Published in Hum Mol Genet on April 15, 2002
Enhanced protein domain discovery by using language modeling techniques from speech recognition. Proc Natl Acad Sci U S A (2003) 6.01
Next-generation genetic testing for retinitis pigmentosa. Hum Mutat (2012) 2.30
Regulation of photoreceptor gene expression by Crx-associated transcription factor network. Brain Res (2007) 1.63
Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet (2007) 1.36
Genetic screening of LCA in Belgium: predominance of CEP290 and identification of potential modifier alleles in AHI1 of CEP290-related phenotypes. Hum Mutat (2010) 1.21
The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival. Proc Natl Acad Sci U S A (2010) 1.15
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci (2009) 1.04
OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness. J Clin Invest (2014) 1.04
Mutation discovered in a feline model of human congenital retinal blinding disease. Invest Ophthalmol Vis Sci (2010) 0.97
Mapping of genetic modifiers of Nr2e3 rd7/rd7 that suppress retinal degeneration and restore blue cone cells to normal quantity. Mamm Genome (2008) 0.94
Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. Mol Cell Biol (2004) 0.94
Two novel CRX mutant proteins causing autosomal dominant Leber congenital amaurosis interact differently with NRL. Hum Mutat (2010) 0.93
A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX. Am J Hum Genet (2012) 0.90
Mechanistically distinct mouse models for CRX-associated retinopathy. PLoS Genet (2014) 0.85
RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model. PLoS One (2013) 0.84
FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. BMC Mol Biol (2008) 0.84
OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Dev Dyn (2011) 0.83
The domestic cat as a large animal model for characterization of disease and therapeutic intervention in hereditary retinal blindness. J Ophthalmol (2011) 0.82
Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies. Dev Dyn (2014) 0.81
CrxRdy Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis. Invest Ophthalmol Vis Sci (2016) 0.79
Cooperative activation of Xenopus rhodopsin transcription by paired-like transcription factors. BMC Mol Biol (2014) 0.78
A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina. Neural Dev (2007) 0.77
Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors. Sci Rep (2017) 0.75
Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis. Dev Dyn (2016) 0.75
Panel-Based Population Next-Generation Sequencing for Inherited Retinal Degenerations. Sci Rep (2016) 0.75
Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice. Invest Ophthalmol Vis Sci (2017) 0.75
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet (2011) 3.55
TiGER: a database for tissue-specific gene expression and regulation. BMC Bioinformatics (2008) 3.37
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A (2010) 3.33
Retracted Chemoembolization combined with radiofrequency ablation for patients with hepatocellular carcinoma larger than 3 cm: a randomized controlled trial. JAMA (2008) 2.63
Study on nanometric cutting of germanium by molecular dynamics simulation. Nanoscale Res Lett (2013) 2.48
Quantifying the integration of quorum-sensing signals with single-cell resolution. PLoS Biol (2009) 2.40
Computational analysis of tissue-specific combinatorial gene regulation: predicting interaction between transcription factors in human tissues. Nucleic Acids Res (2006) 2.26
Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci (2002) 2.03
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet (2011) 1.98
Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model. Invest Ophthalmol Vis Sci (2003) 1.83
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83
Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci (2002) 1.82
Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms. Invest Ophthalmol Vis Sci (2007) 1.74
Genome-wide prediction and characterization of interactions between transcription factors in Saccharomyces cerevisiae. Nucleic Acids Res (2006) 1.65
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment. Am J Pathol (2002) 1.59
AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci (2002) 1.58
Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci U S A (2009) 1.50
Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc Natl Acad Sci U S A (2011) 1.47
A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection. Invest Ophthalmol Vis Sci (2003) 1.46
A splice-site mutation in a retina-specific exon of BBS8 causes nonsyndromic retinitis pigmentosa. Am J Hum Genet (2010) 1.46
Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neurosci (2003) 1.44
Inducible expression of cre recombinase in the retinal pigmented epithelium. Invest Ophthalmol Vis Sci (2008) 1.41
Analysis of the VMD2 promoter and implication of E-box binding factors in its regulation. J Biol Chem (2004) 1.41
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A (2013) 1.36
Analysis of regulatory network topology reveals functionally distinct classes of microRNAs. Nucleic Acids Res (2008) 1.36
Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function. J Biol Chem (2002) 1.34
Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Invest Ophthalmol Vis Sci (2004) 1.33
Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J Neurosci (2007) 1.33
Effect of CNTF on retinal ganglion cell survival in experimental glaucoma. Invest Ophthalmol Vis Sci (2008) 1.31
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A (2013) 1.31
A functional variant in the CFI gene confers a high risk of age-related macular degeneration. Nat Genet (2013) 1.29
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Am J Ophthalmol (2004) 1.26
Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. J Am Coll Surg (2004) 1.25
Analysis of matched case-control data with multiple ordered disease states: possible choices and comparisons. Stat Med (2007) 1.21
