Published in Diabetes on March 01, 2003
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Modulation of appetite by gonadal steroid hormones. Philos Trans R Soc Lond B Biol Sci (2006) 2.30
Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation. Proc Natl Acad Sci U S A (2009) 2.27
The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev (2013) 1.93
Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity. Brain Behav Immun (2008) 1.87
Sex differences in the regulation of body weight. Physiol Behav (2009) 1.68
The control of food intake: behavioral versus molecular perspectives. Cell Metab (2009) 1.56
Sexual differences in the control of energy homeostasis. Front Neuroendocrinol (2009) 1.50
Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females. J Physiol (2008) 1.43
Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol (2009) 1.33
Metabolic impact of sex hormones on obesity. Brain Res (2010) 1.30
Pancreatic signals controlling food intake; insulin, glucagon and amylin. Philos Trans R Soc Lond B Biol Sci (2006) 1.27
Sex differences in the physiology of eating. Am J Physiol Regul Integr Comp Physiol (2013) 1.18
Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiol Behav (2007) 1.15
Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women. Diabetes (2012) 1.12
Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity (Silver Spring) (2006) 1.09
Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav (2011) 1.07
Obesity-programmed mice are rescued by early genetic intervention. J Clin Invest (2012) 1.03
Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes (2010) 1.02
Sex differences in metabolic homeostasis, diabetes, and obesity. Biol Sex Differ (2015) 1.01
Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of oestrogen. J Physiol (2014) 1.01
Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. J Alzheimers Dis (2013) 0.98
Ghrelin-induced adiposity is independent of orexigenic effects. FASEB J (2011) 0.97
Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats. Behav Brain Res (2011) 0.96
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Endocr Rev (2016) 0.96
The role of hypothalamic estrogen receptors in metabolic regulation. Front Neuroendocrinol (2014) 0.93
Sexual dimorphism in the lasting effects of moderate caloric restriction during gestation on energy homeostasis in rats is related with fetal programming of insulin and leptin resistance. Nutr Metab (Lond) (2010) 0.93
Insulin promotes neuronal survival via the alternatively spliced protein kinase CδII isoform. J Biol Chem (2012) 0.93
Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression. Diabetes (2012) 0.92
Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One (2012) 0.91
The utility of animal models to evaluate novel anti-obesity agents. Br J Pharmacol (2011) 0.88
Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells. Nucl Recept Signal (2013) 0.88
Interoceptive "satiety" signals produced by leptin and CCK. Peptides (2007) 0.88
The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis. Physiol Behav (2010) 0.88
Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats. Endocrinology (2013) 0.88
Obesity-induced increases in sympathetic nerve activity: sex matters. Auton Neurosci (2014) 0.87
Evidence for central regulation of glucose metabolism. J Biol Chem (2013) 0.85
Interactions between the central nervous system and pancreatic islet secretions: a historical perspective. Adv Physiol Educ (2013) 0.83
Developmental programming of hypothalamic neuronal circuits: impact on energy balance control. Front Neurosci (2015) 0.81
Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Mol Cell Biol (2004) 0.81
Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats. Endocrinology (2014) 0.80
Oestradiol decreases melanin-concentrating hormone (MCH) and MCH receptor expression in the hypothalamus of female rats. J Neuroendocrinol (2013) 0.80
A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism. Neural Plast (2015) 0.79
Testing the Critical Window Hypothesis of Timing and Duration of Estradiol Treatment on Hypothalamic Gene Networks in Reproductively Mature and Aging Female Rats. Endocrinology (2015) 0.79
Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators. Front Behav Neurosci (2016) 0.79
Sex dimorphism in late gestational sleep fragmentation and metabolic dysfunction in offspring mice. Sleep (2015) 0.78
Is insulin action in the brain clinically relevant? Diabetes (2012) 0.78
Pattern recognition of estradiol, testosterone and dihydrotestosterone in children's saliva samples using stochastic microsensors. Sci Rep (2014) 0.78
Sexual dimorphism in offspring glucose-sensitive hypothalamic gene expression and physiological responses to maternal high-fat diet feeding. Endocrinology (2014) 0.78
No effect of adjunctive, repeated dose intranasal insulin treatment on body metabolism in patients with schizophrenia. Schizophr Res (2013) 0.78
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016. Biochim Biophys Acta (2017) 0.78
CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. Cell Metab (2016) 0.77
Sex differences in the response of total PYY and GLP-1 to moderate-intensity continuous and sprint interval cycling exercise. Eur J Appl Physiol (2017) 0.77
Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice. Physiol Behav (2017) 0.76
Central insulin sensitivity in male and female juvenile rats. Horm Behav (2009) 0.76
Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice. Physiol Behav (2015) 0.76
High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity. Biol Sex Differ (2016) 0.76
Sex and estrogens alter the action of glucagon-like peptide-1 on reward. Biol Sex Differ (2016) 0.76
Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia. PLoS One (2016) 0.75
Regulation of Estrogen Receptor α Expression in the Hypothalamus by Sex Steroids: Implication in the Regulation of Energy Homeostasis. Int J Endocrinol (2015) 0.75
Insulin: a sweet deal for human baroreflex function. J Physiol (2010) 0.75
Leptin levels after subarachnoid haemorrhage are gender dependent. Springerplus (2016) 0.75
Gene and environment interaction: is the differential susceptibility hypothesis relevant for obesity? Neurosci Biobehav Rev (2016) 0.75
Blunted hypothalamic ghrelin signaling reduces diet intake in rats fed a low-protein diet in late pregnancy. Physiol Rep (2015) 0.75
Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly Subjects. Front Neurosci (2017) 0.75
Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability. Endocrinology (2017) 0.75
Leptin independently predicts development of sepsis and its outcome. J Inflamm (Lond) (2017) 0.75
Hypothalamic mTOR signaling regulates food intake. Science (2006) 8.62
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology (2010) 4.11
