Published in EMBO Rep on July 01, 2002
Cytoplasmic foci are sites of mRNA decay in human cells. J Cell Biol (2004) 6.78
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J (2002) 3.03
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
An unappreciated role for RNA surveillance. Genome Biol (2004) 2.28
The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol Cell (2009) 1.45
Aberrant mRNA transcripts and the nonsense-mediated decay proteins UPF2 and UPF3 are enriched in the Arabidopsis nucleolus. Plant Cell (2009) 1.35
Nuclear translation: what is the evidence? RNA (2003) 1.19
Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev (2013) 1.18
Cotranscriptional effect of a premature termination codon revealed by live-cell imaging. RNA (2011) 1.02
Nonsense codons trigger an RNA partitioning shift. J Biol Chem (2008) 0.96
Premature termination codons do not affect the rate of splicing of neighboring introns. RNA (2004) 0.95
Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence. RNA (2004) 0.95
Association of ribosomal proteins with nascent transcripts in S. cerevisiae. RNA (2005) 0.91
A Hox gene mutation that triggers nonsense-mediated RNA decay and affects alternative splicing during Drosophila development. Nucleic Acids Res (2003) 0.90
Expression of two novel alternatively spliced COL2A1 isoforms during chondrocyte differentiation. Matrix Biol (2007) 0.88
When a ribosome encounters a premature termination codon. BMB Rep (2013) 0.83
Control of gene expression through the nonsense-mediated RNA decay pathway. Cell Biosci (2017) 0.75
NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events. PLoS One (2017) 0.75
Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm. Mol Med Rep (2016) 0.75
X-linked hyper IgM (HIGM1) in an African kindred: the first report from South Africa. BMC Pediatr (2003) 0.75
Splicing repression allows the gradual emergence of new Alu-exons in primate evolution. Elife (2016) 0.75
A perfect message: RNA surveillance and nonsense-mediated decay. Cell (1999) 7.08
Nonsense-mediated mRNA decay in health and disease. Hum Mol Genet (1999) 6.90
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA (1995) 5.76
Nonsense mutations in the dihydrofolate reductase gene affect RNA processing. Mol Cell Biol (1989) 5.19
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell (2001) 4.92
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell (1995) 4.55
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature (2001) 3.94
Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J (1998) 3.79
Coupled transcription and translation within nuclei of mammalian cells. Science (2001) 3.62
A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro. J Biol Chem (1995) 3.54
Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature (2001) 3.35
A splicing-dependent regulatory mechanism that detects translation signals. EMBO J (1996) 3.07
Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci U S A (1993) 2.98
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol (1993) 2.85
A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition. Nat Biotechnol (2001) 2.82
A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96. J Cell Biol (1999) 2.76
Mechanisms of mRNA surveillance in eukaryotes. Annu Rev Genet (1999) 2.73
Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus. Science (1997) 2.72
The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr Biol (2001) 2.70
Nonsense surveillance in lymphocytes? Immunity (1998) 2.68
Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. Mol Cell (2000) 2.33
Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability. Proc Natl Acad Sci U S A (1992) 2.13
Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol (1994) 2.13
Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life. Mol Cell Biol (1994) 2.09
The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr Biol (2001) 1.98
Matrix protein and another viral component contribute to induction of apoptosis in cells infected with vesicular stomatitis virus. J Virol (2001) 1.92
The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes. Mol Cell Biol (2000) 1.89
Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis. Cell (1996) 1.88
Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J (1994) 1.87
Curbing the nonsense: the activation and regulation of mRNA surveillance. Genes Dev (2001) 1.87
Precursor RNAs harboring nonsense codons accumulate near the site of transcription. Mol Cell (2001) 1.72
Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap. Mol Cell Biol (2001) 1.68
T cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: a nuclear-associated translation-like mechanism. J Exp Med (1997) 1.67
Effect of vesicular stomatitis virus matrix protein on transcription directed by host RNA polymerases I, II, and III. J Virol (1998) 1.57
RNA surveillance by nuclear scanning? Nat Cell Biol (2002) 1.50
Accumulation of rare and moderately abundant mRNAs in mouse L-cells is mainly post-transcriptionally regulated. J Mol Biol (1984) 1.47
Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA. Mol Cell Biol (1996) 1.31
Nuclear RNA turnover. Cell (2002) 1.25
Pre-mRNA processing: insights from nonsense. Curr Biol (2001) 0.87
The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem (2007) 8.94
Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol (2013) 2.89
Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat Genet (2004) 2.82
Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci (2009) 2.79
Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell (2011) 2.73
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nat Struct Mol Biol (2008) 2.73
Rhox: a new homeobox gene cluster. Cell (2005) 2.62
Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region. PLoS Biol (2008) 2.54
EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length. Nat Struct Mol Biol (2006) 2.39
Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells. Biochim Biophys Acta (2013) 2.30
An alternative branch of the nonsense-mediated decay pathway. EMBO J (2007) 2.01
The meaning of nonsense. Trends Cell Biol (2008) 1.82
Autoregulation of the nonsense-mediated mRNA decay pathway in human cells. RNA (2011) 1.76
Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay. Mol Cell (2002) 1.66
Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. Biochim Biophys Acta (2013) 1.59
The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis. Biol Reprod (2012) 1.54
RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol Cell (2011) 1.50
A GFP-based reporter system to monitor nonsense-mediated mRNA decay. Nucleic Acids Res (2005) 1.49
A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. J Biol Chem (2002) 1.43
T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J (2002) 1.43
Cutting the nonsense: the degradation of PTC-containing mRNAs. Biochem Soc Trans (2010) 1.39
Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5'-half of the VDJ exon. Nucleic Acids Res (2004) 1.38
Alternatively spliced TCR mRNA induced by disruption of reading frame. Science (2002) 1.34
Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev (2006) 1.34
Gene regulation in spermatogenesis. Curr Top Dev Biol (2005) 1.33
Boundary-independent polar nonsense-mediated decay. EMBO Rep (2002) 1.30
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs. Nat Struct Mol Biol (2013) 1.26
RNA splicing promotes translation and RNA surveillance. Nat Struct Mol Biol (2005) 1.25
Regulation of nonsense-mediated mRNA decay. Wiley Interdiscip Rev RNA (2012) 1.24
Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes. Mol Cell (2005) 1.24
GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells. Mol Cell Biol (2008) 1.21
Processing bodies are not required for mammalian nonsense-mediated mRNA decay. RNA (2009) 1.20
Rhox homeobox gene cluster: recent duplication of three family members. Genesis (2006) 1.17
A UPF3-mediated regulatory switch that maintains RNA surveillance. Nat Struct Mol Biol (2009) 1.16
Pem homeobox gene promoter sequences that direct transcription in a Sertoli cell-specific, stage-specific, and androgen-dependent manner in the testis in vivo. Mol Endocrinol (2003) 1.12
The Rhox genes. Reproduction (2010) 1.11
Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. Gene (2002) 1.09
Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways. RNA (2013) 1.07
Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes. Mol Endocrinol (2009) 1.06
The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation. Mol Cell Biol (2011) 1.05
Turnover in the Alps: an mRNA perspective. Workshops on mechanisms and regulation of mRNA turnover. EMBO Rep (2006) 1.03
Transcription and post-transcriptional regulation of spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.02
Tissue-specific and cell type-specific RNA interference in vivo. Nat Protoc (2006) 1.02
Cotranscriptional effect of a premature termination codon revealed by live-cell imaging. RNA (2011) 1.02
eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2013) 0.99
Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay. Mol Cell Biol (2006) 0.98
In vitro spermatogenesis: A long journey to get tails. Spermatogenesis (2012) 0.97
Nonsense codons trigger an RNA partitioning shift. J Biol Chem (2008) 0.96
Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence. RNA (2004) 0.95
The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c. J Biol Chem (2007) 0.95
P-bodies react to stress and nonsense. Cell (2006) 0.94
Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis. J Biol Chem (2002) 0.93
Regulation and function of the Rhox5 homeobox gene. Ann N Y Acad Sci (2007) 0.93
Alternatively spliced T-cell receptor transcripts are up-regulated in response to disruption of either splicing elements or reading frame. J Biol Chem (2007) 0.92
Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open reading frame. RNA (2004) 0.90
Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction (2012) 0.89
The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae. J Mol Biol (2009) 0.89
Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP. Biol Reprod (2005) 0.88
Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility. Hum Mol Genet (2013) 0.87
DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol (2012) 0.87
Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. Biol Reprod (2011) 0.86
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res (2013) 0.86
Expression of the pem homeobox gene in Sertoli cells increases the frequency of adjacent germ cells with deoxyribonucleic acid strand breaks. Endocrinology (2002) 0.85
Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line. RNA (2009) 0.85
A metabolic enzyme doing double duty as a transcription factor. Bioessays (2005) 0.85
Transcriptional silencing of nonsense codon-containing immunoglobulin micro genes requires translation of its mRNA. J Biol Chem (2007) 0.83
Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption. Nucleic Acids Res (2009) 0.83
The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem (2013) 0.82
A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types. J Biol Chem (2002) 0.82
Analysis of nonsense-mediated mRNA decay in mammalian cells. Curr Protoc Cell Biol (2012) 0.82
Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach. Mol Endocrinol (2014) 0.80
tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans. Nucleic Acids Res (2010) 0.80
Catalytic antibody therapy against the insecticide carbaryl. Biochem Biophys Res Commun (2002) 0.79
How to activate a gene: decap its associated noncoding RNA. Mol Cell (2012) 0.79
Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2. PLoS One (2013) 0.79
Intimate liaison with SR proteins brings exon junction complexes to unexpected places. Nat Struct Mol Biol (2012) 0.79
Preparation of soluble extracts from adenovirus-infected cells for studies of RNA splicing. Methods Mol Med (2007) 0.78
RNA decay mechanisms: specificity through diversity. Biochim Biophys Acta (2013) 0.78
Applying the brakes on gene expression. Nat Struct Mol Biol (2005) 0.77
The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. DNA Cell Biol (2005) 0.77
Angiotensinergic neurons in sympathetic coeliac ganglia innervating rat and human mesenteric resistance blood vessels. Regul Pept (2008) 0.77
Characterization of phosphorylation- and RNA-dependent UPF1 interactors by quantitative proteomics. J Proteome Res (2014) 0.77
The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors. J Clin Invest (2016) 0.75