Published in J Biol Chem on June 26, 2002
Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science (2011) 8.88
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
Links between metabolism and cancer. Genes Dev (2012) 5.27
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A (2007) 4.87
N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol (2007) 4.63
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. Proc Natl Acad Sci U S A (2011) 3.39
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol (2003) 2.95
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab (2012) 2.86
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog (2010) 2.48
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest (2006) 2.09
Structure, mechanism and regulation of pyruvate carboxylase. Biochem J (2008) 2.03
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem (2007) 1.85
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest (2013) 1.84
An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer Cell (2016) 1.79
Transcript profiling of the anoxic rice coleoptile. Plant Physiol (2007) 1.73
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol Cell (2014) 1.63
Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res (2015) 1.53
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J Lipid Res (2012) 1.53
Resurgence of serine: an often neglected but indispensable amino Acid. J Biol Chem (2012) 1.51
Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat. J Biol Chem (2008) 1.49
Structure and function of biotin-dependent carboxylases. Cell Mol Life Sci (2012) 1.46
Flux balance analysis of barley seeds: a computational approach to study systemic properties of central metabolism. Plant Physiol (2008) 1.43
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget (2012) 1.33
Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol (2013) 1.29
Glucose metabolism and cardiac hypertrophy. Cardiovasc Res (2011) 1.28
Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism. Nutr Metab (Lond) (2005) 1.25
GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem (2009) 1.23
Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab (2012) 1.22
Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci (2013) 1.21
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J Clin Invest (2015) 1.19
Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulm Circ (2012) 1.19
Genomic makeup of the marine flavobacterium Nonlabens (Donghaeana) dokdonensis and identification of a novel class of rhodopsins. Genome Biol Evol (2013) 1.18
Metabolic reprogramming and metabolic dependency in T cells. Immunol Rev (2012) 1.18
Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem (2010) 1.17
Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. Nat Protoc (2014) 1.15
A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network. PLoS One (2008) 1.14
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol (2010) 1.13
Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. J Biol Chem (2011) 1.11
Carboxylases in natural and synthetic microbial pathways. Appl Environ Microbiol (2011) 1.10
Cardiac anaplerosis in health and disease: food for thought. Cardiovasc Res (2011) 1.09
Fundamentals of cancer metabolism. Sci Adv (2016) 1.09
Bench-to-bedside review: Citrate for continuous renal replacement therapy, from science to practice. Crit Care (2012) 1.08
Hypercarnivory and the brain: protein requirements of cats reconsidered. J Comp Physiol B (2010) 1.08
Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target. Int J Biochem Cell Biol (2012) 1.07
Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab (2014) 1.06
Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol (2015) 1.03
Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. PLoS One (2014) 1.03
Metabolism addiction in pancreatic cancer. Cell Death Dis (2014) 1.02
The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: has it been overlooked? Biochim Biophys Acta (2013) 1.02
Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation. ACS Chem Biol (2010) 1.01
A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis. J Biol Chem (2014) 1.01
Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ. Front Endocrinol (Lausanne) (2011) 0.98
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis (2015) 0.95
Metabolic effects of glutamine on the heart: anaplerosis versus the hexosamine biosynthetic pathway. J Mol Cell Cardiol (2012) 0.95
Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H₂O₂. J Neurochem (2011) 0.93
Thematic minireview series: a perspective on the biology of phosphoenolpyruvate carboxykinase 55 years after its discovery. J Biol Chem (2009) 0.93
Born to run; the story of the PEPCK-Cmus mouse. Biochimie (2008) 0.93
Mass isotopomer study of anaplerosis from propionate in the perfused rat heart. Arch Biochem Biophys (2007) 0.93
Controlled biosynthesis of odd-chain fuels and chemicals via engineered modular metabolic pathways. Proc Natl Acad Sci U S A (2012) 0.93
A high calcium diet containing nonfat dry milk reduces weight gain and associated adipose tissue inflammation in diet-induced obese mice when compared to high calcium alone. Nutr Metab (Lond) (2012) 0.92
First characterization of an archaeal GTP-dependent phosphoenolpyruvate carboxykinase from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1. J Bacteriol (2004) 0.92
The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep. PLoS One (2011) 0.91
Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features. Proc Natl Acad Sci U S A (2016) 0.91
Unmeasured anions: the unknown unknowns. Crit Care (2008) 0.91
Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals. Plant Physiol (2003) 0.91
Phosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosis. PLoS Genet (2009) 0.90