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab (2008) 2.86
Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med (2002) 2.68
Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes (2006) 2.62
Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology (2011) 2.45
Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. Endocrinology (2005) 2.43
A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. Endocrinology (2013) 2.39
Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology (2007) 2.37
A role for central nervous system PPAR-γ in the regulation of energy balance. Nat Med (2011) 2.34
Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes (2008) 2.33
Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab (2004) 2.21
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
Gastrointestinal hormones and food intake. Gastroenterology (2005) 2.00
The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci (2002) 1.95
Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behav Neurosci (2008) 1.90
Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol (2008) 1.84
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol (2007) 1.83
Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology (2010) 1.80
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol (2009) 1.79
Oral health of young Alaska Native children and their caregivers in Southwestern Alaska. Alaska Med (2003) 1.75
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci (2008) 1.71
Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology (2011) 1.64
Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. Behav Neurosci (2004) 1.63
Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes (2007) 1.62
Insulin and leptin as adiposity signals. Recent Prog Horm Res (2004) 1.60
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes (2013) 1.58
Monitoring of stored and available fuel by the CNS: implications for obesity. Nat Rev Neurosci (2003) 1.55
Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy. Sci Transl Med (2013) 1.54
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci (2009) 1.54
Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. J Neurosci (2011) 1.54
Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol (2010) 1.54
Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. Am J Physiol Regul Integr Comp Physiol (2004) 1.49
Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins Leukot Essent Fatty Acids (2011) 1.46
A potential role for the hippocampus in energy intake and body weight regulation. Curr Opin Pharmacol (2007) 1.43
Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiol Behav (2004) 1.43
Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A (2006) 1.40
Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes (2008) 1.39
Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice. Endocrinology (2010) 1.38
Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus (2009) 1.37
Pleasurable behaviors reduce stress via brain reward pathways. Proc Natl Acad Sci U S A (2010) 1.33
Leptin regulates energy balance and motivation through action at distinct neural circuits. Biol Psychiatry (2010) 1.30
Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Comp Physiol (2007) 1.27
The timing of meals. Psychol Rev (2004) 1.26
The role of GM-CSF in adipose tissue inflammation. Am J Physiol Endocrinol Metab (2008) 1.26
Roux en Y gastric bypass increases ethanol intake in the rat. Obes Surg (2013) 1.25
Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci (2010) 1.25
The renin angiotensin system and the metabolic syndrome. Physiol Behav (2010) 1.25
Dynamic body weight and body composition changes in response to subordination stress. Physiol Behav (2007) 1.24
Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol (2005) 1.23
Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metab (2012) 1.23
Assessment of feeding behavior in laboratory mice. Cell Metab (2010) 1.22
Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated. Endocrinology (2002) 1.22
Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiol Behav (2006) 1.21
Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes (2013) 1.20
Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am J Physiol Endocrinol Metab (2008) 1.20
Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging (2010) 1.19
Insulin and leptin combine additively to reduce food intake and body weight in rats. Endocrinology (2002) 1.18
Integrating oral and general health care. N Engl J Med (2014) 1.17
Social stress and recovery: implications for body weight and body composition. Am J Physiol Regul Integr Comp Physiol (2007) 1.16
Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. Physiol Behav (2011) 1.15
Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes (2010) 1.15
Behavioral determinants of brushing young children's teeth: implications for anticipatory guidance. Pediatr Dent (2010) 1.15
Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology (2012) 1.15
Metabolic and endocrine consequences of social stress in a visible burrow system. Physiol Behav (2004) 1.14
The melanocortin antagonist AgRP (83-132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer. Pharmacol Biochem Behav (2007) 1.12
How xylitol-containing products affect cariogenic bacteria. J Am Dent Assoc (2002) 1.12
Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obesity (Silver Spring) (2011) 1.12
Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. J Clin Invest (2004) 1.11
Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. Diabetes (2009) 1.10
Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat Med (2002) 1.09
Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol (2007) 1.09
Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology (2008) 1.08
Meal-anticipatory glucagon-like peptide-1 secretion in rats. Endocrinology (2009) 1.08
The effect of fat removal on glucose tolerance is depot specific in male and female mice. Am J Physiol Endocrinol Metab (2007) 1.08
Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion. Proc Natl Acad Sci U S A (2012) 1.08
Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion. Diabetes (2002) 1.07
Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav (2011) 1.07
Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behav Neurosci (2010) 1.07
Acute exposure to a high-fat diet alters meal patterns and body composition. Physiol Behav (2010) 1.07
Acute third ventricular administration of insulin decreases food intake in two paradigms. Pharmacol Biochem Behav (2002) 1.07
Overview of animal models of obesity. Curr Protoc Pharmacol (2012) 1.06
Insulin, leptin and reward. Trends Endocrinol Metab (2009) 1.06
Xylitol gummy bear snacks: a school-based randomized clinical trial. BMC Oral Health (2008) 1.06
Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology (2013) 1.05