Published in Mol Membr Biol on May 06, 2002
The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J Gen Physiol (2005) 2.15
The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets (2007) 1.86
5-HT3 receptors. Curr Pharm Des (2006) 1.49
Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. J Med Chem (2010) 1.32
Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors. J Physiol (2011) 1.29
Prediction of 5-HT3 receptor agonist-binding residues using homology modeling. Biophys J (2003) 1.22
A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor. Br J Pharmacol (2003) 1.12
5-HT(3) receptors. J Biol Chem (2012) 1.11
Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor. J Pharmacol Exp Ther (2011) 1.10
High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. Proc Natl Acad Sci U S A (2008) 1.09
Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor. Biophys J (2010) 1.08
The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors. Br J Pharmacol (2007) 1.07
Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor. Biophys J (2003) 1.06
Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Mol Membr Biol (2006) 1.05
The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. Invert Neurosci (2008) 1.03
Structural model of rho1 GABAC receptor based on evolutionary analysis: Testing of predicted protein-protein interactions involved in receptor assembly and function. Protein Sci (2009) 1.01
Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols. J Pharmacol Exp Ther (2005) 0.97
Pores formed by the nicotinic receptor m2delta Peptide: a molecular dynamics simulation study. Biophys J (2003) 0.95
Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. BMC Neurosci (2006) 0.95
Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93
Examination of association of genes in the serotonin system to autism. Neurogenetics (2009) 0.93
The cys-loop ligand-gated ion channel superfamily of the honeybee, Apis mellifera. Invert Neurosci (2006) 0.92
Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+. J Physiol (2005) 0.91
Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J Cancer Res Clin Oncol (2008) 0.89
5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. J Gen Physiol (2011) 0.88
Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors. Anesth Analg (2005) 0.88
A conserved cysteine residue in the third transmembrane domain is essential for homomeric 5-HT3 receptor function. J Physiol (2009) 0.88
Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. J Biol Chem (2009) 0.87
Modulating inhibitory ligand-gated ion channels. AAPS J (2006) 0.86
5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol (2007) 0.86
Homology modeling and molecular dynamics simulations of the glycine receptor ligand binding domain. Proteins (2007) 0.86
The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole. Neuropharmacology (2008) 0.85
Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor. J Phys Chem B (2009) 0.85
Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein. Biochemistry (2006) 0.83
Mapping spatial relationships between residues in the ligand-binding domain of the 5-HT3 receptor using a molecular ruler. Biophys J (2010) 0.82
Exploring the binding of serotonin to the 5-HT3 receptor by density functional theory. J Phys Chem B (2006) 0.81
Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity. Diabetes Metab J (2016) 0.80
Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor. Biochemistry (2009) 0.80
High-affinity fluorescent ligands for the 5-HT(3) receptor. Bioorg Med Chem Lett (2011) 0.79
A comparison of the pharmacological properties of guinea-pig and human recombinant 5-HT4 receptors. Br J Pharmacol (2007) 0.79
Purifying selection and demographic expansion affect sequence diversity of the ligand-binding domain of a glutamate-gated chloride channel gene of Haemonchus placei. J Mol Evol (2004) 0.78
Influence of sodium substitutes on 5-HT-mediated effects at mouse 5-HT3 receptors. Br J Pharmacol (2004) 0.78
Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population. J Pharm Health Care Sci (2016) 0.75
Approaching the 5-HT₃ receptor heterogeneity by computational studies of the transmembrane and intracellular domains. J Comput Aided Mol Des (2013) 0.75
Structure-based 3D-QSAR studies on thiazoles as 5-HT3 receptor antagonists. J Mol Model (2006) 0.75
Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists. J Comput Aided Mol Des (2004) 0.75
The structural basis of function in Cys-loop receptors. Q Rev Biophys (2010) 2.45
The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets (2007) 1.86
The 5-HT3 receptor--the relationship between structure and function. Neuropharmacology (2008) 1.70
Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. J Neurosci (2007) 1.45
Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding. J Biol Chem (2005) 1.44
Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis. J Neurosci (2004) 1.35
Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. J Med Chem (2010) 1.32
The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor. J Biol Chem (2004) 1.31