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. Front Oncol (2014) 0.89
Phosphoenolpyruvate carboxykinase in cucumber plants is increased both by ammonium and by acidification, and is present in the phloem. Planta (2004) 0.89
Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport. J Biol Chem (2011) 0.89
Triheptanoin improves brain energy metabolism in patients with Huntington disease. Neurology (2015) 0.89
Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells. J Physiol (2017) 0.88
Triheptanoin--a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment? Epilepsy Res (2011) 0.88
Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells. PLoS One (2015) 0.87
Alteration of mitochondrial function in adult rat offspring of malnourished dams. World J Diabetes (2011) 0.87
Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase. Mol Biol Cell (2012) 0.87
Metabolite profile changes in xylem sap and leaf extracts of strategy I plants in response to iron deficiency and resupply. Front Plant Sci (2011) 0.87
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth. J Biol Chem (2013) 0.86
NADPH-generating systems in bacteria and archaea. Front Microbiol (2015) 0.86
Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease. J Pharmacol Exp Ther (2014) 0.86
Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease. J Alzheimers Dis (2010) 0.86
Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization. Mol Cell Biol (2014) 0.86
MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers. Comput Struct Biotechnol J (2016) 0.85
Metabolic regulation of T cell differentiation and function. Mol Immunol (2015) 0.85
Mitochondrial pyruvate transport: a historical perspective and future research directions. Biochem J (2015) 0.85
Metabolomic profiling of 13C-labelled cellulose digestion in a lower termite: insights into gut symbiont function. Proc Biol Sci (2014) 0.85
Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis (2015) 0.85
(13)C-labelled microdialysis studies of cerebral metabolism in TBI patients. Eur J Pharm Sci (2013) 0.84
c.A2456C-substitution in Pck1 changes the enzyme kinetic and functional properties modifying fat distribution in pigs. Sci Rep (2016) 0.83
Multiplexed quantification for data-independent acquisition. Anal Chem (2015) 0.83
Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury. J Bioenerg Biomembr (2014) 0.83
Effect of intravenous amino acids on glutamine and protein kinetics in low-birth-weight preterm infants during the immediate neonatal period. Am J Physiol Endocrinol Metab (2005) 0.83
A novel nuclear-encoded mitochondrial poly(A) polymerase PAPD1 is a potential candidate gene for the extreme obesity related phenotypes in mammals. Int J Biol Sci (2006) 0.83
Detoxification mechanisms of honey bees (Apis mellifera) resulting in tolerance of dietary nicotine. Sci Rep (2015) 0.82
Glutamine May Repress the Weak LPS and Enhance the Strong Heat Shock Induction of Monocyte and Lymphocyte HSP72 Proteins but May Not Modulate the HSP72 mRNA in Patients with Sepsis or Trauma. Biomed Res Int (2015) 0.82
Metabolomics of Human Amniotic Fluid and Maternal Plasma during Normal Pregnancy. PLoS One (2016) 0.82
Did we get pasteur, warburg, and crabtree on a right note? Front Oncol (2013) 0.82
Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptor γ. Temperature (Austin) (2015) 0.82
2-Hydrazinoquinoline as a Derivatization Agent for LC-MS-Based Metabolomic Investigation of Diabetic Ketoacidosis. Metabolites (2013) 0.82
Impaired mitochondrial metabolism and mammary carcinogenesis. J Mammary Gland Biol Neoplasia (2012) 0.82
Analysis of the adult human plasma metabolome. Pharmacogenomics (2008) 3.74
Glyceroneogenesis and the triglyceride/fatty acid cycle. J Biol Chem (2003) 2.60
Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab (2003) 2.56
Knowledge gaps and research needs for understanding and treating neonatal hypoglycemia: workshop report from Eunice Kennedy Shriver National Institute of Child Health and Human Development. J Pediatr (2009) 2.27
TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes (2002) 2.20
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem (2007) 1.85
Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C. Crit Rev Biochem Mol Biol (2005) 1.85
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab (2010) 1.80
Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism (2010) 1.77
Nanoparticles of compacted DNA transfect postmitotic cells. J Biol Chem (2003) 1.58
What is the metabolic role of phosphoenolpyruvate carboxykinase? J Biol Chem (2009) 1.57
Resurgence of serine: an often neglected but indispensable amino Acid. J Biol Chem (2012) 1.51
Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat. J Biol Chem (2008) 1.49
Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism. Nutr Metab (Lond) (2005) 1.25
A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice. Proc Natl Acad Sci U S A (2002) 1.25
Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha. J Biol Chem (2005) 1.19
SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. J Biol Chem (2004) 1.18
Reassessing triglyceride synthesis in adipose tissue. Trends Endocrinol Metab (2008) 1.18
Aspects of the control of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem (2009) 1.13
Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Am J Physiol Gastrointest Liver Physiol (2004) 1.13
Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. J Biol Chem (2009) 1.12
Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. J Biol Chem (2005) 1.05
Metabolic and genomic response to dietary isocaloric protein restriction in the rat. J Biol Chem (2010) 1.05
