Published in Nat Genet on February 01, 1999
The epigenomics of cancer. Cell (2007) 30.91
Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33
Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods (2010) 9.75
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res (2000) 9.30
High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature (2008) 7.64
Epigenetics in cancer. Carcinogenesis (2009) 7.49
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80
Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell (2012) 6.50
Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat Biotechnol (2010) 5.96
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48
Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology (2008) 5.19
A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature (2012) 5.02
Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics (2013) 4.61
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet (1999) 4.16
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67
Active DNA demethylation mediated by DNA glycosylases. Annu Rev Genet (2009) 3.66
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A (2000) 3.65
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest (2002) 3.23
Interplay between the cancer genome and epigenome. Cell (2013) 3.05
5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci U S A (2000) 2.98
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol (2003) 2.72
Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis. Genome Res (2002) 2.71
Analysis of fecal DNA methylation to detect gastrointestinal neoplasia. J Natl Cancer Inst (2009) 2.57
Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle (2007) 2.55
Concern Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc Natl Acad Sci U S A (2003) 2.52
Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay. PLoS One (2008) 2.46
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol (2010) 2.38
Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol (2003) 2.36
Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut (2002) 2.31
Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Res (2001) 2.27
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol (2002) 2.24
DNA of Drosophila melanogaster contains 5-methylcytosine. EMBO J (2000) 2.09
DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity. Cancer Res (2008) 2.08
Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation. Mol Cell Biol (2000) 1.98
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. J Clin Invest (2008) 1.95
Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma. Carcinogenesis (2009) 1.94
DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol (2011) 1.92
Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women. Gastroenterology (2007) 1.83
Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. World J Gastroenterol (2006) 1.82
Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol (2003) 1.79
Identification of a methylation imprint mark within the mouse Gnas locus. Mol Cell Biol (2000) 1.78
Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev (2009) 1.76
Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147. J Natl Cancer Inst (2014) 1.75
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A (2002) 1.73
Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res (2000) 1.73
Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer. Cancer Biol Ther (2009) 1.72
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. PLoS Med (2008) 1.70
Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis (2003) 1.69
Quantitative assessment of promoter hypermethylation during breast cancer development. Am J Pathol (2002) 1.68
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol (2004) 1.68
Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci U S A (2001) 1.68
Epigenetic reprogramming of cancer cells via targeted DNA methylation. Epigenetics (2012) 1.65
DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines. PLoS One (2010) 1.65
Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res (2009) 1.65
A real-time PCR assay for DNA-methylation using methylation-specific blockers. Nucleic Acids Res (2004) 1.63
Methylated genes in breast cancer: associations with clinical and histopathological features in a familial breast cancer cohort. Cancer Biol Ther (2011) 1.62
Colorectal cancer: a model for epigenetic tumorigenesis. Gut (2006) 1.62
Cancer epigenetics takes center stage. Proc Natl Acad Sci U S A (2001) 1.60
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev (2013) 1.60
Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart. Mol Pharmacol (2007) 1.59
Lsh is involved in de novo methylation of DNA. EMBO J (2006) 1.57
Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility. J Med Genet (2002) 1.57
Heterogeneous genomic molecular clocks in primates. PLoS Genet (2006) 1.55
Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Res (2009) 1.55
Deposition of histone variant H2A.Z within gene bodies regulates responsive genes. PLoS Genet (2012) 1.55
Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells. Proc Natl Acad Sci U S A (1999) 1.55
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev (2001) 1.54
Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. Am J Pathol (2001) 1.53
Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development. Genome Biol (2013) 1.52
Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages. Proc Natl Acad Sci U S A (2001) 1.51
Roles of cell division and gene transcription in the methylation of CpG islands. Mol Cell Biol (1999) 1.49
The functional significance of microRNA-145 in prostate cancer. Br J Cancer (2010) 1.48
Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am J Pathol (2002) 1.48
Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol (2006) 1.47
Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol Cell Biol (2002) 1.46
Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res (2002) 1.45
Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Proc Natl Acad Sci U S A (2004) 1.45
Detection of DNA structural motifs in functional genomic elements. Genome Res (2007) 1.45
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. Proc Natl Acad Sci U S A (1999) 1.45
BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis (2009) 1.44
Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. Mol Cancer (2006) 1.44
ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer (2009) 1.44
DNA demethylation. Proc Natl Acad Sci U S A (1999) 1.43
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc Natl Acad Sci U S A (2011) 1.42
Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions. PLoS One (2010) 1.40
Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut (2004) 1.39
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res (2008) 1.39
DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors. Chem Biol (2015) 1.39
Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Neoplasia (2005) 1.38
Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics (2010) 1.37
Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. World J Gastroenterol (2003) 1.37
MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery. Nucleic Acids Res (2000) 1.34
Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy. Cancer Gene Ther (2005) 1.34
DNA mismatch repair genes and colorectal cancer. Gut (2000) 1.34
COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res (1997) 9.94
MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res (2000) 9.30
Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res (2001) 3.70
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res (1999) 3.66
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev (1996) 3.29
Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res (2000) 2.73
Mature mRNAs of Trypanosoma brucei possess a 5' cap acquired by discontinuous RNA synthesis. Nucleic Acids Res (1985) 1.97
In vivo labelling of intermediates in the discontinuous synthesis of mRNAs in Trypanosoma brucei. EMBO J (1987) 1.87
DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status. Leukemia (2008) 1.70
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc Natl Acad Sci U S A (1997) 1.70
Trans splicing in trypanosomes--archaism or adaptation? Trends Genet (1989) 1.64
Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: evidence for a polycistronic transcription unit in a eukaryote. Nucleic Acids Res (1987) 1.47
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Oncogene (2006) 1.46
Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J Natl Cancer Inst (2000) 1.45
Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene (2007) 1.28
DNA methylation: an alternative pathway to cancer. Ann Surg (2001) 1.24
Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time. Cancer Res (2001) 1.19
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol (2001) 1.17
DNA methylation analysis by MethyLight technology. Methods (2001) 1.15
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow. J Exp Med (1993) 1.12
Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells. Blood (1993) 1.11
Transgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections. Nucleic Acids Res (1995) 1.07
Mouse model systems to study multistep tumorigenesis. Cold Spring Harb Symp Quant Biol (1994) 1.06
DNA methylation profiles of female steroid hormone-driven human malignancies. Curr Top Microbiol Immunol (2006) 1.05
Phase I trial of continuous infusion 5-aza-2'-deoxycytidine. Cancer Chemother Pharmacol (2003) 1.03
Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas. Cancer Epidemiol Biomarkers Prev (2001) 0.92
Stable introduction of exogenous DNA into Trypanosoma brucei. EMBO J (1987) 0.90
Prolonged culture of normal chorionic villus cells yields ICF syndrome-like chromatin decondensation and rearrangements. Cytogenet Genome Res (2002) 0.88
DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. Oncogene (2000) 0.86
Analysis of Pim-1 function in mutant mice. Leukemia (1993) 0.82
Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux. J Surg Res (1999) 0.81