Published in Proc Natl Acad Sci U S A on August 01, 2003
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology (2009) 2.89
The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab (2009) 2.69
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest (2004) 1.71
Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol (2008) 1.66
Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology (2012) 1.58
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes (2009) 1.46
Leptin in human physiology and therapeutics. Front Neuroendocrinol (2010) 1.46
Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience (2008) 1.31
Hypothalamic substrates of metabolic imprinting. Physiol Behav (2007) 1.25
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism (2014) 1.18
Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus. J Neurosci (2008) 1.14
Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice. FASEB J (2011) 1.10
Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. Proc Natl Acad Sci U S A (2012) 1.09
Appetite and energy balance signals from adipocytes. Philos Trans R Soc Lond B Biol Sci (2006) 1.03
Genomics and genetics in the biology of adaptation to exercise. Compr Physiol (2011) 1.02
Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res (2006) 1.02
Orphan GPCR research. Br J Pharmacol (2007) 0.97
Animals models of MCH function and what they can tell us about its role in energy balance. Peptides (2009) 0.93
The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle. Physiol Behav (2007) 0.92
Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus. J Comp Neurol (2013) 0.91
NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab (2011) 0.91
Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1. Endocrinology (2008) 0.91
Mechanism of the anti-obesity effects induced by a novel melanin-concentrating hormone 1-receptor antagonist in mice. Br J Pharmacol (2009) 0.89
Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus. Physiol Behav (2011) 0.88
Molecules affecting hypothalamic control of core body temperature in response to calorie intake. Front Genet (2012) 0.88
New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation. Front Neuroendocrinol (2010) 0.87
The role of melanin-concentrating hormone and its receptors in energy homeostasis. Front Endocrinol (Lausanne) (2013) 0.86
Melanin-concentrating hormone: a new sleep factor? Front Neurol (2011) 0.86
Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One (2014) 0.86
To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance. Front Syst Neurosci (2015) 0.85
Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity. J Biol Chem (2011) 0.85
Embryonic birthdate of hypothalamic leptin-activated neurons in mice. Endocrinology (2012) 0.85
Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks. Nat Commun (2016) 0.84
A role for Melanin-Concentrating Hormone in learning and memory. Peptides (2009) 0.83
Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiol Rev (2017) 0.81
Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions. J Neurosci (2012) 0.81
Putative roles of neuropeptides in vagal afferent signaling. Physiol Behav (2014) 0.80
MCH neurons: vigilant workers in the night. Sleep (2013) 0.80
20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavors. J Endocrinol (2014) 0.79
Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons. Diabetes (2014) 0.79
Hypothalamic Regulation of Brown Adipose Tissue Thermogenesis and Energy Homeostasis. Front Endocrinol (Lausanne) (2015) 0.78
Peptide-cleaving catalyst selective for melanin-concentrating hormone: Oxidative decarboxylation of N-terminal aspartate catalyzed by Co(III)cyclen. J Biol Inorg Chem (2006) 0.77
The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone. Peptides (2009) 0.76
Brain Regulation of Energy Metabolism. Endocrinol Metab (Seoul) (2016) 0.76
The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors. Front Syst Neurosci (2017) 0.75
Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85
Leptin and the regulation of body weight in mammals. Nature (1998) 14.84
Obesity and the regulation of energy balance. Cell (2001) 9.48
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A (2002) 6.00
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science (2002) 5.89
A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature (1996) 3.79
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76
The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature (1995) 3.67
The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol (1992) 3.53
Identification of targets of leptin action in rat hypothalamus. J Clin Invest (1996) 3.49
Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (1998) 3.38
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 3.28
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci U S A (1998) 2.91
Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron (1998) 2.46
Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest (2001) 2.05
Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci U S A (2002) 2.00
Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology (1999) 1.81
Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology (1997) 1.74
Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology (1999) 1.64
Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology (2002) 1.44
Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes. Diabetes (2000) 1.19
Characterization of MCH-mediated obesity in mice. Am J Physiol Endocrinol Metab (2003) 1.16
Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Int J Obes Relat Metab Disord (2002) 1.13
Insulin and dietary fructose induce stearoyl-CoA desaturase 1 gene expression of diabetic mice. J Biol Chem (1994) 1.04
Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res (2001) 0.98
Hormonal regulation of stearoyl coenzyme-A desaturase 1 activity and gene expression in primary cultures of chicken hepatocytes. Arch Biochem Biophys (1999) 0.85
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
