Published in EMBO J on May 24, 2007
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell (2009) 2.69
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J (2007) 2.07
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics (2010) 1.92
Adipocyte CREB promotes insulin resistance in obesity. Cell Metab (2009) 1.72
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation. EMBO J (2010) 1.55
CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metab (2009) 1.55
Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension. Am J Physiol Renal Physiol (2012) 1.47
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. J Biol Chem (2008) 1.35
A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway. Proc Natl Acad Sci U S A (2007) 1.34
Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription. Endocrinology (2008) 1.27
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol (2009) 1.27
CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors. J Neurosci (2011) 1.12
Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest (2013) 1.04
Protein kinase A binds and activates heat shock factor 1. PLoS One (2010) 1.02
GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene. J Lipid Res (2010) 0.99
A functional analysis of the CREB signaling pathway using HaloCHIP-chip and high throughput reporter assays. BMC Genomics (2009) 0.98
Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription. Endocrinology (2010) 0.97
The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. Mol Cell Biol (2007) 0.96
Is histone acetylation the most important physiological function for CBP and p300? Aging (Albany NY) (2012) 0.95
Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways. Cell Cycle (2011) 0.95
Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS One (2009) 0.93
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab (2011) 0.92
TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. J Biol Chem (2009) 0.92
cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter. J Mol Biol (2009) 0.91
Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate. J Biol Chem (2010) 0.90
Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat. Mol Neurobiol (2014) 0.89
Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation. Mol Biol Cell (2008) 0.88
Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation. Cell Death Differ (2012) 0.88
Unique aspects of transcription regulation in male germ cells. Cold Spring Harb Perspect Biol (2011) 0.88
Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase. Biochem Biophys Res Commun (2010) 0.87
Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Res (2014) 0.83
Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression. PLoS One (2013) 0.83
Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation. EMBO J (2009) 0.81
The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1. Open Biol (2013) 0.80
RCAN1 is an important mediator of glucocorticoid-induced apoptosis in human leukemic cells. PLoS One (2012) 0.79
Rasd1 modulates the coactivator function of NonO in the cyclic AMP pathway. PLoS One (2011) 0.79
Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy. Br J Cancer (2014) 0.78
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice. Mol Cell Biol (2012) 0.78
Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. J Neurosci (2009) 0.78
Role of an adenylyl cyclase isoform in ethanol's effect on cAMP regulated gene expression in NIH 3T3 cells. Biochem Biophys Rep (2016) 0.77
TORC: a new twist on corticotropin-releasing hormone gene expression. Endocrinology (2010) 0.77
Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress (2013) 0.77
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis. J Mol Biol (2016) 0.77
Prostaglandins from Cytosolic Phospholipase A2α/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages. J Biol Chem (2016) 0.76
T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One (2014) 0.75
CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene. Cell Rep (2017) 0.75
Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism. Nucleic Acids Res (2016) 0.75
Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway. PLoS One (2015) 0.75
CBP/p300 in cell growth, transformation, and development. Genes Dev (2000) 10.76
Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol (2001) 10.69
Function and regulation of CREB family transcription factors in the nervous system. Neuron (2002) 7.99
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature (2005) 7.14
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73
Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev (2006) 6.32
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
The many faces of CREB. Trends Neurosci (2005) 5.58
Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell (1997) 5.39
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell (2004) 4.53
TORCs: transducers of regulated CREB activity. Mol Cell (2003) 4.42
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell (1991) 4.11
Disruption of CREB function in brain leads to neurodegeneration. Nat Genet (2002) 3.54
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A (2003) 3.21
Biological control through regulated transcriptional coactivators. Cell (2004) 3.05
What turns CREB on? Cell Signal (2004) 3.03
Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell (1993) 2.84
An ORFeome-based analysis of human transcription factor genes and the construction of a microarray to interrogate their expression. Genome Res (2004) 2.77
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev (2002) 2.77
Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr Biol (2004) 2.69
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature (2002) 2.50
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci U S A (1994) 2.24
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J (2007) 2.07
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol (2006) 2.00
A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol (1998) 1.93
Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo. Nucleic Acids Res (2004) 1.81
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell (2004) 1.80
Coactivator cross-talk specifies transcriptional output. Genes Dev (2006) 1.79
Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. Blood (1999) 1.77
Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. Nature (1993) 1.70
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68
Transcriptional regulation by cyclic AMP-responsive factors. Prog Nucleic Acid Res Mol Biol (2000) 1.68
Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly. EMBO J (2003) 1.59
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A (2004) 1.49
Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J (2003) 1.48
Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO J (1996) 1.47
Role of secondary structure in discrimination between constitutive and inducible activators. Mol Cell Biol (1999) 1.47
Transcriptional control of cognitive development. Curr Opin Neurobiol (2005) 1.35
TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth. EMBO J (2005) 1.23
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood (2006) 1.21
Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein (CREB) and compensatory overexpression of the activator CREMtau in the human adrenocortical cancer cell line H295R. J Clin Endocrinol Metab (2000) 1.12
Activating transcription factor 1 and CREB are important for cell survival during early mouse development. Mol Cell Biol (2002) 1.11
TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis. Dev Biol (2005) 1.11
Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Cell Cycle (2006) 1.10
Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates. Mol Cell Biol (2003) 1.07
Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes. Proc Natl Acad Sci U S A (2000) 1.04
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28
Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature (2011) 5.20
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02
CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature (2011) 3.72
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J (2010) 3.25
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature (2002) 2.50
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol (2006) 2.00
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics (2010) 1.92
The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila. Development (2005) 1.81
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell (2004) 1.80
Mucosal immune responses predict clinical outcomes during influenza infection independently of age and viral load. Am J Respir Crit Care Med (2014) 1.75
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation. EMBO J (2010) 1.55
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol (2009) 1.27
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood (2006) 1.21
Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learn Mem (2011) 1.16
Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Cell Cycle (2006) 1.10
JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila. Genetics (2010) 1.05
Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behav Neurosci (2006) 1.02
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Nat Med (2013) 1.02
JIL-1 kinase, a member of the male-specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila. Genesis (2005) 0.99
Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res (2013) 0.95
Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways. Cell Cycle (2011) 0.95
Is histone acetylation the most important physiological function for CBP and p300? Aging (Albany NY) (2012) 0.95
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab (2011) 0.92
Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development (2014) 0.91
Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression. PLoS One (2013) 0.83
Influenza Virus Surveillance in Coordinated Swine Production Systems, United States. Emerg Infect Dis (2015) 0.81