Published in J Virol on June 01, 2002
The coxsackie B virus and adenovirus receptor resides in a distinct membrane microdomain. J Virol (2003) 1.06
Conformational defects slow Golgi exit, block oligomerization, and reduce raft affinity of caveolin-1 mutant proteins. Mol Biol Cell (2004) 1.00
Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells. J Virol (2004) 0.93
Biodistribution of radioiodinated adenovirus fiber protein knob domain after intravenous injection in mice. J Virol (2004) 0.86
The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP). PLoS One (2013) 0.78
The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry. J Virol (2015) 0.77
Functional rafts in cell membranes. Nature (1997) 38.89
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell (1992) 17.81
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science (1997) 14.41
Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta (1999) 6.98
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A (1997) 6.92
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity (1998) 4.56
Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science (1999) 3.24
Protein lipidation in cell signaling. Science (1995) 3.22
Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J Biol Chem (2000) 3.18
Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. J Biol Chem (1999) 3.04
The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol (1998) 2.45
Signalling functions of protein palmitoylation. Biochim Biophys Acta (1998) 2.24
Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection. J Virol (1999) 1.96
Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor. Nat Struct Biol (2001) 1.91
Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution. Structure (2000) 1.89
The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain. Brain Res Mol Brain Res (2000) 1.80
Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc Natl Acad Sci U S A (2000) 1.68
The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy. Cancer Res (2000) 1.55
Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer. J Virol (2000) 1.45
Palmitylation of viral membrane glycoproteins takes place after exit from the endoplasmic reticulum. J Biol Chem (1989) 1.45
The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer: a functional analysis of car protein structure. Cancer Res (2001) 1.45
Regulation of G proteins by covalent modification. Oncogene (2001) 1.38
Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. J Clin Invest (1993) 1.35
Expression of the adenovirus receptor and its interaction with the fiber knob. Exp Cell Res (2000) 1.31
Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways. J Biol Chem (2001) 1.24
Inhibition of the receptor-mediated endocytosis of diferric transferrin is associated with the covalent modification of the transferrin receptor with palmitic acid. J Biol Chem (1990) 1.23
Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting. J Biol Chem (2001) 1.20
Synthesis and use of iodo-fatty acid analogs. Methods Enzymol (1995) 1.16
Receptor for the group B coxsackieviruses and adenoviruses: CAR. Rev Med Virol (2001) 1.10
Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions. J Biol Chem (2000) 1.09
A mouse model for adenovirus gene delivery. Proc Natl Acad Sci U S A (2001) 1.04
Timing of palmitoylation of influenza virus hemagglutinin. FEBS Lett (1993) 0.99
Nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake. J Biol Chem (1990) 0.97
Manipulation of the cytoplasmic and transmembrane domains alters cell surface levels of the coxsackie-adenovirus receptor and changes the efficiency of adenovirus infection. Hum Gene Ther (2001) 0.96
Determination of the structural requirements for palmitoylation of p63. J Biol Chem (1995) 0.96
Targeting proteins to plasma membrane and membrane microdomains by N-terminal myristoylation and palmitoylation. Methods Enzymol (2000) 0.96
Domain-structure of cytoplasmic border region is main determinant for palmitoylation of influenza virus hemagglutinin (H7). Virology (1998) 0.94
Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting. Biochim Biophys Acta (2001) 0.89
A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) 14.63
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med (2003) 4.69
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol (2009) 3.12
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell (2011) 2.42
Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA. Hum Gene Ther (2008) 2.42
Modification of gene expression of the small airway epithelium in response to cigarette smoking. J Mol Med (Berl) (2006) 2.20
Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers. Am J Respir Crit Care Med (2011) 2.12
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J Immunol (2009) 2.05
Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers. Am J Respir Cell Mol Biol (2003) 2.05
Population genetic structure of the people of Qatar. Am J Hum Genet (2010) 1.91
Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest (2005) 1.74
Enhanced survival of the LINCL mouse following CLN2 gene transfer using the rh.10 rhesus macaque-derived adeno-associated virus vector. Mol Ther (2006) 1.71
The human airway epithelial basal cell transcriptome. PLoS One (2011) 1.69
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cell Mol Life Sci (2010) 1.66
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol (2010) 1.61
Lung adenocarcinoma subtypes based on expression of human airway basal cell genes. Eur Respir J (2013) 1.59
Rapid/sustained anti-anthrax passive immunity mediated by co-administration of Ad/AAV. Mol Ther (2007) 1.57
Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations. J Neurosurg Pediatr (2010) 1.57
Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.57
Correction of brain oligodendrocytes by AAVrh.10 intracerebral gene therapy in metachromatic leukodystrophy mice. Hum Gene Ther (2012) 1.55
The bronchopulmonary pathology of alpha-1 antitrypsin (AAT) deficiency: findings of the Death Review Committee of the national registry for individuals with Severe Deficiency of Alpha-1 Antitrypsin. Hum Pathol (2004) 1.55
Correction of a murine model of von Willebrand disease by gene transfer. Blood (2006) 1.54
Gene therapy for rare diseases: summary of a National Institutes of Health workshop, September 13, 2012. Hum Gene Ther (2013) 1.54
Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke. Am J Respir Crit Care Med (2010) 1.48
In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor. J Am Heart Assoc (2012) 1.48
Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking. J Mol Med (Berl) (2006) 1.44
Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res (2004) 1.42
Macaque model for severe acute respiratory syndrome. J Virol (2004) 1.41
Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol (2010) 1.40
Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs. Mol Ther (2004) 1.39
