Published in Mol Cell Biol on March 01, 2002
Adipocyte CREB promotes insulin resistance in obesity. Cell Metab (2009) 1.72
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J (2007) 1.67
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest (2011) 1.50
Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49
Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol (2004) 1.28
MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway. Mol Cell Biol (2003) 1.10
MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. PLoS One (2012) 1.03
MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing. PLoS One (2013) 0.99
ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol (2014) 0.89
ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3. J Biol Chem (2008) 0.87
How one TSH receptor antibody induces thyrocyte proliferation while another induces apoptosis. J Autoimmun (2013) 0.87
The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. J Biol Chem (2015) 0.86
CREB regulates AChE-R-induced proliferation of human glioblastoma cells. Neoplasia (2004) 0.86
cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One (2011) 0.86
Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity. J Biol Chem (2011) 0.85
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS One (2010) 0.85
Reactivation of developmental programs: the cAMP-response element-binding protein pathway is involved in hydra head regeneration. Proc Natl Acad Sci U S A (2004) 0.84
Cyclic AMP response element-binding protein prevents endothelial permeability increase through transcriptional controlling p190RhoGAP expression. Blood (2011) 0.84
CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Res (2012) 0.83
Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem J (2014) 0.79
Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A (2013) 0.79
Post-Translational Modifications of Histones in Vertebrate Neurogenesis. Front Neurosci (2015) 0.78
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis. J Mol Biol (2016) 0.77
Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target. Oncotarget (2016) 0.76
Transcription factor CREB is phosphorylated in human molar odontoblasts and cementoblasts in vivo. Histochem Cell Biol (2012) 0.75
Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms. Sci Rep (2016) 0.75
Developmental transcriptomic analyses for mechanistic insights into critical pathways involved in embryogenesis of pelagic mahi-mahi (Coryphaena hippurus). PLoS One (2017) 0.75
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science (1999) 7.37
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev (1995) 7.13
Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol (1993) 6.38
Expression pattern of the mouse T gene and its role in mesoderm formation. Nature (1990) 4.97
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature (1990) 4.69
The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development (1995) 4.65
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science (1991) 4.53
CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem (1998) 4.12
HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1994) 4.08
Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell (1995) 3.67
Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell (1994) 3.30
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science (1999) 3.13
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J (1996) 2.98
Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron (1995) 2.90
Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature (1996) 2.74
Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature (1996) 2.63
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A (1998) 2.02
Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev Biol (1994) 1.71
Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature (1991) 1.55
CREB and its associated proteins act as survival factors for human melanoma cells. J Biol Chem (1998) 1.37
FGF is an essential regulator of the fifth cell division in preimplantation mouse embryos. Dev Biol (1998) 1.12
Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines. J Biol Chem (1998) 1.12
Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells. Oncogene (1997) 1.08
Adenovirus-directed expression of a nonphosphorylatable mutant of CREB (cAMP response element-binding protein) adversely affects the survival, but not the differentiation, of rat granulosa cells. Mol Endocrinol (1999) 1.00
Expression of the gene encoding transcription factor cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB): regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells. Endocrinology (1995) 0.99
Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment. Oncogene (2000) 0.98
APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells. EMBO J (1998) 0.90
Tumor cell viability in clear cell sarcoma requires DNA binding activity of the EWS/ATF1 fusion protein. J Biol Chem (1999) 0.84
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93
CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science (2003) 5.22
G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med (2007) 4.26
Disruption of CREB function in brain leads to neurodegeneration. Nat Genet (2002) 3.54
Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell (2009) 3.53
Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation. Cell (2010) 3.42
Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron (2006) 3.04
Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci U S A (2005) 2.73
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron (2008) 2.37
Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta. Development (2002) 2.27
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J (2002) 2.15
Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J Neurosci (2005) 2.15
Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death. Neuron (2007) 2.08
Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol (2007) 2.08
SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci (2005) 1.87
MicroRNA loss enhances learning and memory in mice. J Neurosci (2010) 1.82
A sensitive non-radioactive northern blot method to detect small RNAs. Nucleic Acids Res (2010) 1.81
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab (2010) 1.79
New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism. Nature (2010) 1.78
Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest (2010) 1.78
Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci (2003) 1.78
Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc Natl Acad Sci U S A (2009) 1.76
The Tlx gene regulates the timing of neurogenesis in the cortex. J Neurosci (2004) 1.75
Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. Neuron (2002) 1.72
cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs. J Neurosci (2002) 1.71
An in-depth map of polyadenylation sites in cancer. Nucleic Acids Res (2012) 1.71
Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science (2011) 1.64
Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci U S A (2005) 1.64
The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity. J Neurosci (2009) 1.63
Serum response factor controls neuronal circuit assembly in the hippocampus. Nat Neurosci (2006) 1.61
Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension (2011) 1.59
cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement. J Neurosci (2004) 1.59
Metaplasticity of amygdalar responses to the stress hormone corticosterone. Proc Natl Acad Sci U S A (2010) 1.58
OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. Drug Alcohol Depend (2010) 1.55
DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol (2005) 1.55
Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nat Neurosci (2011) 1.53
Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest (2007) 1.51
Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. J Am Soc Nephrol (2007) 1.51
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci (2009) 1.51
The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes Dev (2008) 1.46
TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest (2008) 1.45
Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci U S A (2005) 1.45
The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev (2010) 1.45
Mu-opioid receptor and CREB activation are required for nicotine reward. Neuron (2005) 1.45
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev (2007) 1.45
Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development (2005) 1.44
Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci (2008) 1.41
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest (2002) 1.40
Genetic evidence for a role of CREB in sustained cortical arousal. J Neurophysiol (2003) 1.37
Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test. Psychopharmacology (Berl) (2005) 1.37
High-accuracy amplification of nanogram total RNA amounts for gene profiling. Genomics (2004) 1.35
The glucocorticoid receptor as a potential target to reduce cocaine abuse. J Neurosci (2003) 1.34
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev (2004) 1.30
Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers. Proc Natl Acad Sci U S A (2011) 1.29
cAMP response element-binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb. J Neurosci (2005) 1.29
Antidepressant action: to the nucleus and beyond. Trends Pharmacol Sci (2005) 1.24
Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology (2004) 1.24
Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior. J Pharmacol Exp Ther (2010) 1.24
cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response. J Neurosci (2007) 1.23
Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia. Stroke (2010) 1.22
Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol Endocrinol (2004) 1.21
Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci (2011) 1.20
Expression of Cre recombinase in dopaminoceptive neurons. BMC Neurosci (2007) 1.19
Loss of the tailless gene affects forebrain development and emotional behavior. Physiol Behav (2002) 1.19
Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci (2007) 1.19
The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res (2011) 1.18
Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron. Nat Commun (2013) 1.17
Anaphylactic shock depends on endothelial Gq/G11. J Exp Med (2009) 1.16
CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis. FASEB J (2008) 1.15
Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development. J Clin Invest (2007) 1.15
Endocrine and gene expression changes following forced swim stress exposure during cocaine abstinence in mice. Psychopharmacology (Berl) (2008) 1.14
A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci (2010) 1.14
Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline. Nicotine Tob Res (2010) 1.13
Making a bad thing worse: adverse effects of stress on drug addiction. J Clin Invest (2008) 1.13
Lack of gp130 expression in hepatocytes promotes liver injury. Gastroenterology (2003) 1.12
Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation (2011) 1.12
Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci (2008) 1.12
Molecular and genetic substrates linking stress and addiction. Brain Res (2009) 1.11
Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J (2011) 1.10
Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Development (2007) 1.08
NAC1 regulates the recruitment of the proteasome complex into dendritic spines. J Neurosci (2007) 1.08
An integrated genome research network for studying the genetics of alcohol addiction. Addict Biol (2010) 1.07
Ventral tegmental afferents in stress-induced reinstatement: the role of cAMP response element-binding protein. J Neurosci (2010) 1.06
A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. Biochem J (2012) 1.06
Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety. Neuropharmacology (2009) 1.06
DNA binding by estrogen receptor-alpha is essential for the transcriptional response to estrogen in the liver and the uterus. Mol Endocrinol (2009) 1.05
Cre recombinase-mediated gene targeting of mesenchymal cells. Genesis (2004) 1.05
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A (2011) 1.05
Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models. FASEB J (2011) 1.05
Targeting mammary epithelial cells using a bacterial artificial chromosome. Genesis (2002) 1.05
Community-dwelling persons with dementia: what do they need? What do they demand? What do they do? A systematic review on the subjective experiences of persons with dementia. Aging Ment Health (2012) 1.02
Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A (2012) 1.02
Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Mol Cell Biol (2006) 1.02