Published in Biochim Biophys Acta on March 14, 2002
Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer (2009) 11.25
A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol (2005) 5.68
Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34
Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology (2008) 5.19
Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov (2009) 4.16
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol (2008) 3.80
miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res (2008) 3.19
Tailoring to RB: tumour suppressor status and therapeutic response. Nat Rev Cancer (2008) 3.16
GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol (2003) 2.52
Development of mice expressing a single D-type cyclin. Genes Dev (2002) 2.43
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell (2011) 2.41
Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations. PLoS One (2010) 1.85
Well-differentiated and dedifferentiated liposarcomas. Virchows Arch (2009) 1.84
Crystal structure of human CDK4 in complex with a D-type cyclin. Proc Natl Acad Sci U S A (2009) 1.71
GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol (2008) 1.56
Liposarcoma: molecular genetics and therapeutics. Sarcoma (2010) 1.55
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J (2007) 1.52
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology (2009) 1.50
Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer. Biochemistry (2011) 1.48
Anti cancer effects of curcumin: cycle of life and death. Cell Div (2008) 1.45
Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol (2003) 1.33
Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front Biosci (2008) 1.31
Phosphoinositide 3-kinase controls early and late events in mammalian cell division. EMBO J (2006) 1.28
pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia. PLoS Biol (2004) 1.27
Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest New Drugs (2014) 1.26
Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol Cell Biol (2007) 1.22
An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors. Lab Invest (2010) 1.19
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am J Pathol (2005) 1.18
Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5. J Cell Biol (2003) 1.16
Discovery of a potential allosteric ligand binding site in CDK2. ACS Chem Biol (2011) 1.15
The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light. Nucleic Acids Res (2006) 1.15
Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Carcinogenesis (2008) 1.11
Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics. Am J Pathol (2010) 1.09
CDK4: A Key Player in the Cell Cycle, Development, and Cancer. Genes Cancer (2012) 1.07
Regulation of CDK4. Cell Div (2006) 1.06
Cycling through metabolism. EMBO Mol Med (2010) 1.06
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Cell Death Differ (2013) 1.06
Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PLoS One (2011) 1.06
A systems biology dynamical model of mammalian G1 cell cycle progression. Mol Syst Biol (2007) 1.05
Signaling pathways that control cell proliferation. Cold Spring Harb Perspect Biol (2013) 1.05
Regulation of the retinoblastoma proteins by the human herpesviruses. Cell Div (2009) 1.02
MMP-9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16(INK4a) and mitogen-activated protein kinase pathway. Cancer Res (2007) 1.02
Absence of p16INK4a and truncation of ARF tumor suppressors in chickens. Proc Natl Acad Sci U S A (2002) 1.02
p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1. PLoS One (2011) 1.02
Gene expression profiling of noninvasive primary urothelial tumours using microarrays. Br J Cancer (2005) 1.01
Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. Mol Cell Biol (2009) 1.00
Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets. Oncogene (2015) 0.99
Advances in the targeted therapy of liposarcoma. Onco Targets Ther (2015) 0.99
Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors. Cancers (Basel) (2015) 0.99
New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer. Nutr Cancer (2011) 0.98
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol (2006) 0.98
Radioprotection: smart games with death. J Clin Invest (2010) 0.98
BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. Mol Cell Biol (2013) 0.95
Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. Mol Biol Cell (2004) 0.95
C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proc Natl Acad Sci U S A (2014) 0.95
Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia. Blood (2010) 0.95
Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines. PLoS One (2014) 0.95
miR-105 inhibits prostate tumour growth by suppressing CDK6 levels. PLoS One (2013) 0.94
Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules. PLoS One (2012) 0.94
Cyclin-dependent kinase inhibitors as potential targeted anticancer agents. Invest New Drugs (2009) 0.93
Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS One (2012) 0.93
miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma. BMC Cancer (2012) 0.92
