Published in JAMA on March 24, 2010
Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med (2014) 4.91
C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study. Lancet (2011) 4.23
Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive Care Med (2014) 2.51
Medical management of paraquat ingestion. Br J Clin Pharmacol (2011) 2.09
Apparent declining efficacy in randomized trials: examples of the Thai RV144 HIV vaccine and South African CAPRISA 004 microbicide trials. AIDS (2012) 1.71
Are treatments more effective than placebos? A systematic review and meta-analysis. PLoS One (2013) 1.56
The Clinical Effectiveness of Pneumococcal Conjugate Vaccines. Dtsch Arztebl Int (2016) 1.49
Evaluation of the Cochrane Collaboration's tool for assessing the risk of bias in randomized trials: focus groups, online survey, proposed recommendations and their implementation. Syst Rev (2014) 1.36
Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study). BMC Med Res Methodol (2012) 1.10
Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis. Am J Obstet Gynecol (2011) 1.10
Targeted therapies in neuroendocrine tumors (NET): clinical trial challenges and lessons learned. Oncologist (2013) 1.09
Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. Drug Des Devel Ther (2010) 1.06
Sponsors' participation in conduct and reporting of industry trials: a descriptive study. Trials (2012) 1.04
Terminated Trials in the ClinicalTrials.gov Results Database: Evaluation of Availability of Primary Outcome Data and Reasons for Termination. PLoS One (2015) 1.02
Glycemic Control for Patients With Type 2 Diabetes Mellitus: Our Evolving Faith in the Face of Evidence. Circ Cardiovasc Qual Outcomes (2016) 1.02
The evolution of assessing bias in Cochrane systematic reviews of interventions: celebrating methodological contributions of the Cochrane Collaboration. Syst Rev (2013) 1.00
Systematic review of the risk of adverse outcomes associated with vascular endothelial growth factor inhibitors for the treatment of cancer. PLoS One (2014) 0.97
The thresholds for statistical and clinical significance - a five-step procedure for evaluation of intervention effects in randomised clinical trials. BMC Med Res Methodol (2014) 0.96
Drotrecogin alfa (activated)...a sad final fizzle to a roller-coaster party. Crit Care (2012) 0.96
Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials. Crit Care (2011) 0.93
The effect of tuberculosis treatment on virologic and CD4+ cell count response to combination antiretroviral therapy: a systematic review. AIDS (2014) 0.93
Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia? Acta Paediatr (2014) 0.92
What counts as reliable evidence for public health policy: the case of circumcision for preventing HIV infection. BMC Med Res Methodol (2011) 0.90
Bias and trials stopped early for benefit. JAMA (2010) 0.89
Does Teriparatide Improve Femoral Neck Fracture Healing: Results From A Randomized Placebo-controlled Trial. Clin Orthop Relat Res (2016) 0.88
DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial. PLoS One (2012) 0.88
Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? BMC Med (2013) 0.88
Bias and trials stopped early for benefit. JAMA (2010) 0.87
A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol. Syst Rev (2013) 0.87
Improved clinical outcome 3 months after endovascular treatment, including thrombectomy, in patients with acute ischemic stroke: a meta-analysis. J Neurointerv Surg (2015) 0.87
The Prevention of Delirium and Complications Associated with Surgical Treatments (PODCAST) study: protocol for an international multicentre randomised controlled trial. BMJ Open (2014) 0.86
Oxygen targeting in preterm infants: a physiological interpretation. J Perinatol (2014) 0.85
Can we stop AIDS with antiretroviral-based treatment as prevention? Glob Health Sci Pract (2013) 0.85
Design and execution of clinical trials in orthopaedic surgery. Bone Joint Res (2014) 0.84
Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderly. Clin Interv Aging (2010) 0.84
Bias and trials stopped early for benefit. JAMA (2010) 0.83
Using Adherence Information to Improve Care: From Clinic Visits to Populations. J Gen Intern Med (2016) 0.82
Haematopoietic stem cell transplantation for autoimmune diseases. Nat Rev Rheumatol (2017) 0.81
Cost-effectiveness of eplerenone in patients with systolic heart failure and mild symptoms. Heart (2014) 0.81
Minimizing animal numbers: the variable-criteria sequential stopping rule. Comp Med (2011) 0.80
Protecting clinical trial participants and protecting data integrity: are we meeting the challenges? PLoS Med (2012) 0.80
Should perioperative supplemental oxygen be routinely recommended for surgery patients? A Bayesian meta-analysis. Ann Surg (2012) 0.80
A dream deferred: the rise and fall of recombinant activated protein C. Crit Care (2013) 0.79
Third-wave cognitive therapy versus mentalisation-based treatment for major depressive disorder: a randomised clinical trial. BMJ Open (2014) 0.79
Reassessing the benefits of statins in the prevention of cardiovascular disease in diabetic patients--a systematic review and meta-analysis. Rev Diabet Stud (2013) 0.79
Stopping guidelines for an effectiveness trial: what should the protocol specify? Trials (2016) 0.79
Unsustainable claims. Dtsch Arztebl Int (2015) 0.78
Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design. Trials (2013) 0.78
Rituximab for the first-line maintenance treatment of follicular non-Hodgkin's lymphoma : a NICE single technology appraisal. Pharmacoeconomics (2013) 0.78
Effect of telemedicine on glycated hemoglobin in diabetes: a systematic review and meta-analysis of randomized trials. CMAJ (2016) 0.78
Cochrane: the unfinished symphony of research synthesis. Syst Rev (2016) 0.77
Adjunctive Corticotherapy for Community Acquired Pneumonia: A Systematic Review and Meta-Analysis. PLoS One (2015) 0.77
Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies. PLoS One (2016) 0.77
Transdermal nitroglycerin for the treatment of preterm labor: a systematic review and metaanalysis. Am J Obstet Gynecol (2013) 0.77
Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial. J Vet Intern Med (2016) 0.77
