Published in J Biol Chem on February 12, 2002
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc Natl Acad Sci U S A (2008) 2.54
Evolution of energy metabolism and its compartmentation in Kinetoplastida. Kinetoplastid Biol Dis (2003) 1.33
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.20
pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi. BMC Biotechnol (2006) 1.11
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. J Infect Dis (2012) 1.07
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. Biochem J (2002) 1.04
An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein. J Biol Chem (2009) 1.01
Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence. Int J Parasitol (2009) 1.01
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. Biochem J (2008) 1.01
Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease. Antioxid Redox Signal (2012) 0.95
Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proc Natl Acad Sci U S A (2005) 0.94
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major. FEBS J (2007) 0.91
Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med (2016) 0.91
Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei. Biochem J (2007) 0.90
Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi. Mol Microbiol (2010) 0.86
Redox metabolism in mitochondria of trypanosomatids. Antioxid Redox Signal (2012) 0.86
Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection. Front Immunol (2016) 0.84
Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity. PLoS One (2010) 0.84
The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase. Biochem J (2007) 0.81
Role of Trypanosoma cruzi peroxiredoxins in mitochondrial bioenergetics. J Bioenerg Biomembr (2011) 0.81
Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases. Biochem J (2008) 0.77
Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress. PLoS Negl Trop Dis (2015) 0.77
Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages. PLoS Negl Trop Dis (2016) 0.76
A Comparative In Silico Study of the Antioxidant Defense Gene Repertoire of Distinct Lifestyle Trypanosomatid Species. Evol Bioinform Online (2016) 0.75
An insect molecular clock dates the origin of the insects and accords with palaeontological and biogeographic landmarks. Mol Biol Evol (2002) 4.22
The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications. Infect Genet Evol (2011) 2.87
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc Natl Acad Sci U S A (2008) 2.54
Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy. Proc Natl Acad Sci U S A (2007) 2.41
Mechanism of genetic exchange in American trypanosomes. Nature (2003) 2.10
Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection. PLoS Pathog (2009) 1.91
Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids. Int J Parasitol (2004) 1.89
Trypanocidal drugs: mechanisms, resistance and new targets. Expert Rev Mol Med (2009) 1.84
Rapid diagnostic tests for neurological infections in central Africa. Lancet Infect Dis (2013) 1.82
Emerging Chagas disease in Amazonian Brazil. Trends Parasitol (2002) 1.71
Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD). Int J Parasitol (2006) 1.67
Adequate relief in a treatment trial with IBS patients: a prospective assessment. Am J Gastroenterol (2009) 1.64
Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Mol Microbiol (2004) 1.57
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J (2007) 1.55
Whole genome scan detects an allelic variant of fad2 associated with increased oleic acid levels in maize. Mol Genet Genomics (2007) 1.50
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. Genome Res (2005) 1.47
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free Radic Biol Med (2005) 1.43
Genotyping of Trypanosoma cruzi: systematic selection of assays allowing rapid and accurate discrimination of all known lineages. Am J Trop Med Hyg (2009) 1.42
Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis. Am J Trop Med Hyg (2007) 1.41
Molecular genetics reveal that silvatic Rhodnius prolixus do colonise rural houses. PLoS Negl Trop Dis (2008) 1.39
RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. J Biol Chem (2003) 1.39
Sex, subdivision, and domestic dispersal of Trypanosoma cruzi lineage I in southern Ecuador. PLoS Negl Trop Dis (2010) 1.37
Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin. PLoS Negl Trop Dis (2011) 1.36
Crystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes. Nat Chem (2012) 1.34
Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener. PLoS Negl Trop Dis (2011) 1.30
Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing. PLoS Negl Trop Dis (2012) 1.28
The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. Malar J (2003) 1.28
Design and synthesis of bioactive adamantane spiro heterocycles. Bioorg Med Chem Lett (2007) 1.27
Contemporary cryptic sexuality in Trypanosoma cruzi. Mol Ecol (2012) 1.21
Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. PLoS Negl Trop Dis (2011) 1.20
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives. Curr Top Med Chem (2011) 1.20
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.20
Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease. PLoS Negl Trop Dis (2009) 1.19
Orally acquired Chagas disease: lessons from an urban school outbreak. J Infect Dis (2010) 1.19
Modeling disease vector occurrence when detection is imperfect: infestation of Amazonian palm trees by triatomine bugs at three spatial scales. PLoS Negl Trop Dis (2010) 1.18
