Published in Prog Neurobiol on January 05, 2007
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives. Nat Rev Drug Discov (2010) 4.55
APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain. Biol Psychiatry (2013) 1.95
Body mass index and magnetic resonance markers of brain integrity in adults. Ann Neurol (2008) 1.88
Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J Cereb Blood Flow Metab (2009) 1.85
Spinal cord repair in MS: does mitochondrial metabolism play a role? Neurology (2010) 1.56
Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS. Proc Natl Acad Sci U S A (2016) 1.55
Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. Alcohol Clin Exp Res (2011) 1.50
Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis. Brain (2015) 1.46
Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies. Alzheimers Res Ther (2011) 1.43
Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: an 1H-magnetic resonance spectroscopy study. J Neurotrauma (2009) 1.39
Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia. Anesthesiology (2015) 1.38
Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole. Neuropsychopharmacology (2009) 1.36
Chronic cigarette smoking: implications for neurocognition and brain neurobiology. Int J Environ Res Public Health (2010) 1.36
Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. PLoS One (2011) 1.35
Assessments of function and biochemistry of the anterior cingulate cortex in schizophrenia. Biol Psychiatry (2010) 1.33
The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective. ASN Neuro (2010) 1.26
Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. J Neurosci (2008) 1.23
Loss of neuronal integrity during progressive HIV-1 infection of humanized mice. J Neurosci (2011) 1.22
Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection. Am J Pathol (2009) 1.19
Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction. Ann N Y Acad Sci (2010) 1.17
The structure of creative cognition in the human brain. Front Hum Neurosci (2013) 1.14
A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. Hum Mol Genet (2012) 1.13
The current state-of-the-art of spinal cord imaging: methods. Neuroimage (2013) 1.12
Metabolic changes in concussed American football players during the acute and chronic post-injury phases. BMC Neurol (2011) 1.07
A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder. Biol Psychiatry (2012) 1.07
Combined neuroimaging, neurocognitive and psychiatric factors to predict alcohol consumption following treatment for alcohol dependence. Alcohol Alcohol (2008) 1.06
Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism. J Neurodev Disord (2012) 1.06
Energy failure in multiple sclerosis and its investigation using MR techniques. J Neurol (2011) 1.06
White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis. J Cereb Blood Flow Metab (2012) 1.04
Brain-mapping techniques for evaluating poststroke recovery and rehabilitation: a review. Top Stroke Rehabil (2008) 1.03
Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy. Biol Psychiatry (2009) 1.02
Regional decoupling of N-acetyl-aspartate and glutamate in schizophrenia. Neuropsychopharmacology (2012) 1.02
A longitudinal proton magnetic resonance spectroscopy study of mild traumatic brain injury. J Neurotrauma (2011) 1.02
Beyond vascularization: aerobic fitness is associated with N-acetylaspartate and working memory. Brain Behav (2012) 1.01
Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain. J Comp Neurol (2010) 0.98
Molecular characterization of N-acetylaspartylglutamate synthetase. J Biol Chem (2010) 0.98
Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking. Alzheimers Dement (2012) 0.98
N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation. Front Neuroenergetics (2013) 0.97
Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions. J Neurol Neurosurg Psychiatry (2014) 0.97
Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence. J Stud Alcohol Drugs (2010) 0.97
A narrative review of sports-related concussion and return-to-play testing with asymptomatic athletes. J Chiropr Med (2013) 0.95
Metabolomics of cerebrospinal fluid from humans treated for rabies. J Proteome Res (2012) 0.95
Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy. Epilepsy Res (2009) 0.95
N-acetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) in patients with schizophrenia. Schizophr Bull (2011) 0.94
Global average gray and white matter N-acetylaspartate concentration in the human brain. Neuroimage (2008) 0.94
Investigating axonal damage in multiple sclerosis by diffusion tensor spectroscopy. J Neurosci (2012) 0.94
Reduced frontal glutamate + glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophrenia. Schizophr Bull (2013) 0.94
