A cytosolic tRNA with an unmodified adenosine in the wobble position reads a codon ending with the non-complementary nucleoside cytidine.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMID 11955004)

Published in J Mol Biol on April 05, 2002

Authors

Peng Chen1, Qiang Qian, Shaoping Zhang, Leif A Isaksson, Glenn R Björk

Author Affiliations

1: Department of Molecular Biology, Umeå University, Umeå, 901 87, Sweden.

Articles by these authors

Eukaryotic wobble uridine modifications promote a functionally redundant decoding system. Mol Cell Biol (2008) 2.21

The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing. J Biol Chem (2002) 1.79

The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells. FEBS J (2006) 1.68

Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli. Nucleic Acids Res (2006) 1.52

A gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment. Microbiol Mol Biol Rev (2009) 1.50

A codon window in mRNA downstream of the initiation codon where NGG codons give strongly reduced gene expression in Escherichia coli. Nucleic Acids Res (2004) 1.47

Enzymatic modification of tRNAs: MiaB is an iron-sulfur protein. J Biol Chem (2002) 1.38

The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons. RNA (2007) 1.34

The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium. J Bacteriol (2004) 1.34

Influences on translation initiation and early elongation by the messenger RNA region flanking the initiation codon at the 3' side. Gene (2002) 1.30

Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions. Nucleic Acids Res (2009) 1.29

Over expression of a tRNA(Leu) isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading. J Mol Biol (2005) 1.22

Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification. J Biol Chem (2005) 1.20

Transfer RNA modifications that alter +1 frameshifting in general fail to affect -1 frameshifting. RNA (2003) 1.19

Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways. J Bacteriol (2004) 1.19

Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri. J Bacteriol (2002) 1.17

The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium. J Bacteriol (2002) 1.17

Functional interplay between the jaw domain of bacterial RNA polymerase and allele-specific residues in the product RNA-binding pocket. J Mol Biol (2005) 1.13

Enzymatic conversion of cytidine to lysidine in anticodon of bacterial isoleucyl-tRNA--an alternative way of RNA editing. Trends Biochem Sci (2004) 1.13

Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms. Nucleic Acids Res (2006) 1.12

A "gain of function" mutation in a protein mediates production of novel modified nucleosides. EMBO J (2005) 1.05

The ribosomal grip of the peptidyl-tRNA is critical for reading frame maintenance. J Mol Biol (2008) 1.02

Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast. J Biol Chem (2010) 1.02

Stepping transfer messenger RNA through the ribosome. J Biol Chem (2005) 1.01

A host/plasmid system that is not dependent on antibiotics and antibiotic resistance genes for stable plasmid maintenance in Escherichia coli. J Biotechnol (2004) 1.01

Abortive translation caused by peptidyl-tRNA drop-off at NGG codons in the early coding region of mRNA. FEBS J (2005) 1.00

Adolescent and parental utilities for the health states associated with pelvic inflammatory disease. Sex Transm Infect (2011) 0.98

Influences on gene expression in vivo by a Shine-Dalgarno sequence. Mol Microbiol (2006) 0.97

Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor. Am J Surg Pathol (2008) 0.96

The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes. Biochem J (2010) 0.94

Putrescine or a combination of methionine and arginine restores virulence gene expression in a tRNA modification-deficient mutant of Shigella flexneri: a possible role in adaptation of virulence. Mol Microbiol (2003) 0.94

Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation. J Bacteriol (2006) 0.91

Tandem termination signals: myth or reality? FEBS Lett (2002) 0.91

Putative stem cells in human dental pulp with irreversible pulpitis: an exploratory study. J Endod (2010) 0.90

Cis control of gene expression in E.coli by ribosome queuing at an inefficient translational stop signal. EMBO J (2002) 0.90

Generation and characterization of functional mutants in the translation initiation factor IF1 of Escherichia coli. Eur J Biochem (2004) 0.90

One SmpB molecule accompanies tmRNA during its passage through the ribosomes. FEBS Lett (2008) 0.89

The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance. PLoS One (2013) 0.88

Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Cardiovasc Diabetol (2014) 0.88

The output of the tRNA modification pathways controlled by the Escherichia coli MnmEG and MnmC enzymes depends on the growth conditions and the tRNA species. Nucleic Acids Res (2013) 0.88

Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats. Mol Pharmacol (2006) 0.88

Differential expression of microRNAs in normal and inflamed human pulps. J Endod (2012) 0.88

