Published in J Immunol on July 15, 2002
Nanomedicine in pulmonary delivery. Int J Nanomedicine (2009) 1.68
A review of antisense therapeutic interventions for molecular biological targets in asthma. Biologics (2007) 1.43
Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics (2004) 1.32
The potential of biologics for the treatment of asthma. Nat Rev Drug Discov (2012) 1.11
Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol (2005) 1.10
Getting Syk: spleen tyrosine kinase as a therapeutic target. Trends Pharmacol Sci (2014) 1.10
Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. J Biol Chem (2008) 1.01
Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.01
Effects of nebulized ketamine on allergen-induced airway hyperresponsiveness and inflammation in actively sensitized Brown-Norway rats. J Inflamm (Lond) (2007) 0.99
Differential expression of spleen tyrosine kinase Syk isoforms in tissues: Effects of the microbial flora. Histochem Cell Biol (2006) 0.95
A rat model of exercise-induced asthma: a nonspecific response to a specific immunogen. Am J Physiol Regul Integr Comp Physiol (2011) 0.82
TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens. Allergol Int (2016) 0.77
Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma. Arch Pharm (Weinheim) (2015) 0.75
Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices. Br J Pharmacol (2016) 0.75
PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers. J Clin Pharmacol (2016) 0.75
Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a Chronic Mouse Model of Allergic Airways Inflammation. PLoS One (2017) 0.75
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell (2007) 9.20
Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma. Hepatology (2010) 3.54
Current and former marijuana use: preliminary findings of a longitudinal study of effects on IQ in young adults. CMAJ (2002) 3.20
Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. PLoS Comput Biol (2008) 3.02
Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Appl Physiol (1985) (2010) 2.38
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest (2005) 2.32
Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes (2009) 2.31
Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol (2003) 2.03
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation (2002) 1.82
Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture. Transpl Int (2009) 1.58
BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice. J Leukoc Biol (2009) 1.53
Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc (2011) 1.47
Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase. J Immunol (2004) 1.42
Invasive Haemophilus influenzae disease caused by non-type b strains in Northwestern Ontario, Canada, 2002-2008. Clin Infect Dis (2009) 1.36
Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis. EMBO J (2002) 1.36
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis. J Biol Chem (2002) 1.35
Distribution of nitric oxide synthase in normal and cirrhotic human liver. Proc Natl Acad Sci U S A (2002) 1.33
Invasive disease caused by Haemophilus influenzae type a in Northern Ontario First Nations communities. J Med Microbiol (2010) 1.30
Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis. J Biol Chem (2002) 1.27
Genome-wide histone acetylation data improve prediction of mammalian transcription factor binding sites. Bioinformatics (2010) 1.22
Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.21
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria. Mol Cell Biol (2004) 1.20
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis. J Leukoc Biol (2006) 1.18
Syntaxins 13 and 7 function at distinct steps during phagocytosis. J Immunol (2002) 1.13
The Innate Immune Database (IIDB). BMC Immunol (2008) 1.11
Opposing effects of short- and long-term stress on airway inflammation. Am J Respir Crit Care Med (2003) 1.06
Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects. J Immunol (2003) 1.05
CD4 and CD8: an inside-out coreceptor model for innate immune cells. J Leukoc Biol (2009) 1.05
Role of ubiquitin and proteasomes in phagosome maturation. Mol Biol Cell (2005) 1.01
Fcγ receptor I alpha chain (CD64) expression in macrophages is critical for the onset of meningitis by Escherichia coli K1. PLoS Pathog (2010) 1.01
Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults. Am J Physiol Regul Integr Comp Physiol (2012) 1.01
Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc Natl Acad Sci U S A (2009) 1.00
Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation. Transpl Int (2008) 1.00
