Published in Oncogene on July 18, 2002
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
Retracted GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2009) 3.10
Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions. Cell (2009) 2.62
Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol (2011) 2.56
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol Cell Biol (2004) 1.94
MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood (2008) 1.59
MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation. Proc Natl Acad Sci U S A (2009) 1.54
The Arabidopsis MALE MEIOCYTE DEATH1 gene encodes a PHD-finger protein that is required for male meiosis. Plant Cell (2003) 1.28
MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A (2004) 1.16
Molecular basis for chromatin binding and regulation of MLL5. Proc Natl Acad Sci U S A (2013) 1.15
Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription. Proc Natl Acad Sci U S A (2008) 1.05
Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem (2013) 1.04
UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions. Cell (2012) 0.96
Epigenetic regulation of planarian stem cells by the SET1/MLL family of histone methyltransferases. Epigenetics (2012) 0.92
Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood (2010) 0.90
Mll5 is required for normal spermatogenesis. PLoS One (2011) 0.89
Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry. J Biol Chem (2010) 0.86
The SET domain protein, Set3p, promotes the reliable execution of cytokinesis in Schizosaccharomyces pombe. PLoS One (2012) 0.85
MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin. J Cell Sci (2012) 0.83
Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia. Haematologica (2014) 0.83
Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis. Cancers (Basel) (2012) 0.83
Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS One (2015) 0.82
Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod. PLoS One (2012) 0.81
NKp44L: A new tool for fighting cancer. Oncoimmunology (2014) 0.79
BARD1 may be renamed ROW1 because it functions mainly as a REPRESSOR OF WUSCHEL1. Plant Signal Behav (2009) 0.79
The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation. Chin J Cancer (2013) 0.77
Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people. Meta Gene (2014) 0.76
UpSET-ting the balance: modulating open chromatin features in metazoan genomes. Fly (Austin) (2013) 0.76
MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy. Haematologica (2014) 0.76
The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity. PLoS One (2016) 0.75
upSET, the Drosophila Homologue of SET3, Is Required for Viability and the Proper Balance of Active and Repressive Chromatin Marks. G3 (Bethesda) (2017) 0.75
MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1. J Cell Biol (2016) 0.75
IFN-1 Bid crosstalk: foe or friend to stem cells. Stem Cell Investig (2017) 0.75
A New Three-Way Translocation t(4;11;7)(q21;q23;q22) in a Mixed-Phenotype Acute Leukemia. Case Rep Hematol (2011) 0.75
Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J Mol Biol (2016) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Aligning multiple genomic sequences with the threaded blockset aligner. Genome Res (2004) 24.52
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood (2009) 23.52
LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA. Genome Res (2003) 23.03
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
Distribution and intensity of constraint in mammalian genomic sequence. Genome Res (2005) 18.85
Topographical and temporal diversity of the human skin microbiome. Science (2009) 15.96
A vision for the future of genomics research. Nature (2003) 14.06
Prepublication data sharing. Nature (2009) 12.24
Identification and characterization of multi-species conserved sequences. Genome Res (2003) 10.18
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature (2008) 10.12
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
A high-resolution map of human evolutionary constraint using 29 mammals. Nature (2011) 8.67
Revised international prognostic scoring system for myelodysplastic syndromes. Blood (2012) 8.12
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Res (2007) 7.05
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83
Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing. Genome Res (2010) 5.76
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood (2009) 5.72
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet (2002) 5.55
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
MultiPipMaker and supporting tools: Alignments and analysis of multiple genomic DNA sequences. Nucleic Acids Res (2003) 4.97
A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk. Nature (2005) 4.92
Implementing genomic medicine in the clinic: the future is here. Genet Med (2013) 4.89
Germline KRAS mutations cause Noonan syndrome. Nat Genet (2006) 4.48
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet (2004) 4.45
An intermediate grade of finished genomic sequence suitable for comparative analyses. Genome Res (2004) 4.38
An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing. Proc Natl Acad Sci U S A (2005) 4.38
