Published in Cancer Cell on February 01, 2002
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell (2010) 7.78
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res (2007) 6.91
Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Res (2006) 4.25
A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res (2008) 4.06
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast. Genes Dev (2005) 1.89
Molecular basis for expression of common and rare fragile sites. Mol Cell Biol (2003) 1.78
Telomeres, chromosome instability and cancer. Nucleic Acids Res (2006) 1.67
DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. Oncogene (2008) 1.63
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Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol Cancer (2010) 1.56
Is mammalian chromosomal evolution driven by regions of genome fragility? Genome Biol (2006) 1.54
DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line. Neoplasia (2002) 1.47
High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Natl Acad Sci U S A (2002) 1.46
A mechanism of palindromic gene amplification in Saccharomyces cerevisiae. Genes Dev (2005) 1.45
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol Cell Biol (2002) 1.43
Genomic instability in breast cancer: pathogenesis and clinical implications. Mol Oncol (2010) 1.43
Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes. Genome Res (2006) 1.40
Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution. BMC Evol Biol (2009) 1.40
Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites. Proc Natl Acad Sci U S A (2005) 1.31
Molecular analysis of sister chromatid recombination in mammalian cells. DNA Repair (Amst) (2005) 1.30
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. Cancer Biol Ther (2011) 1.26
Chromosomal instability at common fragile sites in Seckel syndrome. Am J Hum Genet (2004) 1.15
Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer. Mol Cancer (2005) 1.14
DNA instability at chromosomal fragile sites in cancer. Curr Genomics (2010) 1.11
Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal (2009) 1.11
The role of the c-Met pathway in lung cancer and the potential for targeted therapy. Ther Adv Med Oncol (2011) 1.11
Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Sci Signal (2013) 1.10
DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells. Oncogene (2010) 1.09
Common fragile sites are characterized by histone hypoacetylation. Hum Mol Genet (2009) 1.02
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature. Oral Oncol (2007) 1.02
Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. PLoS One (2012) 1.00
Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Invest New Drugs (2009) 0.99
The MET axis as a therapeutic target. Update Cancer Ther (2009) 0.98
Classification of human cancers based on DNA copy number amplification modeling. BMC Med Genomics (2008) 0.97
C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes. Cancer Biol Ther (2008) 0.92
Selective regain of egfr gene copies in CD44+/CD24-/low breast cancer cellular model MDA-MB-468. BMC Cancer (2010) 0.91
Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination. PLoS Genet (2013) 0.91
DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification. Oncogene (2014) 0.90
Deletion at fragile sites is a common and early event in Barrett's esophagus. Mol Cancer Res (2010) 0.89
A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma (2012) 0.89
Assessment of palindromes as platforms for DNA amplification in breast cancer. Genome Res (2011) 0.88
Common fragile sites: genomic hotspots of DNA damage and carcinogenesis. Int J Mol Sci (2012) 0.87
SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma. Neoplasia (2003) 0.86
Homology-mediated end-capping as a primary step of sister chromatid fusion in the breakage-fusion-bridge cycles. Nucleic Acids Res (2013) 0.85
Targeting MET in Lung Cancer: Will Expectations Finally Be MET? J Thorac Oncol (2016) 0.85
Evidence for a novel mechanism for gene amplification in multiple myeloma: 1q12 pericentromeric heterochromatin mediates breakage-fusion-bridge cycles of a 1q12 approximately 23 amplicon. Br J Haematol (2009) 0.84
The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome. Nucleic Acids Res (2009) 0.82
ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. Mutat Res (2010) 0.81
Karyotype structure and chromosome fragility in the grass Phleum echinatum Host. Protoplasma (2014) 0.80
Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats. Hum Genet (2012) 0.80
Impaired replication dynamics at the FRA3B common fragile site. Hum Mol Genet (2010) 0.80
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways. Breast Cancer Res (2014) 0.79
Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity. World J Gastroenterol (2006) 0.79
How a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells. PLoS One (2014) 0.79
Ladder-like amplification of the type I interferon gene cluster in the human osteosarcoma cell line MG63. Chromosome Res (2008) 0.79
Two breakpoint clusters at fragile site FRA3B form phased nucleosomes. Genome Res (2004) 0.79
Prognostic value of MET protein overexpression and gene amplification in locoregionally advanced nasopharyngeal carcinoma. Oncotarget (2015) 0.78
The role of fragile sites in sporadic papillary thyroid carcinoma. J Thyroid Res (2012) 0.77
Genome organization, instabilities, stem cells, and cancer. J Stem Cells Regen Med (2009) 0.77
Rescue from replication stress during mitosis. Cell Cycle (2017) 0.75
High chromosomal instability in workers occupationally exposed to solvents and paint removers. Mol Cytogenet (2016) 0.75
Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites. Sci Rep (2013) 0.75
Fragile Sites of 'Valencia' Sweet Orange (Citrus sinensis) Chromosomes Are Related with Active 45s rDNA. PLoS One (2016) 0.75
Multicolour-banding fluorescence in situ hybridisation (mbanding-FISH) to identify recurrent chromosomal alterations in breast tumour cell lines. Br J Cancer (2005) 0.75
TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. BMC Cancer (2015) 0.75
Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies. Biomolecules (2017) 0.75
FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage. J Med Genet (2007) 0.75
Perturbations in the Replication Program Contribute to Genomic Instability in Cancer. Int J Mol Sci (2017) 0.75
[Different coexisting genotypes in the breast cancer cell line MDA-MB-468]. Pathologe (2008) 0.75
