Published in Chem Res Toxicol on July 01, 2004
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chem Res Toxicol (2011) 1.30
DNA-protein cross-linking by 1,2,3,4-diepoxybutane. J Proteome Res (2010) 1.17
Contributions of human enzymes in carcinogen metabolism. Chem Res Toxicol (2012) 1.11
Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem Res Toxicol (2008) 1.05
Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. Chem Res Toxicol (2006) 1.05
The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems. Chem Res Toxicol (2009) 0.98
Human variants of O6-alkylguanine-DNA alkyltransferase. DNA Repair (Amst) (2007) 0.97
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. Chem Res Toxicol (2007) 0.93
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry (2008) 0.90
DNA repair modulates the vulnerability of the developing brain to alkylating agents. DNA Repair (Amst) (2009) 0.90
DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells. Biochemistry (2013) 0.90
1,2,3,4-Diepoxybutane-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J Proteome Res (2013) 0.88
Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide. Chem Res Toxicol (2008) 0.87
DNA-Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes. Acc Chem Res (2015) 0.83
Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells. Mutat Res (2009) 0.82
Thiol-activated DNA damage by α-bromo-2-cyclopentenone. Chem Res Toxicol (2011) 0.79
Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene. Chem Res Toxicol (2012) 0.79
Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins. Environ Mol Mutagen (2009) 0.78
DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system. Mutat Res (2013) 0.78
Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence. Chem Res Toxicol (2007) 0.77
Covalent DNA-Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells. Chem Res Toxicol (2016) 0.77
Structure elucidation of DNA-protein crosslinks by using reductive desulfurization and liquid chromatography-tandem mass spectrometry. Chembiochem (2014) 0.75
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. Chem Res Toxicol (2013) 0.75
Mass Spectrometry Based Tools to Characterize DNA-Protein Cross-Linking by Bis-electrophiles. Basic Clin Pharmacol Toxicol (2016) 0.75
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med (2013) 8.76
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature (2011) 6.21
Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology (2008) 3.99
Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation (2013) 3.57
DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nat Struct Mol Biol (2004) 2.86
Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity (2010) 2.32
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood (2008) 2.26
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10
Elucidating mechanisms of drug-induced toxicity. Nat Rev Drug Discov (2005) 2.06
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine. J Biol Chem (2005) 2.02
Diabetes and poor outcomes within 6 months after acute ischemic stroke: the China National Stroke Registry. Stroke (2011) 1.91
The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke (2011) 1.90
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell (2009) 1.84
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81
Polyamine catabolism and disease. Biochem J (2009) 1.79
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science (2010) 1.77
Complex reactions catalyzed by cytochrome P450 enzymes. Biochim Biophys Acta (2006) 1.76
Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. J Biol Chem (2005) 1.74
Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nat Struct Mol Biol (2008) 1.71
Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature (2009) 1.70
Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behav Genet (2003) 1.64
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol (2005) 1.63
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nat Struct Biol (2002) 1.63
Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. J Biol Chem (2006) 1.63
Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa. J Biol Chem (2006) 1.62
Chemokines and chemokine receptors: multipurpose players in neuroinflammation. Int Rev Neurobiol (2007) 1.56
Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke (2014) 1.53
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem (2005) 1.52
Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Nature (2011) 1.50
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol (2002) 1.50
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest (2012) 1.50
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors. Proc Natl Acad Sci U S A (2009) 1.48
Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Protein Expr Purif (2002) 1.46
Cytochrome P450 activation of arylamines and heterocyclic amines. Annu Rev Pharmacol Toxicol (2005) 1.46
Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. J Biol Chem (2006) 1.45
X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet (2003) 1.45
Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts. Am J Physiol Cell Physiol (2009) 1.45
miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β. Biochem Biophys Res Commun (2010) 1.42
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev (2013) 1.40
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem (2008) 1.39
Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. J Biol Chem (2007) 1.38
Using recombinant tissue plasminogen activator to treat acute ischemic stroke in China: analysis of the results from the Chinese National Stroke Registry (CNSR). Stroke (2011) 1.37
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair (Amst) (2007) 1.36
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci U S A (2010) 1.35
DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability. J Biol Chem (2002) 1.34
Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Res (2010) 1.34
Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. J Biol Chem (2009) 1.31
Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice. J Neurol Sci (2007) 1.31
Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide. Cancer Res (2002) 1.30
Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. Carcinogenesis (2002) 1.29
Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. J Biol Chem (2005) 1.29
A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc Natl Acad Sci U S A (2009) 1.29
Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods (2009) 1.29
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase. Mol Cell (2007) 1.28
Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta. J Mol Biol (2005) 1.26
Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation. J Leukoc Biol (2008) 1.25
Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Mol Pharmacol (2006) 1.24
Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation. Hepatology (2009) 1.23
A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS Pathog (2009) 1.23
Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. J Biol Chem (2006) 1.22
Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. Chem Res Toxicol (2006) 1.20
Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details. Curr Opin Immunol (2006) 1.19
Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs. J Biol Chem (2006) 1.19
Contrast extravasation on computed tomography angiography predicts clinical outcome in primary intracerebral hemorrhage: a prospective study of 139 cases. Stroke (2011) 1.18
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. J Clin Invest (2009) 1.17
miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops. Cell Res (2012) 1.17
Aminopropyltransferases: function, structure and genetics. J Biochem (2006) 1.16
1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase. J Biol Chem (2002) 1.16
Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers. Toxicol Appl Pharmacol (2004) 1.16
Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. J Biol Chem (2007) 1.16
Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Oncogene (2005) 1.16
Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction. Biochem Mol Biol Educ (2006) 1.16
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. J Biol Chem (2005) 1.16
Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota. J Biol Chem (2006) 1.15
The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A (2008) 1.15
Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps. J Biol Chem (2005) 1.15
Flotillin-1 promotes tumor necrosis factor-α receptor signaling and activation of NF-κB in esophageal squamous cell carcinoma cells. Gastroenterology (2012) 1.15
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis. EMBO J (2010) 1.14
Structure and mechanism of spermidine synthases. Biochemistry (2007) 1.13
Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. J Biol Chem (2012) 1.13
Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. J Mol Biol (2010) 1.12
Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol (2011) 1.12
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One (2012) 1.12
Epidemiological factors of stroke: a survey of the current status in china. J Stroke (2013) 1.12
Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. Chem Res Toxicol (2009) 1.11
The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants. Chem Res Toxicol (2004) 1.11
Contributions of human enzymes in carcinogen metabolism. Chem Res Toxicol (2012) 1.11
Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. J Biol Chem (2005) 1.10
Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1. J Biol Chem (2008) 1.10
Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells. J Biomol NMR (2011) 1.10
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. J Biol Chem (2003) 1.10
Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases. J Biol Chem (2004) 1.10
Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol (2004) 1.10