Low thalamic NAA-concentration corresponds to strong neural activation in working memory in Kleine-Levin syndrome. PLoS One (2013) 0.94
Whole brain N-acetylaspartate concentration is conserved throughout normal aging. Neurobiol Aging (2012) 0.93
Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study. J Psychiatry Neurosci (2012) 0.93
Pathogenesis of CNS involvement in disorders of amino and organic acid metabolism. J Inherit Metab Dis (2008) 0.92
Brain dynamic neurochemical changes in dystonic patients: a magnetic resonance spectroscopy study. Mov Disord (2012) 0.92
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease. J Inherit Metab Dis (2010) 0.92
Recent advances in the application of metabolomics to Alzheimer's Disease. Biochim Biophys Acta (2013) 0.92
Decreased frontal lobe phosphocreatine levels in methamphetamine users. Drug Alcohol Depend (2012) 0.92
Metabolic acetate therapy for the treatment of traumatic brain injury. J Neurotrauma (2010) 0.92
What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of 'centralized' pain? Arthritis Res Ther (2014) 0.92
MRSI and DTI: a multimodal approach for improved detection of white matter abnormalities in alcohol and nicotine dependence. NMR Biomed (2009) 0.92
In vivo characterization of several rodent glioma models by 1H MRS. NMR Biomed (2011) 0.92
Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia. Neuropsychopharmacology (2013) 0.92
Altered anterior cingulate neurochemistry in emerging adult binge drinkers with a history of alcohol-induced blackouts. Alcohol Clin Exp Res (2014) 0.91
Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury. Biomed Res Int (2014) 0.91
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment. AIDS (2014) 0.90
Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment. Alcohol (2010) 0.90
Metabolic aspects of neuron-oligodendrocyte-astrocyte interactions. Front Endocrinol (Lausanne) (2013) 0.90
Biochemical support for the "threshold" theory of creativity: a magnetic resonance spectroscopy study. J Neurosci (2009) 0.90
Characterization of glucose-related metabolic pathways in differentiated rat oligodendrocyte lineage cells. Glia (2015) 0.90
Ovarian cyst fluid of serous ovarian tumors contains large quantities of the brain amino acid N-acetylaspartate. PLoS One (2010) 0.90
Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson's disease. Eur Radiol (2011) 0.89
Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla. Psychiatry Res (2011) 0.89
Neonatal brain metabolite concentrations: an in vivo magnetic resonance spectroscopy study with a clinical MR system at 3 Tesla. PLoS One (2013) 0.89
Relationship between fractional anisotropy of cerebral white matter and metabolite concentrations measured using (1)H magnetic resonance spectroscopy in healthy adults. Neuroimage (2012) 0.89
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology. J Neurotrauma (2010) 0.89
Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder. Depress Res Treat (2010) 0.89
Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging. Schizophr Res (2012) 0.89
Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. PLoS Genet (2011) 0.89
Measuring N-acetylaspartate synthesis in vivo using proton magnetic resonance spectroscopy. J Neurosci Methods (2008) 0.88
Is serum brain-derived neurotrophic factor related to craving for or use of alcohol, cocaine, or methamphetamine? Neuropsychiatr Dis Treat (2011) 0.88
Two-year serial whole-brain N-acetyl-L-aspartate in patients with relapsing-remitting multiple sclerosis. Neurology (2012) 0.88
Functional imaging and related techniques: an introduction for rehabilitation researchers. J Rehabil Res Dev (2010) 0.87
Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination. Neurobiol Dis (2010) 0.87
Axonal damage in multiple sclerosis. Mt Sinai J Med (2011) 0.87
A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis. J Neurodev Disord (2015) 0.87
Absence of age-related prefrontal NAA change in adults with autism spectrum disorders. Transl Psychiatry (2012) 0.87
Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab (2009) 0.87
Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders? J Neuroimmune Pharmacol (2012) 0.87
Neuroimaging after coma. Neuroradiology (2010) 0.87
Extensive aspartoacylase expression in the rat central nervous system. Glia (2011) 0.87
Glutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study. Transl Psychiatry (2014) 0.87
A pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD. Eur Neuropsychopharmacol (2012) 0.87
Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden. J Psychiatry Neurosci (2013) 0.86
Extended findings of brain metabolite normalization in MA-dependent subjects across sustained abstinence: a proton MRS study. Drug Alcohol Depend (2010) 0.86