Comparative phylogeography of Trypanosoma cruzi TCIIc: new hosts, association with terrestrial ecotopes, and spatial clustering. Infect Genet Evol (2009) 1.18
Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. PLoS Negl Trop Dis (2011) 1.17
Ruthenium polypyridyl chemistry; from basic research to applications and back again. Dalton Trans (2006) 1.17
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs. Bioorg Med Chem (2008) 1.14
Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle. Infect Immun (2004) 1.14
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. Cell Microbiol (2014) 1.14
Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand. Proc Natl Acad Sci U S A (2011) 1.13
Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. Genome Biol (2007) 1.13
Resolution of multiclonal infections of Trypanosoma cruzi from naturally infected triatomine bugs and from experimentally infected mice by direct plating on a sensitive solid medium. Int J Parasitol (2006) 1.13
Geographical distribution of Trypanosoma cruzi genotypes in Venezuela. PLoS Negl Trop Dis (2012) 1.12
Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids. Int J Parasitol (2009) 1.12
pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi. BMC Biotechnol (2006) 1.11
Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests. BMC Infect Dis (2013) 1.11
Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrob Agents Chemother (2010) 1.11
Visualisation of Leishmania donovani fluorescent hybrids during early stage development in the sand fly vector. PLoS One (2011) 1.11
Genetic polymorphism within the leishmania donovani complex: correlation with geographic origin. Am J Trop Med Hyg (2004) 1.11
The triatomines of northern Peru, with emphasis on the ecology and infection by trypanosomes of Rhodnius ecuadoriensis (Triatominae). Mem Inst Oswaldo Cruz (2002) 1.10
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. J Biol Chem (2003) 1.10
Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission. Int J Parasitol (2008) 1.09
The Leishmania donovani complex: genotypes of five metabolic enzymes (ICD, ME, MPI, G6PDH, and FH), new targets for multilocus sequence typing. Int J Parasitol (2006) 1.08
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. J Infect Dis (2012) 1.07
The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology. Mol Biochem Parasitol (2006) 1.05
Extraordinary Trypanosoma cruzi diversity within single mammalian reservoir hosts implies a mechanism of diversifying selection. Int J Parasitol (2011) 1.04
Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure. J Biol Chem (2002) 1.04
Candidate targets for Multilocus Sequence Typing of Trypanosoma cruzi: validation using parasite stocks from the Chaco Region and a set of reference strains. Infect Genet Evol (2011) 1.04
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. Biochem J (2002) 1.04
Serum amyloid A protein binds to outer membrane protein A of gram-negative bacteria. J Biol Chem (2005) 1.03
Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease. Expert Rev Anti Infect Ther (2015) 1.02
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Negl Trop Dis (2013) 1.02
Identification and characterization of endoplasmic reticulum-associated degradation proteins differentially affected by endoplasmic reticulum stress. Plant Physiol (2005) 1.01
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. Biochem J (2008) 1.01
The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements. Int J Parasitol (2006) 1.01
Glycoprotein 63 (gp63) genes show gene conversion and reveal the evolution of Old World Leishmania. Int J Parasitol (2006) 1.00
New insights on taxonomy, phylogeny and population genetics of Leishmania (Viannia) parasites based on multilocus sequence analysis. PLoS Negl Trop Dis (2012) 1.00
Comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveals extensive diversity and region-specific polymorphisms. PLoS Negl Trop Dis (2013) 0.99
North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype. Parasit Vectors (2012) 0.97
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Antimicrob Agents Chemother (2006) 0.96
Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. PLoS Negl Trop Dis (2013) 0.96
Validation of spermidine synthase as a drug target in African trypanosomes. Biochem J (2008) 0.95
Molecular epidemiologic source tracking of orally transmitted Chagas disease, Venezuela. Emerg Infect Dis (2013) 0.95
Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proc Natl Acad Sci U S A (2005) 0.94
The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum. Biochem J (2003) 0.92
[Ru(TAP)2(dppz)]2+: a DNA intercalating complex, which luminesces strongly in water and undergoes photo-induced proton-coupled electron transfer with guanosine-5'-monophosphate. Dalton Trans (2004) 0.91
Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents. Chem Soc Rev (2013) 0.90
Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology. Int J Parasitol (2010) 0.89
Monitoring the effect of ultrafast deactivation of the electronic excited states of DNA bases and polynucleotides following 267 nm laser excitation using picosecond time-resolved infrared spectroscopy. Chem Commun (Camb) (2005) 0.89
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. Bioorg Med Chem Lett (2012) 0.88
Wild Trypanosoma cruzi I genetic diversity in Brazil suggests admixture and disturbance in parasite populations from the Atlantic Forest region. Parasit Vectors (2014) 0.88