Cyclin-dependent kinases: a family portrait.

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev (2011) 2.24

The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64

CDK8: a positive regulator of transcription. Transcription (2012) 1.53

Cyclin-dependent kinases. Genome Biol (2014) 1.52

The CDK inhibitors in cancer research and therapy. J Cancer Res Clin Oncol (2011) 1.39

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A (2012) 1.19

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. Genes Cancer (2010) 1.16

Nucleolar stress with and without p53. Nucleus (2014) 1.13

Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol (2011) 1.12

Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases. PLoS Pathog (2010) 1.10

Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs. Cell Cycle (2012) 1.04

Cyclin K goes with Cdk12 and Cdk13. Cell Div (2012) 1.03

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development. Proc Natl Acad Sci U S A (2013) 1.03

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing. Mol Cell Biol (2015) 1.00

Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS One (2011) 0.99

Mediator kinase module and human tumorigenesis. Crit Rev Biochem Mol Biol (2015) 0.98

Cdk5 activity in the brain - multiple paths of regulation. J Cell Sci (2014) 0.95

Highlights of the Latest Advances in Research on CDK Inhibitors. Cancers (Basel) (2014) 0.94

Strategies for immortalization of primary hepatocytes. J Hepatol (2014) 0.93

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS One (2012) 0.93

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells. Oncogene (2013) 0.93

Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia (2013) 0.92

The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J (2016) 0.92

Tumor-suppressive effects of CDK8 in endometrial cancer cells. Cell Cycle (2013) 0.90

The kinome of Phytophthora infestans reveals oomycete-specific innovations and links to other taxonomic groups. BMC Genomics (2010) 0.90

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages. BMC Evol Biol (2014) 0.90

Divide and differentiate: CDK/Cyclins and the art of development. Cell Cycle (2014) 0.89

CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc Natl Acad Sci U S A (2013) 0.88

Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Mol Cell Proteomics (2014) 0.87

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. Breast Cancer Res (2015) 0.87

Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation. BMC Cancer (2015) 0.86

The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. Oncogene (2012) 0.85

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages. Cell Cycle (2015) 0.85

Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma. Br J Cancer (2012) 0.83

The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations. Cancers (Basel) (2014) 0.82

Why cyclin Y? A highly conserved cyclin with essential functions. Fly (Austin) (2010) 0.82

CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation. Oncogene (2015) 0.81

Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth. Sci Rep (2015) 0.81

PFTK1 Promotes Gastric Cancer Progression by Regulating Proliferation, Migration and Invasion. PLoS One (2015) 0.80

Pharmacological cyclin dependent kinase inhibitors: Implications for colorectal cancer. World J Gastroenterol (2016) 0.80

Regulation of the g1/s transition in hepatocytes: involvement of the cyclin-dependent kinase cdk1 in the DNA replication. Int J Hepatol (2012) 0.79

Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation. Front Immunol (2012) 0.79

CDK11p58 inhibits ERα-positive breast cancer invasion by targeting integrin β3 via the repression of ERα signaling. BMC Cancer (2014) 0.79

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. Oncotarget (2016) 0.79

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice. Front Behav Neurosci (2010) 0.78

The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing. J Biol Chem (2010) 0.78

Phosphatase 1 nuclear targeting subunit is an essential regulator of M-phase entry, maintenance, and exit. J Biol Chem (2014) 0.78

Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. J Biol Chem (2014) 0.78

Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells. Oncotarget (2016) 0.77

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding. Sci Rep (2015) 0.77

Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity. Front Cell Dev Biol (2016) 0.77

All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC. Comput Biol Chem (2014) 0.76

Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H. Int J Mol Sci (2015) 0.76

Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design. PLoS One (2013) 0.76

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Biochem J (2017) 0.75

Cdk5 links with DNA damage response and cancer. Mol Cancer (2017) 0.75

3D-QSAR and 3D-QSSR studies of thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as CDK4 inhibitors by CoMFA analysis. Acta Pharmacol Sin (2013) 0.75

An EBV recombinant deleted for residues 130-159 in EBNA3C can deregulate p53/Mdm2 and Cyclin D1/CDK6 which results in apoptosis and reduced cell proliferation. Oncotarget (2016) 0.75

CBX3 promotes colon cancer cell proliferation by CDK6 kinase-independent function during cell cycle. Oncotarget (2017) 0.75

CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment. PLoS One (2016) 0.75

Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila. Cell Cycle (2016) 0.75

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. J Innate Immun (2016) 0.75

Deciphering the Acute Cellular Phosphoproteome Response to Irradiation with X-rays, Protons and Carbon Ions. Mol Cell Proteomics (2017) 0.75

PCTK3/CDK18 regulates cell migration and adhesion by negatively modulating FAK activity. Sci Rep (2017) 0.75

Comprehensive characterization of (S)GTP-binding proteins by orthogonal quantitative (S)GTP-affinity profiling and (S)GTP/GTP competition assays. Anal Chem (2014) 0.75