1H-MRS in spinal cord injury: acute and chronic metabolite alterations in rat brain and lumbar spinal cord. Eur J Neurosci (2011) 0.86
Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis. Cancer Metab (2016) 0.86
Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure. Metabolomics (2012) 0.85
Role of Increased n-acetylaspartate Levels in Cancer. J Natl Cancer Inst (2016) 0.85
Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders. Hum Brain Mapp (2014) 0.85
Proton magnetic resonance spectroscopy of human cervical spondylosis at 3T. Spinal Cord (2013) 0.85
Metabolic changes in the spinal cord after brachial plexus root re-implantation. Neurorehabil Neural Repair (2012) 0.84
A default mode of brain function. Proc Natl Acad Sci U S A (2001) 50.73
Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res (2005) 30.44
Axonal transection in the lesions of multiple sclerosis. N Engl J Med (1998) 12.21
A review of MRI findings in schizophrenia. Schizophr Res (2001) 8.95
The acetate switch. Microbiol Mol Biol Rev (2005) 6.10
Energy substrates for neurons during neural activity: a critical review of the astrocyte-neuron lactate shuttle hypothesis. J Cereb Blood Flow Metab (2003) 4.77
The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol Psychiatry (1999) 4.26
The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem (2002) 4.20
ATP citrate lyase is an important component of cell growth and transformation. Oncogene (2005) 3.48
Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex (2000) 3.37
Glutamine synthetase: glial localization in brain. Science (1977) 3.14
Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Nat Genet (1993) 3.03
Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem (2000) 2.98
Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. Am J Med Genet (1988) 2.78
Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol (2001) 2.75
Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res (1979) 2.62
Neuroimaging in Alzheimer disease: an evidence-based review. Neuroimaging Clin N Am (2003) 2.43
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A (2004) 2.36
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study. Neurology (2000) 2.26
Probable Alzheimer disease: diagnosis with proton MR spectroscopy. Radiology (1995) 2.20
Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport (1996) 2.18
Bringing order to the glutamate chaos in schizophrenia. Neuron (2003) 2.12
Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med (1998) 2.10
Specificity of amino acid acylases. J Biol Chem (1952) 2.07
Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem (1992) 2.05
N-Acetyl-L-aspartic acid in brain. J Biol Chem (1956) 2.01
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem (2000) 2.00
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. AJNR Am J Neuroradiol (2003) 1.96
Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med (1995) 1.92
Preferential utilization of acetate by astrocytes is attributable to transport. J Neurosci (1998) 1.92
Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b. J Neurol (2001) 1.91
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors. Radiology (1989) 1.91
Neurobiology of ammonia. Prog Neurobiol (2002) 1.84
Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology (2005) 1.83
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease. Ann Neurol (2000) 1.82
N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem Res (2003) 1.81
Smaller frontal gray matter volume in postmortem schizophrenic brains. Am J Psychiatry (2002) 1.80
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci (2000) 1.79
Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience (1991) 1.78
Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J Neurochem (2001) 1.77
Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch Gen Psychiatry (1995) 1.71
N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev Neurosci (1998) 1.71
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J Pharmacol Exp Ther (2002) 1.70
Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential. J Neurosci (2005) 1.69
Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain (1994) 1.68
Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain (1998) 1.68
In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. Magn Reson Med (2004) 1.65
Connexins are critical for normal myelination in the CNS. J Neurosci (2003) 1.63
Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain. Hum Gene Ther (2002) 1.60
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease. Proc Natl Acad Sci U S A (2005) 1.60
Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS. NMR Biomed (1997) 1.60
Quantitative proton MRS of Pelizaeus-Merzbacher disease: evidence of dys- and hypomyelination. Neurology (2005) 1.59
