Sphingolipids and cell death.

Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr Rev (2008) 2.96

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol (2009) 1.88

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol (2013) 1.61

Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell (2009) 1.58

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J Cell Biol (2009) 1.49

Global characterization of cell-specific gene expression through fluorescence-activated sorting of nuclei. Plant Physiol (2008) 1.44

Sphingolipid signaling in metabolic disorders. Cell Metab (2012) 1.37

Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr (2011) 1.35

Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med (2010) 1.30

Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. J Proteome Res (2010) 1.29

Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death. J Neurol Sci (2009) 1.26

Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol (2010) 1.24

Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice. J Biol Chem (2010) 1.16

Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12

Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol (2010) 1.09

Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. Blood (2010) 1.09

Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease. J Biol Chem (2011) 1.07

Ceramide and mitochondria in ischemia/reperfusion. J Cardiovasc Pharmacol (2009) 1.04

Regulating survival and development in the retina: key roles for simple sphingolipids. J Lipid Res (2010) 1.02

Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa. Proc Natl Acad Sci U S A (2010) 1.02

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. EMBO J (2010) 0.99

Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem (2011) 0.98

Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis. Alcohol Clin Exp Res (2011) 0.98

Death by committee: organellar trafficking and communication in apoptosis. Traffic (2009) 0.97

Apoptotic sphingolipid ceramide in cancer therapy. J Lipids (2011) 0.97

Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders. Surv Ophthalmol (2013) 0.96

Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochim Biophys Acta (2009) 0.95

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide. J Lipid Res (2010) 0.93

Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. J Biol Chem (2010) 0.92

The equilibria of sphingolipid-cholesterol and sphingolipid-sphingolipid in monolayers at the air-water interface. J Membr Biol (2012) 0.92

Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92

Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol (2011) 0.91

Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK. Cell Cycle (2008) 0.91

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice. Hepatology (2011) 0.90

Mix and measure fluorescence screening for selective quadruplex binders. Nucleic Acids Res (2008) 0.89

Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS One (2012) 0.89

Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer. Mol Cancer Ther (2012) 0.88

Sphingolipids and lifespan regulation. Biochim Biophys Acta (2013) 0.87

Very long chain fatty acid and lipid signaling in the response of plants to pathogens. Plant Signal Behav (2009) 0.87

Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One (2012) 0.87

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J Hepatol (2014) 0.86

Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase. PLoS One (2011) 0.86

Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. BMC Genomics (2009) 0.84

Ceramide and mitochondria in ischemic brain injury. Int J Biochem Mol Biol (2011) 0.84

Lung cancer and lung injury: the dual role of ceramide. Handb Exp Pharmacol (2013) 0.81

Sphingolipids and membrane biology as determined from genetic models. Prostaglandins Other Lipid Mediat (2007) 0.81

Unique sphingomyelin patches are targets of a beta-cell-specific antibody. J Lipid Res (2011) 0.80

Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress. Redox Biol (2014) 0.80

Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells. Biophys J (2012) 0.79

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. Oncotarget (2015) 0.79

Gaucher's disease and cancer: a sphingolipid perspective. Crit Rev Oncog (2013) 0.78

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells. J Pineal Res (2015) 0.78

The effect of antitumor glycosides on glioma cells and tissues as studied by proton HR-MAS NMR spectroscopy. PLoS One (2013) 0.78

Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase. Angew Chem Int Ed Engl (2014) 0.78

Glycosphingolipids and cell death: one aim, many ways. Apoptosis (2015) 0.78

Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). PLoS One (2015) 0.77

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration. PLoS Genet (2016) 0.77

Alterations in lipid mediated signaling and Wnt/ β -catenin signaling in DMH induced colon cancer on supplementation of fish oil. Biomed Res Int (2014) 0.76

Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APP and APP/PS1 Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration? Int J Alzheimers Dis (2010) 0.76

Metabolic Conversion of Ceramides in HeLa Cells - A Cholesteryl Phosphocholine Delivery Approach. PLoS One (2015) 0.76

Unraveling the roles of sphingolipids in plant innate immunity. Plant Signal Behav (2009) 0.76

Scientific literature addressing detection of monosialoganglioside: A 10-year bibliometric analysis. Neural Regen Res (2012) 0.75

Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis. Mol Metab (2017) 0.75

Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis. J Cell Sci (2017) 0.75

Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipid Res (2016) 0.75

High-throughput chinmedomics-based prediction of effective components and targets from herbal medicine AS1350. Sci Rep (2016) 0.75

Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver. Sci Rep (2017) 0.75

Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab (2006) 3.95

Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity (2012) 2.99

Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31

ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med (2005) 2.28

Raft ceramide in molecular medicine. Oncogene (2003) 2.20

Engaging the vascular component of the tumor response. Cancer Cell (2005) 2.05

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest (2011) 1.97

Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? FEBS Lett (2002) 1.86

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One (2011) 1.86

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science (2008) 1.83

Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood (2009) 1.67

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60

Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res (2003) 1.60

Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene (2003) 1.53

Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res (2007) 1.53

CD95 rapidly clusters in cells of diverse origins. Cancer Biol Ther (2003) 1.50

PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther (2009) 1.48

Ceramide-rich platforms in transmembrane signaling. FEBS Lett (2010) 1.46

Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem (2005) 1.44

Giant unilamellar vesicles electroformed from native membranes and organic lipid mixtures under physiological conditions. Biophys J (2007) 1.42

Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys (2008) 1.34

Microvascular function regulates intestinal crypt response to radiation. Cancer Res (2003) 1.30

Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet (2004) 1.29

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett (2007) 1.29

Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics (2002) 1.22

Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology (2006) 1.19

Mitochondrial glutathione: hepatocellular survival-death switch. J Gastroenterol Hepatol (2006) 1.16

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest (2012) 1.15

Health status, work limitations, and return-to-work trajectories in injured workers with musculoskeletal disorders. Qual Life Res (2007) 1.14

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 1.13

Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med (2003) 1.12

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med (2002) 1.12

Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia. J Biol Chem (2004) 1.10

Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. Cancer Res (2010) 1.07

Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem (2005) 1.03

Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer Res (2010) 1.01

Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res (2002) 0.99

The Readiness for Return-To-Work (RRTW) scale: development and validation of a self-report staging scale in lost-time claimants with musculoskeletal disorders. J Occup Rehabil (2007) 0.99

Membrane organization and ionization behavior of the minor but crucial lipid ceramide-1-phosphate. Biophys J (2008) 0.99

Glycosphingolipids and mitochondria: role in apoptosis and disease. Glycoconj J (2004) 0.98

Acid sphingomyelinase-derived ceramide signaling in apoptosis. Subcell Biochem (2002) 0.97

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 0.97

The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes (2011) 0.97

Sphingolipids as therapeutics. Pharmacol Res (2003) 0.96

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res (2010) 0.96

Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys (2009) 0.95

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem (2009) 0.93

Cholesterol and sphingolipids in alcohol-induced liver injury. J Gastroenterol Hepatol (2008) 0.90

Accelerated hematopoietic toxicity by high energy (56)Fe radiation. Int J Radiat Biol (2011) 0.88

Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One (2013) 0.87

Return-to-work self-efficacy: development and validation of a scale in claimants with musculoskeletal disorders. J Occup Rehabil (2011) 0.86

A multivariate analysis of factors associated with early offer and acceptance of a work accommodation following an occupational musculoskeletal injury. J Occup Environ Med (2009) 0.86

The impact of early workplace-based return-to-work strategies on work absence duration: a 6-month longitudinal study following an occupational musculoskeletal injury. J Occup Environ Med (2007) 0.85

Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo. Proc Natl Acad Sci U S A (2008) 0.85

Pharmacological modulation of sphingolipids and role in disease and cancer cell biology. Mini Rev Med Chem (2007) 0.84

Single-step and rapid growth of silver nanoshells as SERS-active nanostructures for label-free detection of pesticides. ACS Appl Mater Interfaces (2014) 0.84

Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res (2004) 0.83

GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway. PLoS One (2009) 0.83

Electroformation of giant unilamellar vesicles from native membranes and organic lipid mixtures for the study of lipid domains under physiological ionic-strength conditions. Methods Mol Biol (2010) 0.83

Model systems of precursor cellular membranes: long-chain alcohols stabilize spontaneously formed oleic acid vesicles. Biophys J (2012) 0.82

Lipid bilayers in the gel phase become saturated by triton X-100 at lower surfactant concentrations than those in the fluid phase. Biophys J (2012) 0.82

Acid sphingomyelinase. Handb Exp Pharmacol (2013) 0.82

The European lipidomics initiative: enabling technologies. Methods Enzymol (2007) 0.82

Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun (2009) 0.82

Retracted The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK. J Biol Chem (2004) 0.81

Predicting time on prolonged benefits for injured workers with acute back pain. J Occup Rehabil (2015) 0.80

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther (2008) 0.80

Health care use associated with work-related musculoskeletal disorders among hospital workers. J Occup Rehabil (2006) 0.77

Using ASMase knockout mice to model human diseases. Handb Exp Pharmacol (2013) 0.77

Polymer-mediated formation and assembly of silver nanoparticles on silica nanospheres for sensitive surface-enhanced Raman scattering detection. ACS Appl Mater Interfaces (2013) 0.76

Corrigendum: Direct Identification of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System for High-Throughput Bioanalysis. Sci Rep (2015) 0.76

To binge or not to binge: binge drinking disrupts glucose homeostasis by impairing hypothalamic but not liver insulin signaling. Hepatology (2013) 0.76

Quantitation of cholesterol incorporation into extruded lipid bilayers. Biochim Biophys Acta (2010) 0.76

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors. PLoS One (2016) 0.75

Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation. PLoS One (2015) 0.75

Changes in Physiotherapy Utilization in One Workforce: Implications for Accessibility among Canadian Working-Age Adults. Healthc Policy (2011) 0.75

Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood (2010) 0.75

Polyimide-organosilicate hybrids with improved thermal and optical properties. ACS Appl Mater Interfaces (2014) 0.75

Caenorhabditis elegans as a model to study sphingolipid signaling. Biol Chem (2015) 0.75

RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance. Expert Rev Mol Med (2009) 0.75