Published in Mol Cell Biol on December 01, 2004
Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol (2011) 6.34
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell (2011) 4.90
Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell (2008) 4.20
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell (2010) 3.47
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase. EMBO J (2006) 2.89
The molecular biology of mixed lineage leukemia. Haematologica (2009) 2.58
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell (2010) 2.50
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood (2013) 2.28
Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci U S A (2007) 2.13
The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell (2007) 2.05
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell (2011) 2.01
Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nat Struct Mol Biol (2009) 1.98
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proc Natl Acad Sci U S A (2008) 1.50
Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43
The dynamics of DNA methylation in schizophrenia and related psychiatric disorders. Neuropsychopharmacology (2012) 1.40
The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain. Nat Commun (2011) 1.37
Therapeutic targeting of MLL. Blood (2009) 1.36
Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1. PLoS One (2011) 1.30
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans (2013) 1.30
Mixed lineage leukemia: a structure-function perspective of the MLL1 protein. FEBS J (2010) 1.28
High resolution structure of the HDGF PWWP domain: a potential DNA binding domain. Protein Sci (2005) 1.19
The PHD fingers of MLL block MLL fusion protein-mediated transformation. Blood (2008) 1.18
Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2013) 1.17
Initiation of MLL-rearranged AML is dependent on C/EBPα. J Exp Med (2013) 1.13
Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis. Leukemia (2010) 1.08
Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics. Oncogene (2012) 0.95
Active DNA demethylation in post-mitotic neurons: a reason for optimism. Neuropharmacology (2013) 0.94
Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia. Mol Cancer (2009) 0.93
Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. J Cell Sci (2011) 0.92
Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members. BMC Cancer (2014) 0.89
PAFc, a key player in MLL-rearranged leukemogenesis. Oncotarget (2010) 0.89
MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters. Nucleic Acids Res (2014) 0.86
Menin as a hub controlling mixed lineage leukemia. Bioessays (2012) 0.85
Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia. Exp Hematol (2014) 0.84
Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis. Cancers (Basel) (2012) 0.83
Integrating DNA methylation dynamics into a framework for understanding epigenetic codes. Bioessays (2013) 0.83
The role of menin in hematopoiesis. Adv Exp Med Biol (2009) 0.82
Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia. J Biol Chem (2013) 0.81
p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia. Mol Oncol (2013) 0.80
Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood (2014) 0.79
Introduction--Epiphanies in epigenetics. Prog Mol Biol Transl Sci (2011) 0.79
Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin. BMC Genomics (2013) 0.79
TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription. Cell Cycle (2016) 0.77
Discovering cooperative relationships of chromatin modifications in human T cells based on a proposed closeness measure. PLoS One (2010) 0.76
Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification. Mol Cell (2017) 0.75
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet (2001) 13.79
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell (2002) 11.83
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell (2002) 6.72
Altered Hox expression and segmental identity in Mll-mutant mice. Nature (1995) 6.60
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell (1992) 6.11
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell (1992) 5.39
Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc Natl Acad Sci U S A (1999) 5.33
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene (2001) 4.70
Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J (1997) 4.03
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev (2003) 4.00
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet (1992) 3.43
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A (1994) 3.08
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Oncogene (1997) 2.69
MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci U S A (1998) 2.65
The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif. Nat Struct Biol (1997) 2.56
Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell (2003) 2.54
Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny. Exp Hematol (2002) 2.53
The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Mol Cell Biol (1998) 2.48
The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation. Nucleic Acids Res (2002) 2.43
Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality. Oncogene (2001) 2.42
MLL2: A new mammalian member of the trx/MLL family of genes. Genomics (1999) 2.37
Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Blood (1998) 2.06
Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet (1997) 1.95
Identification and characterization of the DNA binding domain of CpG-binding protein. J Biol Chem (2001) 1.93
Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia. EMBO J (2000) 1.87
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci U S A (1993) 1.73
A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood (2000) 1.71
The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood (2002) 1.64
MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Oncogene (2002) 1.62
Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. Mol Cell Biol (2000) 1.53
