PubRank

Thomas L James

Author PubWeight™ 45.51‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 DOCK 6: combining techniques to model RNA-small molecule complexes. RNA 2009 2.75
2 Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov 2008 1.95
3 A molecular switch underlies a human telomerase disease. Proc Natl Acad Sci U S A 2002 1.79
4 Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage. Proc Natl Acad Sci U S A 2008 1.35
5 Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA. Chem Biol 2002 1.30
6 Locally disordered conformer of the hamster prion protein: a crucial intermediate to PrPSc? Biochemistry 2002 1.24
7 NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126. Proc Natl Acad Sci U S A 2003 1.22
8 Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms. J Biol Chem 2008 1.20
9 Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A. J Biol Chem 2005 1.19
10 NMR-based characterization of phenothiazines as a RNA binding scaffold. J Am Chem Soc 2004 1.17
11 X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. RNA 2007 1.16
12 Solution structure of a consensus stem-loop D RNA domain that plays important roles in regulating translation and replication in enteroviruses and rhinoviruses. Biochemistry 2004 1.08
13 Structure of TAR RNA complexed with a Tat-TAR interaction nanomolar inhibitor that was identified by computational screening. Chem Biol 2002 1.06
14 Docking to RNA via root-mean-square-deviation-driven energy minimization with flexible ligands and flexible targets. J Chem Inf Model 2008 1.04
15 PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. Brain Res Mol Brain Res 2004 1.02
16 Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J Cereb Blood Flow Metab 2006 1.01
17 Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA. Chem Biol 2006 1.01
18 Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution. Nucleic Acids Res 2007 0.99
19 NMR structure of the full-length linear dimer of stem-loop-1 RNA in the HIV-1 dimer initiation site. J Biol Chem 2006 0.99
20 Pseudoknot structures with conserved base triples in telomerase RNAs of ciliates. Nucleic Acids Res 2007 0.96
21 High-resolution NMR structure of an AT-rich DNA sequence. J Biomol NMR 2002 0.96
22 Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia. J Cereb Blood Flow Metab 2010 0.93
23 Extending the family of UNCG-like tetraloop motifs: NMR structure of a CACG tetraloop from coxsackievirus B3. Biochemistry 2003 0.92
24 NMR structures of loop B RNAs from the stem-loop IV domain of the enterovirus internal ribosome entry site: a single C to U substitution drastically changes the shape and flexibility of RNA. Biochemistry 2004 0.92
25 Discovery of ligands for a novel target, the human telomerase RNA, based on flexible-target virtual screening and NMR. J Med Chem 2008 0.92
26 Slow conformational dynamics in the hamster prion protein. Biochemistry 2004 0.92
27 In vivo monitoring of hepatic glutathione in anesthetized rats by 13C NMR. Magn Reson Med 2002 0.91
28 Nucleocapsid protein-mediated maturation of dimer initiation complex of full-length SL1 stemloop of HIV-1: sequence effects and mechanism of RNA refolding. Nucleic Acids Res 2007 0.89
29 Specific recognition of the C-rich strand of human telomeric DNA and the RNA template of human telomerase by the first KH domain of human poly(C)-binding protein-2. J Biol Chem 2004 0.89
30 Detecting ligand binding to a small RNA target via saturation transfer difference NMR experiments in D(2)O and H(2)O. J Am Chem Soc 2002 0.88
31 Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology 2007 0.88
32 1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries. Pediatr Res 2013 0.87
33 Structure-activity relationships of aminoglycoside-arginine conjugates that bind HIV-1 RNAs as determined by fluorescence and NMR spectroscopy. FEBS Lett 2004 0.84
34 Discovery of ligands by a combination of computational and NMR-based screening: RNA as an example target. Methods Enzymol 2005 0.83
35 RNA structural motifs that entail hydrogen bonds involving sugar-phosphate backbone atoms of RNA. New J Chem 2010 0.82
36 NMR structure of a gemcitabine-substituted model Okazaki fragment. Biochemistry 2002 0.81
37 Dynamic NMR structures of [Rp]- and [Sp]-phosphorothioated DNA-RNA hybrids: is flexibility required for RNase H recognition? Biophys J 2003 0.78
38 NMR structure of the 3' stem-loop from human U4 snRNA. Nucleic Acids Res 2002 0.78
39 Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices. J Neurochem 2002 0.78
40 Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices. J Bioenerg Biomembr 2004 0.78
41 Temperature control of respiring rat brain slices during high field NMR spectroscopy. Brain Res Brain Res Protoc 2003 0.78
42 Binding characteristics of small molecules that mimic nucleocapsid protein-induced maturation of stem-loop 1 of HIV-1 RNA. Biochemistry 2010 0.77
43 13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation. Anesthesiology 2013 0.76
44 A small molecule, Lys-Ala-7-amido-4-methylcoumarin, facilitates RNA dimer maturation of a stem-loop 1 transcript in vitro: structure-activity relationship of the activator. Biochemistry 2008 0.76
45 Resonance assignment of the first and second KH (hnRNP-K homology) domains of human poly(C)-binding protein-2 (PCBP2). J Biomol NMR 2007 0.75
46 Optimizing QSAR models for predicting ligand binding to the drug-metabolizing cytochrome P450 isoenzyme CYP2D6. Chem Biol Drug Des 2011 0.75
47 Does activation of the anti proton, rather than concertedness, determine the stereochemistry of base-catalyzed 1,2-elimination reactions? Anti stereospecificity in E1cB eliminations of β-3-trifluoromethylphenoxy esters, thioesters, and ketones. J Org Chem 2012 0.75