Identification of tissue-specific cis-regulatory modules based on interactions between transcription factors. BMC Bioinformatics (2007) 1.20
Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization. J Cell Physiol (2004) 1.19
Generation of Cre transgenic mice with postnatal RPE-specific ocular expression. Invest Ophthalmol Vis Sci (2011) 1.18
betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development. Mol Cell Neurosci (2007) 1.18
Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2. Mol Cancer Ther (2007) 1.17
Fitting stratified proportional odds models by amalgamating conditional likelihoods. Stat Med (2008) 1.16
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology (2012) 1.16
Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. J Biol Chem (2004) 1.15
MicroRNA profile of the developing mouse retina. Invest Ophthalmol Vis Sci (2009) 1.14
Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive. FASEB J (2005) 1.12
Gene expression variation in the adult human retina. Hum Mol Genet (2003) 1.12
Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray. Invest Ophthalmol Vis Sci (2003) 1.11
Measurement of the copy number of the master quorum-sensing regulator of a bacterial cell. Biophys J (2010) 1.11
Sequence variants in HTRA1 and LOC387715/ARMS2 and phenotype and response to photodynamic therapy in neovascular age-related macular degeneration in populations from Israel. Mol Vis (2008) 1.10
QRX, a novel homeobox gene, modulates photoreceptor gene expression. Hum Mol Genet (2004) 1.10
A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med (2013) 1.09
β-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma. Cancer Res (2013) 1.08
Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation. Nucleic Acids Res (2005) 1.07
Increased expression of iron-regulating genes in monkey and human glaucoma. Invest Ophthalmol Vis Sci (2004) 1.07
Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. Invest Ophthalmol Vis Sci (2012) 1.06
Prolonged blockade of VEGF family members does not cause identifiable damage to retinal neurons or vessels. J Cell Physiol (2008) 1.06
Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Invest Ophthalmol Vis Sci (2012) 1.06
Computational analysis of tissue-specific gene networks: application to murine retinal functional studies. Bioinformatics (2010) 1.05
In vivo micropathology of Best macular dystrophy with optical coherence tomography. Exp Eye Res (2003) 1.04
Prevalence and correlates of HIV and HCV infection among amphetamine-type stimulant users in 6 provinces in China. J Acquir Immune Defic Syndr (2012) 1.04
The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer. Neoplasia (2006) 1.01
Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin. Stem Cells (2012) 1.01
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat. J Cell Sci (2011) 1.01
Bone morphogenetic proteins promote neurite outgrowth in retinal ganglion cells. Mol Vis (2005) 1.01
Cell-specific DNA methylation patterns of retina-specific genes. PLoS One (2012) 1.00
The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration. Invest Ophthalmol Vis Sci (2006) 1.00
Transcriptome analysis of the retina. Genome Biol (2002) 1.00
Butterfly-shaped pattern dystrophy: a genetic, clinical, and histopathological report. Arch Ophthalmol (2002) 0.99
Gene expression profiling of purified rat retinal ganglion cells. Invest Ophthalmol Vis Sci (2004) 0.99
Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs. Nucleic Acids Res (2013) 0.98
Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integr Biol (Camb) (2010) 0.98
The extragenic spacer length between the 5' and 3' ends of the transgene expression cassette affects transgene silencing from plasmid-based vectors. Mol Ther (2012) 0.98
Dynamic usage of alternative splicing exons during mouse retina development. Nucleic Acids Res (2011) 0.97
The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina. Hum Mol Genet (2009) 0.97
VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family. J Biol Chem (2006) 0.96
A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells. Mol Vis (2004) 0.95
Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyes. Invest Ophthalmol Vis Sci (2007) 0.94
Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. Hum Genet (2014) 0.93
BEST1 expression in the retinal pigment epithelium is modulated by OTX family members. Hum Mol Genet (2008) 0.93
Comparative gene expression analysis of murine retina and brain. Mol Vis (2004) 0.93
Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium. J Biol Chem (2014) 0.92
Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters. Invest Ophthalmol Vis Sci (2004) 0.91
Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States. Mol Vis (2013) 0.90
Roles of cell-intrinsic and microenvironmental factors in photoreceptor cell differentiation. Dev Biol (2005) 0.90
Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice. Exp Eye Res (2011) 0.90
Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements. BMC Mol Biol (2005) 0.90
Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells. J Cell Physiol (2010) 0.90
Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake. Invest Ophthalmol Vis Sci (2004) 0.89
Use of laser capture microdissection for analysis of retinal mRNA/miRNA expression and DNA methylation. Methods Mol Biol (2012) 0.88
Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis. J Gastrointest Surg (2003) 0.88
Effect of plasma exchange on hepatocyte oxidative stress, mitochondria function, and apoptosis in patients with acute fatty liver of pregnancy. Artif Organs (2012) 0.88
A system for inducible gene expression in retinal ganglion cells. Invest Ophthalmol Vis Sci (2005) 0.87
A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples. Epigenetics Chromatin (2013) 0.87
Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis. Development (2013) 0.86
Neurite outgrowth in retinal ganglion cell culture. Methods Mol Biol (2007) 0.85