The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Mol Cell Biol (2001) 1.40
Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood (2002) 1.37
MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. Gene (2002) 1.36
MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines. Oncogene (1999) 1.35
Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos. Genesis (2001) 1.35
MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol (2002) 1.29
Transcriptional activation is a key function encoded by MLL fusion partners. Leukemia (2003) 1.28
Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Exp Hematol (1995) 1.23
Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein. Proc Natl Acad Sci U S A (1997) 1.12
The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator. Leukemia (1999) 1.09
Isolation and characterization of a pufferfish MLL (mixed lineage leukemia)-like gene (fMll) reveals evolutionary conservation in vertebrate genes related to Drosophila trithorax. Oncogene (1998) 0.96
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol (2004) 6.55
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell (2006) 6.34
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev (2003) 4.71
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell (2009) 4.43
Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell (2008) 4.20
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev (2007) 4.07
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev (2003) 4.00
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A (2001) 3.87
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell (2005) 3.70
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell (2010) 3.47
A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol (2008) 2.68
Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell (2003) 2.54
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature (2008) 2.51
MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell (2003) 2.33
Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin. Proc Natl Acad Sci U S A (2003) 2.33
Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol (2007) 2.14
Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell (2008) 2.08
The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res (2010) 1.88
Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. Blood (2003) 1.84
Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood (2002) 1.79
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet (2002) 1.75
MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell (2003) 1.65
The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood (2002) 1.64
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. Cancer Cell (2010) 1.57
Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease. Circ Res (2008) 1.54
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A (2003) 1.53
Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood (2002) 1.37
Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. Dev Biol (2003) 1.37
Therapeutic targeting of MLL. Blood (2009) 1.36
B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood (2007) 1.30
MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol (2002) 1.29
Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol (2004) 1.28
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development (2005) 1.25
Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer Cell (2011) 1.25
Pbx3 deficiency results in central hypoventilation. Am J Pathol (2004) 1.22
The TALE homeodomain protein Pbx2 is not essential for development and long-term survival. Mol Cell Biol (2004) 1.21
Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. Mol Cell Biol (2003) 1.21
Epigenetic roles of MLL oncoproteins are dependent on NF-κB. Cancer Cell (2013) 1.20
Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1. Mol Cell (2003) 1.20
Pbx1 is essential for adrenal development and urogenital differentiation. Genesis (2003) 1.20
MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res (2011) 1.17
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol (2013) 1.17
Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biol (2010) 1.16
Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development (2008) 1.15
Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. J Clin Invest (2002) 1.07
Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells? Int J Hematol (2010) 0.98
Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2. Mol Cell Biol (2002) 0.96
Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol (2010) 0.94
Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. J Cell Sci (2011) 0.92
Dimerization: a versatile switch for oncogenesis. Blood (2004) 0.92
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest (2015) 0.92
Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. Blood (2010) 0.88
Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner. Int J Dev Biol (2009) 0.87
Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors. J Cell Sci (2013) 0.87
PBX1: a novel stage-specific regulator of adipocyte development. Stem Cells (2011) 0.86
A novel Gli3 enhancer controls the Gli3 spatiotemporal expression pattern through a TALE homeodomain protein binding site. Mol Cell Biol (2011) 0.84
TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. J Cell Sci (2011) 0.82
Preview. Mutant CEBPA: Priming Stem Cells for Myeloid Leukemogenesis. Cell Stem Cell (2009) 0.80
PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells. Cancer Cell (2006) 0.80
MLL becomes functional through intra-molecular interaction not by proteolytic processing. PLoS One (2013) 0.79
In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla. Brain Res Dev Brain Res (2004) 0.79
Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells. Cancer Sci (2015) 0.78
Essential role for Pbx1 in corneal morphogenesis. Invest Ophthalmol Vis Sci (2009) 0.77
Genomics: The path to retinoblastoma. Nature (2012) 0.77
Novel methods and approaches to acute lymphoblastic leukemia drug discovery. Expert Opin Drug Discov (2014) 0.76