Published in Proc Natl Acad Sci U S A on April 02, 2002
Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol (2004) 4.05
IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med (2002) 1.93
Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J Exp Med (2003) 1.93
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85
A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity (2005) 1.81
Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun (2004) 1.74
Roles of the NF-kappaB pathway in lymphocyte development and function. Cold Spring Harb Perspect Biol (2009) 1.63
Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45
Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc Natl Acad Sci U S A (2004) 1.39
The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms. Mol Cell Biol (2004) 1.39
Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation. J Clin Invest (2004) 1.28
Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation. PLoS One (2007) 1.27
Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits. J Exp Med (2014) 1.07
NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms. Blood (2008) 1.04
The c-Rel Transcription Factor in Development and Disease. Genes Cancer (2011) 1.01
NF-kB inhibitor blocks B cell development at two checkpoints. Med Immunol (2004) 1.00
NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency. J Virol (2009) 0.97
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS One (2009) 0.96
Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice. J Immunol (2010) 0.95
NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells. Blood (2008) 0.94
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. J Immunol (2014) 0.94
Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells. Mol Cell Biol (2004) 0.93
MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres. Nat Commun (2015) 0.90
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation. Immunity (2011) 0.89
c-Rel plays a key role in deficient activation of B cells from a non-X-linked hyper-IgM patient. Blood (2006) 0.88
Formation of B-1 B cells from neonatal B-1 transitional cells exhibits NF-κB redundancy. J Immunol (2011) 0.87
IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. J Exp Med (2014) 0.87
FlowMax: A Computational Tool for Maximum Likelihood Deconvolution of CFSE Time Courses. PLoS One (2013) 0.86
A multi-scale approach reveals that NF-κB cRel enforces a B-cell decision to divide. Mol Syst Biol (2015) 0.85
B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS. Proc Natl Acad Sci U S A (2014) 0.82
The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. EMBO J (2011) 0.82
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med (2016) 0.81
TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. Int Immunol (2009) 0.80
Nfkb1 activation by the E26 transformation-specific transcription factors PU.1 and Spi-B promotes Toll-like receptor-mediated splenic B cell proliferation. Mol Cell Biol (2015) 0.78
The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver. Mol Endocrinol (2012) 0.77
The Paracaspase MALT1. Biochimie (2015) 0.76
Unexpected functions of nuclear factor-κB during germinal center B-cell development: implications for lymphomagenesis. Curr Opin Hematol (2015) 0.76
Differential requirements for the canonical NF-κB transcription factors c-REL and RELA during the generation and activation of mature B cells. Immunol Cell Biol (2016) 0.75
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol (1998) 21.48
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell (1995) 7.55
Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev (1997) 5.65
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene (1999) 4.33
Origin of murine B cell lineages. Annu Rev Immunol (1993) 3.82
B cell differentiation and isotype switching is related to division cycle number. J Exp Med (1996) 2.90
NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci U S A (1999) 2.83
Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev (1999) 2.82
Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation. Mol Cell Biol (1994) 2.75
B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching. J Immunol (1996) 2.53
Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific, IgG1+ B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur J Immunol (1992) 2.32
Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts. Oncogene (1999) 2.27
Rel/NF-kappaB/IkappaB proteins and cancer. Oncogene (1996) 2.21
B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. J Exp Med (1998) 2.00
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells. Immunity (1997) 1.97
c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription. J Exp Med (2001) 1.92
Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation. Proc Natl Acad Sci U S A (1994) 1.89
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A (1996) 1.79
The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J (2000) 1.79
Development and function of B-1 cells. Curr Opin Immunol (2000) 1.78
The subunit composition of NF-kappa B complexes changes during B-cell development. Cell Growth Differ (1994) 1.62
The immunoglobulin class switch: beyond "accessibility". Immunity (1997) 1.55
The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation. Curr Opin Immunol (1998) 1.53
Rel/NF-kappaB transcription factors: key mediators of B-cell activation. Immunol Rev (2000) 1.51
Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. J Exp Med (2000) 1.48
Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Development (1994) 1.34
NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death. J Immunol (2001) 1.32
B-1 cells are made, not born. Immunol Today (1993) 1.32
The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes. Genes Dev (1994) 1.24
Biochemistry of B lymphocyte activation. Adv Immunol (1994) 1.18
Downstream activation of a TATA-less promoter by Oct-2, Bob1, and NF-kappaB directs expression of the homing receptor BLR1 to mature B cells. J Biol Chem (1998) 1.11