Cyclin D does not provide essential Cdk4-independent functions in Drosophila. Genetics (2004) 0.92
Re-thinking cell cycle regulators: the cross-talk with metabolism. Front Oncol (2013) 0.92
Promoter Methylation in Prostate Cancer and its Application for the Early Detection of Prostate Cancer Using Serum and Urine Samples. Biomark Cancer (2010) 0.91
A novel approach to the discovery of small-molecule ligands of CDK2. Chembiochem (2012) 0.91
Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis. World J Gastroenterol (2004) 0.91
Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells. Biomed Pharmacother (2010) 0.89
Evolutionary etiology of high-grade astrocytomas. Proc Natl Acad Sci U S A (2013) 0.89
Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest. J Exp Clin Cancer Res (2013) 0.89
Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals. Cell Div (2010) 0.89
Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1). J Biol Chem (2005) 0.88
Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16. J Mol Biol (2007) 0.88
Discovery of genes implicated in whirling disease infection and resistance in rainbow trout using genome-wide expression profiling. BMC Genomics (2008) 0.88
p16INK4a expression in basal-like breast carcinoma. Int J Clin Exp Pathol (2010) 0.88
Geranylated flavanone tomentodiplacone B inhibits proliferation of human monocytic leukaemia (THP-1) cells. Br J Pharmacol (2011) 0.87
Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins. J Mol Biol (2010) 0.87
E2F1-mediated upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation. PLoS One (2011) 0.87
Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model. Oncotarget (2014) 0.86
Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair. Parasit Vectors (2008) 0.86
An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes. FEBS J (2012) 0.86
Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc Natl Acad Sci U S A (2013) 0.86
CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genet (2014) 0.86
Green tea compound in chemoprevention of cervical cancer. Int J Gynecol Cancer (2010) 0.86
A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and Lymphomas. Clin Cancer Res (2016) 0.85
Alteration of cyclin D1 in gastric carcinoma and its clinicopathologic significance. World J Gastroenterol (2004) 0.85
p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay. PLoS One (2013) 0.84
Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation. Oncogene (2012) 0.83
Role of p16(INK4A) in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells. Biochem Res Int (2012) 0.83
MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL. Cell Cycle (2014) 0.83
p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis. Cell Res (2011) 0.83
CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response. PLoS One (2012) 0.83
The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations. Cancers (Basel) (2014) 0.82
P16/Ki-67 Immunostaining is Useful in Stratification of Atypical Metaplastic Epithelium of the Cervix. Clin Med Pathol (2008) 0.82
Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors. Mol Carcinog (2008) 0.82
Limb-bud and Heart (LBH) functions as a tumor suppressor of nasopharyngeal carcinoma by inducing G1/S cell cycle arrest. Sci Rep (2015) 0.81
Construction and clarification of dynamic gene regulatory network of cancer cell cycle via microarray data. Cancer Inform (2007) 0.81
Circadian variation in expression of G1 phase cyclins D1 and E and cyclin-dependent kinase inhibitors p16 and p21 in human bowel mucosa. World J Gastroenterol (2006) 0.81
Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer (2009) 11.25
Tumour biology: senescence in premalignant tumours. Nature (2005) 10.15
RAS oncogenes: the first 30 years. Nat Rev Cancer (2003) 8.61
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
Mammalian cyclin-dependent kinases. Trends Biochem Sci (2005) 5.54
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell (2003) 5.17
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet (2003) 4.74
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell (2011) 4.49
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell (2004) 4.39
Cdk1 is sufficient to drive the mammalian cell cycle. Nature (2007) 4.26
A pericyte origin of spinal cord scar tissue. Science (2011) 4.12
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell (2008) 4.01
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell (2010) 3.97
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol (2008) 3.31
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet (2007) 3.30
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.59
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell (2011) 2.56
Cell cycle kinases in cancer. Curr Opin Genet Dev (2007) 2.46
Control of cell proliferation pathways by microRNAs. Cell Cycle (2008) 2.33
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell (2011) 2.28
The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle (2011) 2.10
Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol (2009) 1.99
CDK inhibitors in cancer therapy: what is next? Trends Pharmacol Sci (2007) 1.95
