ossification of ligamentum flavum caused by skeletal fluorosis. Eur Spine J (2006) 1.50
Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays. Mod Pathol (2003) 1.50
Characterization of Ser338 phosphorylation for Raf-1 activation. J Biol Chem (2008) 1.48
Trends in resource utilization by children with neurological impairment in the United States inpatient health care system: a repeat cross-sectional study. PLoS Med (2012) 1.47
miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer. Cancer Res (2012) 1.46
Targets of gene amplification and overexpression at 17q in gastric cancer. Cancer Res (2002) 1.46
BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer. Int J Cancer (2006) 1.46
Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression. Infect Immun (2004) 1.45
Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas. Hum Pathol (2003) 1.44
Perioperative risk factors for surgical complications in pediatric urology: a pilot study in preoperative risk assessment in children. Urology (2009) 1.44
Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations. Genesis (2006) 1.43
Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res (2004) 1.43
Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J (2004) 1.43
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. J Clin Invest (2014) 1.40
Predictors of clinical outcomes and hospital resource use of children after tracheotomy. Pediatrics (2009) 1.40
Retracted Inhibition of rho-kinase by fasudil suppresses formation and progression of experimental abdominal aortic aneurysms. PLoS One (2013) 1.39
Tunable bandgap in silicene and germanene. Nano Lett (2011) 1.39
Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA. J Mol Biol (2008) 1.39
E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase. J Mol Biol (2010) 1.36
Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clin Chem (2003) 1.34
miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. J Biol Chem (2010) 1.34
Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J Neurosci (2012) 1.34
Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. Cancer Res (2002) 1.33
Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE). J Cardiovasc Electrophysiol (2007) 1.30
Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer. Cancer Prev Res (Phila) (2011) 1.30
Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a. Biochem J (2007) 1.29
Reforming procedural skills training for pediatric residents: a randomized, interventional trial. Pediatrics (2009) 1.28
Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps. Int J Cancer (2008) 1.27
MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. PLoS One (2013) 1.27
Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr (2006) 1.26
Up-regulation of microRNA-21 correlates with lower kidney cancer survival. PLoS One (2012) 1.26
Executive decline and dysfunction precedes declines in memory: the Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci (2009) 1.24
Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Int J Cancer (2011) 1.24
Engineering strand-specific DNA nicking enzymes from the type IIS restriction endonucleases BsaI, BsmBI, and BsmAI. J Mol Biol (2004) 1.23
RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating. J Virol (2011) 1.23
MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer. PLoS One (2013) 1.23
A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41. J Virol (2006) 1.22
MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling. Infect Immun (2005) 1.22