Published in Endocrinology on June 01, 2002
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol (2008) 1.84
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci (2008) 1.71
The control of food intake: behavioral versus molecular perspectives. Cell Metab (2009) 1.56
Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron (2011) 1.45
Brain insulin: regulation, mechanisms of action and functions. Cell Mol Neurobiol (2003) 1.42
Adult sequelae of intrauterine growth restriction. Semin Perinatol (2008) 1.36
Energy regulatory signals and food reward. Pharmacol Biochem Behav (2010) 1.25
Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology (2011) 1.11
Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav (2011) 1.07
Regulation of food intake and gonadotropin-releasing hormone/luteinizing hormone during lactation: role of insulin and leptin. Endocrinology (2009) 0.99
Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats. Endocrinology (2013) 0.88
Interoceptive "satiety" signals produced by leptin and CCK. Peptides (2007) 0.88
Inconsistencies in the assessment of food intake. Am J Physiol Endocrinol Metab (2012) 0.84
Interactions between the central nervous system and pancreatic islet secretions: a historical perspective. Adv Physiol Educ (2013) 0.83
Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet. Endocrinology (2010) 0.82
Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia. Front Physiol (2014) 0.79
Insulin use and weight maintenance in well-controlled type 2 diabetes: a prospective cohort study. Obesity (Silver Spring) (2008) 0.77
A high-throughput assay for quantifying appetite and digestive dynamics. Am J Physiol Regul Integr Comp Physiol (2015) 0.76
Central insulin sensitivity in male and female juvenile rats. Horm Behav (2009) 0.76
Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice. Physiol Behav (2015) 0.76
Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task. Physiol Behav (2016) 0.75
Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination. Sci Rep (2016) 0.75
Hypothalamic mTOR signaling regulates food intake. Science (2006) 8.62
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology (2010) 4.11
Electrolyte and Acid-Base Disturbances in Patients with Diabetes Mellitus. N Engl J Med (2015) 3.96
A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab (2003) 3.93
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 3.92
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes (2003) 2.90
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab (2008) 2.86
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
A controlled high-fat diet induces an obese syndrome in rats. J Nutr (2003) 2.80
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med (2002) 2.68
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68
Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes (2006) 2.62
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab (2011) 2.61
Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci U S A (2007) 2.59
Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology (2011) 2.45
Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. Endocrinology (2005) 2.43
A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. Endocrinology (2013) 2.39
Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology (2007) 2.37
A role for central nervous system PPAR-γ in the regulation of energy balance. Nat Med (2011) 2.34
Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes (2008) 2.33
The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. J Neurosci (2002) 2.26
Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab (2004) 2.21
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
Comparative analysis of ACTH and corticosterone sampling methods in rats. Am J Physiol Endocrinol Metab (2005) 2.02
Gastrointestinal hormones and food intake. Gastroenterology (2005) 2.00
The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci (2002) 1.95
The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev (2013) 1.93
Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behav Neurosci (2008) 1.90
Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol (2008) 1.84
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol (2007) 1.83
Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. J Clin Invest (2011) 1.81
Differential sensitivity to central leptin and insulin in male and female rats. Diabetes (2003) 1.80
Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology (2010) 1.80
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol (2009) 1.79
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. J Clin Invest (2009) 1.77
All bariatric surgeries are not created equal: insights from mechanistic comparisons. Endocr Rev (2012) 1.74
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci (2008) 1.71
The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation. Annu Rev Physiol (2008) 1.67
Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes (2013) 1.64
Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology (2011) 1.64
Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. Behav Neurosci (2004) 1.63
GLP-1 and energy balance: an integrated model of short-term and long-term control. Nat Rev Endocrinol (2011) 1.62
Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes (2007) 1.62
Insulin and leptin as adiposity signals. Recent Prog Horm Res (2004) 1.60
CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. J Neurosci (2003) 1.60
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes (2013) 1.58
Monitoring of stored and available fuel by the CNS: implications for obesity. Nat Rev Neurosci (2003) 1.55
Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J Gastrointest Surg (2009) 1.54
Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy. Sci Transl Med (2013) 1.54
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci (2009) 1.54
Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab (2013) 1.54
Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. J Neurosci (2011) 1.54
Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol (2010) 1.54
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes (2009) 1.53
Targeted estrogen delivery reverses the metabolic syndrome. Nat Med (2012) 1.51
Sexual differences in the control of energy homeostasis. Front Neuroendocrinol (2009) 1.50
Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. Am J Physiol Regul Integr Comp Physiol (2004) 1.49
Insulin and the blood-brain barrier. Curr Pharm Des (2003) 1.49
Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins Leukot Essent Fatty Acids (2011) 1.46
Gender differences in the control of energy homeostasis. Exp Biol Med (Maywood) (2003) 1.45
Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov (2009) 1.45