Origin-specific reduction of ColE1 plasmid copy number due to mutations in a distinct region of the Escherichia coli RNA polymerase. Mol Genet Genomics (2002) 0.87

Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice. Diabetes (2009) 0.87

Amino acid residues of the Escherichia coli tRNA(m5U54)methyltransferase (TrmA) critical for stability, covalent binding of tRNA and enzymatic activity. Nucleic Acids Res (2007) 0.87

Thiol reducing compounds prevent human amylin-evoked cytotoxicity. FEBS J (2005) 0.85

Clinician perspectives on management of adolescents with pelvic inflammatory disease using standardized patient scenarios. Sex Transm Dis (2013) 0.85

Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code? Trends Biochem Sci (2004) 0.85

fusB is an allele of nadD, encoding nicotinate mononucleotide adenylyltransferase in Escherichia coli. Microbiology (2003) 0.84

Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance. Diabetes (2008) 0.83

Two groups of phenylalanine biosynthetic operon leader peptides genes: a high level of apparently incidental frameshifting in decoding Escherichia coli pheL. Nucleic Acids Res (2010) 0.83

Mutations in 16S rRNA that suppress cold-sensitive initiation factor 1 affect ribosomal subunit association. FEBS J (2011) 0.82

Morphological variation of individual Escherichia coli 50S ribosomal subunits in situ, as revealed by cryo-electron tomography. Exp Cell Res (2004) 0.82

Role of maternal viremia and placental infection in hepatitis B virus intrauterine transmission. Microbes Infect (2013) 0.81

In vivo involvement of mutated initiation factor IF1 in gene expression control at the translational level. FEBS Lett (2005) 0.81

Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats. Proteomics (2009) 0.81

A reduced level of charged tRNAArgmnm5UCU triggers the wild-type peptidyl-tRNA to frameshift. RNA (2005) 0.81

Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats. Cardiovasc Diabetol (2013) 0.81

Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity. Endocrinology (2010) 0.81

Metabolic control through ornithine and uracil of epithelial cell invasion by Shigella flexneri. Microbiology (2009) 0.81

Diet-dependent depletion of queuosine in tRNAs in Caenorhabditis elegans does not lead to a developmental block. J Biosci (2007) 0.80

Translation initiation region dependency of translation initiation in Escherichia coli by IF1 and kasugamycin. FEBS J (2010) 0.80

Characterization and structure of the Aquifex aeolicus protein DUF752: a bacterial tRNA-methyltransferase (MnmC2) functioning without the usually fused oxidase domain (MnmC1). J Biol Chem (2012) 0.80

Alterations in the two globular domains or in the connecting alpha-helix of bacterial ribosomal protein L9 induces +1 frameshifts. J Bacteriol (2007) 0.80

RNA chaperone activity of translation initiation factor IF1. Biochimie (2006) 0.80

Functional EF-Tu with large C-terminal extensions in an E coli strain with a precise deletion of both chromosomal tuf genes. FEBS Lett (2003) 0.79

Structural features of the tmRNA-ribosome interaction. RNA (2009) 0.78

Transient erythromycin resistance phenotype associated with peptidyl-tRNA drop-off on early UGG and GGG codons. J Bacteriol (2007) 0.78

Illuminating the molecular basis of diabetic arteriopathy: a proteomic comparison of aortic tissue from diabetic and healthy rats. Proteomics (2010) 0.78

Spontaneous resorption of a large lumbar disc herniation within 4 months. Pain Physician (2014) 0.78

Morphological variation of individual Escherichia coli 30S ribosomal subunits in vitro and in situ, as revealed by cryo-electron tomography. Exp Cell Res (2004) 0.77

11β-HSD1 modulates LPS-induced innate immune responses in adipocytes by altering expression of PTEN. Mol Endocrinol (2015) 0.77

Transfer RNA Modification. Ecosal Plus (2005) 0.76

(5-Benzoyl-2-methyl-4-{[1-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl]meth-oxy}-1-benzofuran-7-yl)(phen-yl)methanone. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75

Structural aspects of trans-translation. IUBMB Life (2010) 0.75

Suppression of a cold-sensitive mutant initiation factor 1 by alterations in the 23S rRNA maturation region. FEBS J (2011) 0.75

An improvement of LLNA:DA to assess the skin sensitization potential of chemicals. J Toxicol Sci (2017) 0.75

[Human leukocyte antigen-DR expression and transcription in oral squamous cell carcinomas]. Hua Xi Kou Qiang Yi Xue Za Zhi (2003) 0.75