Dynamics of ligand binding to myoglobin.

Protein states and proteinquakes. Proc Natl Acad Sci U S A (1985) 10.43

Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J (1987) 9.64

The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol (2009) 7.36

Crystal structures of myoglobin-ligand complexes at near-atomic resolution. Biophys J (1999) 3.55

Slaving: solvent fluctuations dominate protein dynamics and functions. Proc Natl Acad Sci U S A (2002) 3.40

Conformational substates in a protein: structure and dynamics of metmyoglobin at 80 K. Proc Natl Acad Sci U S A (1982) 3.25

Role of aspartate-96 in proton translocation by bacteriorhodopsin. Proc Natl Acad Sci U S A (1989) 3.22

Fluorescence lifetime distributions in proteins. Biophys J (1987) 3.18

Conformational transitions monitored for single molecules in solution. Proc Natl Acad Sci U S A (1996) 3.17

Observation of strange kinetics in protein folding. Proc Natl Acad Sci U S A (1999) 3.02

NMR spectroscopy brings invisible protein states into focus. Nat Chem Biol (2009) 3.00

The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin. Proc Natl Acad Sci U S A (2001) 2.75

At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis? Proteins (2010) 2.69

Bulk-solvent and hydration-shell fluctuations, similar to alpha- and beta-fluctuations in glasses, control protein motions and functions. Proc Natl Acad Sci U S A (2004) 2.54

Internal motions in proteins and gating kinetics of ionic channels. Biophys J (1988) 2.54

A unified model of protein dynamics. Proc Natl Acad Sci U S A (2009) 2.45

Resolvability of fluorescence lifetime distributions using phase fluorometry. Biophys J (1987) 2.35

Interpretation of fluorescence decays in proteins using continuous lifetime distributions. Biophys J (1987) 2.30

Protein hydration elucidated by molecular dynamics simulation. Proc Natl Acad Sci U S A (1993) 2.26

A model of protein conformational substates. Proc Natl Acad Sci U S A (1985) 2.23

Ensemble refinement of protein crystal structures: validation and application. Structure (2007) 2.16

Spectroscopic studies of oxy- and carbonmonoxyhemoglobin after pulsed optical excitation. Proc Natl Acad Sci U S A (1978) 2.15

Transient non-native hydrogen bonds promote activation of a signaling protein. Cell (2009) 2.12

Photoelectric signals from dried oriented purple membranes of Halobacterium halobium. Biophys J (1983) 2.10

A consistent picture of protein dynamics. Proc Natl Acad Sci U S A (1984) 2.10

Ligand binding to heme proteins. VI. Interconversion of taxonomic substates in carbonmonoxymyoglobin. Biophys J (1996) 2.02

Geminate recombination of O2 and hemoglobin. Proc Natl Acad Sci U S A (1980) 1.97

Thermal properties of water in myoglobin crystals and solutions at subzero temperatures. Biophys J (1986) 1.96

Infrared spectroscopy of photodissociated carboxymyoglobin at low temperatures. Proc Natl Acad Sci U S A (1982) 1.96

Complex landscape of protein structural dynamics unveiled by nanosecond Laue crystallography. Proc Natl Acad Sci U S A (2003) 1.92

Electron transfer and protein dynamics in the photosynthetic reaction center. Biophys J (1998) 1.92

Folding thermodynamics of a model three-helix-bundle protein. Proc Natl Acad Sci U S A (1997) 1.89

Distributed kinetics of the charge movements in bacteriorhodopsin: evidence for conformational substates. Biophys J (1988) 1.89

Protein folding is slaved to solvent motions. Proc Natl Acad Sci U S A (2006) 1.88

X-ray structure determination of a metastable state of carbonmonoxy myoglobin after photodissociation. Proc Natl Acad Sci U S A (1996) 1.86

Evidence that a distribution of bacterial reaction centers underlies the temperature and detection-wavelength dependence of the rates of the primary electron-transfer reactions. Proc Natl Acad Sci U S A (1990) 1.85

Dynamics of myoglobin: comparison of simulation results with neutron scattering spectra. Proc Natl Acad Sci U S A (1990) 1.82

Temperature-derivative spectroscopy: a tool for protein dynamics. Proc Natl Acad Sci U S A (1990) 1.75

DNA sequence alignment by microhomology sampling during homologous recombination. Cell (2015) 1.75

Potential energy landscape and robustness of a gene regulatory network: toggle switch. PLoS Comput Biol (2007) 1.75

A fractional calculus approach to self-similar protein dynamics. Biophys J (1995) 1.70

