Published in Cell on February 11, 2005
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Classification and nomenclature of all human homeobox genes. BMC Biol (2007) 2.61
The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol (2009) 2.17
An alternative branch of the nonsense-mediated decay pathway. EMBO J (2007) 2.01
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev (2006) 1.76
New insights into epididymal biology and function. Hum Reprod Update (2009) 1.73
Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus. BMC Genomics (2008) 1.54
The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis. Biol Reprod (2012) 1.54
The regulation of spermatogenesis by androgens. Semin Cell Dev Biol (2014) 1.47
Regulated expression of Rhox8 in the mouse ovary: evidence for the role of progesterone and RHOX5 in granulosa cells. Biol Reprod (2013) 1.46
An in situ hybridization-based screen for heterogeneously expressed genes in mouse ES cells. Gene Expr Patterns (2007) 1.44
Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution. J Mol Evol (2007) 1.44
Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev (2006) 1.34
LSH and G9a/GLP complex are required for developmentally programmed DNA methylation. Genome Res (2010) 1.21
GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells. Mol Cell Biol (2008) 1.21
Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Genetics (2007) 1.18
Androgens and spermatogenesis: lessons from transgenic mouse models. Philos Trans R Soc Lond B Biol Sci (2010) 1.16
RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev (2012) 1.13
The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages. BMC Evol Biol (2011) 1.13
A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection. BMC Genomics (2006) 1.12
Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model. Proc Natl Acad Sci U S A (2007) 1.06
Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes. Mol Endocrinol (2009) 1.06
The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation. Mol Cell Biol (2011) 1.05
Transcription and post-transcriptional regulation of spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.02
The animal in the genome: comparative genomics and evolution. Philos Trans R Soc Lond B Biol Sci (2008) 1.02
Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. Mol Cell Biol (2009) 1.01
Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Mamm Genome (2006) 0.99
The rat prolactin gene family locus: species-specific gene family expansion. Mamm Genome (2006) 0.98
The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells. Hum Reprod (2013) 0.98
In vitro spermatogenesis: A long journey to get tails. Spermatogenesis (2012) 0.97
Nonsense codons trigger an RNA partitioning shift. J Biol Chem (2008) 0.96
Identification and characterization of Rhox13, a novel X-linked mouse homeobox gene. Gene (2008) 0.93
DNA methylation profiling of embryonic stem cell differentiation into the three germ layers. PLoS One (2011) 0.93
Transcriptional control of spermatogonial maintenance and differentiation. Semin Cell Dev Biol (2014) 0.93
The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos. Nucleic Acids Res (2010) 0.92
Rapid evolution and copy number variation of primate RHOXF2, an X-linked homeobox gene involved in male reproduction and possibly brain function. BMC Evol Biol (2011) 0.92
Homeodomain proteins: an update. Chromosoma (2015) 0.91
Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A. PLoS Genet (2013) 0.91
ParaHox gene expression in larval and postlarval development of the polychaete Nereis virens (Annelida, Lophotrochozoa). BMC Dev Biol (2008) 0.89
Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility. Hum Mol Genet (2013) 0.87
Gene expression alterations by conditional knockout of androgen receptor in adult Sertoli cells of Utp14b jsd/jsd (jsd) mice. Biol Reprod (2011) 0.87
Conservation of ParaHox genes' function in patterning of the digestive tract of the marine gastropod Gibbula varia. BMC Dev Biol (2010) 0.87
Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male. Biol Reprod (2012) 0.87
DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol (2012) 0.87
Ancestral whole-genome duplication in the marine chelicerate horseshoe crabs. Heredity (Edinb) (2015) 0.84
A conserved cluster of three PRD-class homeobox genes (homeobrain, rx and orthopedia) in the Cnidaria and Protostomia. Evodevo (2010) 0.84
Mouse cumulus-denuded oocytes restore developmental capacity completely when matured with optimal supplementation of cysteamine, cystine, and cumulus cells. Biol Reprod (2010) 0.84
Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption. Nucleic Acids Res (2009) 0.83
Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling. Oncotarget (2015) 0.82
Homeobox galore: when reproduction goes RHOX and roll. Cell (2005) 0.82
Comprehensive comparative homeobox gene annotation in human and mouse. Database (Oxford) (2015) 0.82
Misexpression of testicular microRNA in sterile Xenopus hybrids points to tetrapod-specific microRNAs associated with male fertility. J Mol Evol (2011) 0.82
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells. PLoS Genet (2015) 0.82
The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem (2013) 0.82
Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice. Biol Reprod (2010) 0.81
shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects. PLoS One (2015) 0.80
A genome scale overexpression screen to reveal drug activity in human cells. Genome Med (2014) 0.80
Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth. Mol Cancer (2011) 0.80
