Published in Nat Med on May 01, 2005
Animal models for medical countermeasures to radiation exposure. Radiat Res (2010) 2.83
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell (2008) 2.68
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One (2011) 1.86
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60
Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J (2012) 1.57
Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice. PLoS One (2009) 1.55
Microbial regulation of intestinal radiosensitivity. Proc Natl Acad Sci U S A (2005) 1.44
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene (2009) 1.43
Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. PLoS One (2008) 1.37
Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Mol Cancer Res (2011) 1.34
Cancer stem cells and radioresistance. Int J Radiat Biol (2014) 1.20
Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem (2011) 1.13
Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. Int J Radiat Oncol Biol Phys (2008) 1.07
Current approaches and recent developments in the management of head and neck paragangliomas. Endocr Rev (2014) 1.07
A new class of molecular targeted radioprotectors: GSK-3beta inhibitors. Int J Radiat Oncol Biol Phys (2010) 1.05
p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability. Mol Cell Biol (2007) 1.00
Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. J Clin Invest (2014) 0.98
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res (2010) 0.96
Radiotherapy and the tumor stroma: the importance of dose and fractionation. Front Oncol (2014) 0.95
Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells. Proc Natl Acad Sci U S A (2006) 0.94
Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice. Nat Commun (2014) 0.93
Intestinal stem cell injury and protection during cancer therapy. Transl Cancer Res (2013) 0.92
Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization. Int J Mol Sci (2016) 0.91
Breast cancer adaptive resistance: HER2 and cancer stem cell repopulation in a heterogeneous tumor society. J Cancer Res Clin Oncol (2013) 0.87
Radiation's outer limits. Nat Med (2005) 0.87
Fibroblast growth factor type 2 signaling is critical for DNA repair in human keratinocyte stem cells. Stem Cells (2010) 0.86
Intestinal stem cells and their roles during mucosal injury and repair. J Surg Res (2010) 0.86
Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity? Cancer Lett (2016) 0.85
The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance. Am J Cancer Res (2012) 0.83
Effects of irradiation on brain vasculature using an in situ tumor model. Int J Radiat Oncol Biol Phys (2011) 0.82
Biology of high single doses of IORT: RBE, 5 R's, and other biological aspects. Radiat Oncol (2017) 0.79
Are three doses of stereotactic ablative radiotherapy (SABR) more effective than 30 doses of conventional radiotherapy? Transl Lung Cancer Res (2012) 0.78
Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth. Mol Cancer Ther (2015) 0.78
Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells. Angiogenesis (2013) 0.78
Msi RNA-binding proteins control reserve intestinal stem cell quiescence. J Cell Biol (2016) 0.78
Krüppel-Like Factor 5 Promotes Epithelial Proliferation and DNA Damage Repair in the Intestine of Irradiated Mice. Int J Biol Sci (2015) 0.75
Stromal Progenitor Cells in Mitigation of Non-Hematopoietic Radiation Injuries. Curr Pathobiol Rep (2016) 0.75
β-Arrestin-2 modulates radiation-induced intestinal crypt progenitor/stem cell injury. Cell Death Differ (2016) 0.75
Bugging the intestinal response to radiation. Proc Natl Acad Sci U S A (2005) 0.75
Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury. Sci Rep (2016) 0.75
Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86
High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys (2008) 3.78
Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix. J Clin Oncol (2010) 3.76
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity (2012) 2.99
Radiation and ceramide-induced apoptosis. Oncogene (2003) 2.68
High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys (2002) 2.65
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31
Influence of local tumor control on distant metastases and cancer related mortality after external beam radiotherapy for prostate cancer. J Urol (2008) 2.30
Raft ceramide in molecular medicine. Oncogene (2003) 2.20
Engaging the vascular component of the tumor response. Cancer Cell (2005) 2.05
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest (2011) 1.97
Dietary protein intake and risk of osteoporotic hip fracture in elderly residents of Utah. J Bone Miner Res (2004) 1.94
Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS Comput Biol (2010) 1.92
Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? FEBS Lett (2002) 1.86
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One (2011) 1.86
