Published in N Engl J Med on June 27, 2002
Strategies to improve long-term outcomes after renal transplantation. N Engl J Med (2002) 6.76
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet (2008) 13.15
Internet-based learning in the health professions: a meta-analysis. JAMA (2008) 8.74
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet (2006) 8.61
DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med (2006) 7.90
Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol (2007) 7.79
Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid (2011) 7.17
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2010) 7.15
Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med (2007) 6.68
Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2008) 6.48
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2006) 5.58
We need minimally disruptive medicine. BMJ (2009) 5.35
Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ (2008) 5.16
The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab (2008) 4.90
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2011) 4.73
Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab (2008) 4.68
Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials. CMAJ (2004) 4.53
The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med (2009) 4.41
Need for expertise based randomised controlled trials. BMJ (2005) 4.34
Conducting systematic reviews of diagnostic studies: didactic guidelines. BMC Med Res Methodol (2002) 4.19
Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2009) 4.04
Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2012) 4.02
The idolatry of the surrogate. BMJ (2011) 3.81
Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2010) 3.80
A new 'mechanistic-practical" framework for designing and interpreting randomized trials. J Clin Epidemiol (2008) 3.75
Development of a theory of implementation and integration: Normalization Process Theory. Implement Sci (2009) 3.68
Instructional design variations in internet-based learning for health professions education: a systematic review and meta-analysis. Acad Med (2010) 3.56
GRADE guidelines 6. Rating the quality of evidence--imprecision. J Clin Epidemiol (2011) 3.54
Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Endocr Pract (2011) 3.40
Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab (2010) 3.40
Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care (2012) 3.20
Association between lipoprotein-associated phospholipase A2 and cardiovascular disease: a systematic review. Mayo Clin Proc (2007) 3.12
Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ (2007) 3.06
Thyroid cancer: zealous imaging has increased detection and treatment of low risk tumours. BMJ (2013) 3.05
Telecare for patients with type 1 diabetes and inadequate glycemic control: a randomized controlled trial and meta-analysis. Diabetes Care (2004) 2.93
Ultrasound-based transient elastography for the detection of hepatic fibrosis: systematic review and meta-analysis. Clin Gastroenterol Hepatol (2007) 2.93
New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol (2009) 2.92
Helping patients with type 2 diabetes mellitus make treatment decisions: statin choice randomized trial. Arch Intern Med (2007) 2.82
Investing in deliberation: a definition and classification of decision support interventions for people facing difficult health decisions. Med Decis Making (2010) 2.73
Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc (2007) 2.63
Understanding patients' experiences of treatment burden in chronic heart failure using normalization process theory. Ann Fam Med (2011) 2.59
An observational study found that authors of randomized controlled trials frequently use concealment of randomization and blinding, despite the failure to report these methods. J Clin Epidemiol (2004) 2.58
Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology (2008) 2.58
Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes (2003) 2.53
Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion. J Clin Endocrinol Metab (2008) 2.52
Let the patient revolution begin. BMJ (2013) 2.50
GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength. J Clin Epidemiol (2013) 2.46
Clinical review: behavioral interventions to prevent childhood obesity: a systematic review and metaanalyses of randomized trials. J Clin Endocrinol Metab (2008) 2.45
Posttransplantation diabetes: a systematic review of the literature. Diabetes Care (2002) 2.39
What do we mean by web-based learning? A systematic review of the variability of interventions. Med Educ (2010) 2.38
Author self-citation in the diabetes literature. CMAJ (2004) 2.38
The impact of penicillin resistance on short-term mortality in hospitalized adults with pneumococcal pneumonia: a systematic review and meta-analysis. Clin Infect Dis (2006) 2.37