Gender differences in the regulation of amino acid metabolism. J Appl Physiol (1985) (2003) 1.03
Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis rat. Am J Physiol Gastrointest Liver Physiol (2006) 1.02
Methionine metabolism in human pregnancy. Am J Clin Nutr (2009) 1.01
Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula. J Pediatr (2002) 1.01
Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult. Am J Physiol Endocrinol Metab (2006) 0.99
Sarcopenia associated with portosystemic shunting is reversed by follistatin. J Hepatol (2010) 0.99
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology (2012) 0.98
Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. Am J Physiol Gastrointest Liver Physiol (2009) 0.95
Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem (2012) 0.92
Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. J Pediatr (2005) 0.90
Maternal nutrition and optimal infant feeding practices: executive summary. Am J Clin Nutr (2007) 0.90
A computer model of gluconeogenesis and lipid metabolism in the perfused liver. Am J Physiol Endocrinol Metab (2007) 0.90
Plasma levels of asymmetric dimethylarginine in patients with biopsy-proven nonalcoholic fatty liver disease. Metabolism (2010) 0.89
Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans. Metabolism (2008) 0.88
Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol (2011) 0.87
Amino acids, glutamine, and protein metabolism in very low birth weight infants. Pediatr Res (2005) 0.87
Identification of conserved regulatory elements in mammalian promoter regions: a case study using the PCK1 promoter. Genomics Proteomics Bioinformatics (2008) 0.86
Fatty acids, insulin resistance, and protein metabolism. J Clin Endocrinol Metab (2009) 0.86
Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a Western diet. J Biol Chem (2013) 0.85
The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene. Gene (2003) 0.85
Insulin regulation of phosphoenolpyruvate carboxykinase-c gene transcription: the role of sterol regulatory element-binding protein 1c. Nutr Rev (2007) 0.85
Parenteral amino acid and metabolic acidosis in premature infants. JPEN J Parenter Enteral Nutr (2007) 0.84
Multi-scale characterization of the PEPCK-C mouse through 3D cryo-imaging. Int J Biomed Imaging (2010) 0.84
Metabolism of methionine in the newborn infant: response to the parenteral and enteral administration of nutrients. Pediatr Res (2008) 0.83
Effect of intravenous amino acids on glutamine and protein kinetics in low-birth-weight preterm infants during the immediate neonatal period. Am J Physiol Endocrinol Metab (2005) 0.83
Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants. Am J Clin Nutr (2004) 0.82
Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells. J Biol Chem (2013) 0.82
Lactate disposal via gluconeogenesis is increased during exercise in patients with mitochondrial myopathy due to complex I deficiency. Pediatr Res (2002) 0.81
Querying metabolism under different physiological constraints. J Bioinform Comput Biol (2010) 0.81
Metabolic responses to protein restriction during pregnancy in rat and translation initiation factors in the mother and fetus. Pediatr Res (2004) 0.81
A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases. J Theor Biol (2007) 0.81
Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBP-mediated activation. J Biol Chem (2003) 0.81
Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest (2016) 0.81
Optimal protein intake in healthy infants. Am J Clin Nutr (2009) 0.80
Standardized Beck Depression Inventory-II scores for male veterans coping with chronic pain. Psychol Serv (2012) 0.80
Gluconeogenesis in humans with induced hyperlactatemia during low-intensity exercise. Am J Physiol Endocrinol Metab (2003) 0.80
Effect of reduced maternal inspired oxygen on hepatic glucose metabolism in the rat fetus. Pediatr Res (2003) 0.79
Triacylglycerol infusion improves exercise endurance in patients with mitochondrial myopathy due to complex I deficiency. Am J Clin Nutr (2002) 0.79
Simultaneous assay of isotopic enrichment and concentration of guanidinoacetate and creatine by gas chromatography-mass spectrometry. Anal Biochem (2009) 0.79
Glutamine and leucine nitrogen kinetics and their relation to urea nitrogen in newborn infants. Am J Physiol Endocrinol Metab (2002) 0.79
Glutamine supplementation in the newborn infant. Semin Fetal Neonatal Med (2006) 0.79
Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism. J Biol Chem (2011) 0.79
Recovery of chemical estimates by field inhomogeneity neighborhood error detection (REFINED): fat/water separation at 7 tesla. J Magn Reson Imaging (2012) 0.78
Re: "alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins" by Ramakrishnan (Metabolism 2007;56:1550-60). Metabolism (2008) 0.78
Metabolism of threonine in newborn infants. Am J Physiol Endocrinol Metab (2005) 0.77
Regulation of Adipose Tissue Metabolism in Humans: Analysis of Responses to the Hyperinsulinemic-Euglycemic Clamp Experiment. Cell Mol Bioeng (2011) 0.77
Obesity, hepatic metabolism and disease. Nestle Nutr Workshop Ser Pediatr Program (2009) 0.77
Hepatic fat during fasting and refeeding by MRI fat quantification. J Magn Reson Imaging (2014) 0.76
Triacylglycerol infusion does not improve hyperlactemia in resting patients with mitochondrial myopathy due to complex I deficiency. Am J Clin Nutr (2002) 0.76
Sidney Weinhouse and the mechanism of ketone body synthesis from fatty acids. J Biol Chem (2005) 0.75
Concluding remarks. Nestle Nutr Inst Workshop Ser (2013) 0.75
Nutrition. Semin Fetal Neonatal Med (2006) 0.75
Do abnormal liver function tests predict inpatient imaging yield? An evaluation of clinical decision making. J Eval Clin Pract (2002) 0.75