Cytoplasmic dynein mediates adenovirus binding to microtubules. J Virol (2004) 1.36
Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid. J Clin Invest (2005) 1.35
Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1. J Virol (2004) 1.34
Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis. J Neurosci (2006) 1.33
Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions. Hum Gene Ther (2002) 1.33
Genetic medicines: treatment strategies for hereditary disorders. Nat Rev Genet (2006) 1.30
RNA-Seq quantification of the human small airway epithelium transcriptome. BMC Genomics (2012) 1.28
Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathway. J Biol Chem (2003) 1.27
Intracellular trafficking of adenovirus: many means to many ends. Adv Drug Deliv Rev (2007) 1.26
Genetic control of wayward pluripotent stem cells and their progeny after transplantation. Cell Stem Cell (2009) 1.26
Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking. Mol Med (2009) 1.24
Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7. J Orthop Res (2003) 1.19
Intracerebral administration of adeno-associated viral vector serotype rh.10 carrying human SGSH and SUMF1 cDNAs in children with mucopolysaccharidosis type IIIA disease: results of a phase I/II trial. Hum Gene Ther (2014) 1.19
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther (2011) 1.18
EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype. Proc Natl Acad Sci U S A (2013) 1.16
Smoking is associated with shortened airway cilia. PLoS One (2009) 1.16
Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency. Nat Med (2004) 1.15
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers. Cancer Res (2006) 1.14
Epitopes expressed in different adenovirus capsid proteins induce different levels of epitope-specific immunity. J Virol (2006) 1.14
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation (2005) 1.13
Survival advantage of neonatal CNS gene transfer for late infantile neuronal ceroid lipofuscinosis. Exp Neurol (2008) 1.13
Induction of protective immunity to anthrax lethal toxin with a nonhuman primate adenovirus-based vaccine in the presence of preexisting anti-human adenovirus immunity. Infect Immun (2005) 1.13
Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PLoS One (2011) 1.13
Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro. Bone (2006) 1.11
Augmentation therapy with alpha1-antitrypsin: patterns of use and adverse events. Chest (2003) 1.11
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses. J Virol (2004) 1.11
Quality control in microarray assessment of gene expression in human airway epithelium. BMC Genomics (2009) 1.10
Asthma features in severe alpha1-antitrypsin deficiency: experience of the National Heart, Lung, and Blood Institute Registry. Chest (2003) 1.09
Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression. Hum Mol Genet (2013) 1.08
Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells. Blood (2003) 1.07
Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology (2011) 1.07
Safety of direct administration of AAV2(CU)hCLN2, a candidate treatment for the central nervous system manifestations of late infantile neuronal ceroid lipofuscinosis, to the brain of rats and nonhuman primates. Hum Gene Ther (2005) 1.07
Monoallelic up-regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers. Cancer Res (2003) 1.07
Biologic phenotyping of the human small airway epithelial response to cigarette smoking. PLoS One (2011) 1.06
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein. Virology (2005) 1.05
Adenovirus-based genetic vaccines for biodefense. Hum Gene Ther (2005) 1.05
Protective immunity to pseudomonas aeruginosa induced with a capsid-modified adenovirus expressing P. aeruginosa OprF. J Virol (2007) 1.04
Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. Respir Res (2007) 1.04
Protective immunity against respiratory tract challenge with Yersinia pestis in mice immunized with an adenovirus-based vaccine vector expressing V antigen. J Infect Dis (2006) 1.04
Protective immunity evoked against anthrax lethal toxin after a single intramuscular administration of an adenovirus-based vaccine encoding humanized protective antigen. Hum Gene Ther (2003) 1.04
Responses of the human airway epithelium transcriptome to in vivo injury. Physiol Genomics (2006) 1.03
Human embryonic stem cells and gene therapy. Mol Ther (2007) 1.02
Variability in small airway epithelial gene expression among normal smokers. Chest (2008) 1.02
Confronting the issues of therapeutic misconception, enrollment decisions, and personal motives in genetic medicine-based clinical research studies for fatal disorders. Hum Gene Ther (2005) 1.02
Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. Proc Am Thorac Soc (2008) 1.02
Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth. Cancer Res (2006) 1.01
Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations. BMC Genet (2012) 1.01
Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. Am J Respir Cell Mol Biol (2008) 1.01
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes. Mol Ther (2002) 1.01
Decreased expression of intelectin 1 in the human airway epithelium of smokers compared to nonsmokers. J Immunol (2008) 1.01
Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Hum Gene Ther Methods (2012) 1.01
Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells. Ann Am Thorac Soc (2014) 1.00
Cigarette smoking induces overexpression of a fat-depleting gene AZGP1 in the human. Chest (2009) 0.99
Genetic delivery of an anti-RSV antibody to protect against pulmonary infection with RSV. Virology (2008) 0.98
Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals. Chest (2010) 0.98
Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing. Hum Gene Ther (2009) 0.97
Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Hum Mol Genet (2013) 0.96
Angiogenic pretreatment improves the efficacy of cellular cardiomyoplasty performed with fetal cardiomyocyte implantation. J Thorac Cardiovasc Surg (2004) 0.96
Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cell Mol Life Sci (2012) 0.95
Passive immunotherapy for anthrax toxin mediated by an adenovirus expressing an anti-protective antigen single-chain antibody. Mol Ther (2005) 0.95
Ablation of tumor-derived stem cells transplanted to the central nervous system by genetic modification of embryonic stem cells with a suicide gene. Hum Gene Ther (2007) 0.95
Association of adenovirus with the microtubule organizing center. J Virol (2003) 0.95
Adenovirus-mediated delivery of an anti-V antigen monoclonal antibody protects mice against a lethal Yersinia pestis challenge. Infect Immun (2009) 0.94
Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema. J Leukoc Biol (2009) 0.94
Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine (Phila Pa 1976) (2003) 0.94
Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 0.94