Published in J Neurosci on January 03, 2007
Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem (2008) 1.52
Visual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoter. PLoS One (2009) 1.33
Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame? J Biol Chem (2011) 1.31
Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res (2010) 1.15
Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function. Proc Natl Acad Sci U S A (2009) 1.14
Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. J Biol Chem (2010) 1.13
Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degeneration. Mol Vis (2009) 1.04
Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides. J Neurochem (2008) 1.01
Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment. Ann N Y Acad Sci (2014) 1.01
Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration. Invest Ophthalmol Vis Sci (2011) 1.00
Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Proc Natl Acad Sci U S A (2009) 0.99
Phosphatidylinositol 3 kinase-Akt signaling serves as a circadian output in the retina. J Neurochem (2009) 0.97
Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Invest Ophthalmol Vis Sci (2011) 0.95
Insulin receptor signaling in cones. J Biol Chem (2013) 0.95
The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning. Exp Eye Res (2008) 0.92
The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration. Trends Mol Med (2009) 0.91
Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14. Mol Cell Biol (2011) 0.91
Clinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina? Invest Ophthalmol Vis Sci (2007) 0.91
The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development. Scientifica (Cairo) (2013) 0.89
Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. J Neurochem (2010) 0.87
Rhodopsin-regulated insulin receptor signaling pathway in rod photoreceptor neurons. Mol Neurobiol (2010) 0.87
Conditional gene targeting: dissecting the cellular mechanisms of retinal degenerations. J Ophthalmol (2010) 0.86
Insulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors. Invest Ophthalmol Vis Sci (2008) 0.86
Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion (2013) 0.84
Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration. Mol Cell Biol (2011) 0.83
The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina. Sci Rep (2016) 0.83
Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem (2013) 0.82
Conservation and divergence of Grb7 family of Ras-binding domains. Protein Cell (2012) 0.82
Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Commun Signal (2013) 0.80
Retinal insulin receptor signaling in hyperosmotic stress. Vitam Horm (2009) 0.79
All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear. PLoS One (2015) 0.79
Phospho-Site-Specific Antibody Microarray to Study the State of Protein Phosphorylation in the Retina. J Proteomics Bioinform (2008) 0.76
The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival. Biochimie (2015) 0.76
Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Commun Signal (2013) 0.75
Effect of knocking down the insulin receptor on mouse rod responses. Sci Rep (2015) 0.75
Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish. Front Endocrinol (Lausanne) (2017) 0.75
Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal. Int J Mol Sci (2017) 0.75
Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. J Neurochem (2009) 0.75
Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice. Front Mol Neurosci (2017) 0.75
Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. Invest Ophthalmol Vis Sci (2016) 0.75
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet (2011) 3.55
TiGER: a database for tissue-specific gene expression and regulation. BMC Bioinformatics (2008) 3.37
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A (2010) 3.33
Computational analysis of tissue-specific combinatorial gene regulation: predicting interaction between transcription factors in human tissues. Nucleic Acids Res (2006) 2.26
Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci (2002) 2.03
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet (2011) 1.98
Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci U S A (2008) 1.88
Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model. Invest Ophthalmol Vis Sci (2003) 1.83
Molecular determinants differentiating photocurrent properties of two channelrhodopsins from chlamydomonas. J Biol Chem (2008) 1.83
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83
Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci (2002) 1.82
Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms. Invest Ophthalmol Vis Sci (2007) 1.74
Genome-wide prediction and characterization of interactions between transcription factors in Saccharomyces cerevisiae. Nucleic Acids Res (2006) 1.65
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment. Am J Pathol (2002) 1.59
Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants. J Pediatr (2010) 1.58
AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci (2002) 1.58
Mouse opsin promoter-directed Cre recombinase expression in transgenic mice. Mol Vis (2006) 1.56
Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem (2008) 1.52
Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med (2008) 1.51
Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci U S A (2009) 1.50
LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. J Hum Genet (2004) 1.47
Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc Natl Acad Sci U S A (2011) 1.47
A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection. Invest Ophthalmol Vis Sci (2003) 1.46
A splice-site mutation in a retina-specific exon of BBS8 causes nonsyndromic retinitis pigmentosa. Am J Hum Genet (2010) 1.46
The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies. Endocrinology (2014) 1.46
Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neurosci (2003) 1.44
Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis? J Rheumatol (2013) 1.43
Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem (2005) 1.43
Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. Free Radic Biol Med (2007) 1.42
Inducible expression of cre recombinase in the retinal pigmented epithelium. Invest Ophthalmol Vis Sci (2008) 1.41
Analysis of the VMD2 promoter and implication of E-box binding factors in its regulation. J Biol Chem (2004) 1.41
Cerebral blood flow measurements and electroencephalograms during carotid endarterectomy. 1974. J Neurosurg (2007) 1.40
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 August 2009-30 September 2009. Mol Ecol Resour (2010) 1.39
Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy. Hum Mol Genet (2002) 1.37
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A (2013) 1.36
Analysis of regulatory network topology reveals functionally distinct classes of microRNAs. Nucleic Acids Res (2008) 1.36
Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Invest Ophthalmol Vis Sci (2004) 1.33
Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation. Development (2002) 1.33
Effect of CNTF on retinal ganglion cell survival in experimental glaucoma. Invest Ophthalmol Vis Sci (2008) 1.31
Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J Biol Chem (2004) 1.31
Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice. Mol Vis (2004) 1.31
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A (2013) 1.31
Promoter specificity for 6S RNA regulation of transcription is determined by core promoter sequences and competition for region 4.2 of sigma70. Mol Microbiol (2008) 1.29
A functional variant in the CFI gene confers a high risk of age-related macular degeneration. Nat Genet (2013) 1.29
In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. J Biol Chem (2002) 1.29
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Am J Ophthalmol (2004) 1.26
Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci (2005) 1.25
Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein. J Lipid Res (2010) 1.23
Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes. Invest Ophthalmol Vis Sci (2005) 1.23
Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. Am J Clin Nutr (2005) 1.22
Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res (2010) 1.21
Identification of tissue-specific cis-regulatory modules based on interactions between transcription factors. BMC Bioinformatics (2007) 1.20
Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization. J Cell Physiol (2004) 1.19
Generation of Cre transgenic mice with postnatal RPE-specific ocular expression. Invest Ophthalmol Vis Sci (2011) 1.18
Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophys J (2009) 1.18
betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development. Mol Cell Neurosci (2007) 1.18
G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J Biol Chem (2007) 1.17
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology (2012) 1.16
Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. J Biol Chem (2004) 1.15
MicroRNA profile of the developing mouse retina. Invest Ophthalmol Vis Sci (2009) 1.14
Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration. J Neurosci (2003) 1.14
Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes (2006) 1.13
Sensitivity of three loci on the tongue and soft palate to four basic tastes in smokers and non-smokers. Acta Otolaryngol Suppl (2002) 1.12
Gene expression variation in the adult human retina. Hum Mol Genet (2003) 1.12
Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive. FASEB J (2005) 1.12
Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray. Invest Ophthalmol Vis Sci (2003) 1.11
Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase. Biochemistry (2004) 1.10
QRX, a novel homeobox gene, modulates photoreceptor gene expression. Hum Mol Genet (2004) 1.10
Sequence variants in HTRA1 and LOC387715/ARMS2 and phenotype and response to photodynamic therapy in neovascular age-related macular degeneration in populations from Israel. Mol Vis (2008) 1.10
A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med (2013) 1.09
Epidemiological study of urge urinary incontinence and risk factors in China. Int Urogynecol J (2010) 1.09
Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation. Nucleic Acids Res (2005) 1.07
Increased expression of iron-regulating genes in monkey and human glaucoma. Invest Ophthalmol Vis Sci (2004) 1.07
Topography of retinal damage in light-exposed albino rats. Exp Eye Res (2008) 1.07
Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats. Invest Ophthalmol Vis Sci (2007) 1.07
Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. Invest Ophthalmol Vis Sci (2012) 1.06
Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Invest Ophthalmol Vis Sci (2012) 1.06
Prolonged blockade of VEGF family members does not cause identifiable damage to retinal neurons or vessels. J Cell Physiol (2008) 1.06
Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species. J Neurochem (2007) 1.06
Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice. J Lipid Res (2009) 1.06
Computational analysis of tissue-specific gene networks: application to murine retinal functional studies. Bioinformatics (2010) 1.05
Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation. J Virol (2005) 1.05
Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. Dev Neurobiol (2007) 1.04
In vivo micropathology of Best macular dystrophy with optical coherence tomography. Exp Eye Res (2003) 1.04
Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry (2009) 1.04
High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res (2008) 1.03
Protective effect of TEMPOL derivatives against light-induced retinal damage in rats. Invest Ophthalmol Vis Sci (2007) 1.03
Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides. J Neurochem (2008) 1.01
Reduced fMRI activity predicts relapse in patients recovering from stimulant dependence. Hum Brain Mapp (2012) 1.01
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat. J Cell Sci (2011) 1.01
Bone morphogenetic proteins promote neurite outgrowth in retinal ganglion cells. Mol Vis (2005) 1.01
Cell-specific DNA methylation patterns of retina-specific genes. PLoS One (2012) 1.00