PC6 acupoint stimulation for the prevention of postcardiac surgery nausea and vomiting: a protocol for a two-group, parallel, superiority randomised clinical trial. BMJ Open (2014) 0.77
Bias and trials stopped early for benefit. JAMA (2010) 0.77
The efficacy and safety of pemetrexed-based doublet therapy compared to pemetrexed alone for the second-line treatment of advanced non-small-cell lung cancer: an updated meta-analysis. Drug Des Devel Ther (2015) 0.77
An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review. PLoS One (2015) 0.77
Intratympanic gentamicin treatment for Ménière's disease: a randomized, double-blind, placebo-controlled trial on dose efficacy - results of a prematurely ended study. Trials (2014) 0.76
Evaluation of the Cochrane tool for assessing risk of bias in randomized clinical trials: overview of published comments and analysis of user practice in Cochrane and non-Cochrane reviews. Syst Rev (2016) 0.76
Estimation After a Group Sequential Trial. Stat Biosci (2014) 0.76
Methods of Weaning Preterm Babies <30 weeks Off CPAP: A Multicenter Randomized Controlled Trial. J Clin Neonatol (2012) 0.75
Impact of missing participant data for dichotomous outcomes on pooled effect estimates in systematic reviews: a protocol for a methodological study. Syst Rev (2014) 0.75
Bioethics in Practice: Considerations for Stopping a Clinical Trial Early. Ochsner J (2016) 0.75
Uncovering noisy social signals: Using optimization methods from experimental physics to study social phenomena. PLoS One (2017) 0.75
Quantifying over-estimation in early stopped clinical trials and the "freezing effect" on subsequent research. Clin Trials (2016) 0.75
Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study: a pragmatic, randomised clinical trial. BMJ Open (2016) 0.75
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 56.72
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 41.47
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med (2008) 38.76
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ (2008) 33.10
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 26.95
Grading quality of evidence and strength of recommendations. BMJ (2004) 26.08
Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA (2005) 23.44
Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ (2003) 18.72
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet (2008) 13.15
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet (2010) 12.92
Avoidable waste in the production and reporting of research evidence. Lancet (2009) 12.28
GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol (2010) 11.77
Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA (2006) 11.71
Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med (2008) 11.00
Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol (2005) 10.99
GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol (2011) 10.02
Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer. N Engl J Med (2007) 9.53
Early detection of prostate cancer: AUA Guideline. J Urol (2013) 9.14
Internet-based learning in the health professions: a meta-analysis. JAMA (2008) 8.74
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet (2006) 8.61
Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43
Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol (2007) 7.79
Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA (2009) 7.61
Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ (2014) 7.55
Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update. Am J Gastroenterol (2008) 7.45
Going from evidence to recommendations. BMJ (2008) 7.30
Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group. BMC Health Serv Res (2004) 7.20
Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid (2011) 7.17
Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials. BMJ (2010) 7.15
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2010) 7.15
What is "quality of evidence" and why is it important to clinicians? BMJ (2008) 6.99
HIV status in discordant couples in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Infect Dis (2010) 6.95
Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet (2009) 6.92
Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. Lancet (2005) 6.86
Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet (2007) 6.77
A guide for the design and conduct of self-administered surveys of clinicians. CMAJ (2008) 6.72
Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med (2007) 6.68
High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2008) 6.48
Clinical recognition of meningococcal disease in children and adolescents. Lancet (2006) 6.27
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ (2009) 6.27
Aspirin in patients undergoing noncardiac surgery. N Engl J Med (2014) 6.10
Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ (2005) 6.08
Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med (2015) 6.06
Extended follow-up and spatial analysis of the American Cancer Society study linking particulate air pollution and mortality. Res Rep Health Eff Inst (2009) 5.92
Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.88
The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals. AIDS (2010) 5.85
Antibiotics for acute otitis media: a meta-analysis with individual patient data. Lancet (2006) 5.83
Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med (2010) 5.80
Red blood cell transfusion: a clinical practice guideline from the AABB*. Ann Intern Med (2012) 5.77
Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med (2012) 5.67
Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis. Lancet (2012) 5.65
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2006) 5.58
Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis. JAMA (2002) 5.57
No surgical innovation without evaluation: the IDEAL recommendations. Lancet (2009) 5.57
Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev (2013) 5.44
We need minimally disruptive medicine. BMJ (2009) 5.35
When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Ann Intern Med (2011) 5.35
An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am J Respir Crit Care Med (2006) 5.29
A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds. N Engl J Med (2015) 5.28
Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ (2008) 5.16