PubRank

Anthony E Pegg

Author PubWeight™ 111.13‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nat Struct Mol Biol 2004 2.86
2 Polyamine catabolism and disease. Biochem J 2009 1.79
3 Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature 2009 1.70
4 Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol 2005 1.63
5 The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nat Struct Biol 2002 1.63
6 Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol 2002 1.50
7 X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet 2003 1.45
8 Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem 2008 1.39
9 DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair (Amst) 2007 1.36
10 DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability. J Biol Chem 2002 1.34
11 Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide. Cancer Res 2002 1.30
12 Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. Carcinogenesis 2002 1.29
13 Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs. J Biol Chem 2006 1.19
14 Aminopropyltransferases: function, structure and genetics. J Biochem 2006 1.16
15 Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Oncogene 2005 1.16
16 Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. J Biol Chem 2005 1.16
17 The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A 2008 1.15
18 Structure and mechanism of spermidine synthases. Biochemistry 2007 1.13
19 The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants. Chem Res Toxicol 2004 1.11
20 Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases. J Biol Chem 2004 1.10
21 Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol 2004 1.10
22 Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol 2004 1.10
23 Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. J Biol Chem 2003 1.10
24 2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase. J Med Chem 2004 1.09
25 O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. Biochemistry 2003 1.09
26 Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase. J Biol Chem 2004 1.07
27 Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant. Biochemistry 2003 1.05
28 Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. Chem Res Toxicol 2006 1.05
29 Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem Res Toxicol 2008 1.05
30 Spermine synthesis is required for normal viability, growth, and fertility in the mouse. J Biol Chem 2004 1.04
31 Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. J Biol Chem 2008 1.04
32 O6-benzylguanine-mediated enhancement of chemotherapy. Mol Cancer Ther 2002 1.04
33 Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. J Biol Chem 2002 1.03
34 Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Res 2003 1.03
35 Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. J Clin Invest 2004 1.03
36 Function of domains of human O6-alkylguanine-DNA alkyltransferase. Biochemistry 2005 1.03
37 Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase. Protein Sci 2004 1.01
38 Putrescine biosynthesis in mammalian tissues. Biochem J 2004 0.99
39 Characterization of transgenic mice with widespread overexpression of spermine synthase. Biochem J 2004 0.97
40 Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol 2007 0.96
41 The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. Int J Cancer 2010 0.95
42 Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc Natl Acad Sci U S A 2006 0.95
43 Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chem Res Toxicol 2004 0.95
44 Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. Biochemistry 2008 0.95
45 Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine. J Biol Chem 2003 0.94
46 Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase. Biochemistry 2002 0.94
47 Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. Biochem J 2004 0.93
48 Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. J Biol Chem 2010 0.92
49 O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents. Chem Res Toxicol 2005 0.92
50 Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion. FEBS Lett 2002 0.92
51 A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities. Proc Natl Acad Sci U S A 2005 0.92
52 Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis. Carcinogenesis 2002 0.90
53 Effect of spermine synthase on the sensitivity of cells to anti-tumour agents. Biochem J 2003 0.90
54 DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells. Biochemistry 2013 0.90
55 Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. Biochemistry 2003 0.90
56 Expression of arginase II in prostate cancer. Int J Oncol 2008 0.90
57 Interactions of human O(6)-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs. Biochemistry 2008 0.90
58 Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations. Mol Cancer Ther 2004 0.90
59 Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry 2008 0.90
60 New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. J Med Chem 2009 0.89
61 DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases. Cancer Res 2006 0.88
62 Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. DNA Repair (Amst) 2007 0.88
63 Polyamine homeostasis in arginase knockout mice. Am J Physiol Cell Physiol 2007 0.88
64 Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation. Biochemistry 2002 0.87
65 Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide. Chem Res Toxicol 2008 0.87
66 Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds. Mol Carcinog 2007 0.86
67 Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases. J Biol Chem 2009 0.86
68 Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. Angew Chem Int Ed Engl 2013 0.86
69 Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA. J Mol Biol 2009 0.86
70 Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide. Biochim Biophys Acta 2003 0.85
71 In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase. J Chem Inf Model 2007 0.85
72 The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chem Res Toxicol 2009 0.85
73 DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Int J Oncol 2013 0.85
74 Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker. Exp Hematol 2004 0.84
75 O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate. Chem Res Toxicol 2004 0.84
76 Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis. Carcinogenesis 2007 0.83
77 Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). Biochem J 2011 0.83
78 Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase. Biochem Pharmacol 2007 0.83
79 Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. Mol Cancer Ther 2009 0.83
80 Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome). Methods Mol Biol 2011 0.82
81 Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. Chem Res Toxicol 2007 0.82
82 Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids 2011 0.82
83 Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. Biochem J 2006 0.82
84 Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine. J Med Chem 2005 0.82
85 Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells. Mutat Res 2009 0.82
86 Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine. J Med Chem 2007 0.82
87 O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics. Chem Res Toxicol 2003 0.81
88 Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences. Chem Res Toxicol 2006 0.81
89 Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides. J Biol Chem 2009 0.81
90 Brain infarction correlates more closely with acrolein than with reactive oxygen species. Biochem Biophys Res Commun 2010 0.81
91 Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii. Acta Crystallogr D Biol Crystallogr 2008 0.80
92 Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. J Med Chem 2008 0.80
93 Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine. Biochem Pharmacol 2002 0.80
94 Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin. Carcinogenesis 2005 0.80
95 Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine. Protein Sci 2011 0.79
96 Drugs affecting the cell cycle via actions on the polyamine metabolic pathway. Prog Cell Cycle Res 2003 0.79
97 Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine. Clin Cancer Res 2003 0.79
98 Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis 2012 0.79
99 Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus. Biochem J 2003 0.79
100 Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. Cancer Res 2008 0.79
101 Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther 2006 0.78
102 Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine. Cancer Chemother Pharmacol 2004 0.78
103 Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation. Carcinogenesis 2002 0.78
104 Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins. Environ Mol Mutagen 2009 0.78
105 Characterization of transgenic mice with overexpression of spermidine synthase. Amino Acids 2011 0.77
106 DNAzyme-mediated silencing of ornithine decarboxylase. Biochemistry 2005 0.77
107 Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography. Anal Sci 2012 0.76
108 Role of aldehydes in the toxic and mutagenic effects of nitrosamines. Chem Res Toxicol 2013 0.76
109 Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase. Org Biomol Chem 2010 0.76
110 Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr 2010 0.75
111 Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine. J Histochem Cytochem 2004 0.75
112 Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model. Cancer Chemother Pharmacol 2010 0.75
113 Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation. Mol Microbiol 2011 0.75
114 Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine. Methods Mol Biol 2011 0.75