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol (2008) 20.89
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Chimeric nucleases stimulate gene targeting in human cells. Science (2003) 12.12
MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60
Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science (2003) 9.94
Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol (2010) 7.75
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
Circuitry of nuclear factor kappaB signaling. Immunol Rev (2006) 6.49
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A (2002) 6.09
Programmed anuclear cell death delimits platelet life span. Cell (2007) 5.98
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature (2002) 5.98
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med (2008) 5.97
Permissive secondary mutations enable the evolution of influenza oseltamivir resistance. Science (2010) 5.94
Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A (2009) 5.30
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 5.20
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science (2005) 4.83
Cell death. N Engl J Med (2009) 4.75
Medicine. The need for a global HIV vaccine enterprise. Science (2003) 4.70
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity (2010) 4.65
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell (2010) 4.57
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell (2004) 4.53
Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol (2006) 4.53
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J (2003) 3.93
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat Immunol (2009) 3.85
Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature (2011) 3.80
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med (2011) 3.78
microRNA regulation of inflammatory responses. Annu Rev Immunol (2012) 3.47
NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci (2003) 3.40
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature (2002) 3.15
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell (2007) 3.13
Two pathways to NF-kappaB. Mol Cell (2002) 3.12
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med (2007) 3.09
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol (2006) 3.09
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature (2011) 3.08
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A (2006) 3.06
MicroRNAs and immunity: tiny players in a big field. Immunity (2007) 3.01
XIAP discriminates between type I and type II FAS-induced apoptosis. Nature (2009) 3.00
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A (2003) 2.91
CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J (2002) 2.90
Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell (2004) 2.79
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med (2003) 2.77
NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A (2011) 2.74
Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells. Proc Natl Acad Sci U S A (2005) 2.68
Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol (2001) 2.65
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med (2006) 2.65
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity (2008) 2.62
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell (2007) 2.60
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood (2005) 2.54
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature (2009) 2.54
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
Mcl-1 is essential for germinal center formation and B cell memory. Science (2010) 2.42
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate. Nat Cell Biol (2004) 2.42
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A (2010) 2.40
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med (2005) 2.39
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med (2005) 2.34
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci (2002) 2.30
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J (2003) 2.30
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. Proc Natl Acad Sci U S A (2007) 2.30
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nat Immunol (2006) 2.29
Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev (2008) 2.29
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol (2009) 2.27
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic. J Clin Invest (2008) 2.17
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14
Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance. J Immunol (2003) 2.13
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A (2003) 2.12
Regulation of NF-kappaB activity through lysine monomethylation of p65. Proc Natl Acad Sci U S A (2009) 2.10
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol (2009) 2.05
Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat Biotechnol (2008) 2.05
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer (2009) 2.02
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol (2003) 2.01
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol (2005) 2.01
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep (2013) 2.00
Is tumor growth sustained by rare cancer stem cells or dominant clones? Cancer Res (2008) 1.99
Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther (2006) 1.99
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood (2014) 1.97
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood (2002) 1.91
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med (2002) 1.89
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85
Physiological functions for brain NF-kappaB. Trends Neurosci (2005) 1.85
Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease. Nat Clin Pract Rheumatol (2006) 1.85
Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83
Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J Exp Med (2004) 1.83
miR-146a controls the resolution of T cell responses in mice. J Exp Med (2012) 1.81