Biolistic transfection of neuronal cultures using a hand-held gene gun. Nat Protoc (2006) 1.24
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). J Biol Chem (2013) 1.22
Prediction of 5-HT3 receptor agonist-binding residues using homology modeling. Biophys J (2003) 1.22
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22
A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. J Neurosci (2008) 1.18
Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors. J Biol Chem (2007) 1.13
A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor. Br J Pharmacol (2003) 1.12
A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor. Biochemistry (2008) 1.12
Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Mol Membr Biol (2006) 1.05
FlexStation examination of 5-HT3 receptor function using Ca2+ - and membrane potential-sensitive dyes: advantages and potential problems. J Neurosci Methods (2005) 1.04
Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop. J Biol Chem (2006) 1.03
Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket. J Biol Chem (2006) 1.03
Diolistic labeling of neuronal cultures and intact tissue using a hand-held gene gun. Nat Protoc (2006) 1.02
Rapid functional assays of recombinant IP3 receptors. Cell Calcium (2005) 0.99
The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation. J Biol Chem (2007) 0.96
Structural basis of ligand recognition in 5-HT3 receptors. EMBO Rep (2012) 0.96
Molecular modeling of the GABA(C) receptor ligand-binding domain. J Mol Model (2005) 0.95
Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. BMC Neurosci (2006) 0.95
Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Neuropharmacology (2002) 0.94
The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor. Neuropharmacology (2012) 0.93
Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. J Biol Chem (2012) 0.93
Molecular dynamics simulations of GABA binding to the GABAC receptor: the role of Arg104. Biophys J (2008) 0.92
A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Mol Pharmacol (2011) 0.92
Diolistics: incorporating fluorescent dyes into biological samples using a gene gun. Trends Biotechnol (2007) 0.91
Cys-loop receptor channel blockers also block GLIC. Biophys J (2011) 0.90
Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles. BMC Biotechnol (2011) 0.88
An efficient and information-rich biochemical method design for fragment library screening on ion channels. Biotechniques (2010) 0.88
Molecular characterization of agonists that bind to an insect GABA receptor. Biochemistry (2010) 0.88
Biolistic and diolistic transfection: using the gene gun to deliver DNA and lipophilic dyes into mammalian cells. Methods (2004) 0.87
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A. Bioorg Med Chem Lett (2011) 0.86
5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol (2007) 0.86
Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology (2010) 0.86
Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands. J Med Chem (2012) 0.85
Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor. J Phys Chem B (2009) 0.85
GABA(A) receptor modulation by terpenoids from Sideritis extracts. Mol Nutr Food Res (2013) 0.83
An improved method of preparing microcarriers for biolistic transfection. Brain Res Brain Res Protoc (2002) 0.83
Anaesthetic impairment of immune function is mediated via GABA(A) receptors. PLoS One (2011) 0.83
Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket. ACS Chem Neurosci (2011) 0.83
GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study. Biophys J (2012) 0.82
Characterization of 5-HT3 receptor mutations identified in schizophrenic patients. J Mol Neurosci (2006) 0.82
Biolistic transfection of neurons in organotypic brain slices. Methods Mol Biol (2013) 0.81
Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors. J Biol Chem (2009) 0.81
Exploring the binding of serotonin to the 5-HT3 receptor by density functional theory. J Phys Chem B (2006) 0.81
Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain. Bioorg Med Chem (2012) 0.80
High-affinity fluorescent ligands for the 5-HT(3) receptor. Bioorg Med Chem Lett (2011) 0.79
A single amino acid determines the toxicity of Ginkgo biloba extracts. FASEB J (2012) 0.79
Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors. ACS Chem Neurosci (2010) 0.78
Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands. ChemMedChem (2013) 0.78
Calcium modulation of 5-HT3 receptor binding and function. Neuropharmacology (2008) 0.76
Immunological characterization of 5-HT3 receptor transmembrane topology. J Mol Neurosci (2002) 0.76
RDL receptors. Biochem Soc Trans (2009) 0.76
Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function. Biochemistry (2014) 0.76
Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models. J Comput Aided Mol Des (2014) 0.75
Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg Med Chem (2013) 0.75
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors. Neuropharmacology (2012) 0.75
Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features. Mol Membr Biol (2015) 0.75