Published in Dev Cell on December 01, 2004
Virus entry by macropinocytosis. Nat Cell Biol (2009) 3.87
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci U S A (2008) 1.97
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell (2011) 1.76
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J (2006) 1.72
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Res (2010) 1.50
Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors. EMBO Rep (2007) 1.36
c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling. Cell Signal (2008) 1.28
The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging. PLoS Comput Biol (2008) 1.27
Cdc42 and actin control polarized expression of TI-VAMP vesicles to neuronal growth cones and their fusion with the plasma membrane. Mol Biol Cell (2005) 1.26
The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells. PLoS Pathog (2009) 1.26
Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol (2009) 1.18
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res (2010) 1.12
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res (2012) 1.10
Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity (2010) 1.10
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev (2008) 1.10
RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol (2007) 1.09
A biosensor generated via high-throughput screening quantifies cell edge Src dynamics. Nat Chem Biol (2011) 1.09
Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A (2010) 1.07
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. J Cell Biol (2015) 1.05
Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation. J Biol Chem (2009) 1.03
Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation. J Cell Sci (2010) 1.02
RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.02
Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets. J Cell Biol (2007) 1.00
The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway. PLoS One (2009) 0.99
Spatiotemporal regulation of Src and its substrates at invadosomes. Eur J Cell Biol (2012) 0.97
Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc Natl Acad Sci U S A (2014) 0.96
RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci (2007) 0.96
The coordination between actin filaments and adhesion in mesenchymal migration. Cell Adh Migr (2009) 0.95
A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC. PLoS Genet (2007) 0.95
Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a. Mol Biol Cell (2009) 0.94
PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity. Dev Cell (2014) 0.93
RhoB regulates cell migration through altered focal adhesion dynamics. Open Biol (2012) 0.93
RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac. J Cell Biochem (2011) 0.90
The myotubularin family of lipid phosphatases in disease and in spermatogenesis. Biochem J (2011) 0.88
Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane. Cell Adh Migr (2011) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Src kinase mediates productive endocytic sorting of reovirus during cell entry. J Virol (2011) 0.87
Microtubule-mediated Src tyrosine kinase trafficking in neuronal growth cones. Mol Biol Cell (2008) 0.86
Endosomal signaling and cell migration. Curr Opin Cell Biol (2011) 0.86
Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases. Genome Res (2011) 0.86
mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion. Mol Cell Biol (2010) 0.86
A model for phospho-caveolin-1-driven turnover of focal adhesions. Cell Adh Migr (2011) 0.86
Interior decoration: tropomyosin in actin dynamics and cell migration. Cell Adh Migr (2011) 0.85
ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface. PLoS One (2012) 0.85
Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites. Mol Biol Cell (2013) 0.85
Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells. J Biol Chem (2013) 0.84
FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly. Nat Cell Biol (2016) 0.83
Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts. PLoS Comput Biol (2015) 0.82
The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer. Mol Cell Proteomics (2014) 0.82
Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src. PLoS One (2013) 0.82
Vasoconstrictor-induced endocytic recycling regulates focal adhesion protein localization and function in vascular smooth muscle. Am J Physiol Cell Physiol (2013) 0.82
A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. J Biol Chem (2013) 0.82
Endocytosis and the Src family of non-receptor tyrosine kinases. Biomol Concepts (2014) 0.81
Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1. J Cell Sci (2014) 0.81
The small GTPase RhoB regulates TNFα signaling in endothelial cells. PLoS One (2013) 0.80
The N2-Src neuronal splice variant of C-Src has altered SH3 domain ligand specificity and a higher constitutive activity than N1-Src. FEBS Lett (2015) 0.79
A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis. PLoS Genet (2015) 0.79
Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis. Traffic (2011) 0.79
Receptor tyrosine kinases endocytosis in endothelium: biology and signaling. Arterioscler Thromb Vasc Biol (2014) 0.79
Critical functions of RhoB in support of glioblastoma tumorigenesis. Neuro Oncol (2014) 0.79
RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress. Sci Rep (2014) 0.79
Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS One (2014) 0.77
Podosomes and Invadopodia: Related structures with Common Protein Components that May Promote Breast Cancer Cellular Invasion. Breast Cancer (Auckl) (2008) 0.77
The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment. Small GTPases (2015) 0.77
Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria. Infect Immun (2011) 0.76
RhoB is a component of the human cytomegalovirus assembly complex and is required for efficient viral production. Cell Cycle (2015) 0.76
Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation. PLoS One (2012) 0.76
Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking. Mol Cell Biol (2014) 0.76
Src regulates sequence-dependent beta-2 adrenergic receptor recycling via cortactin phosphorylation. Traffic (2014) 0.76
RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border. J Cell Biol (2016) 0.76
The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction. Cell Commun Signal (2015) 0.76
