Published in Nature on February 14, 2002
Probing the limits to positional information. Cell (2007) 6.23
Stability and nuclear dynamics of the bicoid morphogen gradient. Cell (2007) 5.31
Diffusion and scaling during early embryonic pattern formation. Proc Natl Acad Sci U S A (2005) 3.46
Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline. Genome Biol (2006) 3.22
Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature (2005) 3.01
Pre-steady-state decoding of the Bicoid morphogen gradient. PLoS Biol (2007) 2.81
Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation. PLoS Biol (2009) 2.70
Noncanonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seq. PLoS Biol (2011) 2.43
Characterization of the Drosophila segment determination morphome. Dev Biol (2007) 2.39
The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med (2006) 2.13
The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila. Proc Natl Acad Sci U S A (2005) 2.11
Determination of cell fate selection during phage lambda infection. Proc Natl Acad Sci U S A (2008) 2.05
Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors. PLoS Comput Biol (2009) 1.99
Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell (2005) 1.98
A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genes. Cell (2012) 1.96
Embryo stability and vulnerability in an always changing world. Proc Natl Acad Sci U S A (2007) 1.84
Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria. PLoS Biol (2005) 1.84
A high-throughput method for quantifying gene expression data from early Drosophila embryos. Dev Genes Evol (2005) 1.79
Fundamental limits to position determination by concentration gradients. PLoS Comput Biol (2007) 1.76
Removal of background signal from in situ data on the expression of segmentation genes in Drosophila. Dev Genes Evol (2005) 1.70
Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Dev Dyn (2006) 1.68
Modeling the bicoid gradient: diffusion and reversible nuclear trapping of a stable protein. Dev Biol (2007) 1.67
Organismal complexity, protein complexity, and gene duplicability. Proc Natl Acad Sci U S A (2003) 1.67
Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient. Development (2009) 1.66
Modelling the Bicoid gradient. Development (2010) 1.61
A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. PLoS Genet (2008) 1.57
Known maternal gradients are not sufficient for the establishment of gap domains in Drosophila melanogaster. Mech Dev (2006) 1.57
The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA. PLoS Biol (2011) 1.56
The gap gene network. Cell Mol Life Sci (2010) 1.51
Engineering gene networks to emulate Drosophila embryonic pattern formation. PLoS Biol (2005) 1.48
Probing intrinsic properties of a robust morphogen gradient in Drosophila. Dev Cell (2008) 1.48
Canalization of segmentation and its evolution in Drosophila. Proc Natl Acad Sci U S A (2007) 1.47
Anterior-posterior positional information in the absence of a strong Bicoid gradient. Proc Natl Acad Sci U S A (2009) 1.46
Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback. Cold Spring Harb Perspect Biol (2009) 1.41
Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila. Proc Natl Acad Sci U S A (2005) 1.36
Quantitative approaches in developmental biology. Nat Rev Genet (2009) 1.34
Small regulatory RNAs may sharpen spatial expression patterns. PLoS Comput Biol (2007) 1.32
HIV promoter integration site primarily modulates transcriptional burst size rather than frequency. PLoS Comput Biol (2010) 1.30
A single basis for developmental buffering of Drosophila wing shape. PLoS One (2006) 1.27
Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proc Natl Acad Sci U S A (2011) 1.25
The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei. J Cell Biol (2006) 1.21
Gene expression noise in spatial patterning: hunchback promoter structure affects noise amplitude and distribution in Drosophila segmentation. PLoS Comput Biol (2011) 1.21
Determining the scale of the Bicoid morphogen gradient. Proc Natl Acad Sci U S A (2009) 1.18
Efficient reverse-engineering of a developmental gene regulatory network. PLoS Comput Biol (2012) 1.16
A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm. PLoS One (2008) 1.15
Master equation simulation analysis of immunostained Bicoid morphogen gradient. BMC Syst Biol (2007) 1.15
Pipeline for acquisition of quantitative data on segmentation gene expression from confocal images. Fly (Austin) (2008) 1.14
Spatial bistability generates hunchback expression sharpness in the Drosophila embryo. PLoS Comput Biol (2008) 1.14
Accurate measurements of dynamics and reproducibility in small genetic networks. Mol Syst Biol (2013) 1.14
