Published in Biochemistry on April 06, 2010
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A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor. Br J Pharmacol (2003) 1.12
A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor. Biochemistry (2008) 1.12
Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Mol Membr Biol (2006) 1.05
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Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket. J Biol Chem (2006) 1.03
Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop. J Biol Chem (2006) 1.03
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The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor. Neuropharmacology (2012) 0.93
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A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Mol Pharmacol (2011) 0.92
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Cys-loop receptor channel blockers also block GLIC. Biophys J (2011) 0.90
An efficient and information-rich biochemical method design for fragment library screening on ion channels. Biotechniques (2010) 0.88
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5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol (2007) 0.86
Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology (2010) 0.86
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Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor. J Phys Chem B (2009) 0.85
GABA(A) receptor modulation by terpenoids from Sideritis extracts. Mol Nutr Food Res (2013) 0.83
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An improved method of preparing microcarriers for biolistic transfection. Brain Res Brain Res Protoc (2002) 0.83
Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket. ACS Chem Neurosci (2011) 0.83
GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study. Biophys J (2012) 0.82
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Exploring the binding of serotonin to the 5-HT3 receptor by density functional theory. J Phys Chem B (2006) 0.81
Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors. J Biol Chem (2009) 0.81
Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain. Bioorg Med Chem (2012) 0.80
High-affinity fluorescent ligands for the 5-HT(3) receptor. Bioorg Med Chem Lett (2011) 0.79
A single amino acid determines the toxicity of Ginkgo biloba extracts. FASEB J (2012) 0.79
Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors. ACS Chem Neurosci (2010) 0.78
Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands. ChemMedChem (2013) 0.78
Calcium modulation of 5-HT3 receptor binding and function. Neuropharmacology (2008) 0.76
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Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function. Biochemistry (2014) 0.76
Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg Med Chem (2013) 0.75
Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models. J Comput Aided Mol Des (2014) 0.75
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors. Neuropharmacology (2012) 0.75
Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features. Mol Membr Biol (2015) 0.75