Molecular mechanisms of OLIG2 transcription factor in brain cancer. Oncotarget (2016) 0.75

Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells. Stem Cells Int (2015) 0.75

Targeting protein kinases to reverse multidrug resistance in sarcoma. Cancer Treat Rev (2015) 0.75

The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1. BMC Cell Biol (2017) 0.75

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation. EMBO Mol Med (2017) 0.75

CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells. Oncogene (2017) 0.75

RNA interference and deep sequencing as tools for identifying new genes involved in leukemogenesis. Dokl Biochem Biophys (2013) 0.75

Phenotypic and molecular characterisation of CDK13-related congenital heart defects, dysmorphic facial features and intellectual developmental disorders. Genome Med (2017) 0.75

The protein kinase complement of the human genome. Science (2002) 35.36

Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76

Mammalian cyclin-dependent kinases. Trends Biochem Sci (2005) 5.54

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol Cell (2004) 3.34

A Drosophila protein-interaction map centered on cell-cycle regulators. Genome Biol (2004) 2.95

Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. Mol Cell Biol (2006) 2.30

Functional characterization of human PFTK1 as a cyclin-dependent kinase. Proc Natl Acad Sci U S A (2007) 1.22

CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Biochem Biophys Res Commun (2007) 1.20

p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. J Biol Chem (2003) 1.20

Cell cycle-related kinase: a novel candidate oncogene in human glioblastoma. J Natl Cancer Inst (2007) 1.08

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99

Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74

Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09

Targets of the cyclin-dependent kinase Cdk1. Nature (2003) 8.05

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol (2004) 7.59

HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96

Recovery of learning and memory is associated with chromatin remodelling. Nature (2007) 6.72

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69

The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41

Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science (2007) 5.69

Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet (2004) 5.55

Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science (2009) 5.37

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34

Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci (2002) 5.28

The Amphimedon queenslandica genome and the evolution of animal complexity. Nature (2010) 5.11

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet (2003) 4.74

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell (2011) 4.49

A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature (2010) 4.39

Cdk1 is sufficient to drive the mammalian cell cycle. Nature (2007) 4.26

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A (2004) 4.13

Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature (2005) 4.08

Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell (2008) 4.01

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90

Trekking across the brain: the journey of neuronal migration. Cell (2007) 3.90

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell (2003) 3.87

The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell (2012) 3.83

Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta (2002) 3.77

Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71

PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51

Reconstruction of cellular signalling networks and analysis of their properties. Nat Rev Mol Cell Biol (2005) 3.46

Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37

Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron (2004) 3.33

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol (2002) 3.32

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature (2011) 3.32

Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol (2007) 3.32

Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol (2008) 3.31

Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell (2007) 3.26

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (2011) 3.10

Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science (2010) 3.10

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron (2003) 2.97

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res (2009) 2.96

Kinomics: methods for deciphering the kinome. Nat Methods (2005) 2.94

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron (2008) 2.88

Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell (2005) 2.88

The fold of alpha-synuclein fibrils. Proc Natl Acad Sci U S A (2008) 2.82

Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J (2009) 2.78

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell (2003) 2.69

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron (2005) 2.68

An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature (2012) 2.67

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med (2007) 2.65

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell (2002) 2.64

G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell (2005) 2.64

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61

Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J (2007) 2.59

Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57

Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts. Mol Cell (2004) 2.55

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A (2008) 2.53

Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Neuron (2007) 2.53

The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc Natl Acad Sci U S A (2004) 2.50

Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol (2008) 2.48

Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev Cell (2005) 2.48

Life is a journey: a genetic look at neocortical development. Nat Rev Genet (2002) 2.46

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45

Control of cell proliferation pathways by microRNAs. Cell Cycle (2008) 2.33

Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure (2009) 2.33

Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). Proc Natl Acad Sci U S A (2010) 2.30

The conserved transcriptome in human and rodent male gametogenesis. Proc Natl Acad Sci U S A (2007) 2.30

Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature (2007) 2.29

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A (2002) 2.28

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature (2003) 2.28

An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27

14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet (2003) 2.27

APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol (2003) 2.21

Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15

Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol (2003) 2.13

Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature (2006) 2.12

RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature (2012) 2.11

CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11

The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle (2011) 2.10

SMK-1, an essential regulator of DAF-16-mediated longevity. Cell (2006) 2.10

Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci (2003) 2.10

Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron (2010) 2.08

Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08

Cyclin-dependent kinases in brain development and disease. Annu Rev Cell Dev Biol (2011) 2.08

Positive feedback sharpens the anaphase switch. Nature (2008) 2.07

A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol (2004) 2.06

Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell (2009) 2.05

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem (2002) 2.03

Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol (2006) 1.96

A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. Carcinogenesis (2007) 1.95

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell (2011) 1.95