Published in Subcell Biochem on January 01, 2002
The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease. J Inherit Metab Dis (2007) 1.94
Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease. Biochim Biophys Acta (2010) 1.24
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem (2008) 1.09
Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection. J Virol (2012) 1.06
Activation of membrane NADPH oxidase associated with lysosome-targeted acid sphingomyelinase in coronary endothelial cells. Antioxid Redox Signal (2010) 0.96
Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig. Int J Radiat Oncol Biol Phys (2010) 0.96
Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons. J Neurochem (2008) 0.91
Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J Biol Chem (2012) 0.89
Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain. Neurochem Res (2012) 0.82
Oxidized phosphatidylcholine formation and action in oligodendrocytes. J Neurochem (2009) 0.81
Membrane raft redox signalosomes in endothelial cells. Free Radic Res (2010) 0.81
c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins αvβ3 and αvβ5. PLoS One (2012) 0.80
Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers. Front Chem (2014) 0.79
Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia. Mar Drugs (2016) 0.75
Preimplantation diagnosis of a lysosomal storage disorder by in situ enzymatic activity: 'proof of principle' in acid sphingomyelinase-deficient mice. J Inherit Metab Dis (2005) 0.75
Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity (2012) 2.99
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31
ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med (2005) 2.28
Raft ceramide in molecular medicine. Oncogene (2003) 2.20
Engaging the vascular component of the tumor response. Cancer Cell (2005) 2.05
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest (2011) 1.97
Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? FEBS Lett (2002) 1.86
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One (2011) 1.86
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science (2008) 1.83
Sphingolipids and cell death. Apoptosis (2007) 1.71
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood (2009) 1.67
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60
Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res (2003) 1.60
Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene (2003) 1.53
CD95 rapidly clusters in cells of diverse origins. Cancer Biol Ther (2003) 1.50
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther (2009) 1.48
Ceramide-rich platforms in transmembrane signaling. FEBS Lett (2010) 1.46
Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem (2005) 1.44
Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys (2008) 1.34
Microvascular function regulates intestinal crypt response to radiation. Cancer Res (2003) 1.30
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet (2004) 1.29
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics (2002) 1.22
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest (2012) 1.15
Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 1.13
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med (2003) 1.12
Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med (2002) 1.12
Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. Cancer Res (2010) 1.07
Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem (2005) 1.03
Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer Res (2010) 1.01
Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res (2002) 0.99
Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 0.97
The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes (2011) 0.97
Sphingolipids as therapeutics. Pharmacol Res (2003) 0.96
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res (2010) 0.96
Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys (2009) 0.95
A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem (2009) 0.93
Accelerated hematopoietic toxicity by high energy (56)Fe radiation. Int J Radiat Biol (2011) 0.88
Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One (2013) 0.87
Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo. Proc Natl Acad Sci U S A (2008) 0.85
Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res (2004) 0.83
Acid sphingomyelinase. Handb Exp Pharmacol (2013) 0.82
Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun (2009) 0.82
Retracted The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK. J Biol Chem (2004) 0.81
Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther (2008) 0.80
Using ASMase knockout mice to model human diseases. Handb Exp Pharmacol (2013) 0.77
Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood (2010) 0.75
Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors. PLoS One (2016) 0.75
Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation. PLoS One (2015) 0.75
RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance. Expert Rev Mol Med (2009) 0.75
Caenorhabditis elegans as a model to study sphingolipid signaling. Biol Chem (2015) 0.75