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De novo gene disruptions in children on the autistic spectrum. Neuron (2012) 9.69

An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell (2010) 5.00

TET2 promotes histone O-GlcNAcylation during gene transcription. Nature (2012) 2.92

Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol (2012) 2.74

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J (2013) 2.70

The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta (2009) 2.66

Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A (2010) 2.47

Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature (2011) 2.24

Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24

GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc Natl Acad Sci U S A (2009) 2.12

The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96

O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer (2011) 1.87

Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86

Interpreting the language of histone and DNA modifications. Biochim Biophys Acta (2014) 1.80

Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol (2013) 1.65

O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol (2010) 1.50

A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Genes Dev (2009) 1.49

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metab (2012) 1.46

O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Nat Commun (2011) 1.42

Retracted ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. J Biol Chem (2009) 1.35

O-GlcNAc transferase regulates mitotic chromatin dynamics. J Biol Chem (2010) 1.33

Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells. J Biol Chem (2013) 1.24

SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22

Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr (2015) 1.20

Modification of histones by sugar β-N-acetylglucosamine (GlcNAc) occurs on multiple residues, including histone H3 serine 10, and is cell cycle-regulated. J Biol Chem (2011) 1.20

O-GlcNAcylation: A New Cancer Hallmark? Front Endocrinol (Lausanne) (2013) 1.16

Molecular basis for chromatin binding and regulation of MLL5. Proc Natl Acad Sci U S A (2013) 1.15

Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components. Proc Natl Acad Sci U S A (2010) 1.13

Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome. Am J Hum Genet (2013) 1.12

The role of cotranscriptional histone methylations. Cold Spring Harb Symp Quant Biol (2011) 1.11

Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates. J Biol Chem (2012) 1.09

Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07

Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem (2013) 1.04

Epigenetic regulation by RARα maintains ligand-independent transcriptional activity. Nucleic Acids Res (2011) 1.03

Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism. Front Endocrinol (Lausanne) (2014) 0.99

Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription. Proc Natl Acad Sci U S A (2012) 0.98

Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. Proc Natl Acad Sci U S A (2012) 0.98

JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation. J Biol Chem (2012) 0.97

Regulation of intracellular signaling by extracellular glycan remodeling. ACS Chem Biol (2010) 0.97

The active site of O-GlcNAc transferase imposes constraints on substrate sequence. Nat Struct Mol Biol (2015) 0.97

UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions. Cell (2012) 0.96

Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology. Crit Rev Biochem Mol Biol (2014) 0.94

The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection. Viruses (2013) 0.94

O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins. Front Endocrinol (Lausanne) (2014) 0.93

O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. J Biol Chem (2012) 0.92

Epigenetic regulation of planarian stem cells by the SET1/MLL family of histone methyltransferases. Epigenetics (2012) 0.92

O-GlcNAcylation at promoters, nutrient sensors, and transcriptional regulation. Biochim Biophys Acta (2013) 0.91

Diverse functions of PHD fingers of the MLL/KMT2 subfamily. Biochim Biophys Acta (2013) 0.91

Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes. Cell Mol Life Sci (2013) 0.91

Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination. Mol Cell Proteomics (2013) 0.90

Talking to chromatin: post-translational modulation of polycomb group function. Epigenetics Chromatin (2009) 0.90

RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells. J Cell Physiol (2011) 0.89

Mll5 is required for normal spermatogenesis. PLoS One (2011) 0.89

Chromosome imbalance as a driver of sex disparity in disease. J Genomics (2014) 0.88

Solution NMR structure and histone binding of the PHD domain of human MLL5. PLoS One (2013) 0.88

PPAR-gamma Signaling Crosstalk in Mesenchymal Stem Cells. PPAR Res (2010) 0.87

Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry. J Biol Chem (2010) 0.86

Retracted Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes. J Biol Chem (2009) 0.85

Retracted Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1. J Biol Chem (2010) 0.84

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife (2015) 0.83

O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity. Amino Acids (2014) 0.83

MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin. J Cell Sci (2012) 0.83

Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription. Nucleic Acids Res (2010) 0.82

CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity. Proc Natl Acad Sci U S A (2014) 0.82

Neural crest specification and migration independently require NSD3-related lysine methyltransferase activity. Mol Biol Cell (2014) 0.80

Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter. J Mol Cell Biol (2015) 0.79

