PubRank

Giulio Superti-Furga

Author PubWeight™ 245.81‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 2002 45.19
2 Proteome survey reveals modularity of the yeast cell machinery. Nature 2006 20.77
3 Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med 2013 9.65
4 The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol 2007 8.24
5 An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009 7.93
6 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 2004 7.23
7 ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res 2003 6.86
8 Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 2003 5.44
9 Peroxisomes are signaling platforms for antiviral innate immunity. Cell 2010 5.24
10 The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods 2013 4.34
11 Human Proteinpedia enables sharing of human protein data. Nat Biotechnol 2008 4.21
12 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol 2011 4.18
13 Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood 2007 3.59
14 A myristoyl/phosphotyrosine switch regulates c-Abl. Cell 2003 3.48
15 An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells. Nat Methods 2006 3.38
16 Target profiling of small molecules by chemical proteomics. Nat Chem Biol 2009 3.20
17 Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat Rev Mol Cell Biol 2004 3.10
18 Structure-based assembly of protein complexes in yeast. Science 2004 2.89
19 Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 2011 2.64
20 A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol 2010 2.53
21 The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A 2007 2.51
22 Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell 2008 2.46
23 Rediscovering the sweet spot in drug discovery. Drug Discov Today 2003 2.45
24 NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol 2009 2.39
25 Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell 2006 2.28
26 RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell 2004 2.13
27 Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell 2011 2.11
28 Mass spectrometry-based functional proteomics: from molecular machines to protein networks. Nat Methods 2007 2.06
29 c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol 2002 1.98
30 Autoinhibition of c-Abl. Cell 2002 1.93
31 Viral immune modulators perturb the human molecular network by common and unique strategies. Nature 2012 1.86
32 Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med 2011 1.78
33 BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol 2012 1.77
34 The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J 2008 1.76
35 Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J 2006 1.64
36 CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med 2010 1.64
37 Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib. Leuk Lymphoma 2008 1.63
38 SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations. Hum Mutat 2012 1.61
39 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature 2013 1.58
40 A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat Struct Mol Biol 2010 1.47
41 Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia? Biochem Pharmacol 2007 1.44
42 c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J 2002 1.41
43 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A 2009 1.37
44 Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics 2006 1.32
45 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods 2013 1.30
46 Protein complexes and proteome organization from yeast to man. Curr Opin Chem Biol 2003 1.30
47 Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. Mol Cell 2005 1.21
48 Caspase-dependent cleavage of c-Abl contributes to apoptosis. Mol Cell Biol 2003 1.20
49 BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib. Blood 2010 1.19
50 General statistical modeling of data from protein relative expression isobaric tags. J Proteome Res 2011 1.18
51 Initial characterization of the human central proteome. BMC Syst Biol 2011 1.18
52 A complex prediction: three-dimensional model of the yeast exosome. EMBO Rep 2002 1.18
53 Proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ®-labelled specimens. J Proteomics 2010 1.18
54 The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). BMC Struct Biol 2009 1.18
55 A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods 2013 1.17
56 Functional dissection of the TBK1 molecular network. PLoS One 2011 1.16
57 FAM111A mutations result in hypoparathyroidism and impaired skeletal development. Am J Hum Genet 2013 1.06
58 The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood 2008 1.05
59 Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Dev Cell 2012 1.04
60 The TLR-independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature. Eur J Immunol 2009 1.04
61 Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum 2010 1.03
62 Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression. Mol Cell 2012 1.02
63 Cytoplasmic Listeria monocytogenes stimulates IFN-beta synthesis without requiring the adapter protein MAVS. FEBS Lett 2006 1.00
64 Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. J Virol 2014 0.96
65 The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL. Cancer Res 2012 0.95
66 A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry. Nat Protoc 2012 0.95
67 KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. Blood 2011 0.94
68 MASPECTRAS 2: An integration and analysis platform for proteomic data. Proteomics 2010 0.93
69 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol Syst Biol 2013 0.93
70 Phosphorylation of Bruton's tyrosine kinase by c-Abl. Biochem Biophys Res Commun 2002 0.93
71 An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B. Mol Cancer Ther 2011 0.91
72 Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae. Biochemistry 2003 0.91
73 A network solution. Nature 2008 0.90
74 The chemokine interleukin-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in chronic myeloid leukemia. Mol Oncol 2008 0.89
75 Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. Cell Microbiol 2013 0.88
76 A computational approach to analyze the mechanism of action of the kinase inhibitor bafetinib. PLoS Comput Biol 2010 0.85
77 Affinity purification strategies for proteomic analysis of transcription factor complexes. J Proteome Res 2013 0.85
78 Deconvolution of targeted protein-protein interaction maps. J Proteome Res 2012 0.85
79 Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol 2008 0.84
80 Systems biology analysis of protein-drug interactions. Proteomics Clin Appl 2011 0.84
81 Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. Exp Hematol 2008 0.83
82 Charting protein complexes, signaling pathways, and networks in the immune system. Immunol Rev 2006 0.83
83 A miniaturized chemical proteomic approach for target profiling of clinical kinase inhibitors in tumor biopsies. J Proteome Res 2013 0.81
84 Protein interaction networks in innate immunity. Trends Immunol 2013 0.81
85 Drugs in action. Nat Chem Biol 2008 0.81
86 After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. Bioorg Med Chem 2011 0.81
87 Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest 2016 0.80
88 Targeting allosteric regulatory modules in oncoproteins: "drugging the undruggable". Oncotarget 2011 0.80
89 High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system. Biochem Biophys Res Commun 2002 0.80
90 Corrigendum: The promise and peril of chemical probes. Nat Chem Biol 2015 0.79
91 Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes. J Integr OMICS 2012 0.79
92 A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL. PLoS One 2013 0.79
93 Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol 2015 0.78
94 NMR Assignment Reveals an alpha-Helical Fold for the F-Actin Binding Domain of Human Bcr-Abl/c-Abl. J Biomol NMR 2005 0.78
95 Compound immobilization and drug-affinity chromatography. Methods Mol Biol 2012 0.78
96 Cell biology: a key driver of therapeutic innovation. J Cell Biol 2012 0.76
97 Experimental characterization of the human non-sequence-specific nucleic acid interactome. Genome Biol 2013 0.76
98 Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics. ACS Chem Biol 2014 0.75
99 Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine. J Innate Immun 2016 0.75
100 MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type. Am J Med Genet A 2014 0.75
101 Special issue - modular protein domains. FEBS Lett 2012 0.75
102 Corrigendum: NANS-mediated synthesis of sialic acid is required for brain and skeletal development. Nat Genet 2017 0.75
103 A comparative proteomic study of human skin suction blister fluid from healthy individuals using immunodepletion and iTRAQ labeling. J Proteome Res 2012 0.75