Rapid evolution of the trophoblast kunitz domain proteins (TKDPs)-a multigene family in ruminant ungulates. J Mol Evol (2006) 0.80
Sex-specific gene expression in preimplantation mouse embryos. Genome Biol (2006) 0.79
Identification of testosterone-/androgen receptor-regulated genes in mouse Sertoli cells. Asian J Androl (2011) 0.79
Expression of ladybird-like homeobox 2 (LBX2) during ovarian development and folliculogenesis in the mouse. J Mol Histol (2010) 0.78
Functional significance of the sex chromosomes during spermatogenesis. Reproduction (2015) 0.78
Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice. Biol Reprod (2015) 0.78
Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis. BMC Dev Biol (2008) 0.78
Rhox in mammalian reproduction and development. Clin Exp Reprod Med (2013) 0.78
Hormone-induced and DNA demethylation-induced relief of a tissue-specific and developmentally regulated block in transcriptional elongation. J Biol Chem (2014) 0.76
Transcriptional regulation of cell adhesion at the blood-testis barrier and spermatogenesis in the testis. Adv Exp Med Biol (2012) 0.76
The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment. Cell Rep (2016) 0.76
Immunolocalization of insulin-like growth factor-I (IGF-I) and its receptors (IGF-IR) in the equine epididymis. J Reprod Dev (2014) 0.76
Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells. Biol Open (2016) 0.75
Is the Epididymis a Series of Organs Placed Side By Side? Biol Reprod (2016) 0.75
OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis. Sci Rep (2016) 0.75
Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice. Reproduction (2016) 0.75
Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis. Mol Endocrinol (2015) 0.75
RHOXF2 gene, a new candidate gene for spermatogenesis failure. Basic Clin Androl (2014) 0.75
Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis. Sci Rep (2017) 0.75
The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem (2007) 8.94
Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol (2013) 2.89
Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat Genet (2004) 2.82
Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell (2011) 2.73
An alternative branch of the nonsense-mediated decay pathway. EMBO J (2007) 2.01
Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay. Mol Cell (2002) 1.66
Identification of a bone marrow-derived CD8αα+ dendritic cell-like population in inflamed autoimmune target tissue with capability of inducing T cell apoptosis. J Leukoc Biol (2010) 1.61
Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. Biochim Biophys Acta (2013) 1.59
The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis. Biol Reprod (2012) 1.54
Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: does this expand their role in the ovulation process? Mol Endocrinol (2006) 1.51
RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol Cell (2011) 1.50
A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. J Biol Chem (2002) 1.43
T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J (2002) 1.43
Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet (2010) 1.42
Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation. Biol Reprod (2011) 1.42
Alternatively spliced TCR mRNA induced by disruption of reading frame. Science (2002) 1.34
Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev (2006) 1.34
Gene regulation in spermatogenesis. Curr Top Dev Biol (2005) 1.33
Transition nuclear proteins are required for normal chromatin condensation and functional sperm development. Genesis (2004) 1.32
Boundary-independent polar nonsense-mediated decay. EMBO Rep (2002) 1.30
Molecular markers of outcome after radiotherapy in patients with prostate carcinoma: Ki-67, bcl-2, bax, and bcl-x. Cancer (2003) 1.26
RNA splicing promotes translation and RNA surveillance. Nat Struct Mol Biol (2005) 1.25
Regulation of nonsense-mediated mRNA decay. Wiley Interdiscip Rev RNA (2012) 1.24
Intranuclear degradation of nonsense codon-containing mRNA. EMBO Rep (2002) 1.22
GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells. Mol Cell Biol (2008) 1.21
The radiation-induced block in spermatogonial differentiation is due to damage to the somatic environment, not the germ cells. J Cell Physiol (2007) 1.18
Nucleoprotein transitions during spermiogenesis in mice with transition nuclear protein Tnp1 and Tnp2 mutations. Biol Reprod (2004) 1.17
Rhox homeobox gene cluster: recent duplication of three family members. Genesis (2006) 1.17
A UPF3-mediated regulatory switch that maintains RNA surveillance. Nat Struct Mol Biol (2009) 1.16
Abnormalities and reduced reproductive potential of sperm from Tnp1- and Tnp2-null double mutant mice. Biol Reprod (2004) 1.16
Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol (2007) 1.14
Pem homeobox gene promoter sequences that direct transcription in a Sertoli cell-specific, stage-specific, and androgen-dependent manner in the testis in vivo. Mol Endocrinol (2003) 1.12
The Rhox genes. Reproduction (2010) 1.11
Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. Gene (2002) 1.09
Ki-67 staining is an independent correlate of biochemical failure in prostate cancer treated with radiotherapy. Clin Cancer Res (2002) 1.07
Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes. Mol Endocrinol (2009) 1.06
Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice. J Androl (2004) 1.05
The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation. Mol Cell Biol (2011) 1.05
The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod (2011) 1.04