Microtubules regulate PI-3K activity and recruitment to the phagocytic cup during Fcgamma receptor-mediated phagocytosis in nonelicited macrophages. J Leukoc Biol (2007) 0.99
The effect of phosphatases SHP-1 and SHIP-1 on signaling by the ITIM- and ITAM-containing Fcgamma receptors FcgammaRIIB and FcgammaRIIA. J Leukoc Biol (2003) 0.99
Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. J Pharmacol Exp Ther (2002) 0.99
Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line. Biochem Biophys Res Commun (2007) 0.97
Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production. Blood (2004) 0.97
Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology (2009) 0.95
A children's asthma education program: Roaring Adventures of Puff (RAP), improves quality of life. Can Respir J (2010) 0.95
Differential expression of spleen tyrosine kinase Syk isoforms in tissues: Effects of the microbial flora. Histochem Cell Biol (2006) 0.95
The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures. J Bone Joint Surg Am (2010) 0.95
The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes (2008) 0.95
Eosinophils in human oral squamous carcinoma; role of prostaglandin D2. J Inflamm (Lond) (2013) 0.94
Quantitative analysis of membrane remodeling at the phagocytic cup. Mol Biol Cell (2007) 0.93
Platelet FcgammaRIIA binds and internalizes IgG-containing complexes. Exp Hematol (2006) 0.93
Risk of invasive Haemophilus influenzae type b (Hib) disease in adults with secondary immunodeficiency in the post-Hib vaccine era. Clin Vaccine Immunol (2012) 0.92
Coinhibitory T-cell signaling in islet allograft rejection and tolerance. Cell Transplant (2006) 0.92
The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures. Inflamm Res (2011) 0.91
Signal sequence within Fc gamma RIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion. Proc Natl Acad Sci U S A (2003) 0.91
Nitric oxide and cyclic GMP increase the expression of matrix metalloproteinase-9 in vascular smooth muscle. J Pharmacol Exp Ther (2003) 0.90
Rapidly changing perspectives about mast cells at mucosal surfaces. Immunol Rev (2005) 0.90
A quality improvement programme to increase compliance with an anti-infective prescribing policy. J Antimicrob Chemother (2011) 0.89
Phosphorylation-independent ubiquitylation and endocytosis of Fc gammaRIIA. J Biol Chem (2006) 0.89
Histological microstructure of the claws of the African clawed frog, Xenopus laevis (Anura: Pipidae): implications for the evolution of claws in tetrapods. J Exp Zool B Mol Dev Evol (2007) 0.89
Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis. Expert Opin Ther Targets (2005) 0.88
HPV status and second primary tumours in oropharyngeal squamous cell carcinoma. J Otolaryngol Head Neck Surg (2013) 0.88
Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells. J Pharmacol Exp Ther (2005) 0.88
The monocyte Fcgamma receptors FcgammaRI/gamma and FcgammaRIIA differ in their interaction with Syk and with Src-related tyrosine kinases. J Leukoc Biol (2004) 0.88
Role for platelet-endothelial cell adhesion molecule-1 in macrophage Fcgamma receptor function. Am J Respir Cell Mol Biol (2004) 0.88
The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis. J Biol Chem (2002) 0.87
Frontline: Inhibition of allergen-induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro-endocrine pathway. Eur J Immunol (2004) 0.87
Regulation of basolateral Cl(-) channels in airway epithelial cells: the role of nitric oxide. J Membr Biol (2007) 0.87
Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells. J Immunol (2012) 0.86
Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis. Blood (2003) 0.86
Expression of integrins and Toll-like receptors in cervical cancer: effect of infectious agents. Innate Immun (2011) 0.86
Do catheter washouts extend patency time in long-term indwelling urethral catheters? A randomized controlled trial of acidic washout solution, normal saline washout, or standard care. J Wound Ostomy Continence Nurs (2009) 0.86
Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 0.86
Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion. J Immunol (2003) 0.85
Immune-mediated hemolytic anemia. Hematology Am Soc Hematol Educ Program (2004) 0.85
Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells. Biochem Biophys Res Commun (2006) 0.84
Mucosal exposure to cockroach extract induces allergic sensitization and allergic airway inflammation. Allergy Asthma Clin Immunol (2011) 0.84
IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes. Lab Invest (2010) 0.84
Advances in development and evaluation of asthma education programs. Curr Opin Pulm Med (2005) 0.84