Ligand migration pathway and protein dynamics in myoglobin: a time-resolved crystallographic study on L29W MbCO. Proc Natl Acad Sci U S A (2005) 1.69

Conformational substates and motions in myoglobin. External influences on structure and dynamics. Biophys J (1990) 1.69

Orientation of carbon monoxide and structure-function relationship in carbonmonoxymyoglobin. Proc Natl Acad Sci U S A (1988) 1.67

Ligand binding to heme proteins: II. Transitions in the heme pocket of myoglobin. Biophys J (1993) 1.64

The role of cavities in protein dynamics: crystal structure of a photolytic intermediate of a mutant myoglobin. Proc Natl Acad Sci U S A (2000) 1.63

Myoglobin: the hydrogen atom of biology and a paradigm of complexity. Proc Natl Acad Sci U S A (2003) 1.62

Inhomogeneous broadening in spectral bands of carbonmonoxymyoglobin. The connection between spectral and functional heterogeneity. Biophys J (1990) 1.62

Dynamics and function of proteins: the search for general concepts. Proc Natl Acad Sci U S A (1998) 1.62

Extended subnanosecond structural dynamics of myoglobin revealed by Laue crystallography. Proc Natl Acad Sci U S A (2006) 1.61

Picosecond photodissociation and subsequent recombination processes in carbon monoxide hemoglobin. Proc Natl Acad Sci U S A (1978) 1.58

Temperature dependence of the low frequency dynamics of myoglobin. Measurement of the vibrational frequency distribution by inelastic neutron scattering. Biophys J (1990) 1.58

Protein fluctuations are sensed by stimulated infrared echoes of the vibrations of carbon monoxide and azide probes. Proc Natl Acad Sci U S A (1998) 1.56

Determination of rate distributions from kinetic experiments. Biophys J (1992) 1.55

Effect of the environment on the protein dynamical transition: a neutron scattering study. Biophys J (2002) 1.54

Ultrafast dynamics of phytochrome from the cyanobacterium synechocystis, reconstituted with phycocyanobilin and phycoerythrobilin. Biophys J (2002) 1.53

Spectroscopic evidence for conformational relaxation in myoglobin. Proc Natl Acad Sci U S A (1992) 1.53

Harmonic and anharmonic aspects in the dynamics of BPTI: a normal mode analysis and principal component analysis. Protein Sci (1994) 1.51

How Many M Forms are there in the Bacteriorhodopsin Photocycle? Biophys J (1986) 1.48

Cavities and packing defects in the structural dynamics of myoglobin. EMBO Rep (2001) 1.47

Dynamics of activated processes in globular proteins. Proc Natl Acad Sci U S A (1979) 1.47

The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics. Proc Natl Acad Sci U S A (2008) 1.46

Ligand binding and protein dynamics in neuroglobin. Proc Natl Acad Sci U S A (2002) 1.46

Kinetics of hemoglobin and transition state theory. Proc Natl Acad Sci U S A (1978) 1.46

Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer. PLoS Comput Biol (2009) 1.43

Simultaneous determination of intramolecular distance distributions and conformational dynamics by global analysis of energy transfer measurements. Biophys J (1989) 1.43

Mechanisms for excited state relaxation and dissociation of oxymyoglobin and carboxymyoglobin. Proc Natl Acad Sci U S A (1981) 1.42

Extended molecular dynamics simulation of the carbon monoxide migration in sperm whale myoglobin. Biophys J (2004) 1.40

On the role of frustration in the energy landscapes of allosteric proteins. Proc Natl Acad Sci U S A (2011) 1.39

The effect of quaternary structure on the kinetics of conformational changes and nanosecond geminate rebinding of carbon monoxide to hemoglobin. Proc Natl Acad Sci U S A (1988) 1.36

On the nature of a glassy state of matter in a hydrated protein: Relation to protein function. Proc Natl Acad Sci U S A (2001) 1.35

Different dissociation pathways and observation of an excited deoxy state in picosecond photolysis of oxy- and carboxymyoglobin. Proc Natl Acad Sci U S A (1981) 1.34

Nonexponential kinetics of DNA escape from alpha-hemolysin nanopores. Biophys J (2008) 1.33

Direct observation of tiers in the energy landscape of a chromoprotein: a single-molecule study. Proc Natl Acad Sci U S A (2003) 1.33

Exploring the energy landscape in proteins. Proc Natl Acad Sci U S A (1993) 1.32

On the structural convergence of biomolecular simulations by determination of the effective sample size. J Phys Chem B (2007) 1.31

Quantifying robustness and dissipation cost of yeast cell cycle network: the funneled energy landscape perspectives. Biophys J (2007) 1.31

