Published in J Neurosci Methods on July 20, 2005
Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor. J Pharmacol Exp Ther (2011) 1.10
Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Mol Membr Biol (2006) 1.05
Loop B is a major structural component of the 5-HT3 receptor. Biophys J (2008) 0.96
The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane. Biophys J (2013) 0.91
Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors. J Biol Chem (2010) 0.85
Agonists and antagonists induce different palonosetron dissociation rates in 5-HT₃A and 5-HT₃AB receptors. Neuropharmacology (2013) 0.81
Cell-based calcium assay for medium to high throughput screening of TRP channel functions using FlexStation 3. J Vis Exp (2011) 0.78
Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP. ACS Chem Neurosci (2015) 0.76
Unbinding pathways of an agonist and an antagonist from the 5-HT3 receptor. Biophys J (2005) 0.76
Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg Med Chem (2013) 0.75
A fluorescent approach for identifying P2X1 ligands. Neuropharmacology (2015) 0.75
5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems. ACS Chem Neurosci (2015) 0.75
The structural basis of function in Cys-loop receptors. Q Rev Biophys (2010) 2.45
The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets (2007) 1.86
The 5-HT3 receptor--the relationship between structure and function. Neuropharmacology (2008) 1.70
The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review). Mol Membr Biol (2002) 1.58
Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. J Neurosci (2007) 1.45
Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding. J Biol Chem (2005) 1.44
Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis. J Neurosci (2004) 1.35
Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. J Med Chem (2010) 1.32
The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor. J Biol Chem (2004) 1.31
Biolistic transfection of neuronal cultures using a hand-held gene gun. Nat Protoc (2006) 1.24
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). J Biol Chem (2013) 1.22
Prediction of 5-HT3 receptor agonist-binding residues using homology modeling. Biophys J (2003) 1.22
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22
A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. J Neurosci (2008) 1.18
Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors. J Biol Chem (2007) 1.13
A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor. Br J Pharmacol (2003) 1.12
A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor. Biochemistry (2008) 1.12
Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Mol Membr Biol (2006) 1.05
Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket. J Biol Chem (2006) 1.03
Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop. J Biol Chem (2006) 1.03
Diolistic labeling of neuronal cultures and intact tissue using a hand-held gene gun. Nat Protoc (2006) 1.02
Rapid functional assays of recombinant IP3 receptors. Cell Calcium (2005) 0.99
Structural basis of ligand recognition in 5-HT3 receptors. EMBO Rep (2012) 0.96
The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation. J Biol Chem (2007) 0.96
Molecular modeling of the GABA(C) receptor ligand-binding domain. J Mol Model (2005) 0.95
Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. BMC Neurosci (2006) 0.95
Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Neuropharmacology (2002) 0.94
The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor. Neuropharmacology (2012) 0.93
Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. J Biol Chem (2012) 0.93
Molecular dynamics simulations of GABA binding to the GABAC receptor: the role of Arg104. Biophys J (2008) 0.92
A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Mol Pharmacol (2011) 0.92
Diolistics: incorporating fluorescent dyes into biological samples using a gene gun. Trends Biotechnol (2007) 0.91
Cys-loop receptor channel blockers also block GLIC. Biophys J (2011) 0.90
An efficient and information-rich biochemical method design for fragment library screening on ion channels. Biotechniques (2010) 0.88
Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles. BMC Biotechnol (2011) 0.88
Molecular characterization of agonists that bind to an insect GABA receptor. Biochemistry (2010) 0.88
Biolistic and diolistic transfection: using the gene gun to deliver DNA and lipophilic dyes into mammalian cells. Methods (2004) 0.87
Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology (2010) 0.86
5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol (2007) 0.86
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A. Bioorg Med Chem Lett (2011) 0.86
Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands. J Med Chem (2012) 0.85
Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor. J Phys Chem B (2009) 0.85
GABA(A) receptor modulation by terpenoids from Sideritis extracts. Mol Nutr Food Res (2013) 0.83
Anaesthetic impairment of immune function is mediated via GABA(A) receptors. PLoS One (2011) 0.83
An improved method of preparing microcarriers for biolistic transfection. Brain Res Brain Res Protoc (2002) 0.83
Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket. ACS Chem Neurosci (2011) 0.83
GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study. Biophys J (2012) 0.82
Characterization of 5-HT3 receptor mutations identified in schizophrenic patients. J Mol Neurosci (2006) 0.82
Biolistic transfection of neurons in organotypic brain slices. Methods Mol Biol (2013) 0.81
Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors. J Biol Chem (2009) 0.81
Exploring the binding of serotonin to the 5-HT3 receptor by density functional theory. J Phys Chem B (2006) 0.81
Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain. Bioorg Med Chem (2012) 0.80
High-affinity fluorescent ligands for the 5-HT(3) receptor. Bioorg Med Chem Lett (2011) 0.79
A single amino acid determines the toxicity of Ginkgo biloba extracts. FASEB J (2012) 0.79
Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors. ACS Chem Neurosci (2010) 0.78
Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands. ChemMedChem (2013) 0.78
Calcium modulation of 5-HT3 receptor binding and function. Neuropharmacology (2008) 0.76
Immunological characterization of 5-HT3 receptor transmembrane topology. J Mol Neurosci (2002) 0.76
RDL receptors. Biochem Soc Trans (2009) 0.76
Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function. Biochemistry (2014) 0.76
Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg Med Chem (2013) 0.75
Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models. J Comput Aided Mol Des (2014) 0.75
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors. Neuropharmacology (2012) 0.75
Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features. Mol Membr Biol (2015) 0.75