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood (2003) 4.15
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell (2010) 4.11
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell (2008) 4.06
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet (2008) 4.04
New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge. J Clin Oncol (2012) 3.88
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V. Am J Hum Genet (2003) 3.55
Quantitative estimates of sequence divergence for comparative analyses of mammalian genomes. Genome Res (2003) 3.52
Transcription-associated mutational asymmetry in mammalian evolution. Nat Genet (2003) 3.52
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A (2003) 3.46
Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites. Proc Natl Acad Sci U S A (2004) 3.41
Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
Research ethics. The complexities of genomic identifiability. Science (2013) 3.23
The DNA sequence of human chromosome 7. Nature (2003) 3.18
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13
TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. Nat Genet (2011) 3.06
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A (2007) 3.00
Systematic sequencing of cDNA clones using the transposon Tn5. Nucleic Acids Res (2002) 2.78
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood (2003) 2.76
Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A (2003) 2.54
CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood (2012) 2.51
VarSifter: visualizing and analyzing exome-scale sequence variation data on a desktop computer. Bioinformatics (2011) 2.47
Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood (2004) 2.42
Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet (2002) 2.39
Confirming the phylogeny of mammals by use of large comparative sequence data sets. Mol Biol Evol (2008) 2.33
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood (2007) 2.30
The role of aminoacyl-tRNA synthetases in genetic diseases. Annu Rev Genomics Hum Genet (2008) 2.28
The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol (2010) 2.20
Parallel construction of orthologous sequence-ready clone contig maps in multiple species. Genome Res (2002) 2.18
Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins. Genomics (2002) 2.16
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood (2009) 2.15
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome. Genome Res (2003) 2.07
Reconstructing large regions of an ancestral mammalian genome in silico. Genome Res (2004) 2.01
MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility. Blood (2008) 1.98
Regulatory divergence modifies limb length between mammals. Genes Dev (2008) 1.96
Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy. Am J Hum Genet (2010) 1.96
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood (2005) 1.96
c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Blood (2005) 1.96
Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study. J Am Coll Cardiol (2005) 1.90
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell (2006) 1.88
Comparative sequencing provides insights about the structure and conservation of marsupial and monotreme genomes. Proc Natl Acad Sci U S A (2005) 1.88
Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons. J Neurosci (2006) 1.87
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev (2002) 1.87
Data use under the NIH GWAS data sharing policy and future directions. Nat Genet (2014) 1.82
Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res (2002) 1.80
Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. J Med Genet (2006) 1.79
Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium. Leuk Res (2008) 1.77
High-throughput mapping of origins of replication in human cells. EMBO Rep (2007) 1.75
Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet (2013) 1.74
Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model. BMC Med (2004) 1.74
GTPase activating proteins: critical regulators of intracellular signaling. Biochim Biophys Acta (2002) 1.74
A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet (2009) 1.71
A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications. Genome Res (2006) 1.69
Genomics education for health care professionals in the 21st century. JAMA (2011) 1.69
Targets of balancing selection in the human genome. Mol Biol Evol (2009) 1.69
T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6. Pediatr Blood Cancer (2010) 1.67
Targeting oncogenic Ras signaling in hematologic malignancies. Blood (2012) 1.67
Prevention of sudden cardiac death with implantable cardioverter-defibrillators in children and adolescents with hypertrophic cardiomyopathy. J Am Coll Cardiol (2013) 1.65
The value of avian genomics to the conservation of wildlife. BMC Genomics (2009) 1.63
Phenotypic spectrum of disorders associated with glycyl-tRNA synthetase mutations. Brain (2005) 1.63
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell (2012) 1.61
Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. PLoS Genet (2008) 1.60
MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood (2008) 1.59
Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc Natl Acad Sci U S A (2002) 1.57