Structural dynamics of ligand diffusion in the protein matrix: A study on a new myoglobin mutant Y(B10) Q(E7) R(E10). Biophys J (1999) 1.29

Analysis of kinetics using a hybrid maximum-entropy/nonlinear-least-squares method: application to protein folding. Biophys J (2002) 1.29

Unveiling functional protein motions with picosecond x-ray crystallography and molecular dynamics simulations. Proc Natl Acad Sci U S A (2004) 1.28

Coupling between the bacteriorhodopsin photocycle and the protonmotive force in Halobacterium halobium cell envelope vesicles. II. Quantitation and preliminary modeling of the M----bR reactions. Biophys J (1984) 1.28

Comparison of the magnetic properties of deoxy- and photodissociated myoglobin. Proc Natl Acad Sci U S A (1984) 1.28

Exonuclease I hydrolyzes DNA with a distribution of rates. Biophys J (2004) 1.24

Nanosecond flash photolysis study of carbon monoxide binding to the beta chain of hemoglobin Zürich [beta 63(E7)His leads to Arg]. Proc Natl Acad Sci U S A (1983) 1.23

Photoselection in polarized photolysis experiments on heme proteins. Biophys J (1993) 1.23

Hydrated myoglobin's anharmonic fluctuations are not primarily due to dihedral transitions. Proc Natl Acad Sci U S A (1996) 1.22

Funneled landscape leads to robustness of cell networks: yeast cell cycle. PLoS Comput Biol (2006) 1.21

On the photosensitivity of liganded hemoproteins and their metal-substituted analogues. Proc Natl Acad Sci U S A (1978) 1.19

F-actin and myosin II accelerate catecholamine release from chromaffin granules. J Neurosci (2009) 1.19

Structural dynamics of liganded myoglobin. Biophys J (1980) 1.18

More than two pyrrole tautomers of mesoporphyrin stabilized by a protein. High resolution optical spectroscopic study. Biophys J (1992) 1.17

The reaction of cytochrome omicron in Escherichia coli with oxygen. Low-temperature kinetic and spectral studies. Biochem J (1979) 1.16

Theory of Mössbauer spectra of proteins fluctuating between conformational substates. Proc Natl Acad Sci U S A (1984) 1.15

Conformational substates in azurin. Proc Natl Acad Sci U S A (1992) 1.14

Lifetimes of intermediates in the beta -sheet to alpha -helix transition of beta -lactoglobulin by using a diffusional IR mixer. Proc Natl Acad Sci U S A (2001) 1.14

Protein dynamics. Comparative investigation on heme-proteins with different physiological roles. Biophys J (1991) 1.13

Temperature-dependent studies of NO recombination to heme and heme proteins. J Am Chem Soc (2005) 1.13

Hierarchies and logarithmic oscillations in the temporal relaxation patterns of proteins and other complex systems. Proc Natl Acad Sci U S A (1999) 1.12

Molecular dynamics study of the M412 intermediate of bacteriorhodopsin. Biophys J (1995) 1.11

The effect of ligand dynamics on heme electronic transition band III in myoglobin. Biophys J (2002) 1.11

Protein states and proteinquakes. Proc Natl Acad Sci U S A (1985) 10.43

Temperature-dependent X-ray diffraction as a probe of protein structural dynamics. Nature (1979) 9.27

Transmissible plasmid coding early enzymes of naphthalene oxidation in Pseudomonas putida. J Bacteriol (1973) 6.21

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics (1996) 6.12

Pyruvic Acid Metabolism: A Factor Required for Oxidation by Streptococcus faecalis. J Bacteriol (1948) 5.07

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol (1993) 4.92

Plasmid gene organization: naphthalene/salicylate oxidation. Proc Natl Acad Sci U S A (1982) 4.78

A transmissible plasmid controlling camphor oxidation in Pseudomonas putida. Proc Natl Acad Sci U S A (1973) 4.57

Solvent viscosity and protein dynamics. Biochemistry (1980) 4.35

Genetic regulation of octane dissimilation plasmid in Pseudomonas. Proc Natl Acad Sci U S A (1973) 4.29

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol (1991) 3.73

Inducibility of tryptophan synthetase in Pseudomonas putida. Proc Natl Acad Sci U S A (1966) 3.70

Rebinding and relaxation in the myoglobin pocket. Biophys Chem (1987) 3.58

Slaving: solvent fluctuations dominate protein dynamics and functions. Proc Natl Acad Sci U S A (2002) 3.40

The Production of Active Resting Cells of Streptococci. J Bacteriol (1942) 3.36

Rate theories and puzzles of hemeprotein kinetics. Science (1985) 3.30

Conformational substates in a protein: structure and dynamics of metmyoglobin at 80 K. Proc Natl Acad Sci U S A (1982) 3.25

