Published in J Struct Biol on June 14, 2002
Calcium-dependent molecular spring elements in the giant protein titin. Proc Natl Acad Sci U S A (2003) 2.16
Cardiac titin: a multifunctional giant. Circulation (2010) 1.84
Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction. Circulation (2013) 1.83
The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms. Am J Physiol Cell Physiol (2015) 1.61
Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling. J Mol Cell Cardiol (2014) 1.48
In vivo and in vitro heterogeneity of segment length changes in the semimembranosus muscle of the toad. J Physiol (2003) 1.24
Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence. Biophys J (2009) 1.15
Pulling single molecules of titin by AFM--recent advances and physiological implications. Pflugers Arch (2007) 1.13
Single molecule force spectroscopy of the cardiac titin N2B element: effects of the molecular chaperone alphaB-crystallin with disease-causing mutations. J Biol Chem (2009) 1.13
Selection of optimal variants of Gō-like models of proteins through studies of stretching. Biophys J (2008) 1.10
Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy. Biophys J (2011) 1.03
Mechanical strength of 17,134 model proteins and cysteine slipknots. PLoS Comput Biol (2009) 1.01
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J (2007) 0.98
Tuning the molecular giant titin through phosphorylation: role in health and disease. Trends Cardiovasc Med (2013) 0.97
Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy. J Gen Physiol (2014) 0.96
Molecular basis of passive stress relaxation in human soleus fibers: assessment of the role of immunoglobulin-like domain unfolding. Biophys J (2003) 0.96
Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle. Biophys J (2011) 0.95
Tertiary and secondary structure elasticity of a six-Ig titin chain. Biophys J (2010) 0.91
Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations. Prog Biophys Mol Biol (2012) 0.91
Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism. J Biol Chem (2013) 0.88
Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif. Biophys J (2013) 0.88
Titin-isoform dependence of titin-actin interaction and its regulation by S100A1/Ca2+ in skinned myocardium. J Biomed Biotechnol (2010) 0.88
Retracted Stretching to understand proteins - a survey of the protein data bank. Biophys J (2007) 0.86
Mechanical stability and differentially conserved physical-chemical properties of titin Ig-domains. Proteins (2009) 0.86
Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium. Eur Biophys J (2012) 0.84
Structure of giant muscle proteins. Front Physiol (2013) 0.81
Residual force enhancement is regulated by titin in skeletal and cardiac myofibrils. J Physiol (2016) 0.75
Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins. Nat Struct Mol Biol (2017) 0.75
The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circ Res (2004) 3.30
Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation (2004) 3.29
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. Nat Genet (2002) 2.67
Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation (2002) 2.43
Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res (2004) 2.38
Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. EMBO J (2006) 2.17
Calcium-dependent molecular spring elements in the giant protein titin. Proc Natl Acad Sci U S A (2003) 2.16
Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin. Am J Hum Genet (2002) 2.14
MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. J Mol Biol (2005) 2.13
The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol (2003) 2.12
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. Neurology (2013) 2.09
Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy. J Mol Med (Berl) (2006) 2.05
Titin and its associated proteins: the third myofilament system of the sarcomere. Adv Protein Chem (2005) 2.00
Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. Mol Biol Cell (2008) 1.94
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res (2009) 1.91
Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol (2010) 1.88
Cardiac titin: a multifunctional giant. Circulation (2010) 1.84
Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction. Circulation (2013) 1.83
Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury. Circulation (2010) 1.80
Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency. Hum Mol Genet (2009) 1.73
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A (2007) 1.70
Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling. J Muscle Res Cell Motil (2005) 1.62
Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J Biol Chem (2002) 1.61
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J (2007) 1.61
Cardiac titin: an adjustable multi-functional spring. J Physiol (2002) 1.56
Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients. Am J Respir Crit Care Med (2015) 1.52
Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation (2011) 1.51
C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy. Ann Neurol (2007) 1.47
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem (2002) 1.47
The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles. Structure (2007) 1.45
Nebulin: the nebulous, multifunctional giant of striated muscle. Trends Cardiovasc Med (2003) 1.44
Actin-related myopathy without any missense mutation in the ACTA1 gene. J Child Neurol (2004) 1.42
Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost. J Biol Chem (2009) 1.41
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle. J Physiol (2003) 1.39
Association of the chaperone alphaB-crystallin with titin in heart muscle. J Biol Chem (2003) 1.31
Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease. J Mol Cell Cardiol (2009) 1.30
Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells. Muscle Nerve (2007) 1.29
Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction. Circ Res (2009) 1.29
Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance. J Mol Cell Cardiol (2006) 1.28
Molecular dissection of the interaction of desmin with the C-terminal region of nebulin. J Struct Biol (2002) 1.27
The sensitive giant: the role of titin-based stretch sensing complexes in the heart. Trends Cell Biol (2004) 1.26
The complete mouse nebulin gene sequence and the identification of cardiac nebulin. J Mol Biol (2003) 1.26
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol (2009) 1.22
Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility. J Mol Biol (2007) 1.21
Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin. FASEB J (2007) 1.21
Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum Mol Genet (2008) 1.21
Cardiac titin: structure, functions and role in disease. Clin Chim Acta (2006) 1.20
Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2). J Struct Biol (2009) 1.20
Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovasc Res (2009) 1.18
MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies. J Mol Biol (2008) 1.17
Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle. FASEB J (2008) 1.17
Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility. Cardiovasc Res (2006) 1.16
Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. Hum Mol Genet (2011) 1.16
Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice. J Mol Biol (2008) 1.16
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling. J Mol Biol (2004) 1.15
Single molecule force spectroscopy of the cardiac titin N2B element: effects of the molecular chaperone alphaB-crystallin with disease-causing mutations. J Biol Chem (2009) 1.13
Titin and diaphragm dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.13
Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells. J Gen Physiol (2011) 1.12
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3. J Biol Chem (2003) 1.11
Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet (2012) 1.10
Interaction forces between F-actin and titin PEVK domain measured with optical tweezers. Biophys J (2007) 1.10
Three-dimensional structure in lipid micelles of the pediocin-like antimicrobial peptide sakacin P and a sakacin P variant that is structurally stabilized by an inserted C-terminal disulfide bridge. Biochemistry (2003) 1.10
MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. J Struct Biol (2010) 1.10
Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem (2008) 1.10
Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect. Biochem J (2003) 1.09
Selective diaphragm muscle weakness after contractile inactivity during thoracic surgery. Ann Surg (2011) 1.09
Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle. Pflugers Arch (2004) 1.09
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. Circulation (2007) 1.08
A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain. Proc Natl Acad Sci U S A (2008) 1.08
Effect of diastolic pressure on MLC2v phosphorylation in the rat left ventricle. Arch Biochem Biophys (2006) 1.08
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07
Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development. J Cell Sci (2004) 1.07
Nebulin, a major player in muscle health and disease. FASEB J (2010) 1.06
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements. J Mol Cell Cardiol (2012) 1.06