Published in Annu Rev Biochem on November 09, 2001
Potassium buffering in the central nervous system. Neuroscience (2004) 3.05
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet (2013) 2.83
Hypoxia. 2. Hypoxia regulates cellular metabolism. Am J Physiol Cell Physiol (2010) 2.03
Binding of Src to Na+/K+-ATPase forms a functional signaling complex. Mol Biol Cell (2005) 1.92
Homology modeling of the cation binding sites of Na+K+-ATPase. Proc Natl Acad Sci U S A (2002) 1.85
Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts. Cardiovasc Res (2006) 1.67
X-linked juvenile retinoschisis: clinical diagnosis, genetic analysis, and molecular mechanisms. Prog Retin Eye Res (2012) 1.66
Mechanism of Cu+-transporting ATPases: soluble Cu+ chaperones directly transfer Cu+ to transmembrane transport sites. Proc Natl Acad Sci U S A (2008) 1.65
The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase. Annu Rev Physiol (2010) 1.58
Molecular modeling and dynamics studies with explicit inclusion of electronic polarizability. Theory and applications. Theor Chem Acc (2009) 1.54
A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps. Nat Rev Mol Cell Biol (2011) 1.52
Autosis and autophagic cell death: the dark side of autophagy. Cell Death Differ (2014) 1.49
beta-Subunit overexpression alters the stoicheometry of assembled Na-K-ATPase subunits in MDCK cells. Am J Physiol Renal Physiol (2008) 1.49
The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades. Pflugers Arch (2008) 1.46
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol (2011) 1.43
A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes. PLoS One (2014) 1.39
Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase. Br J Cancer (2012) 1.35
Na,K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci (2009) 1.30
RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Mol Syst Biol (2011) 1.27
A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control. Development (2007) 1.26
Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase. J Cell Biol (2008) 1.22
The C terminus of Na+,K+-ATPase controls Na+ affinity on both sides of the membrane through Arg935. J Biol Chem (2009) 1.20
The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochim Biophys Acta (2010) 1.17
Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Mol Biol Cell (2008) 1.16
Inter-connection between mitochondria and HIFs. J Cell Mol Med (2010) 1.14
Bacterial transition metal P(1B)-ATPases: transport mechanism and roles in virulence. Biochemistry (2011) 1.13
The Na-K-ATPase and calcium-signaling microdomains. Physiology (Bethesda) (2008) 1.11
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. J Biol Chem (2008) 1.11
S-glutathionylation of the Na,K-ATPase catalytic α subunit is a determinant of the enzyme redox sensitivity. J Biol Chem (2012) 1.09
FXYD proteins stabilize Na,K-ATPase: amplification of specific phosphatidylserine-protein interactions. J Biol Chem (2011) 1.08
Na,K-ATPase and the role of alpha isoforms in behavior. J Bioenerg Biomembr (2007) 1.07
Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol (2015) 1.06
Digitoxin and its analogs as novel cancer therapeutics. Exp Hematol Oncol (2012) 1.06
A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis. ACS Med Chem Lett (2010) 1.05
NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells. J Biol Chem (2009) 1.04
A specific and essential role for Na,K-ATPase α3 in neurons co-expressing α1 and α3. J Biol Chem (2012) 1.04
The regulation of proximal tubular salt transport in hypertension: an update. Curr Opin Nephrol Hypertens (2009) 1.03
Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca2+-ATPase assists in catalysis of E2/E2P partial reactions. Proc Natl Acad Sci U S A (2004) 1.03
The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site. J Biol Chem (2010) 1.03
Proximal nephron. Compr Physiol (2013) 1.02
Spatial distribution of Na+-K+-ATPase in dendritic spines dissected by nanoscale superresolution STED microscopy. BMC Neurosci (2011) 1.01
The cardiac glycoside binding site on the Na,K-ATPase alpha2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle. Proc Natl Acad Sci U S A (2009) 1.00
Evidence for a potential tumor suppressor role for the Na,K-ATPase beta1-subunit. Histol Histopathol (2008) 0.99
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. Proc Natl Acad Sci U S A (2005) 0.99
α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient. EMBO J (2015) 0.98
Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells. J Biol Chem (2011) 0.97
Na,K-ATPase alpha4 isoform is essential for sperm fertility. Proc Natl Acad Sci U S A (2010) 0.97
Regulation of WNK1 expression by miR-192 and aldosterone. J Am Soc Nephrol (2010) 0.97
Na,K-ATPase signal transduction triggers CREB activation and dendritic growth. Proc Natl Acad Sci U S A (2009) 0.96
Transglutaminase-catalyzed transamidation: a novel mechanism for Rac1 activation by 5-hydroxytryptamine2A receptor stimulation. J Pharmacol Exp Ther (2008) 0.95
Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Paediatr Drugs (2013) 0.95
Regulation of sodium pump endocytosis by cardiotonic steroids: Molecular mechanisms and physiological implications. Pathophysiology (2007) 0.95
