Published in Am J Physiol Cell Physiol on December 01, 2010
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell (2011) 7.33
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol (2011) 2.07
DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells. PLoS One (2015) 2.02
Extracellular metabolic energetics can promote cancer progression. Cell (2015) 1.74
Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells. PLoS Pathog (2014) 1.61
Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57
How wasting is saving: weight loss at altitude might result from an evolutionary adaptation. Bioessays (2014) 1.45
Neuroprotection and repair in multiple sclerosis. Nat Rev Neurol (2012) 1.41
Renal oxygenation and haemodynamics in acute kidney injury and chronic kidney disease. Clin Exp Pharmacol Physiol (2013) 1.14
Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci (2013) 1.10
FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function. EMBO J (2011) 1.09
Metabolic signature identifies novel targets for drug resistance in multiple myeloma. Cancer Res (2015) 1.08
Nutrient-sensing pathways and metabolic regulation in stem cells. J Cell Biol (2013) 1.08
Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery. Am J Physiol Cell Physiol (2011) 1.07
MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nat Commun (2015) 0.99
Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption. J Biol Chem (2013) 0.96
Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment. Antioxid Redox Signal (2014) 0.96
Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus. Extrem Physiol Med (2014) 0.93
A non-traditional model of the metabolic syndrome: the adaptive significance of insulin resistance in fasting-adapted seals. Front Endocrinol (Lausanne) (2013) 0.91
Metabolomics--a novel window into inflammatory disease. Swiss Med Wkly (2013) 0.91
Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells. Am J Physiol Renal Physiol (2013) 0.90
Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition. PLoS One (2013) 0.90
Differentiation of human adipocytes at physiological oxygen levels results in increased adiponectin secretion and isoproterenol-stimulated lipolysis. Adipocyte (2012) 0.89
Mitochondria-controlled signaling mechanisms of brain protection in hypoxia. Front Neurosci (2015) 0.88
A specialized microvascular domain in the mouse neural stem cell niche. PLoS One (2013) 0.88
Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol (2015) 0.87
Adiposity and fat metabolism in lactating and fasting northern elephant seals. Adv Nutr (2014) 0.86
Autophagy in the human placenta throughout gestation. PLoS One (2013) 0.86
Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One (2013) 0.85
Essential role of hemoglobin beta-93-cysteine in posthypoxia facilitation of breathing in conscious mice. J Appl Physiol (1985) (2014) 0.85
CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells. Front Immunol (2015) 0.84
Role of oxygen consumption in hypoxia protection by translation factor depletion. J Exp Biol (2013) 0.84
A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (Hemiscyllum ocellatum). J Comp Physiol B (2011) 0.84
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free Radic Biol Med (2013) 0.84
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude. Physiol Genomics (2014) 0.84
Ascent to altitude as a weight loss method: the good and bad of hypoxia inducible factor activation. Obesity (Silver Spring) (2013) 0.84
Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS One (2014) 0.83
The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors. Cardiovasc Diagn Ther (2012) 0.83
Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol (2016) 0.83
Inhibition of peroxisome proliferator-activated receptor γ: a potential link between chronic maternal hypoxia and impaired fetal growth. FASEB J (2013) 0.82
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. Int J Oncol (2012) 0.82
Effect of proline analogues on activity of human prolyl hydroxylase and the regulation of HIF signal transduction pathway. PLoS One (2014) 0.79
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation. Nucleic Acids Res (2015) 0.79
The greening after extended darkness1 is an N-end rule pathway mutant with high tolerance to submergence and starvation. Plant Physiol (2015) 0.79
Directed oxygen gradients initiate a robust early remodeling response in engineered vascular grafts. Tissue Eng Part A (2013) 0.78
Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. PLoS One (2014) 0.78
Chronic sustained hypoxia-induced redox remodeling causes contractile dysfunction in mouse sternohyoid muscle. Front Physiol (2015) 0.78
Modulation of redox regulatory molecules and electron transport chain activity in muscle of air breathing fish Heteropneustes fossilis under air exposure stress. J Comp Physiol B (2013) 0.77
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano. J Physiol (2015) 0.77
Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma. Oncotarget (2014) 0.77
Redox signaling in cardiac renewal. Antioxid Redox Signal (2014) 0.77
Increased Cardiometabolic Risk and Worsening Hypoxemia at High Altitude. High Alt Med Biol (2016) 0.77
Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy. Haematologica (2015) 0.76
Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy. Mol Pain (2015) 0.76
Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice. Oxid Med Cell Longev (2015) 0.76
AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett (2016) 0.76
Differential regulation of pro- and antiapoptotic proteins in fish adipocytes during hypoxic conditions. Fish Physiol Biochem (2016) 0.76
Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells. PLoS One (2015) 0.75
Control of the heart rate of rat embryos during the organogenic period. Hypoxia (Auckl) (2016) 0.75
NADPH oxidases-do they play a role in TRPC regulation under hypoxia? Pflugers Arch (2015) 0.75
Stress-induced haematopoietic stem cell proliferation: new roles for p38α and purine metabolism. Stem Cell Investig (2016) 0.75
Impaired Na(+)/K(+)-ATPase Function in Patients with Interstitial Cystitis/Painful Bladder Syndrome. J Korean Med Sci (2016) 0.75
Hypoxia and Inactivity Related Physiological Changes (Constipation, Inflammation) Are Not Reflected at the Level of Gut Metabolites and Butyrate Producing Microbial Community: The PlanHab Study. Front Physiol (2017) 0.75
Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats. Respir Physiol Neurobiol (2017) 0.75
Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure. Hypoxia (Auckl) (2014) 0.75
Hypoxia inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease. Am J Physiol Renal Physiol (2017) 0.75
Renal Oxygenation in the Pathophysiology of Chronic Kidney Disease. Front Physiol (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (2001) 23.83
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature (1999) 23.45
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem (1956) 20.40
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell (2001) 19.75
The mammalian unfolded protein response. Annu Rev Biochem (2005) 16.31
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell (2008) 13.49
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab (2006) 13.22
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev (1998) 12.48
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
The control of flux. Symp Soc Exp Biol (1973) 12.14
A conserved family of prolyl-4-hydroxylases that modify HIF. Science (2001) 11.50
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab (2006) 10.14
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
Purification and characterization of hypoxia-inducible factor 1. J Biol Chem (1995) 8.53
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51
The ATP synthase--a splendid molecular machine. Annu Rev Biochem (1997) 7.50
A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell (2007) 6.31
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol (2002) 5.39
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J (2001) 5.20
Oxidative phosphorylation at the fin de siècle. Science (1999) 4.48
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett (1994) 4.19
TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell (2003) 4.13
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol (2002) 4.11
Biochemistry of Na,K-ATPase. Annu Rev Biochem (2001) 4.00
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet (2008) 3.94
Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci U S A (1996) 3.89
Life with oxygen. Science (2007) 3.88
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem (2003) 3.88
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature (2002) 3.78
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett (1994) 3.75
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68
Defense strategies against hypoxia and hypothermia. Science (1986) 3.50
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res (2007) 3.31
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab (2009) 3.30
Human brown adipose tissue. Cell Metab (2010) 3.30
JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) (2009) 2.94
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans (2003) 2.81
Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem (1995) 2.80
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol (2002) 2.73
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J (2007) 2.72
Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol (2004) 2.68
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation (2003) 2.68
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41
A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc Natl Acad Sci U S A (1998) 2.34
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem (2004) 2.26
Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J (2002) 2.25
The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration. J Biol Chem (1988) 2.25
Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest (2003) 2.14
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ (2010) 2.09
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One (2010) 2.05
Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res (2002) 1.99
Control of respiration and oxidative phosphorylation in isolated rat liver cells. Eur J Biochem (1990) 1.89
Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene (2010) 1.88
Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol (2005) 1.85
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radic Biol Med (2009) 1.78
On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proc Natl Acad Sci U S A (1999) 1.76
Regulation of transcription and translation by hypoxia. Cancer Biol Ther (2004) 1.74
Dopamine-induced endocytosis of Na+,K+-ATPase is initiated by phosphorylation of Ser-18 in the rat alpha subunit and Is responsible for the decreased activity in epithelial cells. J Biol Chem (1999) 1.59
Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res (2000) 1.57
Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal (2008) 1.57
A 'top-down' approach to the determination of control coefficients in metabolic control theory. Eur J Biochem (1990) 1.54
Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J Biol Chem (1997) 1.51
Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem (2008) 1.51
Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta. Mol Biol Cell (2002) 1.45
Oxygen conformance of cellular respiration in hepatocytes. Am J Physiol (1993) 1.42
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. Mol Cell Biol (2009) 1.37
Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine. J Biol Chem (1997) 1.33
Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes. Am J Physiol (1996) 1.29
Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circ Res (2006) 1.27
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J (1996) 1.24
HIF-1alpha in endurance training: suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol (2007) 1.22
Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 sensor. J Biol Chem (1998) 1.18
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. Gastroenterology (2009) 1.18
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem (2010) 1.18
Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res (1991) 1.16
Molecular oxygen modulates cytochrome c oxidase function. J Biol Chem (1996) 1.14
Hypoxia decreases proteins involved in epithelial electrolyte transport in A549 cells and rat lung. Am J Physiol Lung Cell Mol Physiol (2000) 1.12
Inhibition of cytochrome-c oxidase activity during prolonged hypoxia. Am J Physiol (1995) 1.04
Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat. J Cardiovasc Pharmacol (2010) 1.04
Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia. Am J Physiol (1997) 1.01
Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. FASEB J (2007) 1.00
Energy costs of ion pumping by animal tissues. J Nutr (1985) 0.98
Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury. J Cardiovasc Pharmacol (2008) 0.97
Calcium, mitochondria and oxygen sensing in the pulmonary circulation. Cell Calcium (2004) 0.97
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A (2010) 8.12
Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab (2005) 5.61
Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity (2013) 4.08
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature (2012) 3.85
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell (2004) 3.62
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17
Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol (2002) 2.90
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal (2013) 2.78
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol (2007) 2.45
The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev (2011) 2.38
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest (2007) 2.36
Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metab (2011) 2.21
Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest (2003) 2.14
Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. J Natl Cancer Inst (2005) 2.10
Rethinking antioxidants in the intensive care unit. Am J Respir Crit Care Med (2013) 2.05
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol (2005) 1.97
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A (2008) 1.92
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Am J Respir Crit Care Med (2010) 1.84
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radic Biol Med (2009) 1.78
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol (2011) 1.77
Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia. Mol Cell Biol (2007) 1.71
Targeting glucose metabolism for cancer therapy. J Exp Med (2012) 1.64
Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. Am J Physiol Lung Cell Mol Physiol (2002) 1.63
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Lett (2011) 1.63
Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci U S A (2006) 1.59
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis. J Clin Invest (2008) 1.58
Mitochondrial reactive oxygen species regulate hypoxic signaling. Curr Opin Cell Biol (2009) 1.58
Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med (2006) 1.57
Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells. J Biol Chem (2003) 1.55
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Mol Cell (2013) 1.54
Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci (2009) 1.49
Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling. J Biol Chem (2012) 1.39
Compound C inhibits hypoxic activation of HIF-1 independent of AMPK. FEBS Lett (2007) 1.39