Citric Acid Fermentation by Streptococci and Lactobacilli. J Bacteriol (1944) 3.25

Transduction and the clustering of genes in fluorescent Pseudomonads. Proc Natl Acad Sci U S A (1968) 3.23

A Study of the So-Called Marburg and the Lawrence and Ford Strains of Bacillus subtilis. J Bacteriol (1944) 3.06

The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA (1989) 3.03

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450. J Biol Chem (1985) 2.95

DNA electrophoresis in microlithographic arrays. Nature (1992) 2.95

The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95

A soluble cytochrome P-450 functional in methylene hydroxylation. J Biol Chem (1968) 2.86

Ligand binding to heme proteins: connection between dynamics and function. Biochemistry (1991) 2.85

Tyrosine Decarboxylase: II. Pyridoxine-deficient Medium for Apoenzyme Production. J Bacteriol (1945) 2.85

The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin. Proc Natl Acad Sci U S A (2001) 2.75

Biotechnology at low Reynolds numbers. Biophys J (1996) 2.72

Importance of DNA stiffness in protein-DNA binding specificity. Nature (1987) 2.70

Compactness of the denatured state of a fast-folding protein measured by submillisecond small-angle x-ray scattering. Proc Natl Acad Sci U S A (1999) 2.53

Repression of malic enzyme by acetate in Pseudomonas. Biochem Biophys Res Commun (1966) 2.51

Tyrosine Decarboxylation by Streptococci: Growth Requirements for Active Cell Production. J Bacteriol (1944) 2.31

Binding of carbon monoxide to isolated hemoglobin chains. Biochemistry (1978) 2.31

Thermal expansion of a protein. Biochemistry (1987) 2.25

Fourier transform infrared difference spectroscopy of bacteriorhodopsin and its photoproducts. Proc Natl Acad Sci U S A (1982) 2.18

An Alcohol Oxidation System in Streptococci Which Functions without Hydrogen Peroxide Accumulation. J Bacteriol (1944) 2.08

Isolation of metabolic plasmid DNA from Pseudomonas putida. Biochem Biophys Res Commun (1977) 2.06

Ligand binding to heme proteins. VI. Interconversion of taxonomic substates in carbonmonoxymyoglobin. Biophys J (1996) 2.02

Nucleotide sequence of the Pseudomonas putida cytochrome P-450cam gene and its expression in Escherichia coli. J Biol Chem (1986) 2.00

Control and pH dependence of ligand binding to heme proteins. Biochemistry (1982) 1.97

Infrared spectroscopy of photodissociated carboxymyoglobin at low temperatures. Proc Natl Acad Sci U S A (1982) 1.96

Autonomous replication of a defective transducing phage in Pseudomonas putida. Virology (1969) 1.91

Bacterial P-450cam methylene monooxygenase components: cytochrome m, putidaredoxin, and putidaredoxin reductase. Methods Enzymol (1978) 1.90

Rotational diffusion of cell surface components by time-resolved phosphorescence anisotropy. Proc Natl Acad Sci U S A (1979) 1.84

Defective phage and chromosome mobilization in Pseudomonas putida. Proc Natl Acad Sci U S A (1969) 1.80

Insulating behavior of lambda-DNA on the micron scale. Phys Rev Lett (2002) 1.75

Nucleotide sequence and expression of gene nahH of plasmid NAH7 and homology with gene xylE of TOL pWWO. Gene (1987) 1.74

Nucleotide sequence of plasmid NAH7 gene nahR and DNA binding of the nahR product. J Bacteriol (1988) 1.72

Cloning of genes for naphthalene metabolism in Pseudomonas putida. J Bacteriol (1983) 1.72

Nucleotide sequence analysis of the Pseudomonas putida PpG7 salicylate hydroxylase gene (nahG) and its 3'-flanking region. Biochemistry (1991) 1.70

Conformational substates and motions in myoglobin. External influences on structure and dynamics. Biophys J (1990) 1.69

Orientation of carbon monoxide and structure-function relationship in carbonmonoxymyoglobin. Proc Natl Acad Sci U S A (1988) 1.67

Anthranilate synthase enzyme system and complementation in Pseudomonas species. Proc Natl Acad Sci U S A (1970) 1.65

Ligand binding to heme proteins: II. Transitions in the heme pocket of myoglobin. Biophys J (1993) 1.64

Inhomogeneous broadening in spectral bands of carbonmonoxymyoglobin. The connection between spectral and functional heterogeneity. Biophys J (1990) 1.62