Long-term results of conformal radiotherapy for prostate cancer: impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes. Int J Radiat Oncol Biol Phys (2008) 1.85
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science (2008) 1.83
Sphingolipids and cell death. Apoptosis (2007) 1.71
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood (2009) 1.67
Normalization of serum testosterone levels in patients treated with neoadjuvant hormonal therapy and three-dimensional conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys (2002) 1.67
Feasibility of a smoking cessation intervention for teens in the emergency department: reach, implementation fidelity, and acceptability. Am J Crit Care (2008) 1.66
Prostate-specific antigen and perfluoroalkyl acids in the C8 health study population. J Occup Environ Med (2015) 1.66
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60
Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res (2003) 1.60
Ultra-high dose (86.4 Gy) IMRT for localized prostate cancer: toxicity and biochemical outcomes. Int J Radiat Oncol Biol Phys (2007) 1.54
Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene (2003) 1.53
Predictors of biochemical outcome with salvage conformal radiotherapy after radical prostatectomy for prostate cancer. J Clin Oncol (2003) 1.51
CD95 rapidly clusters in cells of diverse origins. Cancer Biol Ther (2003) 1.50
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther (2009) 1.48
Ceramide-rich platforms in transmembrane signaling. FEBS Lett (2010) 1.46
MicroRNA expression characterizes oligometastasis(es). PLoS One (2011) 1.45
Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem (2005) 1.44
Retracted Pharmacologic inactivation of kinase suppressor of Ras1 sensitizes epidermal growth factor receptor and oncogenic Ras-dependent tumors to ionizing radiation treatment. Mol Cancer Ther (2010) 1.43
Right ventricular outflow pacing induces less regional wall motion abnormalities in the left ventricle compared with apical pacing. Europace (2011) 1.42
Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys (2008) 1.34
Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation. Cancer Res (2003) 1.33
Microvascular function regulates intestinal crypt response to radiation. Cancer Res (2003) 1.30
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet (2004) 1.29
Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett (2007) 1.29
Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures. J Biomed Inform (2010) 1.28
Pretreatment nomogram that predicts 5-year probability of metastasis following three-dimensional conformal radiation therapy for localized prostate cancer. J Clin Oncol (2003) 1.27
A 3D canted antiferromagnetic porous metal-organic framework with anatase topology through assembly of an analogue of polyoxometalate. J Am Chem Soc (2005) 1.27
Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell. Biochem Biophys Res Commun (2012) 1.24
Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. Biochem Biophys Res Commun (2012) 1.23
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics (2002) 1.22
The regulation of Toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells. Mol Cancer (2013) 1.19
Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma. Int J Radiat Oncol Biol Phys (2011) 1.16
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. Autophagy (2009) 1.16
Single sample expression-anchored mechanisms predict survival in head and neck cancer. PLoS Comput Biol (2012) 1.16
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest (2012) 1.15
Accurate setup of paraspinal patients using a noninvasive patient immobilization cradle and portal imaging. Med Phys (2005) 1.13
Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 1.13
Predictors of local control after single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases. Int J Radiat Oncol Biol Phys (2010) 1.13
X-ray nanodiffraction on a single SiGe quantum dot inside a functioning field-effect transistor. Nano Lett (2011) 1.13
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med (2003) 1.12
Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med (2002) 1.12
Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys (2005) 1.12
From IMRT to IGRT: frontierland or neverland? Radiother Oncol (2006) 1.11
Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation. Int J Biochem Cell Biol (2012) 1.11
Human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo. PLoS One (2010) 1.11
IMRT of large fields: whole-abdomen irradiation. Int J Radiat Oncol Biol Phys (2002) 1.09
Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis. Am J Physiol Cell Physiol (2010) 1.09
Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer. Carcinogenesis (2012) 1.08
Intensity-modulated radiotherapy. Cancer J (2002) 1.07
Synthesis of the 6-deoxytalose-containing tetrasaccharide of the glycopeptidolipid from Mycobacterium intracellare serotype 7. Carbohydr Res (2008) 1.07