Stabilization of the α2 isoform of Na,K-ATPase by mutations in a phospholipid binding pocket. J Biol Chem (2011) 0.95
Knockout of the Na,K-ATPase α₂-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension. Am J Physiol Heart Circ Physiol (2011) 0.94
Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src. Biochemistry (2013) 0.94
Tissue-specific role of the Na,K-ATPase α2 isozyme in skeletal muscle. J Biol Chem (2012) 0.93
Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function. Cell Mol Life Sci (2010) 0.93
Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. Am J Physiol Heart Circ Physiol (2012) 0.93
AS160 associates with the Na+,K+-ATPase and mediates the adenosine monophosphate-stimulated protein kinase-dependent regulation of sodium pump surface expression. Mol Biol Cell (2010) 0.93
Metal transport across biomembranes: emerging models for a distinct chemistry. J Biol Chem (2012) 0.93
Ouabain affinity determining residues lie close to the Na/K pump ion pathway. Proc Natl Acad Sci U S A (2006) 0.92
Comparative properties of caveolar and noncaveolar preparations of kidney Na+/K+-ATPase. Biochemistry (2011) 0.92
Spontaneous calcium spike activity in embryonic spinal neurons is regulated by developmental expression of the Na+, K+-ATPase beta3 subunit. J Neurosci (2009) 0.91
The beta subunit of the Na+/K+-ATPase follows the conformational state of the holoenzyme. J Gen Physiol (2005) 0.91
A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae. J Biol Chem (2006) 0.91
Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. Int J Nephrol (2012) 0.90
Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts. J Mol Cell Cardiol (2010) 0.90
Localization of intracellular compartments that exchange Na,K-ATPase molecules with the plasma membrane in a hormone-dependent manner. Br J Pharmacol (2007) 0.89
Na,K-ATPase expression is increased in the lungs of alcohol-fed rats. Alcohol Clin Exp Res (2008) 0.89
Modulation of Na(+)-K(+)-ATPase cell surface abundance through structural determinants on the α1-subunit. Am J Physiol Cell Physiol (2010) 0.89
The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions. J Gen Physiol (2010) 0.89
The beta1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis. Hum Mol Genet (2010) 0.89
Neutral phospholipids stimulate Na,K-ATPase activity: a specific lipid-protein interaction. J Biol Chem (2013) 0.89
The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol (2013) 0.88
A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans. PLoS One (2010) 0.88
Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells. J Biol Chem (2010) 0.88
Curcumin modulation of Na,K-ATPase: phosphoenzyme accumulation, decreased K+ occlusion, and inhibition of hydrolytic activity. Br J Pharmacol (2005) 0.88
Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models. Hum Genomics (2013) 0.87
Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation. Am J Physiol Renal Physiol (2011) 0.87
Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase. Biochem Biophys Res Commun (2010) 0.87
Effect of clotrimazole on the pump cycle of the Na,K-ATPase. Biophys J (2008) 0.87
Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis. Proc Natl Acad Sci U S A (2014) 0.87
A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2. J Biol Chem (2014) 0.86
Role of ubiquitination in Na,K-ATPase regulation during lung injury. Proc Am Thorac Soc (2010) 0.86
Osmotic stress and viscous retardation of the Na,K-ATPase ion pump. Biophys J (2007) 0.86
Subunit isoform selectivity in assembly of Na,K-ATPase α-β heterodimers. J Biol Chem (2012) 0.86
Astroglial glutamate transporters coordinate excitatory signaling and brain energetics. Neurochem Int (2016) 0.86
Na+/K+ ATPase regulates the expression and localization of acetylcholine receptors in a pump activity-independent manner. Mol Cell Neurosci (2008) 0.86
Nuclear Na+/K+-ATPase plays an active role in nucleoplasmic Ca2+ homeostasis. J Cell Sci (2012) 0.86
Transcriptional regulators of Na,K-ATPase subunits. Front Cell Dev Biol (2015) 0.86
Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia. Schizophr Res (2014) 0.86
Regulation of Na(+)/K(+)-ATPase by nuclear respiratory factor 1: implication in the tight coupling of neuronal activity, energy generation, and energy consumption. J Biol Chem (2012) 0.85
Mechanism of ATPase-mediated Cu+ export and delivery to periplasmic chaperones: the interaction of Escherichia coli CopA and CusF. J Biol Chem (2014) 0.85
Biochemical characterization of P-type copper ATPases. Biochem J (2014) 0.84
Human breast tumor cells are more resistant to cardiac glycoside toxicity than non-tumorigenic breast cells. PLoS One (2013) 0.84
Regulation of Na(+)/K(+)-ATPase by neuron-specific transcription factor Sp4: implication in the tight coupling of energy production, neuronal activity and energy consumption in neurons. Eur J Neurosci (2013) 0.84
Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis. Proc Jpn Acad Ser B Phys Biol Sci (2009) 0.84
Methodological limitations in determining astrocytic gene expression. Front Endocrinol (Lausanne) (2013) 0.84
Role of endothelin-1 in acute lung injury. Transl Res (2009) 0.84
Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol (2013) 0.84