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. Mol Cell Biol (2009) 1.37
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J Biol Chem (2008) 1.37
Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol (2002) 1.36
Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochim Biophys Acta (2010) 1.35
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ. Am J Respir Crit Care Med (2011) 1.34
A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation. Proc Natl Acad Sci U S A (2008) 1.33
Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins. J Biol Chem (2002) 1.32
Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis. Free Radic Biol Med (2010) 1.29
Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circ Res (2006) 1.27
Mitochondrial metabolism and cancer. Ann N Y Acad Sci (2009) 1.26
Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. J Biol Chem (2011) 1.24
Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis. Am J Physiol Lung Cell Mol Physiol (2004) 1.20
Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species. Essays Biochem (2007) 1.19
Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol (2011) 1.18
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol (2011) 1.18
Active transforming growth factor-beta1 activates the procollagen I promoter in patients with acute lung injury. Intensive Care Med (2004) 1.15
Inter-connection between mitochondria and HIFs. J Cell Mol Med (2010) 1.14
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS. FASEB J (2008) 1.14
Mitochondrial regulation of oxygen sensing. Mitochondrion (2005) 1.12
microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proc Natl Acad Sci U S A (2012) 1.11
ROS links glucose metabolism to breast cancer stem cell and EMT phenotype. Cancer Cell (2013) 1.10
Targeting SOD1 reduces experimental non–small-cell lung cancer. J Clin Invest (2014) 1.07
The promise and perils of antioxidants for cancer patients. N Engl J Med (2014) 1.06
Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway. Am J Physiol Lung Cell Mol Physiol (2005) 1.06
Cell biology. Warburg effect and redox balance. Science (2011) 1.05
Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation. Am J Respir Cell Mol Biol (2006) 1.05
p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology (2011) 1.05
c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. J Biol Chem (2003) 1.04
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. Sci Rep (2012) 1.03
Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Mol Cell Biol (2006) 1.02
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. FASEB J (2009) 1.01
Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. FASEB J (2007) 1.00
Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. PLoS One (2009) 1.00
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest (2014) 1.00
MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism. FASEB J (2012) 0.99
Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes. Free Radic Biol Med (2007) 0.98
The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. J Immunol (2007) 0.97
Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption. J Biol Chem (2013) 0.96
Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 0.95
Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum (2010) 0.95
Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med (2015) 0.94
Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments. FASEB J (2009) 0.92
BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK. PLoS One (2009) 0.92
Oxygen sensing: getting pumped by sterols. Sci STKE (2005) 0.92
Role of Bcl-2 family members in anoxia induced cell death. Cell Cycle (2007) 0.92
Bcl-2 family members regulate anoxia-induced cell death. Antioxid Redox Signal (2007) 0.91
Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation. Crit Care Med (2007) 0.91
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling. Thorax (2011) 0.90
Metabolic changes in cancer cells upon suppression of MYC. Cancer Metab (2013) 0.88
Hypoxia sensitizes cells to nitric oxide-induced apoptosis. J Biol Chem (2002) 0.87
Mitochondrial regulation of cell survival and death during low-oxygen conditions. Antioxid Redox Signal (2009) 0.85
Targeting the mitochondria for cancer therapy: regulation of hypoxia-inducible factor by mitochondria. Antioxid Redox Signal (2008) 0.84
Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response. Am J Respir Cell Mol Biol (2013) 0.84
HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth. Am J Respir Crit Care Med (2014) 0.81
Genetics of mitochondrial electron transport chain in regulating oxygen sensing. Methods Enzymol (2007) 0.80
Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor. PLoS One (2012) 0.79
ROS. Curr Biol (2013) 0.78
Seeing the light: probing ROS in vivo using redox GFP. Cell Metab (2011) 0.76
Corrigendum: The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nat Immunol (2015) 0.76
Mitochondria and telomeres: the promiscuous roles of TIN2. Mol Cell (2012) 0.76
Reply: antioxidants in the intensive care unit. Am J Respir Crit Care Med (2014) 0.75
Introduction to hypoxia and consequences: from molecule to malady. Ann N Y Acad Sci (2009) 0.75