Post-translational modifications: A shift for the O-GlcNAc paradigm. Nat Chem Biol (2010) 0.77

Epigenetic modifications and potential new treatment targets in diabetic retinopathy. J Ophthalmol (2014) 0.77

The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression. Curr Signal Transduct Ther (2010) 0.76

Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people. Meta Gene (2014) 0.76

UpSET-ting the balance: modulating open chromatin features in metazoan genomes. Fly (Austin) (2013) 0.76

Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells. J Cell Mol Med (2016) 0.75

Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2013) 0.75

Setd5 is essential for mammalian development and co-transcriptional regulation of histone acetylation. Development (2016) 0.75

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

The language of covalent histone modifications. Nature (2000) 44.92

The role of chromatin during transcription. Cell (2007) 26.48

The mammalian epigenome. Cell (2007) 18.13

A decade of molecular biology of retinoic acid receptors. FASEB J (1996) 9.70

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev (2001) 9.54

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature (2007) 8.48

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell (2002) 6.72

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell (2004) 6.08

O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. Cell (1988) 5.82

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem (2007) 4.79

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev (2003) 4.73

Hepatic glucose sensing via the CREB coactivator CRTC2. Science (2008) 4.05

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature (2008) 3.98

Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature (2007) 3.59

Histone variants meet their match. Nat Rev Mol Cell Biol (2005) 2.47

The role of retinoids and retinoic acid receptors in normal hematopoiesis. Leukemia (2002) 2.13

Retracted The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell (2003) 1.88

O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. J Biol Chem (2004) 1.77

Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin. Cell (1989) 1.63

MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Oncogene (2002) 1.62

Retracted Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. EMBO J (2005) 1.43

CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells. J Clin Invest (2007) 1.07

Characterization of two novel retinoic acid-resistant cell lines derived from HL-60 cells following long-term culture with all-trans-retinoic acid. Jpn J Cancer Res (1999) 0.89

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86

Modulation of microRNA processing by p53. Nature (2009) 7.88

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12

Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03

Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46

Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell (2004) 5.30

Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity (2004) 4.48

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46

Retracted DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol (2007) 4.45

Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med (2008) 4.25

S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell (2003) 4.03

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell (2002) 3.99

Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82

Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol (2004) 3.70

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell (2008) 3.60

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature (2007) 3.59

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med (2012) 3.46

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42

Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37

Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med (2009) 3.32

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell (2003) 2.97

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest (2005) 2.91

Retracted DNA demethylation in hormone-induced transcriptional derepression. Nature (2009) 2.90

MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87

The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. Mol Cell (2005) 2.79

Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem (2004) 2.72

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70

30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol (2008) 2.62

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A (2006) 2.60

Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med (2005) 2.59

Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res (2012) 2.53

Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol (2009) 2.50

Retracted Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell (2009) 2.48

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell (2003) 2.31

Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell (2011) 2.30

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell (2010) 2.25

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell (2010) 2.20

Suppression of the antiviral response by an influenza histone mimic. Nature (2012) 2.18

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A (2006) 2.16

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Neuron (2002) 2.15

GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14

Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology (2003) 2.10

Retracted Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol (2003) 2.08

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev (2013) 2.07

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06

Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med (2012) 2.04

H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell (2013) 2.00

Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development (2002) 1.99

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A (2005) 1.97

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med (2012) 1.90

E protein silencing by the leukemogenic AML1-ETO fusion protein. Science (2004) 1.89

Retracted The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell (2003) 1.88

Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87

Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85

FGF10 maintains stem cell compartment in developing mouse incisors. Development (2002) 1.84

Limited internal radiation exposure associated with resettlements to a radiation-contaminated homeland after the Fukushima Daiichi nuclear disaster. PLoS One (2013) 1.81

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A (2008) 1.80

A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing. EMBO Rep (2011) 1.79

Requirements for FGF3 and FGF10 during inner ear formation. Development (2003) 1.76

Retracted Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol Cell (2002) 1.75

Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol (2006) 1.75

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A (2002) 1.72

Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest (2013) 1.70

HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A (2013) 1.67

CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc Natl Acad Sci U S A (2011) 1.65

STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem (2008) 1.64

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A (2009) 1.63

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A (2012) 1.61

Wnt/beta-catenin and estrogen signaling converge in vivo. J Biol Chem (2004) 1.60

The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med (2010) 1.59

A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A (2006) 1.58