Precision of hunchback expression in the Drosophila embryo. Curr Biol (2012) 1.14
Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness. PLoS Genet (2011) 1.13
Stochastic simulations of the origins and implications of long-tailed distributions in gene expression. Proc Natl Acad Sci U S A (2005) 1.12
Computational approaches for modeling regulatory cellular networks. Trends Cell Biol (2004) 1.11
The measure of success: constraints, objectives, and tradeoffs in morphogen-mediated patterning. Cold Spring Harb Perspect Biol (2009) 1.10
Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci U S A (2011) 1.09
Stable, precise, and reproducible patterning of bicoid and hunchback molecules in the early Drosophila embryo. PLoS Comput Biol (2009) 1.09
A genetic and computational approach to structurally classify neuronal types. Nat Commun (2014) 1.08
Measurement and perturbation of morphogen lifetime: effects on gradient shape. Biophys J (2011) 1.08
Spatial stochastic dynamics enable robust cell polarization. PLoS Comput Biol (2013) 1.08
Tracking operator state fluctuations in gene expression in single cells. Biophys J (2004) 1.08
mRNA localization and translational control in Drosophila oogenesis. Cold Spring Harb Perspect Biol (2012) 1.06
The selective values of alleles in a molecular network model are context dependent. Genetics (2004) 1.05
Precision and scaling in morphogen gradient read-out. Mol Syst Biol (2010) 1.05
Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network. Proc Natl Acad Sci U S A (2013) 1.05
On the attenuation and amplification of molecular noise in genetic regulatory networks. BMC Bioinformatics (2006) 1.04
Theoretical and experimental approaches to understand morphogen gradients. Mol Syst Biol (2008) 1.04
Shaping a morphogen gradient for positional precision. Biophys J (2010) 1.03
Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos. Nat Cell Biol (2010) 1.02
Morphogen rules: design principles of gradient-mediated embryo patterning. Development (2015) 1.01
A multiscale investigation of bicoid-dependent transcriptional events in Drosophila embryos. PLoS One (2011) 1.01
Size regulation in the segmentation of Drosophila: interacting interfaces between localized domains of gene expression ensure robust spatial patterning. Phys Rev Lett (2009) 1.01
Scaling of the Bicoid morphogen gradient by a volume-dependent production rate. Development (2011) 0.99
Robust generation and decoding of morphogen gradients. Cold Spring Harb Perspect Biol (2009) 0.99
Mechanisms of scaling in pattern formation. Development (2013) 0.96
The Bicoid gradient is shaped independently of nuclei. Development (2010) 0.96
Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster. Evolution (2011) 0.95
A mechanism for morphogen-controlled domain growth. J Math Biol (2006) 0.94
Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos. Development (2013) 0.94
A two-dimensional simulation model of the bicoid gradient in Drosophila. PLoS One (2010) 0.94
Lack of tailless leads to an increase in expression variability in Drosophila embryos. Dev Biol (2013) 0.94
Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos. BMC Dev Biol (2010) 0.94
Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells. Mol Syst Biol (2009) 0.94
Cell lineage transport: a mechanism for molecular gradient formation. Mol Syst Biol (2006) 0.93
Engineering multicellular systems by cell-cell communication. Curr Opin Biotechnol (2009) 0.92
Maternal origins of developmental reproducibility. Curr Biol (2014) 0.92
Morphogen gradient formation and action: insights from studying Bicoid protein degradation. Fly (Austin) (2011) 0.91
Uncovering a dynamic feature of the transcriptional regulatory network for anterior-posterior patterning in the Drosophila embryo. PLoS One (2013) 0.91
Evaluating the Drosophila Bicoid morphogen gradient system through dissecting the noise in transcriptional bursts. Bioinformatics (2012) 0.91
Fluctuation and response in biology. Cell Mol Life Sci (2010) 0.90
Modeling cellular processes in 3D. Trends Cell Biol (2011) 0.90
Singular Spectrum Analysis of Gene Expression Profiles of Early Drosophila embryo: Exponential-in-Distance Patterns. Res Lett Signal Process (2008) 0.90
Assessment of Transport Mechanisms Underlying the Bicoid Morphogen Gradient. Cell Mol Bioeng (2011) 0.89
Interplay between positive and negative activities that influence the role of Bicoid in transcription. Nucleic Acids Res (2005) 0.89
Positional information, positional error, and readout precision in morphogenesis: a mathematical framework. Genetics (2014) 0.87
Mutual repression enhances the steepness and precision of gene expression boundaries. PLoS Comput Biol (2012) 0.87
