Published in Nat Struct Mol Biol on May 30, 2010
A form of the metabolic syndrome associated with mutations in DYRK1B. N Engl J Med (2014) 4.01
GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. Cancer Res (2011) 1.81
SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway. Cancer Lett (2012) 1.34
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.14
Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res (2013) 1.08
Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Res (2011) 1.05
The hedgehog processing pathway is required for NSCLC growth and survival. Oncogene (2012) 1.05
Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Cell (2016) 1.04
Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas. EMBO Mol Med (2010) 1.01
Cooperative Hedgehog-EGFR signaling. Front Biosci (Landmark Ed) (2012) 0.95
Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells. PLoS One (2012) 0.92
Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89
The Yes-associated protein controls the cell density regulation of Hedgehog signaling. Oncogenesis (2014) 0.88
An ID2-dependent mechanism for VHL inactivation in cancer. Nature (2016) 0.88
Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. Expert Rev Mol Med (2015) 0.87
Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas. Neoplasia (2011) 0.87
RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. Cancer Res (2015) 0.87
Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition. Int J Cancer (2012) 0.86
Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors. Cancers (Basel) (2012) 0.85
Driver mutations: a roadmap for getting close and personal in pancreatic cancer. Cancer Biol Ther (2010) 0.85
Targeting the hedgehog signaling pathway with interacting peptides to Patched-1. J Gastroenterol (2011) 0.84
Wdr68 requires nuclear access for craniofacial development. PLoS One (2013) 0.84
Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench. Surgery (2012) 0.83
The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. J Biol Chem (2014) 0.83
SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. J Cell Sci (2015) 0.83
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett (2013) 0.82
Sonic hedgehog pathway expression in non-small cell lung cancer. Ther Adv Med Oncol (2012) 0.82
Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells. Cell Death Dis (2014) 0.82
Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1. Nat Commun (2015) 0.80
Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells. Genes Cancer (2014) 0.80
Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling. Nat Commun (2014) 0.79
Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells. Cell Death Dis (2016) 0.77
DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance. Oncotarget (2016) 0.77
Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis. F1000Res (2014) 0.75
Disrupting the balance between tumor epithelia and stroma is a possible therapeutic approach for pancreatic cancer. Med Sci Monit (2014) 0.75
Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling. Cell Commun Signal (2017) 0.75
Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Res (2016) 0.75
Deregulation of the miR-16-KRAS axis promotes colorectal cancer. Sci Rep (2016) 0.75
Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development. PLoS One (2016) 0.75
Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review. World J Gastrointest Pathophysiol (2016) 0.75
DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway. Oncotarget (2016) 0.75
Epithelial and non-epithelial Ptch1 play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland. Development (2017) 0.75
KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway. Oncotarget (2016) 0.75
Non-genomic androgen action regulates proliferative/migratory signaling in stromal cells. Front Endocrinol (Lausanne) (2015) 0.75
Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome. Cell Mol Life Sci (2015) 0.75
The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy. Oncotarget (2017) 0.75
New paradigms for the Hedgehog signaling network in mammary gland development and breast Cancer. Biochim Biophys Acta (2017) 0.75
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer (2007) 10.27
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature (2000) 10.04
RAS oncogenes: the first 30 years. Nat Rev Cancer (2003) 8.61
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38
Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev (2006) 8.26
A paracrine requirement for hedgehog signalling in cancer. Nature (2008) 8.16
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov (2006) 5.30
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell (2003) 5.17
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res (2007) 5.12
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev (2009) 4.21
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A (2007) 4.15
PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol (2005) 4.04
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell (2006) 3.62
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci U S A (2007) 3.20
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A (2009) 3.13
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res (2007) 3.02
Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71
Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res (2005) 2.64
Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res (2009) 2.43
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem (2007) 2.34
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2007) 2.17
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle (2007) 2.16
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut (2008) 1.82
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol (2004) 1.76
Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem (2002) 1.60
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell (2008) 1.58
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature (2007) 1.54
Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res (2006) 1.52
Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Cancer Res (2004) 1.49
Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev Dyn (2008) 1.27
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. Cancer Res (2007) 1.18
SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell. Cancer Res (2008) 1.06
Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem Cells (2008) 1.06
Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: implications for the molecular analysis of clinically available biopsies. Diagn Mol Pathol (2007) 1.04
Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling. Oncogene (2007) 0.96
Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli. Oncogene (2007) 0.94
The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. Pancreatology (2008) 0.92
Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer (2009) 11.25
Tumour biology: senescence in premalignant tumours. Nature (2005) 10.15
RAS oncogenes: the first 30 years. Nat Rev Cancer (2003) 8.61
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Mammalian cyclin-dependent kinases. Trends Biochem Sci (2005) 5.54
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell (2003) 5.17
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res (2007) 5.12
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet (2003) 4.74
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell (2004) 4.39
Cdk1 is sufficient to drive the mammalian cell cycle. Nature (2007) 4.26
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A (2007) 4.15
A pericyte origin of spinal cord scar tissue. Science (2011) 4.12
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell (2010) 3.97
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta (2002) 3.77
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell (2006) 3.62
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet (2007) 3.30
Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta (2010) 3.21
Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA (2010) 2.87
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.59
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell (2011) 2.56
Cell cycle kinases in cancer. Curr Opin Genet Dev (2007) 2.46
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell (2011) 2.28
Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters! World J Surg (2007) 2.21
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther (2008) 2.21
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle (2007) 2.16
Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors. Crit Care Med (2016) 2.03
Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol (2009) 1.99
CDK inhibitors in cancer therapy: what is next? Trends Pharmacol Sci (2007) 1.95
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A (2006) 1.93
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A (2011) 1.89
Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol (2006) 1.83
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene (2004) 1.82
What we have learned about pancreatic cancer from mouse models. Gastroenterology (2012) 1.78
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell (2005) 1.78
Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem (2003) 1.72
PTCH mutations: distribution and analyses. Hum Mutat (2006) 1.68
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J (2010) 1.66
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene (2003) 1.62
A catalyst for change: the European cancer Patient's Bill of Rights. Oncologist (2014) 1.55
Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions. Gut (2012) 1.55
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev Biol (2009) 1.52
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology (2013) 1.48
Use of Intensive Care Services for Medicare Beneficiaries Undergoing Major Surgical Procedures. Anesthesiology (2016) 1.47
The hair follicle-a stem cell zoo. Exp Cell Res (2010) 1.46
Inactivation of Brca2 cooperates with Trp53(R172H) to induce invasive pancreatic ductal adenocarcinomas in mice: a mouse model of familial pancreatic cancer. Cancer Biol Ther (2011) 1.45
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell (2011) 1.44
Reduced complication rate after modified binding purse-string-mattress sutures pancreatogastrostomy versus duct-to-mucosa pancreaticojejunostomy. Surgeon (2013) 1.41
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest (2008) 1.38
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A (2010) 1.36
Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. Int J Oncol (2004) 1.35
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing. BMC Cancer (2013) 1.31
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. Int J Oncol (2004) 1.31
Development of mammary tumors by conditional expression of GLI1. Cancer Res (2009) 1.30
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. J Cell Sci (2006) 1.25
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal. J Biol Chem (2008) 1.23
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell (2005) 1.23
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. J Pathol (2009) 1.22
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. PLoS One (2011) 1.22
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther (2011) 1.18
Innervation of the pancreas from the perspective of perineural invasion of pancreatic cancer. Pancreas (2003) 1.17
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein. Oncogene (2002) 1.15
Genetically engineered mouse models of pancreatic adenocarcinoma. Mol Oncol (2013) 1.15
Overall Cdk activity modulates the DNA damage response in mammalian cells. J Cell Biol (2009) 1.14
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer (2012) 1.13
Prescription of tamoxifen for breast cancer prevention by primary care physicians. Arch Intern Med (2006) 1.12
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proc Natl Acad Sci U S A (2013) 1.11
Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. Proc Natl Acad Sci U S A (2004) 1.11
Transabdominal preperitoneal versus totally extraperitoneal repair of inguinal hernia: a meta-analysis of randomized studies. Am J Surg (2013) 1.11
Interest in BRCA1/2 testing in a primary care population. Prev Med (2002) 1.10
Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis. Breast Cancer Res Treat (2006) 1.10
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J (2012) 1.08
Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J (2004) 1.08
Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell (2006) 1.08
Risk factors for dementia after critical illness in elderly Medicare beneficiaries. Crit Care (2012) 1.07
Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway. Genes Cancer (2010) 1.07
Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06