Transcription and post-transcriptional regulation of spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.02
Tissue-specific and cell type-specific RNA interference in vivo. Nat Protoc (2006) 1.02
Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis. Reproduction (2006) 1.02
Spermatogonial morphology and kinetics during testis development in mice: a high-resolution light microscopy approach. Reproduction (2011) 1.01
The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun (2007) 1.00
Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay. Mol Cell Biol (2006) 0.98
Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias. Blood (2010) 0.98
Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations. Endocrinology (2006) 0.97
In vitro spermatogenesis: A long journey to get tails. Spermatogenesis (2012) 0.97
Hormonal approaches to preservation and restoration of male fertility after cancer treatment. J Natl Cancer Inst Monogr (2005) 0.97
Irradiated mouse testes efficiently support spermatogenesis derived from donor germ cells of mice and rats. J Androl (2005) 0.96
Testicular edema is associated with spermatogonial arrest in irradiated rats. Endocrinology (2005) 0.96
Nonsense codons trigger an RNA partitioning shift. J Biol Chem (2008) 0.96
The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c. J Biol Chem (2007) 0.95
Protamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patients. Hum Reprod (2006) 0.95
P-bodies react to stress and nonsense. Cell (2006) 0.94
Changes in gene expression in somatic cells of rat testes resulting from hormonal modulation and radiation-induced germ cell depletion. Biol Reprod (2009) 0.94
Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. J Androl (2009) 0.94
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol Reprod (2011) 0.93
Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis. J Biol Chem (2002) 0.93
NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21. Cancer Res (2003) 0.93
Regulation and function of the Rhox5 homeobox gene. Ann N Y Acad Sci (2007) 0.93
Both testosterone and follicle-stimulating hormone independently inhibit spermatogonial differentiation in irradiated rats. Endocrinology (2005) 0.92
Alternatively spliced T-cell receptor transcripts are up-regulated in response to disruption of either splicing elements or reading frame. J Biol Chem (2007) 0.92
Genetic factors contributing to defective spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice. Biol Reprod (2007) 0.90
Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction (2012) 0.89
The missing niche for spermatogonial stem cells: do blood vessels point the way? Cell Stem Cell (2007) 0.89
Genetic disease in offspring of long-term survivors of childhood and adolescent cancer treated with potentially mutagenic therapies. Am J Hum Genet (2002) 0.89
Decline in fertility of mouse sperm with abnormal chromatin during epididymal passage as revealed by ICSI. Hum Reprod (2005) 0.89
The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae. J Mol Biol (2009) 0.89
Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP. Biol Reprod (2005) 0.88
Estrogen enhances recovery from radiation-induced spermatogonial arrest in rat testes. J Androl (2009) 0.88
Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility. Hum Mol Genet (2013) 0.87
Gene expression alterations by conditional knockout of androgen receptor in adult Sertoli cells of Utp14b jsd/jsd (jsd) mice. Biol Reprod (2011) 0.87
DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol (2012) 0.87
Age and insertion site dependence of repeat number instability of a human DM1 transgene in individual mouse sperm. Hum Mol Genet (2002) 0.86
Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. Biol Reprod (2011) 0.86
Fetal radiation exposure induces testicular cancer in genetically susceptible mice. PLoS One (2012) 0.86
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res (2013) 0.86
Donor Sertoli cells transplanted into irradiated rat testes stimulate partial recovery of endogenous spermatogenesis. Reproduction (2008) 0.85
Expression of the pem homeobox gene in Sertoli cells increases the frequency of adjacent germ cells with deoxyribonucleic acid strand breaks. Endocrinology (2002) 0.85
A metabolic enzyme doing double duty as a transcription factor. Bioessays (2005) 0.85
Defining the cellular and molecular mechanisms of toxicant action in the testis. Toxicol Lett (2002) 0.84
Inhibition of recovery of spermatogenesis in irradiated rats by different androgens. Endocrinology (2002) 0.84
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol Reprod (2010) 0.84
Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption. Nucleic Acids Res (2009) 0.83
Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure. J Androl (2005) 0.83
Changes in the journal of andrology in the electronic age. J Androl (2008) 0.83
Effects of medroxyprogesterone and estradiol on the recovery of spermatogenesis in irradiated rats. Endocrinology (2004) 0.83
A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types. J Biol Chem (2002) 0.82
The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem (2013) 0.82
C-terminal phosphorylation of murine testis-specific histone H1t in elongating spermatids. J Proteome Res (2008) 0.82
Differences in radiation sensitivity of recovery of spermatogenesis between rat strains. Toxicol Sci (2012) 0.82
Glucocorticoid regulation of human pulmonary surfactant protein-B (SP-B) mRNA stability is independent of activated glucocorticoid receptor. Am J Physiol Lung Cell Mol Physiol (2011) 0.81