Published in Nucleic Acids Res on December 09, 2009
Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. Biochim Biophys Acta (2013) 1.59
RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol Cell (2011) 1.50
The maize glossy13 gene, cloned via BSR-Seq and Seq-walking encodes a putative ABC transporter required for the normal accumulation of epicuticular waxes. PLoS One (2013) 0.88
Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development. Mol Cell Biol (2011) 0.86
Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways in vivo. PLoS One (2011) 0.77
Unspliced precursors of NMD-sensitive β-globin transcripts exhibit decreased steady-state levels in erythroid cells. PLoS One (2012) 0.75
Predictive identification of exonic splicing enhancers in human genes. Science (2002) 16.86
ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Res (2003) 12.81
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem Sci (2000) 10.77
Exon recognition in vertebrate splicing. J Biol Chem (1995) 10.08
The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem (2007) 8.94
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci (2007) 7.96
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA (1995) 5.76
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nat Genet (2001) 5.02
Identification of a regulated pathway for nuclear pre-mRNA turnover. Cell (2000) 4.38
A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell (2002) 3.88
Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. Science (2002) 3.84
A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro. J Biol Chem (1995) 3.54
Rates of in situ transcription and splicing in large human genes. Nat Struct Mol Biol (2009) 3.39
Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product. Genes Dev (1992) 3.26
A splicing-dependent regulatory mechanism that detects translation signals. EMBO J (1996) 3.07
The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet (2008) 3.00
Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell (2004) 2.96
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol (1993) 2.85
Nonsense surveillance in lymphocytes? Immunity (1998) 2.68
Rhox: a new homeobox gene cluster. Cell (2005) 2.62
A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer. Genes Dev (2002) 2.61
A splicing enhancer exhibits both constitutive and regulated activities. Genes Dev (1994) 2.46
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev (2008) 2.26
Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution. Proc Natl Acad Sci U S A (2005) 2.12
Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. J Biomed Sci (2004) 2.11
Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs. Mol Cell (2002) 2.05
An alternative branch of the nonsense-mediated decay pathway. EMBO J (2007) 2.01
Maintenance of an open reading frame as an additional level of scrutiny during splice site selection. Nat Genet (1994) 2.00
Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis. Cell (1996) 1.88
Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J (1994) 1.87
Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol (1993) 1.85
Cytoplasmic degradation of splice-defective pre-mRNAs and intermediates. Mol Cell (2003) 1.85
RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns. Mol Cell (2003) 1.83
Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene. Nucleic Acids Res (1992) 1.83
The meaning of nonsense. Trends Cell Biol (2008) 1.82
Precursor RNAs harboring nonsense codons accumulate near the site of transcription. Mol Cell (2001) 1.72
T cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: a nuclear-associated translation-like mechanism. J Exp Med (1997) 1.67
Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay. Mol Cell (2002) 1.66
T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates. Mol Cell Biol (1993) 1.63
In vivo kinetics of mRNA splicing and transport in mammalian cells. Mol Cell Biol (2002) 1.63
Direct selection for mutations affecting specific splice sites in a hamster dihydrofolate reductase minigene. Mol Cell Biol (1993) 1.57
RNA surveillance by nuclear scanning? Nat Cell Biol (2002) 1.50
A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. J Biol Chem (2002) 1.43
T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J (2002) 1.43
Alternatively spliced TCR mRNA induced by disruption of reading frame. Science (2002) 1.34
Boundary-independent polar nonsense-mediated decay. EMBO Rep (2002) 1.30
RNA splicing promotes translation and RNA surveillance. Nat Struct Mol Biol (2005) 1.25
Nuclear translation: what is the evidence? RNA (2003) 1.19
NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on. Genes Dev (2002) 1.10
Splicing of designer exons reveals unexpected complexity in pre-mRNA splicing. RNA (2009) 1.04
T cell receptor-beta mRNA splicing during thymic maturation in vivo and in an inducible T cell clone in vitro. J Immunol (1993) 1.01
A subset of Mer1p-dependent introns requires Bud13p for splicing activation and nuclear retention. RNA (2006) 1.00
Nonsense codons trigger an RNA partitioning shift. J Biol Chem (2008) 0.96
Premature termination codons do not affect the rate of splicing of neighboring introns. RNA (2004) 0.95
A premature termination codon in either exon of minute virus of mice P4 promoter-generated pre-mRNA can inhibit nuclear splicing of the intervening intron in an open reading frame-dependent manner. J Biol Chem (1999) 0.95
An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex. J Biol Chem (2008) 0.93
Role of purine-rich exonic splicing enhancers in nuclear retention of pre-mRNAs. Proc Natl Acad Sci U S A (2007) 0.93
