Published in Nat Rev Neurosci on November 01, 2003
The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest (2005) 4.55
PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest (2005) 3.34
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Intracellular signalling pathways activated by leptin. Biochem J (2006) 2.93
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab (2008) 1.93
Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci (2009) 1.92
Central control of body weight and appetite. J Clin Endocrinol Metab (2008) 1.91
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci (2008) 1.71
Neuropeptide transmission in brain circuits. Neuron (2012) 1.69
Sex differences in the regulation of body weight. Physiol Behav (2009) 1.68
The control of food intake: behavioral versus molecular perspectives. Cell Metab (2009) 1.56
Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov (2009) 1.45
Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour. J Physiol (2006) 1.34
Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol (2009) 1.33
Metabolic impact of sex hormones on obesity. Brain Res (2010) 1.30
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nat Rev Drug Discov (2012) 1.29
Pancreatic signals controlling food intake; insulin, glucagon and amylin. Philos Trans R Soc Lond B Biol Sci (2006) 1.27
The renin angiotensin system and the metabolic syndrome. Physiol Behav (2010) 1.25
Metabolic state alters economic decision making under risk in humans. PLoS One (2010) 1.23
Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A (2008) 1.06
Engineering approaches to energy balance and obesity: opportunities for novel collaborations and research: report of a joint national science foundation and national institutes of health workshop. J Diabetes Sci Technol (2007) 1.05
Glucocorticoid actions on synapses, circuits, and behavior: implications for the energetics of stress. Front Neuroendocrinol (2013) 1.03
Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. J Neurophysiol (2011) 1.03
Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration. Psychopharmacology (Berl) (2007) 1.02
Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight. Diabetes (2010) 1.00
Costs of pair-bonding and paternal care in male prairie voles (Microtus ochrogaster). Physiol Behav (2009) 0.95
The role of hypothalamic estrogen receptors in metabolic regulation. Front Neuroendocrinol (2014) 0.93
Pharmacogenetics of antipsychotic-induced weight gain. Psychopharmacology (Berl) (2004) 0.92
The pathophysiology of obesity and its clinical manifestations. Gastroenterol Hepatol (N Y) (2007) 0.87
New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation. Front Neuroendocrinol (2010) 0.87
Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes (2012) 0.87
Evidence for central regulation of glucose metabolism. J Biol Chem (2013) 0.85
Modeling obesity and its associated disorders in Drosophila. Physiology (Bethesda) (2013) 0.85
Estrogen, astrocytes and the neuroendocrine control of metabolism. Rev Endocr Metab Disord (2013) 0.84
Interactions between the central nervous system and pancreatic islet secretions: a historical perspective. Adv Physiol Educ (2013) 0.83
Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. Physiol Behav (2009) 0.83
Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A (2007) 0.81
Controversies about a common etiology for eating and mood disorders. Front Psychol (2014) 0.81
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. Exp Mol Med (2016) 0.80
Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition. J Neurophysiol (2010) 0.80
Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus. PLoS One (2016) 0.78
INSR gene variation is associated with decreased insulin sensitivity in Iraqi women with PCOs. Iran J Reprod Med (2014) 0.76
Persisting neural and endocrine modifications induced by a single fat meal. Cell Mol Neurobiol (2005) 0.76
A temperature hypothesis of hypothalamus-driven obesity. Yale J Biol Med (2014) 0.76
Comparative Physiology of Energy Metabolism: Fishing for Endocrine Signals in the Early Vertebrate Pool. Front Endocrinol (Lausanne) (2017) 0.76
Melatonin and peripheral circuitries: insights on appetite and metabolism in Danio rerio. Zebrafish (2013) 0.76
New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis. Front Cell Neurosci (2017) 0.75
Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons. PLoS One (2016) 0.75
Reduction of smoking urges with intranasal insulin: a randomized, crossover, placebo-controlled clinical trial. Mol Psychiatry (2017) 0.75
Hypothalamic mTOR signaling regulates food intake. Science (2006) 8.62
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology (2010) 4.11
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab (2008) 2.86
Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med (2002) 2.68
Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes (2006) 2.62
Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology (2011) 2.45
Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. Endocrinology (2005) 2.43
A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. Endocrinology (2013) 2.39
Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology (2007) 2.37
A role for central nervous system PPAR-γ in the regulation of energy balance. Nat Med (2011) 2.34
Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes (2008) 2.33
Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab (2004) 2.21
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
Gastrointestinal hormones and food intake. Gastroenterology (2005) 2.00
The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci (2002) 1.95
Differential sensitivity to central leptin and insulin in male and female rats. Diabetes (2003) 1.80
Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology (2010) 1.80
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol (2009) 1.79
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci (2008) 1.71
Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology (2011) 1.64
Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes (2007) 1.62
Insulin and leptin as adiposity signals. Recent Prog Horm Res (2004) 1.60
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy. Sci Transl Med (2013) 1.54
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci (2009) 1.54
Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. J Neurosci (2011) 1.54
Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol (2010) 1.54
Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. Am J Physiol Regul Integr Comp Physiol (2004) 1.49
Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes (2008) 1.39
Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice. Endocrinology (2010) 1.38
Pleasurable behaviors reduce stress via brain reward pathways. Proc Natl Acad Sci U S A (2010) 1.33
Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Comp Physiol (2007) 1.27
The timing of meals. Psychol Rev (2004) 1.26
The role of GM-CSF in adipose tissue inflammation. Am J Physiol Endocrinol Metab (2008) 1.26
Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci (2010) 1.25
The renin angiotensin system and the metabolic syndrome. Physiol Behav (2010) 1.25
Dynamic body weight and body composition changes in response to subordination stress. Physiol Behav (2007) 1.24
Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol (2005) 1.23
Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metab (2012) 1.23
Assessment of feeding behavior in laboratory mice. Cell Metab (2010) 1.22
Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated. Endocrinology (2002) 1.22
Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiol Behav (2006) 1.21
Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes (2013) 1.20
Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am J Physiol Endocrinol Metab (2008) 1.20
Insulin and leptin combine additively to reduce food intake and body weight in rats. Endocrinology (2002) 1.18
Social stress and recovery: implications for body weight and body composition. Am J Physiol Regul Integr Comp Physiol (2007) 1.16
Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. Physiol Behav (2011) 1.15
Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes (2010) 1.15
Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology (2012) 1.15
Metabolic and endocrine consequences of social stress in a visible burrow system. Physiol Behav (2004) 1.14
Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obesity (Silver Spring) (2011) 1.12
Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. J Clin Invest (2004) 1.11
Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. Diabetes (2009) 1.10
Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat Med (2002) 1.09
Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol (2007) 1.09
The effect of fat removal on glucose tolerance is depot specific in male and female mice. Am J Physiol Endocrinol Metab (2007) 1.08
Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion. Proc Natl Acad Sci U S A (2012) 1.08
Meal-anticipatory glucagon-like peptide-1 secretion in rats. Endocrinology (2009) 1.08
Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav (2011) 1.07
Acute exposure to a high-fat diet alters meal patterns and body composition. Physiol Behav (2010) 1.07
Acute third ventricular administration of insulin decreases food intake in two paradigms. Pharmacol Biochem Behav (2002) 1.07
Overview of animal models of obesity. Curr Protoc Pharmacol (2012) 1.06
Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology (2013) 1.05
Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesity (Silver Spring) (2009) 1.04
The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate. Am J Physiol Gastrointest Liver Physiol (2007) 1.04
Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. J Neurosci (2011) 1.04
Effect of vertical sleeve gastrectomy on food selection and satiation in rats. Am J Physiol Endocrinol Metab (2012) 1.04
High-fat-diet exposure induces IgG accumulation in hypothalamic microglia. Dis Model Mech (2012) 1.03
The endocrinology of food intake. Nat Rev Endocrinol (2013) 1.03
Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy. Am J Physiol Endocrinol Metab (2007) 1.03
Exercise protects against high-fat diet-induced hypothalamic inflammation. Physiol Behav (2012) 1.03
Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiol Behav (2003) 1.02
Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol. Endocrinology (2008) 1.02
CNS leptin action modulates immune response and survival in sepsis. J Neurosci (2010) 1.01
High calorie diet triggers hypothalamic angiopathy. Mol Metab (2012) 1.01
Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. J Lipid Res (2013) 1.01
Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. Endocrinology (2004) 1.00
Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight. Diabetes (2010) 1.00
Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology (2007) 1.00
Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. Am J Physiol Gastrointest Liver Physiol (2008) 1.00
Central angiotensin II has catabolic action at white and brown adipose tissue. Am J Physiol Endocrinol Metab (2011) 0.98
Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiol Behav (2008) 0.98
Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity. J Neurosci (2013) 0.97
Pharmaceutical approaches to the treatment of obesity. Drug Discov Today (2004) 0.97
The central insulin system and energy balance. Handb Exp Pharmacol (2012) 0.97
Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats. Alcohol Clin Exp Res (2005) 0.97
Ghrelin-induced adiposity is independent of orexigenic effects. FASEB J (2011) 0.97
Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes (2008) 0.97
Regulation of energy homeostasis and health consequences in obesity. Am J Med (2009) 0.97
Glucose parameters are altered in mouse offspring produced by assisted reproductive technologies and somatic cell nuclear transfer. Biol Reprod (2010) 0.96
Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. Biochemistry (2004) 0.96
The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis. Endocrinology (2009) 0.95
Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. Am J Physiol Endocrinol Metab (2012) 0.95
Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology (2003) 0.95
Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress. J Neurosci (2011) 0.95
Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. Am J Physiol Regul Integr Comp Physiol (2007) 0.94
Individual differences in initial sensitivity and acute tolerance predict patterns of chronic drug tolerance to nitrous-oxide-induced hypothermia in rats. Psychopharmacology (Berl) (2005) 0.93
The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides. Peptides (2005) 0.93
Meal patterns and hypothalamic NPY expression during chronic social stress and recovery. Am J Physiol Regul Integr Comp Physiol (2010) 0.93