Adipose tissue as an endocrine organ. J Clin Endocrinol Metab (2004) 11.94
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab (2007) 9.34
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res (2005) 8.98
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ (2008) 6.97
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2008) 6.82
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab (2009) 5.32
STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature (2003) 5.27
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest (2011) 5.12
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Leptin regulation of the mesoaccumbens dopamine pathway. Neuron (2006) 4.53
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature (2010) 4.36
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology (2004) 4.10
Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science (2005) 4.01
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985) (2008) 3.54
Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes (2010) 3.30
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) (2009) 3.15
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One (2010) 3.03
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med (2004) 2.98
Molecular and anatomical determinants of central leptin resistance. Nat Neurosci (2005) 2.98
Transcriptional control of adipose lipid handling by IRF4. Cell Metab (2011) 2.95
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology (2007) 2.95
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes (2003) 2.90
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology (2009) 2.89
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes (2010) 2.80
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med (2006) 2.77
Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. EMBO J (2007) 2.75
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes (2005) 2.72
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68
A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab (2007) 2.64
Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci U S A (2006) 2.55
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes (2007) 2.54
Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab (2006) 2.52
Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes (2006) 2.50
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology (2010) 2.50
The gut and energy balance: visceral allies in the obesity wars. Science (2005) 2.24
Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol (2004) 2.14
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2005) 2.13
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes (2004) 2.12
Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem (2004) 2.11
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (2005) 2.08
The adipocyte as an active participant in energy balance and metabolism. Gastroenterology (2007) 2.02
Identification of CD105 (endoglin)-positive stem-like cells in rhabdoid meningioma. J Neurooncol (2011) 2.01
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology (2011) 2.00
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology (2003) 1.99
Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J Comp Neurol (2007) 1.96
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab (2008) 1.96
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab (2006) 1.96
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. Mol Endocrinol (2007) 1.96
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest (2003) 1.95
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol (2008) 1.93
Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring) (2006) 1.92
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest (2007) 1.91
Critical role for hypothalamic mTOR activity in energy balance. Cell Metab (2009) 1.90
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest (2011) 1.89
The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci (2005) 1.86
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A (2008) 1.83
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab (2006) 1.83
Influenza pandemic preparedness action plan for the United States: 2002 update. Clin Infect Dis (2002) 1.82
Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem (2004) 1.75
Critical role of STAT3 in leptin's metabolic actions. Cell Metab (2006) 1.70
Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. Proc Natl Acad Sci U S A (2010) 1.69
Human pregnancy up-regulates Tim-3 in innate immune cells for systemic immunity. J Immunol (2009) 1.68
Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology (2012) 1.68
PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A (2009) 1.67
Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci (2007) 1.66
The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1--blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2009) 1.64
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J Biol Chem (2005) 1.64
The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab (2003) 1.64
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem (2009) 1.63
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab (2007) 1.63
Effects of angiotensin-converting enzyme inhibition in low-risk patients early after coronary artery bypass surgery. Circulation (2007) 1.62
PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab (2007) 1.61
Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science (2011) 1.60
Retracted Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab (2011) 1.60
LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes (2004) 1.59
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem (2002) 1.57
Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine study. Eur Heart J (2008) 1.55
Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am J Clin Nutr (2011) 1.55
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss. Am J Physiol Endocrinol Metab (2009) 1.54
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem (2007) 1.53