Published in Biochem Biophys Res Commun on June 28, 2002
NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc Natl Acad Sci U S A (2004) 2.42
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A (2004) 1.38
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol (2013) 1.16
Role of NFAT5 in inflammatory disorders associated with osmotic stress. Curr Genomics (2010) 1.10
Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest (2009) 1.05
Mechanistic heterogeneity in site recognition by the structurally homologous DNA-binding domains of the ETS family transcription factors Ets-1 and PU.1. J Biol Chem (2014) 0.91
Novel nuclear localization signal regulated by ambient tonicity in vertebrates. J Biol Chem (2008) 0.89
Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression. Exp Mol Med (2008) 0.88
TonEBP is inhibited by RNA helicase A via interaction involving the E'F loop. Biochem J (2006) 0.86
Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T-cells 5 in vitro. Arthritis Res Ther (2010) 0.82
Nitric oxide decreases expression of osmoprotective genes via direct inhibition of TonEBP transcriptional activity. Pflugers Arch (2008) 0.81
LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding. Sci Rep (2016) 0.77
Modulation of TonEBP activity by SUMO modification in response to hypertonicity. Front Physiol (2014) 0.76
Effect of renal denervation on prenatal programming of hypertension and renal tubular transporter abundance. Am J Physiol Renal Physiol (2008) 1.82
TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity. Mol Cell Biol (2002) 1.72
Maturation of TonEBP expression in developing rat kidney. Am J Physiol Renal Physiol (2004) 1.70
NF-AT5 is a critical regulator of inflammatory arthritis. Arthritis Rheum (2011) 1.68
TonEBP transcriptional activator in the cellular response to increased osmolality. Pflugers Arch (2002) 1.43
Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity. Mol Biol Cell (2010) 1.38
Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells. J Am Soc Nephrol (2006) 1.28
Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5). Am J Physiol Cell Physiol (2011) 1.15
Silencing of TonEBP/NFAT5 transcriptional activator by RNA interference. J Am Soc Nephrol (2003) 1.12
Glibenclamide-10-h Treatment Window in a Clinically Relevant Model of Stroke. Transl Stroke Res (2012) 1.10
Comparison of experimental lung injury from acute renal failure with injury due to sepsis. Respiration (2006) 1.05
NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells. J Biol Chem (2008) 1.01
Multiple domains of TonEBP cooperate to stimulate transcription in response to hypertonicity. J Biol Chem (2003) 1.00
Sequential expression of NKCC2, TonEBP, aldose reductase, and urea transporter-A in developing mouse kidney. Am J Physiol Renal Physiol (2006) 0.99
Hypertonic stress in the kidney: a necessary evil. Physiology (Bethesda) (2009) 0.99
Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. Stroke (2013) 0.97
Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation. Arterioscler Thromb Vasc Biol (2011) 0.97
Downregulation of renal sodium transporters and tonicity-responsive enhancer binding protein by long-term treatment with cyclosporin A. J Am Soc Nephrol (2007) 0.96
Regulation of TonEBP transcriptional activator in MDCK cells following changes in ambient tonicity. Am J Physiol Cell Physiol (2002) 0.96
Downregulation of renal TonEBP in hypokalemic rats. Am J Physiol Renal Physiol (2007) 0.95
Involvement of multiple kinase pathways in stimulation of gene transcription by hypertonicity. Am J Physiol Cell Physiol (2002) 0.95
TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: organic osmolyte-dependent and -independent pathways. Am J Physiol Renal Physiol (2011) 0.94
RGS2 promotes formation of neurites by stimulating microtubule polymerization. Cell Signal (2006) 0.92
NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration. Front Physiol (2012) 0.92
Adaptation of kidney medulla to hypertonicity: role of the transcription factor TonEBP. Int Rev Cytol (2002) 0.91
Transcriptional activator TonE-binding protein in cellular protection and differentiation. Methods Enzymol (2007) 0.90
Novel nuclear localization signal regulated by ambient tonicity in vertebrates. J Biol Chem (2008) 0.89
Interstitial tonicity controls TonEBP expression in the renal medulla. Kidney Int (2008) 0.88
Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B. Nat Cell Biol (2006) 0.87
Mre11-Rad50-Nbs1 complex is activated by hypertonicity. Am J Physiol Renal Physiol (2006) 0.86
TonEBP is inhibited by RNA helicase A via interaction involving the E'F loop. Biochem J (2006) 0.86
Chronic ouabain treatment induces vasa recta endothelial dysfunction in the rat. Am J Physiol Renal Physiol (2008) 0.85
Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity. Pflugers Arch (2009) 0.85
Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis. Am J Physiol Renal Physiol (2008) 0.84
Renal ischemia-reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct. Histochem Cell Biol (2011) 0.83
The xanthine oxidase-NFAT5 pathway regulates macrophage activation and TLR-induced inflammatory arthritis. Eur J Immunol (2014) 0.83
Inhibition of phospholipase C-beta1-mediated signaling by O-GlcNAc modification. J Cell Physiol (2006) 0.82
A Method for Assaying Deubiquitinating Enzymes. Biol Proced Online (1998) 0.81
Diverse cellular and physiological roles of phospholipase C-γ1. Adv Biol Regul (2012) 0.80
Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes. Biochem Biophys Res Commun (2006) 0.79
Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes. Biochem Biophys Res Commun (2008) 0.79
Distinct cellular pathways for resistance to urea stress and hypertonic stress. Am J Physiol Cell Physiol (2010) 0.78
Hypertonicity stimulates PGE2 signaling in the renal medulla by promoting EP3 and EP4 receptor expression. Kidney Int (2008) 0.77
Protein misfolding in hypertonic stress: new insights into an old idea. Focus on "genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged protein as an essential hypertonic stress response". Am J Physiol Cell Physiol (2008) 0.76
Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis. J Clin Invest (2017) 0.75