Published in Immunity on September 05, 2013
Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol (2014) 4.28
Necroptosis and its role in inflammation. Nature (2015) 3.01
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res (2013) 2.38
The diverse role of RIP kinases in necroptosis and inflammation. Nat Immunol (2015) 2.36
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell (2014) 2.06
Getting TRAIL back on track for cancer therapy. Cell Death Differ (2014) 1.86
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A (2014) 1.78
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun (2015) 1.54
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proc Natl Acad Sci U S A (2014) 1.54
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature (2014) 1.53
Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Respir Crit Care Med (2014) 1.52
Regulated cell death in AKI. J Am Soc Nephrol (2014) 1.50
RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation. Cell (2017) 1.39
The two faces of receptor interacting protein kinase-1. Mol Cell (2014) 1.37
Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell (2015) 1.35
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Rep (2014) 1.33
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. Cell Death Dis (2014) 1.33
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ (2014) 1.33
A plug release mechanism for membrane permeation by MLKL. Structure (2014) 1.29
Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis. Cell Death Differ (2014) 1.29
Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol (2014) 1.27
Die another way--non-apoptotic mechanisms of cell death. J Cell Sci (2014) 1.27
RIPK1- and RIPK3-induced cell death mode is determined by target availability. Cell Death Differ (2014) 1.20
Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell Res (2015) 1.15
RIP kinases: key decision makers in cell death and innate immunity. Cell Death Differ (2014) 1.14
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J (2016) 1.13
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. Elife (2014) 1.12
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ (2015) 1.11
Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology (2015) 1.11
Kinases and pseudokinases: lessons from RAF. Mol Cell Biol (2014) 1.10
TAK1 control of cell death. Cell Death Differ (2014) 1.09
Necroptosis: is there a role for mitochondria? Front Physiol (2014) 1.08
Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death. EMBO Rep (2014) 1.07
Staying alive: cell death in antiviral immunity. Mol Cell (2014) 1.06
Necroptosis induced by RIPK3 requires MLKL but not Drp1. Cell Death Dis (2014) 1.04
SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes. EMBO J (2016) 1.03
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun (2015) 1.02
Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. Mol Cell (2016) 1.01
True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity. J Immunol (2014) 0.99
Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death. Oncogene (2015) 0.99
Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner. Cell Death Dis (2015) 0.99
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury. Cell Death Differ (2016) 0.98
Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling. Nat Commun (2015) 0.97
Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol (2016) 0.96
The molecular regulation of Janus kinase (JAK) activation. Biochem J (2014) 0.95
Necrosis-dependent and independent signaling of the RIP kinases in inflammation. Cytokine Growth Factor Rev (2013) 0.95
Dying cells actively regulate adaptive immune responses. Nat Rev Immunol (2017) 0.94
TRAF2 is a biologically important necroptosis suppressor. Cell Death Differ (2015) 0.94
Suppression of RIP3-dependent necroptosis by human cytomegalovirus. J Biol Chem (2015) 0.93
A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc Natl Acad Sci U S A (2015) 0.93
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. Sci Immunol (2016) 0.92
MLKL forms cation channels. Cell Res (2016) 0.92
Necroptosis: The Trojan horse in cell autonomous antiviral host defense. Virology (2015) 0.91
Programmed cell death as a defence against infection. Nat Rev Immunol (2017) 0.91
RIPK1 inhibits ZBP1-driven necroptosis during development. Nature (2016) 0.91
CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN. Cell Rep (2016) 0.90
Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ (2015) 0.90
Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Cell Death Dis (2015) 0.89
Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure. BMC Neurosci (2014) 0.88
Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement. Proc Natl Acad Sci U S A (2015) 0.88
Questions and controversies: the role of necroptosis in liver disease. Cell Death Discov (2016) 0.88
Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Cell Rep (2016) 0.87
Beyond apoptosis in lupus. Curr Opin Rheumatol (2014) 0.87
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death Dis (2015) 0.87
RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage. Cell Death Dis (2014) 0.86
An outline of necrosome triggers. Cell Mol Life Sci (2016) 0.86
The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. J Immunol (2015) 0.86
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest (2016) 0.86
Structural Basis for the Non-catalytic Functions of Protein Kinases. Structure (2016) 0.84
Necroptotic signaling in adaptive and innate immunity. Semin Cell Dev Biol (2014) 0.84
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell Death Dis (2016) 0.84
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun (2015) 0.84
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol (2015) 0.84
Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy. Oncoimmunology (2016) 0.84
CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. Nat Cell Biol (2016) 0.84
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses. Biochem J (2014) 0.83
Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice. J Biol Chem (2014) 0.83
Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis. Mediators Inflamm (2015) 0.83
Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal (2015) 0.82
Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta (2016) 0.82
Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis (2016) 0.82
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. Biochem J (2015) 0.82
Parkin and mitophagy in cancer. Oncogene (2016) 0.81
Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis (2015) 0.81
The serine threonine kinase RIP3: lost and found. BMB Rep (2015) 0.80
Death in the fast lane: what's next for necroptosis? FEBS J (2015) 0.80
Therapeutic applications of TRAIL receptor agonists in cancer and beyond. Pharmacol Ther (2015) 0.80
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death. F1000Res (2015) 0.80
The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation. Cell Res (2014) 0.80
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife (2015) 0.79
Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53. Sci Rep (2015) 0.79
Roles of Caspases in Necrotic Cell Death. Cell (2016) 0.79
A motive for killing: effector functions of regulated lytic cell death. Immunol Cell Biol (2016) 0.79
Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis. Proc Natl Acad Sci U S A (2016) 0.79
Evolutionary divergence of the necroptosis effector MLKL. Cell Death Differ (2016) 0.79
Programmed cell death and its role in inflammation. Mil Med Res (2015) 0.79
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis. Immunity (2016) 0.79
Interleukin-1 Family Cytokines in Liver Diseases. Mediators Inflamm (2015) 0.79
Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. Oncotarget (2016) 0.78
The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol (2008) 20.89
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60
Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science (2003) 9.94
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell (2007) 7.74
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64
Programmed anuclear cell death delimits platelet life span. Cell (2007) 5.98
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature (2002) 5.98
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature (2011) 5.32
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 5.20
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Linear ubiquitination prevents inflammation and regulates immune signalling. Nature (2011) 4.85
Cell death. N Engl J Med (2009) 4.75
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol (2006) 4.53
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol (2006) 4.01
Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci U S A (2009) 4.00
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol (2004) 3.76
IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol (2005) 3.68
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell (2009) 3.66
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity (2012) 3.51
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell (2007) 3.39
BCL-2 family antagonists for cancer therapy. Nat Rev Drug Discov (2008) 3.24
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature (2002) 3.15
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell (2007) 3.13
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med (2007) 3.09
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol (2006) 3.09
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A (2006) 3.06
XIAP discriminates between type I and type II FAS-induced apoptosis. Nature (2009) 3.00
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A (2003) 2.91
Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias. Brain (2011) 2.80
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med (2003) 2.77
Selective amygdalohippocampectomy versus anterior temporal lobectomy in the management of mesial temporal lobe epilepsy: a meta-analysis of comparative studies. J Neurosurg (2013) 2.71
Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol (2001) 2.65
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med (2006) 2.65
The SOCS box: a tale of destruction and degradation. Trends Biochem Sci (2002) 2.64
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity (2008) 2.62
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell (2007) 2.60
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood (2005) 2.54
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature (2009) 2.54
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity (2012) 2.50
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat Immunol (2005) 2.44
Mcl-1 is essential for germinal center formation and B cell memory. Science (2010) 2.42
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate. Nat Cell Biol (2004) 2.42
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med (2005) 2.39
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med (2005) 2.34
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem (2001) 2.33
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity (2012) 2.30
BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci (2002) 2.30
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J (2003) 2.30
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol (2009) 2.27
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity. Nucleic Acids Res (2011) 2.23
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet (2008) 2.19
Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1. Immunol Cell Biol (2013) 2.18
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic. J Clin Invest (2008) 2.17
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A (2003) 2.12
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol (2008) 2.11
Inhibitors of cytokine signal transduction. J Biol Chem (2003) 2.10
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol (2009) 2.05
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol (2008) 2.04
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol (2009) 2.02
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer (2009) 2.02
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol (2005) 2.01