Alternatively spliced T-cell receptor transcripts are up-regulated in response to disruption of either splicing elements or reading frame. J Biol Chem (2007) 0.92
Stop codon-mediated suppression of splicing is a novel nuclear scanning mechanism not affected by elements of protein synthesis and NMD. RNA (2004) 0.91
A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent manner. Mol Cell Biol (1999) 0.86
Mutant LYS2 mRNAs retained and degraded in the nucleus of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2006) 0.84
The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem (2007) 8.94
Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol (2013) 2.89
Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat Genet (2004) 2.82
Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell (2011) 2.73
Rhox: a new homeobox gene cluster. Cell (2005) 2.62
An alternative branch of the nonsense-mediated decay pathway. EMBO J (2007) 2.01
Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay. Mol Cell (2002) 1.66
Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. Biochim Biophys Acta (2013) 1.59
The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis. Biol Reprod (2012) 1.54
RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol Cell (2011) 1.50
Metallated conjugated polymers as a new avenue towards high-efficiency polymer solar cells. Nat Mater (2007) 1.44
A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. J Biol Chem (2002) 1.43
T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J (2002) 1.43
Alternatively spliced TCR mRNA induced by disruption of reading frame. Science (2002) 1.34
Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev (2006) 1.34
Gene regulation in spermatogenesis. Curr Top Dev Biol (2005) 1.33
Boundary-independent polar nonsense-mediated decay. EMBO Rep (2002) 1.30
RNA splicing promotes translation and RNA surveillance. Nat Struct Mol Biol (2005) 1.25
Regulation of nonsense-mediated mRNA decay. Wiley Interdiscip Rev RNA (2012) 1.24
Intranuclear degradation of nonsense codon-containing mRNA. EMBO Rep (2002) 1.22
GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells. Mol Cell Biol (2008) 1.21
Rhox homeobox gene cluster: recent duplication of three family members. Genesis (2006) 1.17
A UPF3-mediated regulatory switch that maintains RNA surveillance. Nat Struct Mol Biol (2009) 1.16
Pem homeobox gene promoter sequences that direct transcription in a Sertoli cell-specific, stage-specific, and androgen-dependent manner in the testis in vivo. Mol Endocrinol (2003) 1.12
The Rhox genes. Reproduction (2010) 1.11
Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. Gene (2002) 1.09
Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes. Mol Endocrinol (2009) 1.06
The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation. Mol Cell Biol (2011) 1.05
Transcription and post-transcriptional regulation of spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.02
Tissue-specific and cell type-specific RNA interference in vivo. Nat Protoc (2006) 1.02
Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay. Mol Cell Biol (2006) 0.98
In vitro spermatogenesis: A long journey to get tails. Spermatogenesis (2012) 0.97
Nonsense codons trigger an RNA partitioning shift. J Biol Chem (2008) 0.96
The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c. J Biol Chem (2007) 0.95
P-bodies react to stress and nonsense. Cell (2006) 0.94
Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis. J Biol Chem (2002) 0.93
Regulation and function of the Rhox5 homeobox gene. Ann N Y Acad Sci (2007) 0.93
Alternatively spliced T-cell receptor transcripts are up-regulated in response to disruption of either splicing elements or reading frame. J Biol Chem (2007) 0.92
Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction (2012) 0.89
The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae. J Mol Biol (2009) 0.89
Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP. Biol Reprod (2005) 0.88
Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility. Hum Mol Genet (2013) 0.87
DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol (2012) 0.87
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res (2013) 0.86
Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. Biol Reprod (2011) 0.86
Expression of the pem homeobox gene in Sertoli cells increases the frequency of adjacent germ cells with deoxyribonucleic acid strand breaks. Endocrinology (2002) 0.85
A metabolic enzyme doing double duty as a transcription factor. Bioessays (2005) 0.85
The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem (2013) 0.82
A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types. J Biol Chem (2002) 0.82
Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach. Mol Endocrinol (2014) 0.80
Tuning the absorption, charge transport properties, and solar cell efficiency with the number of thienyl rings in platinum-containing poly(aryleneethynylene)s. J Am Chem Soc (2007) 0.80
Catalytic antibody therapy against the insecticide carbaryl. Biochem Biophys Res Commun (2002) 0.79
How to activate a gene: decap its associated noncoding RNA. Mol Cell (2012) 0.79
Very-low-bandgap metallopolyynes of platinum with a cyclopentadithiophenone ring for organic solar cells absorbing down to the near-infrared spectral region. Macromol Rapid Commun (2010) 0.77
The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. DNA Cell Biol (2005) 0.77
The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors. J Clin Invest (2016) 0.75
Polymer solar cells based on very narrow-bandgap polyplatinynes with photocurrents extended into the near-infrared region. Dalton Trans (2008) 0.75