Single vesicle imaging indicates distinct modes of rapid membrane retrieval during nerve growth. BMC Biol (2012) 0.76
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism. EMBO Mol Med (2017) 0.75
Stress-induced EGF receptor signaling through STAT3 and tumor progression in triple-negative breast cancer. Mol Cell Endocrinol (2017) 0.75
The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions. Mol Biol Cell (2016) 0.75
Increased adenovirus Type 5 mediated transgene expression due to RhoB down-regulation. PLoS One (2014) 0.75
Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking. PLoS One (2016) 0.75
Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland. Oncogene (2014) 0.75
N1-Src kinase is required for primary neurogenesis in Xenopus tropicalis. J Neurosci (2017) 0.75
β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells. PLoS One (2017) 0.75
Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation. Nat Commun (2017) 0.75
Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19
Proteome survey reveals modularity of the yeast cell machinery. Nature (2006) 20.77
Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med (2013) 9.65
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol (2009) 8.63
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol (2009) 7.93
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol (2004) 7.23
ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res (2003) 6.86
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer (2005) 5.57
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Peroxisomes are signaling platforms for antiviral innate immunity. Cell (2010) 5.24
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med (2005) 4.92
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol (2011) 4.18
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol (2004) 3.76
Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood (2007) 3.59
Integrins: masters and slaves of endocytic transport. Nat Rev Mol Cell Biol (2009) 3.52
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res (2007) 3.44
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells. Nat Methods (2006) 3.38
Actin stress fibres. J Cell Sci (2007) 3.28
Target profiling of small molecules by chemical proteomics. Nat Chem Biol (2009) 3.20
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat Rev Mol Cell Biol (2004) 3.10
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
Structure-based assembly of protein complexes in yeast. Science (2004) 2.89
Integrin trafficking and the control of cell migration. Traffic (2006) 2.89
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res (2007) 2.78
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med (2009) 2.73
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature (2011) 2.64
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A (2007) 2.64
Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J Cell Biol (2008) 2.61
The Rho family GTPase Rif induces filopodia through mDia2. Curr Biol (2005) 2.58
IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov (2012) 2.56
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol (2010) 2.53
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A (2007) 2.51
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol (2002) 2.50
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Endocytic recycling pathways: emerging regulators of cell migration. Curr Opin Cell Biol (2006) 2.48
Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev (2008) 2.47
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol (2004) 2.46
Rediscovering the sweet spot in drug discovery. Drug Discov Today (2003) 2.45
v-Src's hold over actin and cell adhesions. Nat Rev Mol Cell Biol (2002) 2.40
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol (2009) 2.39
alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol (2007) 2.31
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
E-cadherin-integrin crosstalk in cancer invasion and metastasis. J Cell Sci (2013) 2.23
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci U S A (2008) 2.18
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol (2007) 2.18
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood (2011) 2.11
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell (2011) 2.11
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
Mass spectrometry-based functional proteomics: from molecular machines to protein networks. Nat Methods (2007) 2.06
Mechanisms of integrin activation and trafficking. Curr Opin Cell Biol (2011) 2.00
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol (2002) 1.98
Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol Cell Biol (2004) 1.93
Autoinhibition of c-Abl. Cell (2002) 1.93
VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood (2006) 1.87
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell (2011) 1.87
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
Indoleamine 2,3-dioxygenase in immune suppression and cancer. Curr Cancer Drug Targets (2007) 1.86
Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis (2011) 1.86
Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking. Curr Biol (2012) 1.86
Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol (2005) 1.85
Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem (2006) 1.81
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol (2012) 1.77
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J (2008) 1.76
Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules. Mol Microbiol (2002) 1.71
PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions. EMBO J (2004) 1.69
Src and focal adhesion kinase as therapeutic targets in cancer. Curr Opin Pharmacol (2008) 1.69
A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr Biol (2003) 1.67
Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther (2006) 1.66
Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J (2006) 1.64
CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med (2010) 1.64
Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors. Clin Cancer Res (2009) 1.63
Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib. Leuk Lymphoma (2008) 1.63
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations. Hum Mutat (2012) 1.61