A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. Carcinogenesis (2007) 1.95
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A (2006) 1.93
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell (2011) 1.87
MicroRNAs and the cell cycle. Biochim Biophys Acta (2011) 1.81
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
What we have learned about pancreatic cancer from mouse models. Gastroenterology (2012) 1.78
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell (2005) 1.78
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J (2010) 1.66
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase. Cancer Cell (2010) 1.63
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene (2003) 1.62
A catalyst for change: the European cancer Patient's Bill of Rights. Oncologist (2014) 1.55
Cyclin-dependent kinases. Genome Biol (2014) 1.52
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol (2010) 1.49
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology (2013) 1.48
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell (2011) 1.44
Tpx2 controls spindle integrity, genome stability, and tumor development. Cancer Res (2012) 1.39
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest (2008) 1.38
A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell (2013) 1.37
From Plk1 to Plk5: functional evolution of polo-like kinases. Cell Cycle (2011) 1.36
Targeting cell cycle kinases for cancer therapy. Curr Med Chem (2007) 1.33
Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals. Proc Natl Acad Sci U S A (2013) 1.33
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
A GRFa2/Prop1/stem (GPS) cell niche in the pituitary. PLoS One (2009) 1.31
Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling. Mol Cell Biol (2010) 1.29
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat Struct Mol Biol (2010) 1.26
Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J (2006) 1.25
Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr Opin Pharmacol (2008) 1.24
The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res (2002) 1.23
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell (2005) 1.23
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. J Pathol (2009) 1.22
The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions. Biochem Soc Trans (2010) 1.22
Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. Oncogene (2003) 1.18
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Sci Rep (2011) 1.16
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development (2011) 1.15
Genetically engineered mouse models of pancreatic adenocarcinoma. Mol Oncol (2013) 1.15
Overall Cdk activity modulates the DNA damage response in mammalian cells. J Cell Biol (2009) 1.14
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proc Natl Acad Sci U S A (2013) 1.11
Non-mitotic functions of the Anaphase-Promoting Complex. Semin Cell Dev Biol (2011) 1.10
SUMOylation modulates the function of Aurora-B kinase. J Cell Sci (2010) 1.10
TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol Cell Biol (2009) 1.09
Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell (2006) 1.08
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J (2012) 1.08
E2F2 represses cell cycle regulators to maintain quiescence. Cell Cycle (2008) 1.07
Mice deficient for N-ras: impaired antiviral immune response and T-cell function. Cancer Res (2003) 1.07
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol (2011) 1.06
HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol Cell (2012) 1.05
Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res (2006) 1.03
Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway. Blood (2011) 1.02
Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2. Genes Cancer (2012) 1.02
Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proc Natl Acad Sci U S A (2011) 1.02
Mice thrive without Cdk4 and Cdk2. Mol Oncol (2007) 1.02
Cell cycle control of pituitary development and disease. J Mol Endocrinol (2008) 1.01
Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J Cell Sci (2010) 1.01
Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. J Biol Chem (2011) 1.01
Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Res (2005) 0.96
Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. Hum Mutat (2007) 0.95
Driving the cell cycle to cancer. Adv Exp Med Biol (2003) 0.93
Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. Am J Pathol (2006) 0.91
c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood (2011) 0.91
The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. Mol Cell (2013) 0.91
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1). Cell Cycle (2013) 0.91
Mitosis-targeting therapies: a troubleshooting guide. Curr Opin Pharmacol (2013) 0.90
Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. Carcinogenesis (2013) 0.88
The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat Commun (2013) 0.88
The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice. Learn Mem (2012) 0.88
Cdk6-dependent regulation of G(1) length controls adult neurogenesis. Stem Cells (2011) 0.88