The "enemies within": regions of the genome that are inherently difficult to replicate. F1000Res (2017) 0.75
Global variation in copy number in the human genome. Nature (2006) 57.50
Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
The diploid genome sequence of an individual human. PLoS Biol (2007) 44.80
Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
Structural variation in the human genome. Nat Rev Genet (2006) 21.40
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet (2010) 13.70
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Prepublication data sharing. Nature (2009) 12.24
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
Copy number variation: new insights in genome diversity. Genome Res (2006) 8.66
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Genome assembly comparison identifies structural variants in the human genome. Nat Genet (2006) 6.93
Copy-number variations associated with neuropsychiatric conditions. Nature (2008) 6.78
Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays. Genome Res (2006) 5.97
Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med (2009) 5.50
Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res (2006) 5.50
Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors. Oncogene (2002) 5.40
Severe expressive-language delay related to duplication of the Williams-Beuren locus. N Engl J Med (2005) 5.37
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly. Proc Natl Acad Sci U S A (2002) 5.18
Contribution of SHANK3 mutations to autism spectrum disorder. Am J Hum Genet (2007) 5.04
Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell (2011) 4.83
Structural variants: changing the landscape of chromosomes and design of disease studies. Hum Mol Genet (2006) 4.60
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet (2009) 4.52
Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. N Engl J Med (2003) 4.43
The Database of Genomic Variants: a curated collection of structural variation in the human genome. Nucleic Acids Res (2013) 4.42
Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial. Lancet (2008) 4.35
Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence. Genome Biol (2003) 4.32
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Public data archives for genomic structural variation. Nat Genet (2010) 3.92
Copy-number variation in control population cohorts. Hum Mol Genet (2007) 3.88
Mutations in SUFU predispose to medulloblastoma. Nat Genet (2002) 3.78
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat Genet (2010) 3.73
Hotspots for copy number variation in chimpanzees and humans. Proc Natl Acad Sci U S A (2006) 3.68
Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing. Nat Genet (2010) 3.49
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A (2009) 3.49
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants. Nat Biotechnol (2011) 3.25
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A (2005) 3.16
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet (2011) 3.16
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet (2010) 3.11
Human chromosome 7: DNA sequence and biology. Science (2003) 3.02
Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clin Cancer Res (2005) 2.98
Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature (2012) 2.96
Germ-line DNA copy number variation frequencies in a large North American population. Hum Genet (2007) 2.94
Genetic architecture in autism spectrum disorder. Curr Opin Genet Dev (2012) 2.86
Towards a comprehensive structural variation map of an individual human genome. Genome Biol (2010) 2.79
Copy number variations and risk for schizophrenia in 22q11.2 deletion syndrome. Hum Mol Genet (2008) 2.76
CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290. Am J Hum Genet (2008) 2.68
Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. PLoS Genet (2012) 2.65
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature (2011) 2.59
Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry (2012) 2.48
Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet (2013) 2.47
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet (2010) 2.46
Alterations in the common fragile site gene Parkin in ovarian and other cancers. Oncogene (2003) 2.44
Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. J Biol Chem (2003) 2.40
Chromosomal regions containing high-density and ambiguously mapped putative single nucleotide polymorphisms (SNPs) correlate with segmental duplications in the human genome. Hum Mol Genet (2002) 2.34
Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Sci Transl Med (2011) 2.29
Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy. Clin Cancer Res (2005) 2.29
Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder. J Med Genet (2009) 2.27
Genomic inversions of human chromosome 15q11-q13 in mothers of Angelman syndrome patients with class II (BP2/3) deletions. Hum Mol Genet (2003) 2.25
Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome. Proc Natl Acad Sci U S A (2008) 2.22
Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer (2004) 2.20
Genetic analysis of patients with the Saethre-Chotzen phenotype. Am J Med Genet (2002) 2.17
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene (2002) 2.16
Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia. Am J Hum Genet (2006) 2.14
3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer. BMC Genomics (2009) 2.12
Enrichment of segmental duplications in regions of breaks of synteny between the human and mouse genomes suggest their involvement in evolutionary rearrangements. Hum Mol Genet (2003) 2.07
Discovery of human inversion polymorphisms by comparative analysis of human and chimpanzee DNA sequence assemblies. PLoS Genet (2005) 2.05
The clinical context of copy number variation in the human genome. Expert Rev Mol Med (2010) 2.00
Long, abundantly expressed non-coding transcripts are altered in cancer. Hum Mol Genet (2007) 2.00
Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. Oncogene (2003) 2.00
Mutations in NHLRC1 cause progressive myoclonus epilepsy. Nat Genet (2003) 2.00
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites. Mol Cell (2011) 1.98
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
Mutations in CHEK2 associated with prostate cancer risk. Am J Hum Genet (2003) 1.96
Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas. Blood (2012) 1.96
hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. Gastroenterology (2004) 1.95
Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease. Am J Psychiatry (2010) 1.95