The metabolic fate of 13N-labeled ammonia in rat brain. J Biol Chem (1979) 1.58
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis (2001) 1.57
Tricarboxylic acid cycle of glia in the in vivo human brain. NMR Biomed (2002) 1.57
Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease. J Cell Biol (1998) 1.53
Immunohistochemical localization of N-acetylaspartate in rat brain. Neuroreport (1991) 1.52
Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS. J Neurosci (2003) 1.48
N-acetylaspartate in neuropsychiatric disorders. Prog Neurobiol (1995) 1.47
Immunohistochemical localization of aspartoacylase in the rat central nervous system. J Comp Neurol (2004) 1.47
Magnetic resonance spectroscopy. J Neuroophthalmol (2005) 1.47
Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolites. Alcohol Clin Exp Res (2004) 1.45
N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSI. Schizophr Res (2005) 1.44
Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. J Biol Chem (2005) 1.42
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice. J Neurosci (2005) 1.42
Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation. Proc Natl Acad Sci U S A (2005) 1.42
Spongy degeneration of the central nervous system (van Bogaert and Bertrand type; Canavan's disease). A review. Hum Pathol (1973) 1.42
Canavan disease: mutations among Jewish and non-Jewish patients. Am J Hum Genet (1994) 1.40
Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging. Neurology (1993) 1.39
Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem J (1979) 1.39
N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues. J Neurochem (1972) 1.38
Anaplerotic molecules: current and future. J Inherit Metab Dis (2006) 1.36
Canavan disease: from spongy degeneration to molecular analysis. J Pediatr (1995) 1.36
Three or more copies of the proteolipid protein gene PLP1 cause severe Pelizaeus-Merzbacher disease. Brain (2005) 1.36
ATP-citrate lyase deficiency in the mouse. J Biol Chem (2003) 1.35
Sex differences in N-acetylaspartate correlates of general intelligence: an 1H-MRS study of normal human brain. Neuroimage (2005) 1.30
Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance. Radiology (1992) 1.28
Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling. J Neurochem (2000) 1.28
MRS shows abnormalities before symptoms in familial Alzheimer disease. Neurology (2006) 1.28
Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease. J Cell Biol (2002) 1.27
Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport (1998) 1.27
Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system. J Gene Med (2000) 1.27
Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol (1999) 1.27
Reduced glutamate neurotransmission in patients with Alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy study. MAGMA (2003) 1.26
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. J Neurochem (2001) 1.26
Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res (2004) 1.25
Control of brain volume during hyperosmolar and hypoosmolar conditions. Annu Rev Med (1993) 1.25
Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med (1990) 1.24
Studies on the distribution of N-acetyl-L-aspartic acid in brain. J Biol Chem (1957) 1.24
Acetate and fluoroacetate as possible markers for glial metabolism in vivo. Brain Res (1986) 1.24
Metabolism of glucose and glutamate by synaptosomes from mammalian cerebral cortex. J Neurochem (1969) 1.24
Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am J Psychiatry (1996) 1.23
Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making. NeuroRx (2005) 1.23
Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle. J Biol Chem (1994) 1.22
Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study. J Psychiatr Res (2006) 1.22
Characterization of the major brain osmolytes that accumulate in salt-loaded rats. Am J Physiol (1989) 1.21
Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis. Mult Scler (2005) 1.21
Progressive multifocal leukoencephalopathy: JC virus induced demyelination in the immune compromised host. J Neurovirol (2000) 1.21
In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo. J Neurochem (2000) 1.20
Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease. Proc Natl Acad Sci U S A (2005) 1.60
Prolonged laryngeal mask anaesthesia in a spontaneously breathing child. Paediatr Anaesth (2002) 1.40
Neurospectroscopy: the past, present and future. Chem Rev (2010) 1.21
Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients. NMR Biomed (2009) 1.12
Canavan disease and the role of N-acetylaspartate in myelin synthesis. Mol Cell Endocrinol (2006) 1.04
Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. Brain Res (2010) 1.04