Physics and the canalization of morphogenesis: a grand challenge in organismal biology. Phys Biol (2011) 0.87
Getting the measure of positional information. PLoS Biol (2009) 0.86
Modeling the establishment of PAR protein polarity in the one-cell C. elegans embryo. Biophys J (2008) 0.86
Noise and information transmission in promoters with multiple internal States. Biophys J (2014) 0.86
Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change. Mol Biol Evol (2014) 0.85
Bacterial persistence as a phenotypic switch. Science (2004) 15.80
Phenotypic diversity, population growth, and information in fluctuating environments. Science (2005) 8.21
Combinatorial synthesis of genetic networks. Science (2002) 5.91
Resilient circadian oscillator revealed in individual cyanobacteria. Nature (2004) 3.84
Mechanisms of noise-resistance in genetic oscillators. Proc Natl Acad Sci U S A (2002) 3.78
Protein sectors: evolutionary units of three-dimensional structure. Cell (2009) 3.76
Dynamic persistence of antibiotic-stressed mycobacteria. Science (2013) 3.34
Patterned gene expression directs bipolar planar polarity in Drosophila. Dev Cell (2004) 3.30
Bacterial persistence: a model of survival in changing environments. Genetics (2005) 2.97
Simpson's paradox in a synthetic microbial system. Science (2009) 2.97
Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev Cell (2003) 2.95
SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila. J Cell Biol (2002) 2.31
DNA looping and physical constraints on transcription regulation. J Mol Biol (2003) 2.26
slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo. Dev Cell (2002) 2.12
Modeling network dynamics: the lac operon, a case study. J Cell Biol (2003) 2.03
Somatic stem cell niche tropism in Wolbachia. Nature (2006) 2.00
Environmental stresses can alleviate the average deleterious effect of mutations. J Biol (2003) 1.76
Rethinking WNT signaling. Trends Genet (2004) 1.63
Modelling the Bicoid gradient. Development (2010) 1.61
Wolbachia utilizes host microtubules and Dynein for anterior localization in the Drosophila oocyte. PLoS Pathog (2005) 1.49
An interdomain sector mediating allostery in Hsp70 molecular chaperones. Mol Syst Biol (2010) 1.42
Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development (2002) 1.41
Three-dimensional epithelial morphogenesis in the developing Drosophila egg. Dev Cell (2013) 1.37
Contingency and statistical laws in replicate microbial closed ecosystems. Cell (2012) 1.23
Cooperation and Hamilton's rule in a simple synthetic microbial system. Mol Syst Biol (2010) 1.22
Neuronal couplings between retinal ganglion cells inferred by efficient inverse statistical physics methods. Proc Natl Acad Sci U S A (2009) 1.20
Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila. Genes Dev (2005) 1.19
Control of cleavage cycles in Drosophila embryos by frühstart. Dev Cell (2003) 1.19
A nuclear function for armadillo/beta-catenin. PLoS Biol (2004) 1.19
Local actin-dependent endocytosis is zygotically controlled to initiate Drosophila cellularization. Dev Cell (2008) 1.17
Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. Dev Cell (2006) 1.17
Quantitation of cellular dynamics in growing Arabidopsis roots with light sheet microscopy. PLoS One (2011) 1.10
Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization. J Cell Sci (2008) 1.10
Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster. Genome Res (2012) 1.09
src64 and tec29 are required for microfilament contraction during Drosophila cellularization. Development (2004) 1.09
Measurement and perturbation of morphogen lifetime: effects on gradient shape. Biophys J (2011) 1.08
Speed, dissipation, and error in kinetic proofreading. Proc Natl Acad Sci U S A (2012) 0.97
The Bicoid gradient is shaped independently of nuclei. Development (2010) 0.96
Torso RTK controls Capicua degradation by changing its subcellular localization. Development (2012) 0.95
Printing multistrain bacterial patterns with a piezoelectric inkjet printer. PLoS One (2007) 0.95
Microbial population dynamics by digital in-line holographic microscopy. Rev Sci Instrum (2010) 0.91
Behavioral diversity in microbes and low-dimensional phenotypic spaces. Proc Natl Acad Sci U S A (2013) 0.86
A nuclear escort for beta-catenin. Nat Cell Biol (2004) 0.86
Junctions as organizing centers in epithelial cells? A fly perspective. Traffic (2002) 0.85
Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. BMC Mol Biol (2007) 0.85
Polymer-population mapping and localization in the space of phenotypes. Phys Rev Lett (2006) 0.82
Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions. Mol Biol Cell (2002) 0.79
Walter Gehring (1939–2014). Curr Biol (2014) 0.75