Synthesizing evidence: shifting the focus from individual studies to the body of evidence. JAMA (2013) 2.31
Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials. J Clin Endocrinol Metab (2008) 2.21
Ethical issues in stopping randomized trials early because of apparent benefit. Ann Intern Med (2007) 2.21
Systematic reviewers neglect bias that results from trials stopped early for benefit. J Clin Epidemiol (2007) 2.20
Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction. Diabetes (2006) 2.20
Early stopping of randomized clinical trials for overt efficacy is problematic. J Clin Epidemiol (2008) 2.18
Cumulative complexity: a functional, patient-centered model of patient complexity can improve research and practice. J Clin Epidemiol (2012) 2.16
The chest pain choice decision aid: a randomized trial. Circ Cardiovasc Qual Outcomes (2012) 2.15
Perspective: the role of numeracy in health care. J Health Commun (2008) 2.11
Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis. J Clin Endocrinol Metab (2011) 2.11
Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. BMJ (2010) 2.05
Patient-important outcomes in registered diabetes trials. JAMA (2008) 2.00
Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2008) 1.99
Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab (2003) 1.92
An analysis of general medical and specialist journals that endorse CONSORT found that reporting was not enforced consistently. J Clin Epidemiol (2005) 1.89
Randomized trials in oncology stopped early for benefit. J Clin Oncol (2008) 1.89
Rethinking the patient: using Burden of Treatment Theory to understand the changing dynamics of illness. BMC Health Serv Res (2014) 1.81
Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab (2011) 1.81
Uncovering treatment burden as a key concept for stroke care: a systematic review of qualitative research. PLoS Med (2013) 1.79
Development of a clinical prediction rule for 30-day cardiac events in emergency department patients with chest pain and possible acute coronary syndrome. Ann Emerg Med (2011) 1.78
The design of a decision aid about diabetes medications for use during the consultation with patients with type 2 diabetes. Patient Educ Couns (2008) 1.75
Factors associated with 30-day readmission rates after percutaneous coronary intervention. Arch Intern Med (2011) 1.70
Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease. Stroke (2013) 1.68
Continuous glucose monitoring: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab (2011) 1.67
The Society for Vascular Surgery: clinical practice guidelines for the surgical placement and maintenance of arteriovenous hemodialysis access. J Vasc Surg (2008) 1.67
The undue influence of significant p-values on the perceived importance of study results. Acta Orthop (2005) 1.65
Pharmacologic interventions for painful diabetic neuropathy: An umbrella systematic review and comparative effectiveness network meta-analysis. Ann Intern Med (2014) 1.65
Factors associated with citation rates in the orthopedic literature. Can J Surg (2007) 1.63
Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns. J Clin Epidemiol (2007) 1.63
Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nat Clin Pract Endocrinol Metab (2006) 1.63
Clinical review: Drugs commonly associated with weight change: a systematic review and meta-analysis. J Clin Endocrinol Metab (2015) 1.63
Prevalence of thyroid cancer in multinodular goiter versus single nodule: a systematic review and meta-analysis. Thyroid (2013) 1.59
Clinical review: Antiandrogens for the treatment of hirsutism: a systematic review and metaanalyses of randomized controlled trials. J Clin Endocrinol Metab (2008) 1.58
A systematic review and meta-analysis of randomized trials of carotid endarterectomy vs stenting. J Vasc Surg (2011) 1.56
Pituitary incidentaloma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2011) 1.54
A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. J Clin Endocrinol Metab (2008) 1.53
Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc (2007) 1.52
Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol (2008) 1.52
Propensity score analysis with a time-dependent intervention is an acceptable although not an optimal analytical approach when treatment selection bias and survivor bias coexist. J Clin Epidemiol (2009) 1.51
Diurnal pattern of insulin action in type 1 diabetes: implications for a closed-loop system. Diabetes (2013) 1.51
Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: systematic review and meta-analysis. Mayo Clin Proc (2008) 1.51
The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis. J Clin Endocrinol Metab (2013) 1.50
Determining the reporting quality of RCTs in clinical pharmacology. Br J Clin Pharmacol (2004) 1.49
Clinical review: Adult height in patients with congenital adrenal hyperplasia: a systematic review and metaanalysis. J Clin Endocrinol Metab (2010) 1.47