Published in J Biol Chem on March 31, 2003
Calcium-dependent signaling and kinases in apicomplexan parasites. Cell Host Microbe (2009) 2.46
Gametocytogenesis: the puberty of Plasmodium falciparum. Malar J (2004) 2.29
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. Nucleic Acids Res (2011) 1.48
cDNA sequences reveal considerable gene prediction inaccuracy in the Plasmodium falciparum genome. BMC Genomics (2007) 1.35
Heterologous expression of plasmodial proteins for structural studies and functional annotation. Malar J (2008) 1.22
Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle. J Cell Biol (2005) 1.20
Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. PLoS Pathog (2008) 1.16
The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands. PLoS One (2008) 1.06
Cyclic nucleotide kinases and tachyzoite-bradyzoite transition in Toxoplasma gondii. Int J Parasitol (2005) 0.99
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol (2004) 0.96
Molecular machinery of signal transduction and cell cycle regulation in Plasmodium. Mol Biochem Parasitol (2009) 0.95
Alternate intron processing of family 5 endoglucanase transcripts from the genus Phytophthora. Curr Genet (2007) 0.89
PfSRPK1, a novel splicing-related kinase from Plasmodium falciparum. J Biol Chem (2010) 0.89
Branch point identification and sequence requirements for intron splicing in Plasmodium falciparum. Eukaryot Cell (2011) 0.87
Identification of putative potassium channel homologues in pathogenic protozoa. PLoS One (2012) 0.85
cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. PLoS Pathog (2015) 0.83
Niche metabolism in parasitic protozoa. Philos Trans R Soc Lond B Biol Sci (2006) 0.82
A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes. Nucleic Acids Res (2012) 0.81
Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. PLoS One (2012) 0.80
Ubiquitin proteasome system and the atypical kinase PfPK7 are involved in melatonin signaling in Plasmodium falciparum. J Pineal Res (2012) 0.78
Transcript maturation in apicomplexan parasites. Curr Opin Microbiol (2014) 0.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The trypanosomiases. Lancet (2003) 5.96
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J Infect Dis (2006) 4.21
Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin Infect Dis (2006) 4.14
Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect Dis (2008) 4.07
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J (2004) 3.80
Genome variation and evolution of the malaria parasite Plasmodium falciparum. Nat Genet (2006) 3.68
Antimalarial combinations. Lancet (2004) 3.54
Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria. Infect Immun (2008) 3.51
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (2010) 3.27
Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. J Infect Dis (2010) 3.21
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol (2005) 3.18
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol (2005) 3.02
Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites. Mol Biol Evol (2006) 3.01
Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum. Lancet (2006) 2.96
Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon. J Infect Dis (2005) 2.58
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc Natl Acad Sci U S A (2008) 2.54
Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg (2006) 2.52
Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda. J Infect Dis (2013) 2.41
Severe falciparum malaria in Gabonese children: clinical and laboratory features. Malar J (2005) 2.35
Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. J Neurosci (2007) 2.35
Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey. PLoS One (2011) 2.24
Profiling the antibody immune response against blood stage malaria vaccine candidates. Clin Chem (2007) 2.23
A novel and accurate diagnostic test for human African trypanosomiasis. Lancet (2004) 2.22
The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa. Trop Med Int Health (2007) 2.17
Improved synchronous production of Plasmodium falciparum gametocytes in vitro. Mol Biochem Parasitol (2007) 2.06
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat Cell Biol (2002) 1.97
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (2005) 1.94
A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management. Clin Infect Dis (2003) 1.93
The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium. Nature (2012) 1.89
Trypanocidal drugs: mechanisms, resistance and new targets. Expert Rev Mol Med (2009) 1.84
Human African trypanosomiasis. BMJ (2002) 1.79
Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biol (2011) 1.72
Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. Malar J (2010) 1.72
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J Pharmacol Exp Ther (2002) 1.70
Adequate relief in a treatment trial with IBS patients: a prospective assessment. Am J Gastroenterol (2009) 1.64
Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase. PLoS Biol (2008) 1.63
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biol (2013) 1.62
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. J Pharmacol Exp Ther (2002) 1.59
Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria. Antimicrob Agents Chemother (2002) 1.59
Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Mol Microbiol (2004) 1.57
Evolutionary origin of cAMP-based chemoattraction in the social amoebae. Proc Natl Acad Sci U S A (2005) 1.56
Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness. PLoS One (2012) 1.55
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J (2007) 1.55
Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res (2011) 1.53
History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, Gabon. Wien Klin Wochenschr (2007) 1.52
Assessment of volume depletion in children with malaria. PLoS Med (2004) 1.51
Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance. Malar J (2010) 1.50
Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. J Infect Dis (2006) 1.49
Risk factors for herpes simplex virus transmission to pregnant women: a couples study. Am J Obstet Gynecol (2005) 1.48
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. Genome Res (2005) 1.47
A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. PLoS Pathog (2009) 1.46
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free Radic Biol Med (2005) 1.43
Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients. PLoS Med (2006) 1.42
The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. Eukaryot Cell (2009) 1.39
RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. J Biol Chem (2003) 1.39
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target. Proc Natl Acad Sci U S A (2003) 1.38
Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology (2010) 1.36
Acute respiratory distress syndrome in Plasmodium vivax malaria: case report and review of the literature. Trans R Soc Trop Med Hyg (2007) 1.35
Crystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes. Nat Chem (2012) 1.34
Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients. PLoS One (2011) 1.34
cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection. J Muscle Res Cell Motil (2002) 1.32
The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters. Clin Infect Dis (2005) 1.30
Design and synthesis of bioactive adamantane spiro heterocycles. Bioorg Med Chem Lett (2007) 1.27
Waking up to sleeping sickness. Trends Parasitol (2003) 1.25
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277). Antimicrob Agents Chemother (2006) 1.25
Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality. Mol Microbiol (2009) 1.25
Evidence of non-neutral polymorphism in Plasmodium falciparum gamete surface protein genes Pfs47 and Pfs48/45. Mol Biochem Parasitol (2007) 1.24
Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes. Eukaryot Cell (2006) 1.22
Aquaporin water channels and brain edema. Mt Sinai J Med (2002) 1.22
Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth. Antimicrob Agents Chemother (2007) 1.21
Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling. Pharmacol Rev (2012) 1.21
Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats. Psychopharmacology (Berl) (2007) 1.20
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives. Curr Top Med Chem (2011) 1.20
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.20
Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial. Clin Infect Dis (2005) 1.18
Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon. Antimicrob Agents Chemother (2003) 1.18
Artemisinins: activities and actions. Microbes Infect (2004) 1.18
Ruthenium polypyridyl chemistry; from basic research to applications and back again. Dalton Trans (2006) 1.17
Differences in presentation of severe malaria in urban and rural Gabon. Am J Trop Med Hyg (2007) 1.17
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. J Biol Chem (2002) 1.16
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. PLoS Pathog (2013) 1.16
Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage. Proc Natl Acad Sci U S A (2006) 1.15
Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family. Biochem J (2002) 1.15
Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats. Psychopharmacology (Berl) (2007) 1.15
A STAT-regulated, stress-induced signalling pathway in Dictyostelium. J Cell Sci (2003) 1.14
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs. Bioorg Med Chem (2008) 1.14
Involvement of noradrenergic neurotransmission in the stress- but not cocaine-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: role for β-2 adrenergic receptors. Neuropsychopharmacology (2010) 1.14
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. Cell Microbiol (2014) 1.14
Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob Agents Chemother (2010) 1.14
Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand. Proc Natl Acad Sci U S A (2011) 1.13
Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2. J Neurosci (2011) 1.13
Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. Genome Biol (2007) 1.13
Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom. Antimicrob Agents Chemother (2009) 1.12
The relevance of malaria pathophysiology to strategies of clinical management. Curr Opin Infect Dis (2005) 1.12
A novel cyclic GMP-dependent protein kinase is expressed in the ring stage of the Plasmodium falciparum life cycle. Mol Microbiol (2002) 1.12