Ligand binding to heme proteins: the effect of light on ligand binding in myoglobin. Biochemistry (1994) 1.61

Separation of 100-kilobase DNA molecules in 10 seconds. Anal Chem (2001) 1.58

Regulation of naphthalene catabolic genes of plasmid NAH7. J Bacteriol (1985) 1.58

Tunneling in ligand binding to heme proteins. Science (1976) 1.58

Determination of rate distributions from kinetic experiments. Biophys J (1992) 1.55

Time resolved collapse of a folding protein observed with small angle x-ray scattering. Phys Rev Lett (2001) 1.54

Spectroscopic evidence for conformational relaxation in myoglobin. Proc Natl Acad Sci U S A (1992) 1.53

Microsecond rotational motions of eosin-labeled myosin measured by time-resolved anisotropy of absorption and phosphorescence. J Mol Biol (1984) 1.48

Evidence for kinks in DNA folding in the nucleosome. Nature (1987) 1.48

Enzyme induction and repression in anabolic and catabolic pathways. Arch Mikrobiol (1967) 1.46

The iron electron-nuclear double resonance (ENDOR) of two-iron ferredoxins from spinach, parsley, pig adrenal cortex and Pseudomonas putida. Biochim Biophys Acta (1971) 1.46

Mixed function oxidation. IV. An induced methylene hydroxylase in camphor oxidation. J Biol Chem (1965) 1.45

Autooxidation and hydroxylation reactions of oxygenated cytochrome P-450cam. J Biol Chem (1976) 1.44

Fourier-transform infrared difference spectroscopy of rhodopsin and its photoproducts at low temperature. Biochemistry (1985) 1.42

Spin-state changes in cytochrome P-450cam on binding of specific substrates. Proc Natl Acad Sci U S A (1970) 1.42

Deformation and flow of red blood cells in a synthetic lattice: evidence for an active cytoskeleton. Biophys J (1995) 1.42

A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase. Proc Natl Acad Sci U S A (1976) 1.41

Composition and structure of camphor hydroxylase components and homology between putidaredoxin and adrenodoxin. Biochem Biophys Res Commun (1971) 1.37

The number of iron atoms in the paramagnetic center (G =1.94) of reduced putidaredoxin, a nonheme iron protein. Proc Natl Acad Sci U S A (1968) 1.37

Oxygenase-catalyzed biological hydroxylations. Annu Rev Biochem (1975) 1.35

Transduction and genetic homology between Pseudomonas species putida and aeruginosa. J Bacteriol (1970) 1.34

Monoxygenases. VII. Camphor ketolactonase I and the role of three protein components. J Biol Chem (1969) 1.33

Mixed function oxidation. V. Flavin interaction with a reduced diphosphopyridine nucleotide dehydrogenase, one of the enzymes participating in camphor lactonization. J Biol Chem (1966) 1.32

NIC, a conjugative nicotine-nicotinate degradative plasmid in Pseudomonas convexa. J Bacteriol (1978) 1.32

Rotational diffusion of biological macromolecules by time-resolved delayed luminescence (phosphorescence, fluorescence) anisotropy. Ann N Y Acad Sci (1981) 1.31

Physical studies of DNA premelting equilibria in duplexes with and without homo dA.dT tracts: correlations with DNA bending. Biochemistry (1990) 1.30

The ferroprotein component of a methylene hydroxylase. Biochem Biophys Res Commun (1967) 1.30

Comparison of the magnetic properties of deoxy- and photodissociated myoglobin. Proc Natl Acad Sci U S A (1984) 1.28

Ligand binding to heme proteins: III. FTIR studies of His-E7 and Val-E11 mutants of carbonmonoxymyoglobin. Biophys J (1993) 1.28

Fourier transform infrared difference spectroscopy of bacteriorhodopsin and its photoproducts regenerated with deuterated tyrosine. Biochemistry (1986) 1.27

Fusion and compatibility of camphor and octane plasmids in Pseudomonas. Proc Natl Acad Sci U S A (1974) 1.23

Nanosecond flash photolysis study of carbon monoxide binding to the beta chain of hemoglobin Zürich [beta 63(E7)His leads to Arg]. Proc Natl Acad Sci U S A (1983) 1.23

Recombination of carbon monoxide to ferrous horseradish peroxidase types A and C. J Mol Biol (1987) 1.22

Ligand binding to heme proteins: relevance of low-temperature data. Biochemistry (1986) 1.22

Crystalline cytochrome P-450cam. Biochem Biophys Res Commun (1970) 1.22

DNA flexibility variation may dominate DNase I cleavage. Proc Natl Acad Sci U S A (1989) 1.20