Aspartoacylase is a regulated nuclear-cytoplasmic enzyme. FASEB J (2006) 1.02
Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain. J Comp Neurol (2010) 0.98
Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice. J Neurotrauma (2011) 0.98
Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy. Appl Opt (2007) 0.98
Systematic analysis of pleiotropy in C. elegans early embryogenesis. PLoS Comput Biol (2008) 0.96
Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain. J Pharmacol Exp Ther (2005) 0.95
Metabolic acetate therapy for the treatment of traumatic brain injury. J Neurotrauma (2010) 0.92
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease. J Inherit Metab Dis (2010) 0.92
Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators. J Neurochem (2006) 0.91
Magnetic resonance spectroscopic studies of alcoholism: from heavy drinking to alcohol dependence and back again. Alcohol Clin Exp Res (2005) 0.87
Extensive aspartoacylase expression in the rat central nervous system. Glia (2011) 0.87
Halting the revolving door of faculty turnover: recruiting and retaining clinician educators in an academic medical simulation center. Simul Healthc (2011) 0.87
N-acetylaspartate synthesis in the brain: mitochondria vs. microsomes. Brain Res (2008) 0.87
Expression of N-acetylaspartate and N-acetylaspartylglutamate in the nervous system. Adv Exp Med Biol (2006) 0.86
Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells. J Neurochem (2008) 0.86
Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal. J Cell Physiol (2007) 0.85
Automated data processing of [1H-decoupled] 13C MR spectra acquired from human brain in vivo. J Magn Reson (2003) 0.84
Hydrogen sulfide and asthma. Exp Physiol (2011) 0.84
Mutational analysis of aspartoacylase: implications for Canavan disease. Brain Res (2007) 0.83
Synthesis and characterization of silica-embedded iron oxide nanoparticles for magnetic resonance imaging. J Nanosci Nanotechnol (2004) 0.83
Magnetic resonance spectroscopy in neurological diagnosis. Neurol Clin (2009) 0.83
Predicting outcome of patients with high-grade gliomas after radiotherapy using quantitative analysis of T1-weighted magnetic resonance imaging. Int J Radiat Oncol Biol Phys (2007) 0.82
Defective myelin lipid synthesis as a pathogenic mechanism of Canavan disease. Adv Exp Med Biol (2006) 0.82
Modulation of cholinergic pathways and inflammatory mediators in blast-induced traumatic brain injury. Chem Biol Interact (2012) 0.82
Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells. Neurochem Int (2009) 0.82
NAA synthesis and functional roles. Adv Exp Med Biol (2006) 0.81
N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells. J Biol Chem (2013) 0.81
Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells. PLoS One (2013) 0.80
The Macy Interprofessional Collaborative Project, the University of Washington. J Allied Health (2010) 0.80
Contribution of systemic factors in the pathophysiology of repeated blast-induced neurotrauma. Neurosci Lett (2013) 0.79
Enzyme stabilization by glass-derived silicates in glass-exposed aqueous solutions. Homeopathy (2010) 0.79
Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study. Neuropsychiatr Dis Treat (2011) 0.79
SH-SY5Y neuroblastoma cells: a model system for studying biosynthesis of NAAG. Neuroreport (2004) 0.79
Do reductions in brain N-acetylaspartate levels contribute to the etiology of some neuropsychiatric disorders? J Neurosci Res (2013) 0.78
Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures. J Rehabil Res Dev (2012) 0.78
Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. Neurosci Lett (2011) 0.78
ISIS: The Institute for Simulation and Interprofessional Studies at the University of Washington. J Surg Educ (2011) 0.77
Laboratory research in homeopathy: con. Integr Cancer Ther (2006) 0.77
Repeated blast exposures cause brain DNA fragmentation in mice. J Neurotrauma (2014) 0.77
MRI tracer study of the cerebrospinal fluid drainage pathway in normal and hydrocephalic guinea pig brain. Tokai J Exp Clin Med (2005) 0.77
Preoperative fasting after soft drink intake: 2 hours may be enough. J Anesth (2002) 0.76
Preface: a brief review of N-acetylaspartate. Adv Exp Med Biol (2006) 0.75
Hydrogen sulphide in human nasal air quantified using thermal desorption and selected ion flow tube mass spectrometry. J Breath Res (2014) 0.75
Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells. Brain Res (2010) 0.75
Simopoly: improving simulation center operations through a tabletop simulation exercise. Simul Healthc (2014) 0.75
Persistent and high-level expression of human liver prolidase in vivo in mice using adenovirus. Chem Biol Interact (2012) 0.75
Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia. Adv Exp Med Biol (2006) 0.75